FR19C1056I1 - COMBINED TREATMENT OF TUMORS EXPRESSING CD38 - Google Patents

COMBINED TREATMENT OF TUMORS EXPRESSING CD38

Info

Publication number
FR19C1056I1
FR19C1056I1 FR19C1056C FR19C1056C FR19C1056I1 FR 19C1056 I1 FR19C1056 I1 FR 19C1056I1 FR 19C1056 C FR19C1056 C FR 19C1056C FR 19C1056 C FR19C1056 C FR 19C1056C FR 19C1056 I1 FR19C1056 I1 FR 19C1056I1
Authority
FR
France
Prior art keywords
combined treatment
tumors expressing
tumors
expressing
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR19C1056C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genmab AS
Original Assignee
Genmab AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39156080&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR19C1056(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genmab AS filed Critical Genmab AS
Publication of FR19C1056I1 publication Critical patent/FR19C1056I1/en
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
FR19C1056C 2006-09-26 2019-10-09 COMBINED TREATMENT OF TUMORS EXPRESSING CD38 Active FR19C1056I1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84732906P 2006-09-26 2006-09-26
DKPA200601232 2006-09-26
PCT/DK2007/000418 WO2008037257A2 (en) 2006-09-26 2007-09-26 Anti-cd38 plus corticosteroids plus a non-corticosteroid chemotherapeutic for treating tumors

Publications (1)

Publication Number Publication Date
FR19C1056I1 true FR19C1056I1 (en) 2019-11-15

Family

ID=39156080

Family Applications (6)

Application Number Title Priority Date Filing Date
FR19C1057C Active FR19C1057I1 (en) 2006-09-26 2019-10-09 COMBINED TREATMENT OF TUMORS EXPRESSING CD38
FR19C1056C Active FR19C1056I1 (en) 2006-09-26 2019-10-09 COMBINED TREATMENT OF TUMORS EXPRESSING CD38
FR19C1055C Active FR19C1055I1 (en) 2006-09-26 2019-10-09 COMBINED TREATMENT OF TUMORS EXPRESSING CD38
FR20C1034C Active FR20C1034I1 (en) 2006-09-26 2020-07-16 COMBINATION TREATMENT OF CD38-EXPRESSING TUMORS
FR21C1063C Active FR21C1063I1 (en) 2006-09-26 2021-12-20 COMBINATION TREATMENT OF CD38-EXPRESSING TUMORS
FR21C1062C Active FR21C1062I1 (en) 2006-09-26 2021-12-20 COMBINATION TREATMENT OF CD38-EXPRESSING TUMORS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR19C1057C Active FR19C1057I1 (en) 2006-09-26 2019-10-09 COMBINED TREATMENT OF TUMORS EXPRESSING CD38

Family Applications After (4)

Application Number Title Priority Date Filing Date
FR19C1055C Active FR19C1055I1 (en) 2006-09-26 2019-10-09 COMBINED TREATMENT OF TUMORS EXPRESSING CD38
FR20C1034C Active FR20C1034I1 (en) 2006-09-26 2020-07-16 COMBINATION TREATMENT OF CD38-EXPRESSING TUMORS
FR21C1063C Active FR21C1063I1 (en) 2006-09-26 2021-12-20 COMBINATION TREATMENT OF CD38-EXPRESSING TUMORS
FR21C1062C Active FR21C1062I1 (en) 2006-09-26 2021-12-20 COMBINATION TREATMENT OF CD38-EXPRESSING TUMORS

Country Status (22)

