FR2021123A1 - 1,3-diaminopropan-2-ols having cns and local anaesthe - tic activity - Google Patents

1,3-diaminopropan-2-ols having cns and local anaesthe - tic activity

Info

Publication number
FR2021123A1
FR2021123A1 FR6935183A FR6935183A FR2021123A1 FR 2021123 A1 FR2021123 A1 FR 2021123A1 FR 6935183 A FR6935183 A FR 6935183A FR 6935183 A FR6935183 A FR 6935183A FR 2021123 A1 FR2021123 A1 FR 2021123A1
Authority
FR
France
Prior art keywords
opt
alkyl
unsaturated
cns
local
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6935183A
Other languages
French (fr)
Inventor
Leone Dall Asta
Alessandro Degli Angeli
Andrea Pedrazzoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ERASME ET RECH APP SCIENT MED
Original Assignee
ERASME ET RECH APP SCIENT MED
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ERASME ET RECH APP SCIENT MED filed Critical ERASME ET RECH APP SCIENT MED
Publication of FR2021123A1 publication Critical patent/FR2021123A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

having CNS and local anaesthetic activity. M3A. are new compds. of formula: including their acid addition salts. where R2, R3 = H, opt. unsaturated alkyl (C1-C4), cycloalkyl (C3-C6), halogen, CF3; A 1-naphthyl group; R' = opt. unsaturated alkyl (C1-C6), cycloalkylmethyl (total C4-C7); B = monoalkylamino (alkyl opt. unsaturated C1-C6), monocycloalkylamino (C3-C6), Where R4, R5 = alkyl (C1-C6) opt. unsaturated or R4 and R5 and the attached N atom form a heterocyclic ring, optional containing another hetero-atom which, if N, may be substituted by opt. unsatd. alkyl (C1-C6)). Used as sympathaticolytic, myolitic, psychotropic, tranquillising, analgesic and esp. as local anaesthetic agents; low acute toxicity and well tolerated for prolonged use.
FR6935183A 1968-10-21 1969-10-14 1,3-diaminopropan-2-ols having cns and local anaesthe - tic activity Withdrawn FR2021123A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4991668 1968-10-21

Publications (1)

Publication Number Publication Date
FR2021123A1 true FR2021123A1 (en) 1970-07-17

Family

ID=10453982

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6935183A Withdrawn FR2021123A1 (en) 1968-10-21 1969-10-14 1,3-diaminopropan-2-ols having cns and local anaesthe - tic activity

Country Status (3)

Country Link
BE (1) BE740389A (en)
DE (1) DE1952872A1 (en)
FR (1) FR2021123A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088623A1 (en) * 1982-03-08 1983-09-14 Mitsubishi Gas Chemical Company, Inc. Polyamine compound of M-xylenediamine and its use as hardening agent

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2564465B1 (en) * 1984-05-16 1986-10-03 Cortial NOVEL 1,3-DIAMINO-PROPANOLS-2, THEIR PREPARATION METHODS AND THERAPEUTIC APPLICATIONS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088623A1 (en) * 1982-03-08 1983-09-14 Mitsubishi Gas Chemical Company, Inc. Polyamine compound of M-xylenediamine and its use as hardening agent

Also Published As

Publication number Publication date
DE1952872A1 (en) 1970-05-06
BE740389A (en) 1970-04-01

Similar Documents

Publication Publication Date Title
AU550774B2 (en) 1-aryl-2-aminomethyl cyclopropane carboxylates
JPS568361A (en) Pyroglutamic acid derivative and analogue
GB1120463A (en) Derivatives of 1,3-diazafluoranthene-1-oxide
ES369802A1 (en) N-phenylsuccinimide derivatives
GB1342520A (en) Alpha-alkyl-substituted benzyl or thenyl-benzyloxy derivatives of amines
FR2021123A1 (en) 1,3-diaminopropan-2-ols having cns and local anaesthe - tic activity
GB1117063A (en) N-substituted ortho-aminoarylketimines
FR2024548A1 (en) Ortho-substd phenethylamines and medicaments
ES405456A1 (en) 7-Alkoxycarbonyl-4-hydroxymethyl-1-phthalazone compounds
ES8307258A1 (en) Cephalosporins, processes for their preparation and pharmaceutical compositions containing these compounds.
GB1064293A (en) Substituted 2-pyrrylketones
GB1124261A (en) Naphthofuran derivatives
GB1079467A (en) N-(4-amino-2-butynyl) cyclicimides
ES345690A1 (en) 2-aminomethyl benzofuran derivatives
GB1046001A (en) Propanolamine derivatives
ES402660A1 (en) 2-(Aryl)-3-(dimethylamino)butyl-3,4,5-trimethoxybenzoates
ES357055A1 (en) 5-substituted benzodiazepines
GB1081635A (en) Novel amines and a process for the preparation thereof
GB1037375A (en) A process for the manufacture of benzodiazepine derivatives
ES394969A1 (en) 5-(2-amino-alkoxy-phenoxy-methyl)-3-alkyl-isoxazoles - useful as hypotensives and sedatives
GB1067695A (en) 2-alkyl-4-alkylamino-6-alkoxy-s-triazines
ES394968A1 (en) 5-(2-amino-alkoxy-phenoxy-methyl)-3-alkyl-isoxazoles - useful as hypotensives and sedatives
FR2244514A1 (en) 1,2-Dihydroquinoline derivs - useful as anti-inflammatories
GB1164496A (en) 0-Oxaphenanthridine Derivatives and Method for the Preparation
FR2085645A1 (en) 1-phenyl-2,3-benzodiazepin-4-ones - as tranquillizers

Legal Events

Date Code Title Description
RE Withdrawal of published application