FR2047865A2 - Naphthacene derivs anti-tumour - Google Patents

Naphthacene derivs anti-tumour

Info

Publication number
FR2047865A2
FR2047865A2 FR6918032A FR6918032A FR2047865A2 FR 2047865 A2 FR2047865 A2 FR 2047865A2 FR 6918032 A FR6918032 A FR 6918032A FR 6918032 A FR6918032 A FR 6918032A FR 2047865 A2 FR2047865 A2 FR 2047865A2
Authority
FR
France
Prior art keywords
tumour
derivs
naphthacene
sulphomethylamino
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6918032A
Other languages
French (fr)
Other versions
FR2047865B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Priority to FR6918032A priority Critical patent/FR2047865A2/en
Priority to FI691982A priority patent/FI51808C/en
Priority to US841552A priority patent/US3665018A/en
Priority to NO02942/69A priority patent/NO128710B/no
Priority to DK380469AA priority patent/DK127412B/en
Priority to IL32619A priority patent/IL32619A/en
Priority to IE955/69A priority patent/IE33477B1/en
Priority to GB1228570D priority patent/GB1228570A/en
Priority to BE736079D priority patent/BE736079A/xx
Priority to SE09949/69A priority patent/SE360067B/xx
Priority to CH1076569A priority patent/CH500930A/en
Priority to NL6910860.A priority patent/NL164271C/en
Priority to DE1935967A priority patent/DE1935967C3/en
Priority to ES369528A priority patent/ES369528A1/en
Priority to AT680469A priority patent/AT286499B/en
Publication of FR2047865A2 publication Critical patent/FR2047865A2/en
Application granted granted Critical
Publication of FR2047865B2 publication Critical patent/FR2047865B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compds. (I) and their salts with acids and bases. R = cyclohexyl substd. by aminomethyl or by one or more amino, (1-5C)-alkylamino, (1-5C)-dialkylamino, sulphomethylamino and opt. by one or more OH or 1-5C-alkanoyloxy groups or a phenyl (1-5C)-alkyl radical wherein the alkyl radical is substd. by (ClCH2CH2)2N or piperidyl. Anti-tumour agents of low toxicity. (b) (I R= aminocyclohexyl) (I, R= sulphomethylamino-cyclohexyl) In any reaction, free amino groups are protected and the protecting agent subsequently removed. (II) is the aglycone of daunorubicin (rubidomycin) and prepd. therefrom by acid hydrolysis.
FR6918032A 1968-07-15 1969-06-02 Naphthacene derivs anti-tumour Granted FR2047865A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR6918032A FR2047865A2 (en) 1969-06-02 1969-06-02 Naphthacene derivs anti-tumour
FI691982A FI51808C (en) 1968-07-15 1969-07-03 Method for the preparation of naphthacene derivatives of new tumors.
SE09949/69A SE360067B (en) 1968-07-15 1969-07-14
DK380469AA DK127412B (en) 1968-07-15 1969-07-14 Analogous process for the preparation of therapeutically active naphthacene derivatives or their therapeutically acceptable acid addition salts, quaternary ammonium salts or metal salts.
IL32619A IL32619A (en) 1968-07-15 1969-07-14 Naphthacene derivatives,process for the preparation thereof and compositions containing the same
IE955/69A IE33477B1 (en) 1968-07-15 1969-07-14 Naphthacene derivatives
GB1228570D GB1228570A (en) 1968-07-15 1969-07-14
BE736079D BE736079A (en) 1968-07-15 1969-07-14
US841552A US3665018A (en) 1968-07-15 1969-07-14 Naphthacene derivatives
CH1076569A CH500930A (en) 1968-07-15 1969-07-14 Process for the preparation of naphtacene derivatives
NO02942/69A NO128710B (en) 1968-07-15 1969-07-14
NL6910860.A NL164271C (en) 1968-07-15 1969-07-15 PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATION WITH AN ACTION AGAINST TUMORS AND LEUKEMIA.
DE1935967A DE1935967C3 (en) 1968-07-15 1969-07-15 Naphthacene derivatives, processes for their preparation and pharmaceutical compositions containing these compounds
ES369528A ES369528A1 (en) 1968-07-15 1969-07-15 Naphthacene derivatives
AT680469A AT286499B (en) 1968-07-15 1969-07-15 Process for the production of new naphthacene derivatives, their salts and quaternary ammonium derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6918032A FR2047865A2 (en) 1969-06-02 1969-06-02 Naphthacene derivs anti-tumour

Publications (2)

Publication Number Publication Date
FR2047865A2 true FR2047865A2 (en) 1971-03-19
FR2047865B2 FR2047865B2 (en) 1973-03-16

Family

ID=9034985

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6918032A Granted FR2047865A2 (en) 1968-07-15 1969-06-02 Naphthacene derivs anti-tumour

Country Status (1)

Country Link
FR (1) FR2047865A2 (en)

Also Published As

Publication number Publication date
FR2047865B2 (en) 1973-03-16

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