FR2043464A1 - Benzoxazine and benzothiazine derivs cns depressants - Google Patents

Benzoxazine and benzothiazine derivs cns depressants

Info

Publication number
FR2043464A1
FR2043464A1 FR6915060A FR6915060A FR2043464A1 FR 2043464 A1 FR2043464 A1 FR 2043464A1 FR 6915060 A FR6915060 A FR 6915060A FR 6915060 A FR6915060 A FR 6915060A FR 2043464 A1 FR2043464 A1 FR 2043464A1
Authority
FR
France
Prior art keywords
alkyl
aryl
derivs
benzothiazine
benzoxazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6915060A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Priority to FR6915060A priority Critical patent/FR2043464A1/en
Publication of FR2043464A1 publication Critical patent/FR2043464A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/16—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with only hydrogen or carbon atoms directly attached in positions 2 and 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of general formula:- (I) and salts thereof. Ar = (X')n-substd. aryl (aryl includes furyl, naphthyl, thienyl, pyridyl) R = H, alkyl, (X2)n-substd. aryl R', R" = H or together form =O Y = O, S, SO, SO2 X, X', X2 = same or different H, alkyl, alkoxy, NH2, dialkylamino, halo, alkylthio, OH, CN, NO2, CF3 n = 1-3; r = 0-3 A = alkylene Q = OH or B where B= a basic N-containing radical, e.g. NH2, alkylamino, dialkylamino, hydroxyalkylamino, di(hydroxy-alkyl)amino, phenylalkylamino, or a saturated N-containing heterocyclic ring having 5-7 ring atoms including an optional additional hetero atom CNS depressants, tranquillisers, antibacterials. 2,3-dihydro-3-(3-hydroxypropyl)-2-phenyl-4H-1, 3-benzothiazin-4-one, m.p. 124-126 deg.C.
FR6915060A 1969-05-09 1969-05-09 Benzoxazine and benzothiazine derivs cns depressants Withdrawn FR2043464A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR6915060A FR2043464A1 (en) 1969-05-09 1969-05-09 Benzoxazine and benzothiazine derivs cns depressants

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6915060A FR2043464A1 (en) 1969-05-09 1969-05-09 Benzoxazine and benzothiazine derivs cns depressants

Publications (1)

Publication Number Publication Date
FR2043464A1 true FR2043464A1 (en) 1971-02-19

Family

ID=9033793

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6915060A Withdrawn FR2043464A1 (en) 1969-05-09 1969-05-09 Benzoxazine and benzothiazine derivs cns depressants

Country Status (1)

Country Link
FR (1) FR2043464A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636065A1 (en) * 1988-09-08 1990-03-09 Fabre Sa Pierre NOVEL 2,3-DIHYDRO-ARYLACOYLAMINOALCOYL-3H-BENZOXAZINE-1,3-ONES-4 DERIVATIVES, THEIR PREPARATION AND THEIR USE AS THERAPEUTIC USEFUL MEDICAMENTS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB694489A (en) * 1950-01-16 1953-07-22 Ici Ltd Benzoxazine derivatives
US2776281A (en) * 1956-01-30 1957-01-01 American Cyanamid Co Certain dihydro-benzoxazine-ones and dihydro benzothiazine-ones and process

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB694489A (en) * 1950-01-16 1953-07-22 Ici Ltd Benzoxazine derivatives
US2776281A (en) * 1956-01-30 1957-01-01 American Cyanamid Co Certain dihydro-benzoxazine-ones and dihydro benzothiazine-ones and process

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636065A1 (en) * 1988-09-08 1990-03-09 Fabre Sa Pierre NOVEL 2,3-DIHYDRO-ARYLACOYLAMINOALCOYL-3H-BENZOXAZINE-1,3-ONES-4 DERIVATIVES, THEIR PREPARATION AND THEIR USE AS THERAPEUTIC USEFUL MEDICAMENTS
EP0359627A1 (en) * 1988-09-08 1990-03-21 Pierre Fabre Medicament 2,3-Dihydro-3-arylalkylaminoalkyl-4H-1,3-benzoxazin-4-one derivatives, their preparation and their use as therapeutic agents

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Legal Events

Date Code Title Description
ST Notification of lapse