FR17C1059I2 - PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES - Google Patents

PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES

Info

Publication number
FR17C1059I2
FR17C1059I2 FR17C1059C FR17C1059C FR17C1059I2 FR 17C1059 I2 FR17C1059 I2 FR 17C1059I2 FR 17C1059 C FR17C1059 C FR 17C1059C FR 17C1059 C FR17C1059 C FR 17C1059C FR 17C1059 I2 FR17C1059 I2 FR 17C1059I2
Authority
FR
France
Prior art keywords
pyrrolopyrimidine compounds
pyrrolopyrimidine
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR17C1059C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Astex Therapeutics Ltd
Original Assignee
Novartis AG
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41171100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR17C1059(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG, Astex Therapeutics Ltd filed Critical Novartis AG
Publication of FR17C1059I1 publication Critical patent/FR17C1059I1/fr
Application granted granted Critical
Publication of FR17C1059I2 publication Critical patent/FR17C1059I2/en
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR17C1059C 2008-08-22 2017-12-15 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES Active FR17C1059I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9103708P 2008-08-22 2008-08-22
PCT/EP2009/060793 WO2010020675A1 (en) 2008-08-22 2009-08-20 Pyrrolopyrimidine compounds as cdk inhibitors

Publications (2)

Publication Number Publication Date
FR17C1059I1 FR17C1059I1 (en) 2018-02-16
FR17C1059I2 true FR17C1059I2 (en) 2019-01-11

Family

ID=41171100

Family Applications (1)

Application Number Title Priority Date Filing Date
FR17C1059C Active FR17C1059I2 (en) 2008-08-22 2017-12-15 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES

Country Status (49)

Country Link
US (8) US8685980B2 (en)
EP (2) EP2716643A1 (en)
JP (2) JP5560496B2 (en)
KR (2) KR20130140222A (en)
CN (2) CN103788100A (en)
AR (2) AR073116A1 (en)
AU (1) AU2009284098B2 (en)
BR (1) BRPI0917791B1 (en)
CA (1) CA2734802C (en)
CL (1) CL2011000306A1 (en)
CO (1) CO6341561A2 (en)
CR (1) CR20110101A (en)
CU (1) CU24062B1 (en)
CY (2) CY1115703T1 (en)
DK (1) DK2331547T3 (en)
DO (1) DOP2011000057A (en)
EA (1) EA019094B1 (en)
EC (1) ECSP11010843A (en)
ES (1) ES2522346T3 (en)
FR (1) FR17C1059I2 (en)
GE (1) GEP20135785B (en)
HK (1) HK1156625A1 (en)
HN (1) HN2011000542A (en)
HR (1) HRP20141018T1 (en)
HU (1) HUS1700051I1 (en)
IL (1) IL211164A (en)
JO (1) JO2924B1 (en)
LT (1) LTC2331547I2 (en)
LU (1) LUC00048I2 (en)
MA (1) MA32555B1 (en)
ME (1) ME01282B (en)
MX (1) MX2011001879A (en)
MY (1) MY150560A (en)
NI (1) NI201100042A (en)
NL (1) NL300909I2 (en)
NO (1) NO2017059I2 (en)
NZ (1) NZ591176A (en)
PE (1) PE20110419A1 (en)
PL (1) PL2331547T3 (en)
PT (1) PT2331547E (en)
RS (1) RS53574B1 (en)
SI (1) SI2331547T1 (en)
SM (1) SMT201500017B (en)
TN (1) TN2011000062A1 (en)
TW (1) TWI468409B (en)
UA (1) UA103628C2 (en)
UY (2) UY32067A (en)
WO (1) WO2010020675A1 (en)
ZA (1) ZA201100994B (en)