Country Link
US (3) US9040050B2 (en)
EP (3) EP2081595B1 (en)
JP (6) JP5476122B2 (en)
AU (2) AU2007302448C1 (en)
CA (1) CA2664740C (en)
CY (5) CY1121813T1 (en)
DK (1) DK2081595T3 (en)
EA (1) EA034877B1 (en)
ES (1) ES2732278T3 (en)
FR (6) FR19C1057I1 (en)
HR (1) HRP20191115T1 (en)
HU (6) HUE044136T2 (en)
IL (2) IL197727A (en)
LT (7) LT2081595T (en)
ME (1) ME03503B (en)
NZ (1) NZ576122A (en)
PL (1) PL2081595T3 (en)
PT (1) PT2081595T (en)
RS (1) RS59005B1 (en)
SI (1) SI2081595T1 (en)
TR (1) TR201910145T4 (en)
WO (1) WO2008037257A2 (en)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA015584B1 (en) * 2005-03-23 2011-10-31 Генмаб А/С Antibody to human cd38 and use thereof
CA2664740C (en) * 2006-09-26 2021-11-16 Genmab A/S Combination treatment of cd38-expressing tumors
EP2191842A1 (en) * 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine
EP2191840A1 (en) * 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan
EP2191841A1 (en) * 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine
JP2013508400A (en) * 2009-10-21 2013-03-07 イミュノジェン・インコーポレーテッド Novel dosing regimens and treatments
WO2011154453A1 (en) 2010-06-09 2011-12-15 Genmab A/S Antibodies against human cd38
MX350540B (en) 2010-09-27 2017-09-08 Morphosys Ag Anti-cd38 antibody and lenalidomide or bortezomib for the treatment of multiple myeloma and nhl.
UA112170C2 (en) * 2010-12-10 2016-08-10 Санофі ANTI-TUMOR COMBINATION CONTAINING AN ANTIBODY SPECIFICALLY RECOGNIZING CD38 AND BORTESOMB
JOP20210044A1 (en) * 2010-12-30 2017-06-16 Takeda Pharmaceuticals Co Anti-cd38 antibodies
US9427477B2 (en) 2011-05-09 2016-08-30 Mayo Foundation For Medical Education And Research Cancer treatments
KR102037541B1 (en) 2011-10-28 2019-10-29 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 Polypeptide constructs and uses thereof
EP2900232B1 (en) 2012-09-25 2017-11-15 MorphoSys AG Combinations and uses thereof
ES2899643T3 (en) 2012-10-01 2022-03-14 Mayo Found Medical Education & Res cancer treatments
US10342869B2 (en) 2012-12-07 2019-07-09 The Regents Of The University Of California Compositions comprising anti-CD38 antibodies and lenalidomide
UA118255C2 (en) * 2012-12-07 2018-12-26 Санофі Compositions comprising anti-cd38 antibodies and lenalidomide
RU2670127C2 (en) * 2013-03-13 2018-10-18 Санофи Compositions comprising antibody to cd38 and carfilzomib
PT2992013T (en) * 2013-04-29 2020-03-05 Teva Pharmaceuticals Australia Pty Ltd Anti-cd38 antibodies and fusions to attenuated interferon alpha-2b
US11117975B2 (en) 2013-04-29 2021-09-14 Teva Pharmaceuticals Australia Pty Ltd Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
US9603927B2 (en) 2014-02-28 2017-03-28 Janssen Biotech, Inc. Combination therapies with anti-CD38 antibodies
US9732154B2 (en) * 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
UA119352C2 (en) 2014-05-01 2019-06-10 Тева Фармасьютикалз Острейліа Пті Лтд Combination of lenalidomide or pomalidomide and cd38 antibody-attenuated interferon-alpha constructs, and the use thereof
EP3154595A4 (en) * 2014-06-16 2018-01-24 Mayo Foundation for Medical Education and Research Treating myelomas
