FR2005687A1 - 1-3-hydroxyphenyl-2-3-phenyl-2-methylprop-2-ylamino - Google Patents
1-3-hydroxyphenyl-2-3-phenyl-2-methylprop-2-ylaminoInfo
- Publication number
- FR2005687A1 FR2005687A1 FR6909745A FR6909745A FR2005687A1 FR 2005687 A1 FR2005687 A1 FR 2005687A1 FR 6909745 A FR6909745 A FR 6909745A FR 6909745 A FR6909745 A FR 6909745A FR 2005687 A1 FR2005687 A1 FR 2005687A1
- Authority
- FR
- France
- Prior art keywords
- phenyl
- oral
- mice
- methanol
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1-(3-Hydroxyphenyl)-2-(3-phenyl-2-methylprop-2-ylamino)-ethan-1-o- l Analgesic and anti-inflammatory agent. Oral LD50 in mice 725 mg/kg.; i.v. LD50 in mice 34 mg/kg. Single oral doses of 10-300 mg/kg. against kaolin- and carrageenin-induced oedema in the rat have a similar effect to that of 2,3-dimethyl-4-dimethylamino-1-phenyl-3-pyrazolin-5-one. An oral dose of 100 mg/kg reduces oedema by 30%. Single doses of 25-50 mg/kg. of the cpd. in rabbits increases the pain threshold by 30-60% when their dental pulp is electrically stimulated. 2-(3-Phenyl-2-methylpropylamino)-3'-hydroxy-acetophenone (65.4 g.) in methanol (400 ml) was hydrogenated over PtO2 (1.2 g.) at 45 deg.C and 2 atmos. in a rocking hydrogenator for 2 hrs. The catalyst was filtered off, washed with methanol and the combined filtrates were evap. The residue was dissolved in ether, the soln. was washed with water, dried and the solvent distilled. The residue was crystallised by cooling and seeding to give the title compound.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19681768167 DE1768167A1 (en) | 1968-04-06 | 1968-04-06 | 1- (3-Hydroxyphenyl) -2- [3-phenyl-2-methylpropyl- (2) -amino] -aethynol- (1) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2005687A1 true FR2005687A1 (en) | 1969-12-12 |
Family
ID=5699625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR6909745A Withdrawn FR2005687A1 (en) | 1968-04-06 | 1969-03-31 | 1-3-hydroxyphenyl-2-3-phenyl-2-methylprop-2-ylamino |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE730712A (en) |
| DE (1) | DE1768167A1 (en) |
| DK (1) | DK120160B (en) |
| FR (1) | FR2005687A1 (en) |
| IL (1) | IL31896A0 (en) |
| NL (1) | NL6904746A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0004835A1 (en) * | 1978-04-10 | 1979-10-17 | Aktiebolaget DRACO | Ethanolamine compounds, processes for their preparation, pharmaceutical preparations containing them and their medicinal use |
-
1968
- 1968-04-06 DE DE19681768167 patent/DE1768167A1/en active Pending
-
1969
- 1969-03-25 IL IL31896A patent/IL31896A0/en unknown
- 1969-03-26 DK DK166969AA patent/DK120160B/en unknown
- 1969-03-27 NL NL6904746A patent/NL6904746A/xx unknown
- 1969-03-28 BE BE730712D patent/BE730712A/xx unknown
- 1969-03-31 FR FR6909745A patent/FR2005687A1/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0004835A1 (en) * | 1978-04-10 | 1979-10-17 | Aktiebolaget DRACO | Ethanolamine compounds, processes for their preparation, pharmaceutical preparations containing them and their medicinal use |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1768167A1 (en) | 1971-08-05 |
| NL6904746A (en) | 1969-10-08 |
| BE730712A (en) | 1969-09-29 |
| IL31896A0 (en) | 1969-05-28 |
| DK120160B (en) | 1971-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |