FR18C1006I2 - QUINOLINE DERIVATIVES HAVING AN AZOLYL GROUP AND QUINAZOLINE DERIVATIVES - Google Patents

QUINOLINE DERIVATIVES HAVING AN AZOLYL GROUP AND QUINAZOLINE DERIVATIVES

Info

Publication number
FR18C1006I2
FR18C1006I2 FR18C1006C FR18C1006C FR18C1006I2 FR 18C1006 I2 FR18C1006 I2 FR 18C1006I2 FR 18C1006 C FR18C1006 C FR 18C1006C FR 18C1006 C FR18C1006 C FR 18C1006C FR 18C1006 I2 FR18C1006 I2 FR 18C1006I2
Authority
FR
France
Prior art keywords
derivatives
represent
azolyl group
quinazoline
quinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR18C1006C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Kirin Co Ltd
Original Assignee
Kyowa Hakko Kirin Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18980738&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR18C1006(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kyowa Hakko Kirin Co Ltd filed Critical Kyowa Hakko Kirin Co Ltd
Publication of FR18C1006I1 publication Critical patent/FR18C1006I1/en
Application granted granted Critical
Publication of FR18C1006I2 publication Critical patent/FR18C1006I2/en
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

An object of the present invention is to provide compounds having potent antitumor activity. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein X and Z represent CH or N; Y represents O or S; R 1 , R 2 , and R 3 represent H, alkoxy or the like; R 4 represents H; R 5 , R 6 , R 7 , and R 8 represent H, halogen, alkoxy or the like; R 9 and R 10 represent H, alkyl or the like; and R 11 represents optionally substituted azolyl.
FR18C1006C 2001-04-27 2018-02-06 QUINOLINE DERIVATIVES HAVING AN AZOLYL GROUP AND QUINAZOLINE DERIVATIVES Active FR18C1006I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001132775 2001-04-27
PCT/JP2002/004279 WO2002088110A1 (en) 2001-04-27 2002-04-26 Quinoline derivative having azolyl group and quinazoline derivative

Publications (2)

Publication Number Publication Date
FR18C1006I1 FR18C1006I1 (en) 2018-03-16
FR18C1006I2 true FR18C1006I2 (en) 2019-03-01

Family

ID=18980738

Family Applications (1)

Application Number Title Priority Date Filing Date
FR18C1006C Active FR18C1006I2 (en) 2001-04-27 2018-02-06 QUINOLINE DERIVATIVES HAVING AN AZOLYL GROUP AND QUINAZOLINE DERIVATIVES

Country Status (25)

Country Link
US (2) US6821987B2 (en)
EP (2) EP1652847B1 (en)
JP (1) JP2010077131A (en)
KR (1) KR100879669B1 (en)
CN (1) CN1273466C (en)
AT (1) ATE396988T1 (en)
AU (1) AU2002255284B2 (en)
BE (1) BE2018C008I2 (en)
BR (1) BRPI0209216B8 (en)
CA (1) CA2445333C (en)
DE (2) DE60226912D1 (en)
DK (1) DK1382604T3 (en)
ES (1) ES2256466T3 (en)
FR (1) FR18C1006I2 (en)
HK (1) HK1070649A1 (en)
IL (1) IL158459A0 (en)
MX (1) MXPA03009662A (en)
NL (1) NL300927I9 (en)
NO (2) NO326325B1 (en)
NZ (1) NZ529046A (en)
PL (1) PL209822B1 (en)
RU (1) RU2283841C2 (en)
TW (1) TWI324154B (en)
WO (1) WO2002088110A1 (en)
ZA (1) ZA200307861B (en)

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Publication number Publication date
BE2018C008I2 (en) 2021-02-04
ES2256466T3 (en) 2006-07-16
DE60208364D1 (en) 2006-02-02
TWI324154B (en) 2010-05-01
US7211587B2 (en) 2007-05-01
DE60226912D1 (en) 2008-07-10
ZA200307861B (en) 2004-10-08
EP1652847A3 (en) 2006-08-02
HK1070649A1 (en) 2005-06-24
BR0209216A (en) 2004-07-06
EP1382604A1 (en) 2004-01-21
NL300927I1 (en) 2018-12-04
CA2445333A1 (en) 2002-11-07
ATE396988T1 (en) 2008-06-15
EP1652847B1 (en) 2008-05-28
BRPI0209216B1 (en) 2017-05-30
US20030087907A1 (en) 2003-05-08
PL209822B1 (en) 2011-10-31
EP1382604B1 (en) 2005-12-28
NO20034595D0 (en) 2003-10-14
CN1543459A (en) 2004-11-03
CA2445333C (en) 2011-03-22
EP1382604A4 (en) 2004-09-08
FR18C1006I1 (en) 2018-03-16
WO2002088110A1 (en) 2002-11-07
RU2283841C2 (en) 2006-09-20
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RU2003134376A (en) 2005-04-20
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NO2018005I1 (en) 2018-02-05
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