FR2049015A2 - 17-beta-acetoxy-3-beta-fluoro-oestr-5(10)- - ene process and intermediates - Google Patents

17-beta-acetoxy-3-beta-fluoro-oestr-5(10)- - ene process and intermediates

Info

Publication number
FR2049015A2
FR2049015A2 FR6911741A FR6911741A FR2049015A2 FR 2049015 A2 FR2049015 A2 FR 2049015A2 FR 6911741 A FR6911741 A FR 6911741A FR 6911741 A FR6911741 A FR 6911741A FR 2049015 A2 FR2049015 A2 FR 2049015A2
Authority
FR
France
Prior art keywords
beta
acetoxy
delta5
fluoro
oestrene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR6911741A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to FR6911741A priority Critical patent/FR2049015A2/en
Publication of FR2049015A2 publication Critical patent/FR2049015A2/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

17-Beta-actoxy-3-beta-fluoro-oestr-5(10)-ene process and intermediates. Cpd. of formula (I): is prepd. from cpd. of partial formula (II) via 3 beta-fluoro-5 alpha-bromo-6 beta, 17 beta-di-hydroxy androstane, 17 beta-acetoxy-19 hydroxy-DELTA5 androstane, 17 beta-acetoxy-19 methyl sulphonoxy DELTA5 androstene, 6 beta-hydroxymethyl-17 beta hydroxy DELTA5(10) oestrene, 6 beta-acetoxy methyl-17 beta acetoxy DELTA5(10) oestrene, 6 beta-hydroxymethyl 17 beta-acetoxy DELTA5(10) oestrene, and finally 6 beta-formyl 17 beta-acetoxy DELTA5(10) oestrene.
FR6911741A 1968-07-26 1969-04-16 17-beta-acetoxy-3-beta-fluoro-oestr-5(10)- - ene process and intermediates Pending FR2049015A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR6911741A FR2049015A2 (en) 1968-07-26 1969-04-16 17-beta-acetoxy-3-beta-fluoro-oestr-5(10)- - ene process and intermediates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR160854A FR1602905A (en) 1968-07-26 1968-07-26
FR6911741A FR2049015A2 (en) 1968-07-26 1969-04-16 17-beta-acetoxy-3-beta-fluoro-oestr-5(10)- - ene process and intermediates

Publications (1)

Publication Number Publication Date
FR2049015A2 true FR2049015A2 (en) 1971-03-26

Family

ID=8653110

Family Applications (2)

Application Number Title Priority Date Filing Date
FR160854A Expired FR1602905A (en) 1968-07-26 1968-07-26
FR6911741A Pending FR2049015A2 (en) 1968-07-26 1969-04-16 17-beta-acetoxy-3-beta-fluoro-oestr-5(10)- - ene process and intermediates

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR160854A Expired FR1602905A (en) 1968-07-26 1968-07-26

Country Status (1)

Country Link
FR (2) FR1602905A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011138460A1 (en) * 2010-05-07 2011-11-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Progesterone receptor antagonists and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011138460A1 (en) * 2010-05-07 2011-11-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Progesterone receptor antagonists and uses thereof

Also Published As

Publication number Publication date
FR1602905A (en) 1971-02-22

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