EA035098B1 (en) * 2014-07-31 2020-04-27 Санофи Method of treating relapsed and/or refractory multiple myeloma
US10617757B2 (en) * 2014-08-08 2020-04-14 The Regents Of The University Of California Methods for treating multiple myeloma
PE20170676A1 (en) 2014-09-09 2017-05-22 Janssen Biotech Inc COMBINATION THERAPIES WITH ANTI-CD38 ANTIBODIES
US9446148B2 (en) 2014-10-06 2016-09-20 Mayo Foundation For Medical Education And Research Carrier-antibody compositions and methods of making and using the same
EA037749B1 (en) 2014-10-29 2021-05-18 Тева Фармасьютикалз Острэйлиа Пти Лтд INTERFERON 2b VARIANTS
BR112017011749A2 (en) * 2014-12-04 2018-05-15 Janssen Biotech Inc anti-cd38 antibodies for the treatment of acute myeloid leukemia
JP7160533B2 (en) * 2015-05-13 2022-10-25 モルフォシス・アーゲー Treatment of multiple myeloma (MM)
EA201792546A1 (en) 2015-05-20 2018-04-30 Янссен Байотек, Инк. ANTIBODIES TO CD38 FOR THE TREATMENT OF AMYLOIDOSIS OF LUNG CHAINS AND OTHER CD38-POSITIVE HEMATOLOGICAL MALIGNANT TUMORS
CN107708734B (en) 2015-06-22 2022-01-11 詹森生物科技公司 Combination therapy of heme malignancies with anti-CD 38 antibodies and survivin inhibitors
US20170044265A1 (en) * 2015-06-24 2017-02-16 Janssen Biotech, Inc. Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
MY193727A (en) * 2015-06-24 2022-10-27 Janssen Biotech Inc Immune modulation and treatment of solid tumors with antibodies that specifically bind cd38
TW201707725A (en) 2015-08-18 2017-03-01 美國馬友醫藥教育研究基金會 Carrier-antibody compositions and methods of making and using the same
TW201713360A (en) 2015-10-06 2017-04-16 Mayo Foundation Methods of treating cancer using compositions of antibodies and carrier proteins
US10781261B2 (en) 2015-11-03 2020-09-22 Janssen Biotech, Inc. Subcutaneous formulations of anti-CD38 antibodies and their uses
PT3827845T (en) 2015-11-03 2022-07-08 Janssen Biotech Inc Subcutaneous formulations of anti-cd38 antibodies and their uses
EP3399861A4 (en) 2016-01-07 2019-08-07 Mayo Foundation for Medical Education and Research Methods of treating cancer with interferon
EP3413874A4 (en) 2016-02-12 2020-01-22 Mayo Foundation for Medical Education and Research Hematologic cancer treatments
US11878061B2 (en) 2016-03-21 2024-01-23 Mayo Foundation For Medical Education And Research Methods for improving the therapeutic index for a chemotherapeutic drug
WO2017165440A1 (en) 2016-03-21 2017-09-28 Mayo Foundation For Medical Education And Research Methods for reducing toxicity of a chemotherapeutic drug
US10618969B2 (en) 2016-04-06 2020-04-14 Mayo Foundation For Medical Education And Research Carrier-binding agent compositions and methods of making and using the same
KR20190053203A (en) 2016-09-01 2019-05-17 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 Methods and compositions for targeting T-cell cancers
CA3035378A1 (en) 2016-09-01 2018-03-08 Mayo Foundation For Medical Education And Research Carrier-pd-l1 binding agent compositions for treating cancers
KR102486055B1 (en) 2016-09-06 2023-01-09 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 Paclitaxel-albumin-binder compositions and methods of use and preparation thereof
