FR2009078A1 - N-substd n-acyl pyrazolidine cpds intermediates for - Google Patents

N-substd n-acyl pyrazolidine cpds intermediates for

Info

Publication number
FR2009078A1
FR2009078A1 FR6916284A FR6916284A FR2009078A1 FR 2009078 A1 FR2009078 A1 FR 2009078A1 FR 6916284 A FR6916284 A FR 6916284A FR 6916284 A FR6916284 A FR 6916284A FR 2009078 A1 FR2009078 A1 FR 2009078A1
Authority
FR
France
Prior art keywords
aldehyde
subst
reacted
hydrazine
component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6916284A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2009078A1 publication Critical patent/FR2009078A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems

Abstract

Production of new N'-subst. N-acyl-pyrazolidine cpds. by reacting with loss of H2O, (A) an aldehyde or a reactive functional deriv. thereof with (B) an N'-monosubst. N-acyl-hydrazine and (C) an olefin the C=C double bond of which is comprised in a strained ring system and/or is conjugated with at least one further multiple bond. A large number of specific products are claimed per se. Intermediates, esp. for pharmaceuticals. Suitable aldehyde components include HCHO, PhCHO and 4-nitrobenzaldehyde; an example of an aldehyde reactive functional deriv. is EtOOCC A variety of subst. hydrazine starting materials can be used. Suitable olefinic starting materials include norbornene, benzo-norbornadiene, 1,4-dihydro-1,4-epoxynaphthalene, styrene, ethyl acrylate, ethyl cinnamate, 1,1-diphenylethylene, 1,2-dihydronaphthalene, acrylonitrile and indene. The process can be carried out in a number of ways. For example, the 3 components are mixed (either using equimolar proportions thereof in an inert solvent which permits azeotropic distillation of H2O, or using an excess of the aldehyde or olefin component to act as solvent) and refluxed 1-10 hrs., the condensate being passed through a water separator or over a solid drying agent. In one variant procedure, the aldehyde component is first reacted with the subst. hydrazine (e.g. by heating to ca 50 deg. in an inert solvent) and the resulting intermediate (optionally after isolation and purification) reacted with the olefinic component under the above water-separating conditions. In another variant procedure, the aldehyde component is reacted with the subst. hydrazine under dehydrating conditions and the resulting intermediate (without isolation) reacted with the olefinic component at elevated temp.
FR6916284A 1968-05-22 1969-05-20 N-substd n-acyl pyrazolidine cpds intermediates for Withdrawn FR2009078A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH765868 1968-05-22
CH1884568 1968-12-18
CH447069 1969-03-25

Publications (1)

Publication Number Publication Date
FR2009078A1 true FR2009078A1 (en) 1970-01-30

Family

ID=27174860

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6916284A Withdrawn FR2009078A1 (en) 1968-05-22 1969-05-20 N-substd n-acyl pyrazolidine cpds intermediates for

Country Status (2)

Country Link
DE (1) DE1926024A1 (en)
FR (1) FR2009078A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10346676A1 (en) 2003-10-08 2005-05-04 Bsh Bosch Siemens Hausgeraete Dishwasher with integrated spray channels

Also Published As

Publication number Publication date
DE1926024A1 (en) 1969-11-27

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