Families Citing this family (214)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8685980B2 (en) 2008-08-22 2014-04-01 Novartis Ag Pyrrolopyrimidine compounds and their uses
CA2761896A1 (en) 2009-05-13 2010-11-18 The University Of North Carolina At Chapel Hill Cyclin dependent kinase inhibitors and methods of use
UY33227A (en) * 2010-02-19 2011-09-30 Novartis Ag PIRROLOPIRIMIDINE COMPOUNDS AS INHIBITORS OF THE CDK4 / 6
UY33226A (en) * 2010-02-19 2011-09-30 Novartis Ag PIRROLOPIRIMIDINE COMPUTERS DEUTERATED AS INHIBITORS OF THE CDK4 / 6
CN102869358B (en) * 2010-04-13 2016-03-23 诺华股份有限公司 Be used for the treatment of the combination comprising cell cycle protein dependent kinase 4 or cell cycle protein dependent kinase 6 (CDK4/6) inhibitor and mTOR inhibitors of cancer
CN103221810B (en) 2010-08-18 2016-08-03 生命科技股份有限公司 Immersion coating for the micropore of electrochemical detection device
RU2621674C2 (en) * 2010-10-25 2017-06-07 Г1 Терапьютикс Инк., Inhibitors of cdk
US8691830B2 (en) 2010-10-25 2014-04-08 G1 Therapeutics, Inc. CDK inhibitors
AR083797A1 (en) * 2010-11-10 2013-03-20 Novartis Ag DIMETHYL ACID SUCCINATE 7-CYCLOPENTIL-2- (5-PIPERAZIN-1-IL-PIRIDIN-2-IL-AMINO) -7H-PIRROLO- [2,3-D] PIRIMIDIN-6-CARBOXILICO, PROCESS FOR PREPARE IT, INTERMEDIARIES OF SUCH SYNTHESIS AND PREPARATION PROCESS OF THE SAME
CN103501789A (en) 2010-11-17 2014-01-08 北卡罗来纳大学查珀尔希尔分校 Protection of renal tissues from ischemia through inhibition of the proliferative kinases CDK4 and CDK6
AU2014259534B2 (en) * 2011-01-04 2016-05-19 Novartis Ag Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (AMD)
CA2823665A1 (en) * 2011-01-04 2012-07-12 Novartis Ag Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (amd)
MX359406B (en) 2011-07-01 2018-09-27 Novartis Ag Combination therapy comprising a cdk4/6 inhibitor and a pi3k inhibitor for use in the treatment of cancer.
CN103781480A (en) 2011-07-01 2014-05-07 诺华股份有限公司 Combination therapy
WO2013059634A1 (en) 2011-10-20 2013-04-25 The Regents Of The University Of California Use of cdk9 inhibitors to reduce cartilage degradation
US9194840B2 (en) 2012-01-19 2015-11-24 Life Technologies Corporation Sensor arrays and methods for making same
CA2868966C (en) 2012-03-29 2021-01-26 Francis Xavier Tavares Lactam kinase inhibitors
CA2870019C (en) 2012-04-26 2020-08-18 Francis Xavier Tavares Synthesis of lactams
JP6209605B2 (en) 2012-06-28 2017-10-04 ノバルティス アーゲー Pyrrolidine derivatives and their use as complement pathway regulators
US9487483B2 (en) 2012-06-28 2016-11-08 Novartis Ag Complement pathway modulators and uses thereof
JP6154897B2 (en) 2012-06-28 2017-06-28 ノバルティス アーゲー Pyrrolidine derivatives and their use as complement pathway regulators
ES2647124T3 (en) 2012-06-28 2017-12-19 Novartis Ag Pyrrolidine derivatives and their use as modulators of the complement pathway
WO2014002051A2 (en) 2012-06-28 2014-01-03 Novartis Ag Complement pathway modulators and uses thereof
ES2687983T3 (en) 2012-07-12 2018-10-30 Novartis Ag Modulators of the complement path and uses thereof
AR091876A1 (en) * 2012-07-26 2015-03-04 Novartis Ag PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
AU2013296237B2 (en) 2012-08-03 2019-05-16 Foundation Medicine, Inc. Human papilloma virus as predictor of cancer prognosis
EP2742940B1 (en) 2012-12-13 2017-07-26 IP Gesellschaft für Management mbH Fumarate salt of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-l-aza-bicyclo-[2.2.2]octane for adminstration once daily, twice daily or thrice daily
WO2014097125A1 (en) 2012-12-20 2014-06-26 Novartis Ag Pharmaceutical combination comprising binimetinib
WO2014109858A1 (en) 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
EP3696276A1 (en) 2013-02-25 2020-08-19 Novartis AG Novel androgen receptor mutation
US9650358B2 (en) 2013-03-13 2017-05-16 Abbvie Inc. Pyridine CDK9 kinase inhibitors
CA2901929A1 (en) * 2013-03-13 2014-10-02 Abbvie Inc. Cdk9 kinase inhibitors
CA2903538A1 (en) * 2013-03-14 2014-10-02 Abbvie Inc. Pyrrolopyrimindine cdk9 kinase inhibitors
UY35419A (en) 2013-03-14 2014-10-31 Abbvie Inc PIRROLO KINASA CDK9 INHIBITORS (2,3- B) PIRIDINE
EP2970264A1 (en) 2013-03-14 2016-01-20 AbbVie Inc. Pyrrolo[2,3-b]pyridine cdk9 kinase inhibitors
US20140274896A1 (en) * 2013-03-15 2014-09-18 G1 Therapeutics, Inc. Transient Protection of Hematopoietic Stem and Progenitor Cells Against Ionizing Radiation
