FR2015199A1 - Hypoglycaemic indolyl (or furyl or thienyl or pyrrolyl) - pyridinium salts - Google Patents

Hypoglycaemic indolyl (or furyl or thienyl or pyrrolyl) - pyridinium salts

Info

Publication number
FR2015199A1
FR2015199A1 FR6922745A FR6922745A FR2015199A1 FR 2015199 A1 FR2015199 A1 FR 2015199A1 FR 6922745 A FR6922745 A FR 6922745A FR 6922745 A FR6922745 A FR 6922745A FR 2015199 A1 FR2015199 A1 FR 2015199A1
Authority
FR
France
Prior art keywords
lower alkyl
hypoglycaemic
pyrrolyl
indolyl
furyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6922745A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FR2015199A1 publication Critical patent/FR2015199A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Hypoglycaemic indolyl (or furyl or thienyl or pyrrolyl) pyridinium salts. N3A. Are of formula (I) (where R = lower alkyl, lower alkenyl, cycloalkyl (lower alkyl), or alkoxy, lower alkyl; where A = H, lower alkyl, lower O-alkyl, or hal; B = H, lower alkyl, lower alkenyl, cycloalkyl-lower alkyl, or lower alkoxy- lower alkyl; Y = H or lower alkyl; Z = O, S, or NH; and X = an anion e.g. Cl, Br, I). Preparation is by reacting (II) with (III) in a solvent at 0-150 degrees C.
FR6922745A 1968-08-07 1969-07-04 Hypoglycaemic indolyl (or furyl or thienyl or pyrrolyl) - pyridinium salts Withdrawn FR2015199A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75075168A 1968-08-07 1968-08-07
US75572168A 1968-08-27 1968-08-27

Publications (1)

Publication Number Publication Date
FR2015199A1 true FR2015199A1 (en) 1970-04-24

Family

ID=27115318

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6922745A Withdrawn FR2015199A1 (en) 1968-08-07 1969-07-04 Hypoglycaemic indolyl (or furyl or thienyl or pyrrolyl) - pyridinium salts

Country Status (5)

Country Link
BE (1) BE735578A (en)
DE (1) DE1933853A1 (en)
FR (1) FR2015199A1 (en)
IL (1) IL32503A0 (en)
NL (1) NL6910401A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006102079A1 (en) * 2005-03-17 2006-09-28 Novartis Ag N- [3- (1-amin0-5, 6, 7, 8-tetrahydro-2 , 4, 4b-triazafluoren-9-yl)-phenyl] benzamides as tyrosine/threonine kinase inhibitors, in particular b-raf kinase

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006102079A1 (en) * 2005-03-17 2006-09-28 Novartis Ag N- [3- (1-amin0-5, 6, 7, 8-tetrahydro-2 , 4, 4b-triazafluoren-9-yl)-phenyl] benzamides as tyrosine/threonine kinase inhibitors, in particular b-raf kinase

Also Published As

Publication number Publication date
IL32503A0 (en) 1969-08-27
BE735578A (en) 1970-01-05
NL6910401A (en) 1970-02-10
DE1933853A1 (en) 1970-02-12

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Legal Events

Date Code Title Description
ST Notification of lapse