EP3509635A1 (en) 2016-09-06 2019-07-17 Vavotar Life Sciences LLC Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins
KR20230011473A (en) 2016-09-06 2023-01-20 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 Methods of treating pd-l1 expressing cancer
JP2020504086A (en) * 2016-11-23 2020-02-06 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Pharmaceutical combinations containing histone deacetylase inhibitors and CD38 inhibitors and methods of using the same
CN110248669B (en) 2016-12-09 2023-09-08 昂克医疗有限公司 Engineered natural killer cells and uses thereof
ES2911243T3 (en) * 2017-08-10 2022-05-18 Grifols Diagnostic Solutions Inc Compositions, methods and/or kits comprising a recombinant extracellular domain of human cd38
WO2019035938A1 (en) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. Multispecific molecules that bind to bcma and uses thereof
US11618787B2 (en) 2017-10-31 2023-04-04 Janssen Biotech, Inc. Methods of treating high risk multiple myeloma
JP6648171B2 (en) * 2018-02-02 2020-02-14 テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド Fusion with anti-CD38 antibody and attenuated interferon alpha-2B
EP3793599A1 (en) * 2018-05-16 2021-03-24 Janssen Biotech, Inc. Bcma/cd3 and gprdc5d/cd3 bispecific antibodies for use in cancer therapy
CA3106146A1 (en) 2018-07-13 2020-01-16 Genmab A/S Variants of cd38 antibody and uses thereof
JP2021526845A (en) 2018-07-13 2021-10-11 ゲンマブ エー／エス Treatment via trogocytosis with CD38 antibody
US20200109394A1 (en) * 2018-10-03 2020-04-09 Prescient Pharma Llc Compositions and methods for isolating circulating cells
WO2020187718A1 (en) 2019-03-15 2020-09-24 Morphosys Ag Anti-cd38 antibodies and pharmaceutical compositions thereof for the treatment of autoantibody-mediated autoimmune disease
CN113993543A (en) 2019-06-10 2022-01-28 武田药品工业株式会社 Combination therapy with anti-CD 38 antibodies
GB201916150D0 (en) 2019-11-06 2019-12-18 Univ Of Ireland Galway Treatment of multiple myeloma
CN112876563B (en) 2019-11-29 2022-08-16 康诺亚生物医药科技（成都）有限公司 Pharmaceutical composition, preparation method and application thereof
JP6853392B2 (en) * 2020-01-15 2021-03-31 テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド Fusion with anti-CD38 antibody and attenuated interferon alfa-2B
IL294453A (en) 2020-01-16 2022-09-01 Genmab As Formulations of cd38 antibodies and uses thereof
KR20220159989A (en) 2020-02-26 2022-12-05 바이오그래프 55, 인크. C19 C38 bispecific antibody
US11684676B2 (en) 2020-05-08 2023-06-27 University Of Southern California Site-specific antibody-drug conjugates by ADP-ribosyl cyclases
US20240101695A1 (en) * 2020-09-01 2024-03-28 The Regents Of The University Of California Immunoglobulin e antibody compositions and methods of use
AU2022208200A1 (en) 2021-01-14 2023-07-20 Morphosys Ag Anti-cd38 antibodies and their uses
TW202302642A (en) 2021-03-01 2023-01-16 德商莫菲西斯公司 Anti-cd38 antibodies for use in the treatment of antibody-mediated transplant rejection
TW202321303A (en) 2021-07-19 2023-06-01 德商莫菲西斯公司 Treatment of anti-pla2r-autoantibody-mediated membranous nephropathy

