FR2013455A1 - Organo arsenic or organo antimony peni - cillins - Google Patents
Organo arsenic or organo antimony peni - cillinsInfo
- Publication number
- FR2013455A1 FR2013455A1 FR6924765A FR6924765A FR2013455A1 FR 2013455 A1 FR2013455 A1 FR 2013455A1 FR 6924765 A FR6924765 A FR 6924765A FR 6924765 A FR6924765 A FR 6924765A FR 2013455 A1 FR2013455 A1 FR 2013455A1
- Authority
- FR
- France
- Prior art keywords
- organo
- alkylene
- arylene
- cillins
- peni
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 Organo arsenic Chemical compound 0.000 title abstract 4
- 229930182555 Penicillin Natural products 0.000 title abstract 3
- 229910052787 antimony Inorganic materials 0.000 title abstract 2
- 229910052785 arsenic Inorganic materials 0.000 title abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 4
- 125000000732 arylene group Chemical group 0.000 abstract 3
- 108010087702 Penicillinase Proteins 0.000 abstract 2
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 229950009506 penicillinase Drugs 0.000 abstract 2
- 150000002960 penicillins Chemical class 0.000 abstract 2
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 1
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 1
- 241000589884 Treponema pallidum Species 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical group C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 abstract 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/90—Antimony compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/66—Arsenic compounds
- C07F9/70—Organo-arsenic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
Abstract
Penicillins with side-chain R-CO-NH- at position 6, (where R = X-R1- R2 n- R3 m; R1 is alkyl, cycloalkyl, aralkyl, indolyalkyl, naphthyl, benzyl, thienyl, or substd. phenyl; R2 is S, O, NH, N-allylamino, alkylene, arylene, alkenylene or a substd. isoxazole or isothiazole ring; R3 is alkylene, alkenylene, arylene; n and m are each 0-4; X is -As=Z or -Sb=Z; Z is O, S or two alkoxy, aryloxy, arylamino, alkylathio, arylthio gps., or -O- R8 t-S-; R8 is alkylene, arylene, cycloalkylene, alkylene; t is 1-4) are prepd. by treating 6-amino-penicillanic acid with R-CO-Y (Y=halogen). These penicillins are stable to penicillinase and are active against penicillinase-producing organisms; by virtue of their As or Sb content they are also active against spirillae (Treponema pallidum) and trypanosomes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3494968 | 1968-07-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2013455A1 true FR2013455A1 (en) | 1970-04-03 |
Family
ID=10371976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR6924765A Withdrawn FR2013455A1 (en) | 1968-07-22 | 1969-07-21 | Organo arsenic or organo antimony peni - cillins |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2013455A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003509516A (en) * | 1999-09-20 | 2003-03-11 | ユニサーチ・リミテッド | Compounds substantially impermeable to cell membranes and uses thereof |
-
1969
- 1969-07-21 FR FR6924765A patent/FR2013455A1/en not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| NEANT * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003509516A (en) * | 1999-09-20 | 2003-03-11 | ユニサーチ・リミテッド | Compounds substantially impermeable to cell membranes and uses thereof |
| JP4707294B2 (en) * | 1999-09-20 | 2011-06-22 | ニューサウス イノベイションズ ピーティーワイ リミテッド | Substantially cell membrane impermeable compounds and uses thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |