FR2035899A1 - Substituted benzophenones as bacterial lipase - inhibitors - Google Patents

Substituted benzophenones as bacterial lipase - inhibitors

Info

Publication number
FR2035899A1
FR2035899A1 FR7010587A FR7010587A FR2035899A1 FR 2035899 A1 FR2035899 A1 FR 2035899A1 FR 7010587 A FR7010587 A FR 7010587A FR 7010587 A FR7010587 A FR 7010587A FR 2035899 A1 FR2035899 A1 FR 2035899A1
Authority
FR
France
Prior art keywords
inhibitors
substituted benzophenones
halogen
methyl
bacterial lipase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7010587A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck et Cie
Merck and Co Inc
Original Assignee
Merck et Cie
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck et Cie, Merck and Co Inc filed Critical Merck et Cie
Publication of FR2035899A1 publication Critical patent/FR2035899A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/784—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic with all keto groups bound to a non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composition in pharmaceutical support contains an inhibitor of formula: (in which R is methyl or halogen, R' is H, methyl or halogen and each R" is OH, methyl or halogen, n is 1, 2, or 3 and when n is 2 or 3, the R" may be identical or different), e.g. 2,3',4,6-tetramethyl-4'-hydroxyfluorobenzophenone, which may be prepared by reaction of an aromatic acid halide with an aromatic hydrocarbon in the presence of anhydrous aluminium chloride.
FR7010587A 1969-03-26 1970-03-24 Substituted benzophenones as bacterial lipase - inhibitors Withdrawn FR2035899A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81084069A 1969-03-26 1969-03-26

Publications (1)

Publication Number Publication Date
FR2035899A1 true FR2035899A1 (en) 1970-12-24

Family

ID=25204842

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7010587A Withdrawn FR2035899A1 (en) 1969-03-26 1970-03-24 Substituted benzophenones as bacterial lipase - inhibitors

Country Status (5)

Country Link
BE (1) BE747912A (en)
DE (1) DE2014514A1 (en)
FR (1) FR2035899A1 (en)
IL (1) IL34082A0 (en)
NL (1) NL7003628A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8700647A1 (en) * 1984-10-11 1986-11-16 Raychem Corp Preparation of aromatic carbonyl compounds.
DE59308382D1 (en) * 1992-11-29 1998-05-14 Clariant Gmbh New asymmetric, halogenated benzophenones and processes for their production
US6680344B1 (en) 1999-06-01 2004-01-20 The University Of Texas Southwestern Medical Center Method of treating hair loss using diphenylmethane derivatives
AU3507700A (en) 1999-06-01 2000-12-18 University Of Texas Southwestern Medical Center, The Method of treating hair loss using diphenylether derivatives
MXPA01012494A (en) 1999-06-01 2002-07-02 Univ Texas Southwestern Med Ct Method of treating hair loss using sulfonyl thyromimetic compounds.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1231994A (en) * 1958-07-29 1960-10-04 Rohm & Haas Manufacturing process of diarylketones

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1231994A (en) * 1958-07-29 1960-10-04 Rohm & Haas Manufacturing process of diarylketones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
The Journal of the American Chemical Society, vol. 66, (1944), page 733 - 735 *

Also Published As

Publication number Publication date
IL34082A0 (en) 1970-05-21
BE747912A (en) 1970-09-25
DE2014514A1 (en) 1970-10-08
NL7003628A (en) 1970-09-29

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Legal Events

Date Code Title Description
ST Notification of lapse