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4474893A (en) 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (en) 1984-08-15 1986-03-07 Res Dev Corp Of Japan Chimera monoclonal antibody and its preparation
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (en) 1984-12-04 1986-06-21 Teijin Ltd Expression of hybrid antibody gene
US5618920A (en) * 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
DE3689123T2 (en) 1985-11-01 1994-03-03 Xoma Corp MODULAR UNIT OF ANTIBODY GENES, ANTIBODIES MADE THEREOF AND USE.
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4954617A (en) 1986-07-07 1990-09-04 Trustees Of Dartmouth College Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5750172A (en) 1987-06-23 1998-05-12 Pharming B.V. Transgenic non human mammal milk
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
HUT53672A (en) 1988-02-25 1990-11-28 Gen Hospital Corp Quick immunoselective cloning process
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9014932D0 (en) 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
CA2109602C (en) 1990-07-10 2002-10-01 Gregory P. Winter Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
JPH06504186A (en) 1990-07-13 1994-05-19 ザ ジェネラル ホスピタル コーポレイション CD53 cell surface antigen and its uses
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
ES2246502T3 (en) 1990-08-29 2006-02-16 Genpharm International, Inc. TRANSGENIC NON-HUMAN ANIMALS ABLE TO PRODUCE HETEROLOGICAL ANTIBODIES.
US5194594A (en) 1990-09-07 1993-03-16 Techniclone, Inc. Modified antibodies
EP0564531B1 (en) 1990-12-03 1998-03-25 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
DK1279731T3 (en) 1991-03-01 2007-09-24 Dyax Corp Process for the development of binding mini-proteins
DE69233367T2 (en) 1991-04-10 2005-05-25 The Scripps Research Institute, La Jolla LIBRARIES OF HETERODIMERIC RECEPTORS BY PHAGEMIDES
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
WO1992022645A1 (en) 1991-06-14 1992-12-23 Genpharm International, Inc. Transgenic immunodeficient non-human animals
JPH06508880A (en) 1991-07-08 1994-10-06 ユニバーシティ　オブ　マサチューセッツ　アット　アムハースト Thermotropic liquid crystal segmented block copolymer
DE4122599C2 (en) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid for screening antibodies
WO1993006213A1 (en) 1991-09-23 1993-04-01 Medical Research Council Production of chimeric antibodies - a combinatorial approach
JPH05244982A (en) 1991-12-06 1993-09-24 Sumitomo Chem Co Ltd Humanized b-b10
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9223377D0 (en) 1992-11-04 1992-12-23 Medarex Inc Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes
AU6123894A (en) 1993-01-29 1994-08-15 Board Of Trustees Of The Leland Stanford Junior University Modulation of physiological responses of lymphocytes by cd38 or antibodies thereto
WO1994019935A1 (en) 1993-03-09 1994-09-15 Genzyme Corporation Isolation of components of interest from milk
AU6819494A (en) 1993-04-26 1994-11-21 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
GB9424449D0 (en) 1994-12-02 1995-01-18 Wellcome Found Antibodies
JP4233608B2 (en) 1996-10-15 2009-03-04 塩野義製薬株式会社 Autoantibody measurement method
WO1998016254A1 (en) 1996-10-17 1998-04-23 Immunomedics, Inc. Non-antigenic toxin-conjugate and fusion protein of internalizing receptor system
WO2000006194A2 (en) 1997-02-05 2000-02-10 Biotransplant, Inc. Depletion of cells responsible for antibody-mediated graft rejection
JP3835827B2 (en) 1997-05-02 2006-10-18 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ，アズ リプレゼンティッド バイ ザ セクレタリーオブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ Immunotoxin containing onc protein against malignant cells
US6171586B1 (en) * 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US6719977B1 (en) 1998-02-12 2004-04-13 The General Hospital Corporation Methods to potentiate cancer therapies
WO1999050392A1 (en) 1998-03-31 1999-10-07 Geron Corporation Methods and compositions for eliciting an immune response to a telomerase antigen
