FR2043480A1 - Cephalosporin derivs - Google Patents

Cephalosporin derivs

Info

Publication number
FR2043480A1
FR2043480A1 FR6916944A FR6916944A FR2043480A1 FR 2043480 A1 FR2043480 A1 FR 2043480A1 FR 6916944 A FR6916944 A FR 6916944A FR 6916944 A FR6916944 A FR 6916944A FR 2043480 A1 FR2043480 A1 FR 2043480A1
Authority
FR
France
Prior art keywords
derivs
cephalosporin
cephalosporin derivs
prods
prepd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6916944A
Other languages
French (fr)
Other versions
FR2043480B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR6916944A priority Critical patent/FR2043480A1/en
Priority to IL32383A priority patent/IL32383A/en
Priority to PL1969134368A priority patent/PL82615B1/en
Priority to CH967969A priority patent/CH513921A/en
Priority to CH1929370A priority patent/CH536322A/en
Priority to BE735128D priority patent/BE735128A/xx
Priority to SU691342468A priority patent/SU483830A3/en
Priority to NL6909858A priority patent/NL6909858A/xx
Priority to DE19691932505 priority patent/DE1932505C3/en
Priority to AT618369A priority patent/AT301019B/en
Priority to GB32568/69A priority patent/GB1271014A/en
Priority to JP44050290A priority patent/JPS4840360B1/ja
Priority to ES379942A priority patent/ES379942A1/en
Publication of FR2043480A1 publication Critical patent/FR2043480A1/en
Application granted granted Critical
Publication of FR2043480B1 publication Critical patent/FR2043480B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/42—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by an araliphatic carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Cephalosporin derivs. of formula (I) are prepd. by condensation and reduction of (II) and (III): (where X = an anion; X1 = a reactive gp. e.g., halogen). The prods. are active against Gram-positive bacteria, esp. Staphylococcus.
FR6916944A 1968-06-27 1969-05-23 Cephalosporin derivs Granted FR2043480A1 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR6916944A FR2043480A1 (en) 1969-05-23 1969-05-23 Cephalosporin derivs
IL32383A IL32383A (en) 1968-06-27 1969-06-11 Process for preparing acylated derivatives of ypsilon-lactams of cephalosporin and compounds of this type
CH967969A CH513921A (en) 1968-06-27 1969-06-24 New process for the preparation of acylated cephalosporin derivatives
CH1929370A CH536322A (en) 1968-06-27 1969-06-24 New process for the preparation of acylated cephalosporin derivatives
PL1969134368A PL82615B1 (en) 1968-06-27 1969-06-24 Cephalosporin derivatives, processes for their preparation, and compositions incorporating them [gb1271014a]
SU691342468A SU483830A3 (en) 1968-06-27 1969-06-25 Method for preparing 7-acylaminocephalosporins
BE735128D BE735128A (en) 1968-06-27 1969-06-25
NL6909858A NL6909858A (en) 1968-06-27 1969-06-26
DE19691932505 DE1932505C3 (en) 1968-06-27 1969-06-26 Racemic or optically active γ-lactam of 6H, TH-cis ^ -p-aminophenylacetamido-saminomethyl-ceph-3-em-4-carboxylic acid and its salts and a process for their preparation
AT618369A AT301019B (en) 1968-06-27 1969-06-27 Process for the preparation of new cephalosporin derivatives
GB32568/69A GB1271014A (en) 1968-06-27 1969-06-27 Cephalosporin derivatives, processes for their preparation, and compositions incorporating them
JP44050290A JPS4840360B1 (en) 1968-06-27 1969-06-27
ES379942A ES379942A1 (en) 1969-05-23 1970-05-22 A procedure for the preparation of the salts of the gamma-lactama of the acid 6h, 7h-cis-7- (para-aminopenylacetamido) -3-aminomethyl-cef-3-em-4-carboxylic in the optically active or racemical form. (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6916944A FR2043480A1 (en) 1969-05-23 1969-05-23 Cephalosporin derivs

Publications (2)

Publication Number Publication Date
FR2043480A1 true FR2043480A1 (en) 1971-02-19
FR2043480B1 FR2043480B1 (en) 1974-08-09

Family

ID=9034548

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6916944A Granted FR2043480A1 (en) 1968-06-27 1969-05-23 Cephalosporin derivs

Country Status (2)

Country Link
ES (1) ES379942A1 (en)
FR (1) FR2043480A1 (en)

Also Published As

Publication number Publication date
ES379942A1 (en) 1972-09-16
FR2043480B1 (en) 1974-08-09

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Legal Events

Date Code Title Description
ST Notification of lapse