JP2003524587A (en) * 1998-06-05 2003-08-19 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ Use of a genetically engineered antibody against CD38 to treat multiple myeloma
EA004107B1 (en) * 1998-08-11 2003-12-25 Айдек Фармацевтикалс Корпорэйшн Combination therapies for b-cell lymphomas comprising administration of anti-cd20 antibody
US7223397B1 (en) 1999-01-07 2007-05-29 Research Development Foundation Potentiation of anti-CD38-Immunotoxin cytotoxicity
US20050037969A1 (en) * 1999-05-14 2005-02-17 Arbor Vita Corporation Molecular interactions in hematopoietic cells
IL147765A0 (en) 1999-07-29 2002-08-14 Medarex Inc HUMAN MONOCLONAL ANTIBODIES TO HER2/neu
EP1212422B1 (en) 1999-08-24 2007-02-21 Medarex, Inc. Human ctla-4 antibodies and their uses
EP1174440A1 (en) 2000-07-19 2002-01-23 U-BISys B.V. A selectively-expressed epitope on the human CD38 molecule detected by a phage display library-derived human scFv antibody fragment
US20070042436A1 (en) 2000-10-17 2007-02-22 Lund Frances E CD38 modulated chemotaxis
AU1331802A (en) 2000-10-17 2002-04-29 Trudeau Inst Inc Cd38 modulated chemotaxis
AU2002235141A1 (en) 2000-11-27 2002-06-03 Geron Corporation Glycosyltransferase vectors for treating cancer
IL155977A0 (en) 2000-11-30 2003-12-23 Medarex Inc Transgenic transchromosomal rodents for making human antibodies
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
RU2335507C2 (en) 2001-06-13 2008-10-10 Генмаб А/С Human monoclonal antibodies to receptor of epidermal growth factor (egfr), method of their preparation and usage, hybridome, transfectome, transgene animal, expression vector
US20040166490A1 (en) 2002-12-17 2004-08-26 Morris David W. Novel therapeutic targets in cancer
US20040019915A1 (en) * 2002-04-01 2004-01-29 Challita-Eid Pia M. Nucleic acid and corresponding protein entitled 213P1F11 useful in treatment and detection of cancer
EP1393720A1 (en) 2002-08-27 2004-03-03 Universiteit Utrecht Vesicle-encapsulated corticosteroids for treatment of cancer
KR20100050587A (en) 2002-10-17 2010-05-13 젠맵 에이/에스 Human monoclonal antibodies against cd20
CA2505991C (en) 2002-11-15 2018-02-27 Genmab A/S Human monoclonal antibodies against cd25
US7282568B2 (en) 2002-12-16 2007-10-16 Medarex, Inc. Human monoclonal antibodies against interleukin 8 (IL-8)
WO2005012493A2 (en) * 2003-07-31 2005-02-10 Immunomedics, Inc. Anti-cd19 antibodies
EP1689435A4 (en) 2003-10-22 2007-10-03 Univ Rochester Anti-thymocyte antiserum and use thereof to trigger b cell apoptosis
KR101128777B1 (en) * 2003-11-04 2012-04-13 조마 테크놀로지 리미티드 Use of antagonist anti-cd40 monoclonal antibodies for treatment of multiple myeloma
AU2004288714A1 (en) * 2003-11-06 2005-05-26 Celgene Corporation Methods and compositions using thalidomide for the treatment and management of cancers and other diseases.
CA2555185C (en) * 2004-02-06 2020-03-24 Morphosys Ag Anti-cd38 human antibodies and uses therefor
BRPI0507489A (en) 2004-02-06 2007-07-10 Morphosys Ag anti-cd38 human antibodies and their uses
US20050266008A1 (en) * 2004-03-29 2005-12-01 Medarex, Inc. Human anti-IRTA-5 antibodies
CN100416371C (en) * 2004-04-21 2008-09-03 大日本印刷株式会社 Color filter and liquid crystal display device provided with same
US20060019303A1 (en) * 2004-07-23 2006-01-26 Boehringer Ingelheim Pharmaceuticals, Inc. Method to identify and analyze genes having modified expression in stimulated T cells
EA015584B1 (en) 2005-03-23 2011-10-31 Генмаб А/С Antibody to human cd38 and use thereof
US20090123950A1 (en) 2005-05-24 2009-05-14 Morphosys Ag Generation And Profiling Of Fully Human Hucal Gold®-Derived Therapeutic Antibodies Specific For Human CD38
CA2664740C (en) * 2006-09-26 2021-11-16 Genmab A/S Combination treatment of cd38-expressing tumors
US20090076249A1 (en) * 2007-09-19 2009-03-19 Michel De Weers Antibodies against CD38 for treatment of multiple myeloma

Also Published As

Publication number Publication date
CY2019037I1 (en) 2020-05-29
US20200114000A1 (en) 2020-04-16
HRP20191115T1 (en) 2019-09-20
HUS2100056I1 (en) 2022-01-28
IL248204A0 (en) 2016-11-30
FR21C1063I1 (en) 2022-02-18
JP2014141492A (en) 2014-08-07
CY2019035I2 (en) 2020-05-29
FR19C1055I1 (en) 2019-11-15
JP2023120436A (en) 2023-08-29
LTPA2019516I1 (en) 2019-10-25
ES2732278T3 (en) 2019-11-21
HUS1900045I1 (en) 2019-11-28
HUS1900043I1 (en) 2019-11-28
CA2664740C (en) 2021-11-16
AU2013203186B2 (en) 2016-06-16
CY1121813T1 (en) 2020-05-29
EP3569245A1 (en) 2019-11-20
CY2020016I2 (en) 2020-11-25
WO2008037257A2 (en) 2008-04-03
AU2007302448B2 (en) 2013-12-19
CY2019036I2 (en) 2020-05-29
LT2081595T (en) 2019-07-10
LTPA2019515I1 (en) 2019-10-25
CY2020016I1 (en) 2020-11-25
PT2081595T (en) 2019-07-16
AU2013203186A1 (en) 2013-05-02
EP2081595A2 (en) 2009-07-29
EA034877B1 (en) 2020-04-01
FR21C1062I1 (en) 2022-02-18
JP2016188228A (en) 2016-11-04
EP3753576A1 (en) 2020-12-23
DK2081595T3 (en) 2019-07-15
AU2013203186C1 (en) 2019-02-14
IL197727A (en) 2017-01-31
PL2081595T3 (en) 2019-11-29
IL197727A0 (en) 2011-08-01
HUS1900044I1 (en) 2019-11-28
EA200970317A1 (en) 2009-10-30
LTPA2021015I1 (en) 2022-01-25
ME03503B (en) 2020-04-20
EP2081595B1 (en) 2019-04-10
TR201910145T4 (en) 2019-08-21
CY2019036I1 (en) 2020-05-29
LTPA2019514I1 (en) 2019-10-25
AU2007302448C1 (en) 2019-02-14
FR19C1057I1 (en) 2019-11-15
CA2664740A1 (en) 2008-04-03
JP6607825B2 (en) 2019-11-20
JP5476122B2 (en) 2014-04-23
US20100092489A1 (en) 2010-04-15
LTPA2021014I1 (en) 2022-01-10
HUE044136T2 (en) 2019-09-30
CY2019035I1 (en) 2020-05-29
NZ576122A (en) 2012-09-28
JP2010504363A (en) 2010-02-12
LTPA2020520I1 (en) 2020-07-27
AU2007302448A1 (en) 2008-04-03
JP6907165B2 (en) 2021-07-21
WO2008037257A3 (en) 2008-06-05
SI2081595T1 (en) 2019-10-30
CY2019037I2 (en) 2020-05-29
JP2021119198A (en) 2021-08-12
RS59005B1 (en) 2019-08-30
US20150231235A1 (en) 2015-08-20
HUS2100057I1 (en) 2022-01-28
JP2019001804A (en) 2019-01-10
US9040050B2 (en) 2015-05-26
FR20C1034I1 (en) 2020-10-02

Similar Documents

Publication Publication Date Title
FR19C1055I1 (en) COMBINED TREATMENT OF TUMORS EXPRESSING CD38
BRPI0821779A2 (en) therapeutic treatment of cancer
LTC2787345I2 (en) Remedies for treatment of Fabri disease
BRPI0908026A2 (en) Methods for the treatment of bowel diseases
BRPI0821660A2 (en) Combinations of therapeutic agents for cancer treatment
BRPI0814624A2 (en) TREATMENT OF PROGRESIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
BRPI0811265A2 (en) TREATMENT OF SYNUCLEINOPATHIES
ATE434620T1 (en) DIHYDROTHIENOPYRIMIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES
EP2049139A4 (en) Treatment of ras-expressing tumors
BRPI0719202A2 (en) Diagnosis and treatment of cancer using antiereg antibody
HK1131047A1 (en) Treatment of inflammatory diseases
IL197315A0 (en) Treatment of cancer
BRPI0921482A2 (en) treatment of acute lymphoblastic leukemia
BRPI0912683A2 (en) treatment of metastatic tumors
DE602007006594D1 (en) Endoscope treatment instrument
BRPI0815551A2 (en) TREATMENT THROUGH HUCBC OF BETA-AMYLOID DISEASE
DK2056842T3 (en) Modified galactosylceramide for the treatment of cancerous diseases
GB0700972D0 (en) Treatment of inflammatory disease
EP2385114A4 (en) Diagnosis of treatment of cancer using anti-tm4sf20 antibody
FI20095600A (en) Composition for the treatment of skin diseases
BRPI0715728A2 (en) treatment of cartilaginous disorder
LTC2066352I2 (en) Treatment of Multiple Sclerosis (MS) with Campan-1H
FR2897533B1 (en) OXIDIZING AGENT FOR THE TREATMENT OF HAIR
EP2170351A4 (en) Methods and compositions for treatment of cancer and other angiogenesis - related diseases
GB0720976D0 (en) Treatment of inflammatory disease