US9527857B2 (en) 2013-03-15 2016-12-27 GI Therapeutics, Inc. HSPC-sparing treatments for RB-positive abnormal cellular proliferation
CN105407723A (en) 2013-03-15 2016-03-16 G1治疗公司 Highly active anti-neoplastic and anti-proliferative agents
CN105209073A (en) 2013-03-21 2015-12-30 诺华股份有限公司 Combination therapy comprising a B-Raf inhibitor and a second inhibitor
WO2014172479A1 (en) 2013-04-16 2014-10-23 Memorial Sloan-Kettering Cancer Center Companion diagnostic for cdk4 inhibitors
HUE057061T2 (en) * 2013-08-14 2022-04-28 Novartis Ag Combination therapy for the treatment of cancer
JP6479812B2 (en) * 2013-08-28 2019-03-06 ノバルティス アーゲー Combination of an ALK inhibitor and a CDK inhibitor to treat a cell proliferative disorder
EP3757130A1 (en) 2013-09-26 2020-12-30 Costim Pharmaceuticals Inc. Methods for treating hematologic cancers
TW201605857A (en) * 2013-10-03 2016-02-16 赫孚孟拉羅股份公司 Therapeutic inhibitors of CDK8 and uses thereof
US20160257688A1 (en) * 2013-10-24 2016-09-08 Francis Xavier Tavares Process for Synthesis of Lactams
MX2016006894A (en) * 2013-11-27 2016-08-17 Novartis Ag Combination therapy comprising an inhibitor of jak, cdk and pim.
US9476853B2 (en) 2013-12-10 2016-10-25 Life Technologies Corporation System and method for forming microwells
WO2015095840A1 (en) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of cdk and erk inhibitors
CN105848656B (en) * 2013-12-23 2019-10-25 诺华股份有限公司 Pharmaceutical composition
US20160339023A1 (en) * 2013-12-23 2016-11-24 Fang Li Pharmaceutical Combinations
CA2935103C (en) * 2013-12-31 2018-08-28 Xuanzhu Pharma Co., Ltd. Kinase inhibitor and use thereof
US9949976B2 (en) 2013-12-31 2018-04-24 Xuanzhu Pharma Co., Ltd. Kinase inhibitor and use thereof
JOP20200094A1 (en) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc Antibody molecules to pd-1 and uses thereof
JOP20200096A1 (en) 2014-01-31 2017-06-16 Children’S Medical Center Corp Antibody molecules to tim-3 and uses thereof
AU2015229103C9 (en) 2014-03-14 2020-11-26 Immutep S.A.S Antibody molecules to LAG-3 and uses thereof
CN106659765B (en) 2014-04-04 2021-08-13 德玛医药 Use of dianhydrogalactitol and analogs or derivatives thereof for treating non-small cell lung cancer and ovarian cancer
WO2015160986A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
WO2015161287A1 (en) 2014-04-17 2015-10-22 G1 Therapeutics, Inc. Tricyclic lactams for use in the protection of normal cells during chemotherapy
CA2950330C (en) * 2014-05-28 2019-04-30 Shanghai Fochon Pharmaceutical Co Ltd Certain protein kinase inhibitors
CN105294737B (en) * 2014-07-26 2019-02-12 广东东阳光药业有限公司 The compound and application thereof of CDK type small molecular inhibitor
EP3191098A4 (en) 2014-09-12 2018-04-25 G1 Therapeutics, Inc. Combinations and dosing regimes to treat rb-positive tumors
WO2016040848A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
EP3925622A1 (en) 2014-09-13 2021-12-22 Novartis AG Combination therapies
US20170209574A1 (en) 2014-10-03 2017-07-27 Novartis Ag Combination therapies
MA41044A (en) 2014-10-08 2017-08-15 Novartis Ag COMPOSITIONS AND METHODS OF USE FOR INCREASED IMMUNE RESPONSE AND CANCER TREATMENT
TWI716362B (en) 2014-10-14 2021-01-21 瑞士商諾華公司 Antibody molecules to pd-l1 and uses thereof
AU2015333689A1 (en) 2014-10-14 2017-05-25 The Regents Of The University Of California Use of CDK9 and BRD4 inhibitors to inhibit inflammation
MX2017006167A (en) 2014-11-12 2018-03-23 Siamab Therapeutics Inc Glycan-interacting compounds and methods of use.
US9994579B2 (en) 2014-12-12 2018-06-12 Crystal Pharmatech Co., Ltd. Salt of pyrrolo[2,3-D]pyrimidine compound and novel polymorph of salt
CN105111215B (en) * 2014-12-12 2019-06-18 苏州晶云药物科技股份有限公司 A kind of crystal form and preparation method thereof of cyclin-dependent kinase inhibitor
US10138250B2 (en) 2014-12-12 2018-11-27 Crystal Pharmatech Co., Ltd. Salt of pyrrolo[2,3-D]pyrimidine compound and novel polymorph of salt
WO2016126889A1 (en) * 2015-02-03 2016-08-11 G1 Therapeutics, Inc. Cdk4/6 inhibitor dosage formulations for the protection of hematopoietic stem and progenitor cells during chemotherapy
JP6692826B2 (en) 2015-03-10 2020-05-13 アドゥロ バイオテック，インク． Compositions and methods for activation of "interferon gene stimulator" dependent signaling
CN107787226A (en) * 2015-03-25 2018-03-09 诺华股份有限公司 Drug regimen
EP4197530A1 (en) 2015-04-16 2023-06-21 Novartis AG Ribociclib tablet
CN106146515B (en) 2015-04-17 2020-09-04 常州隆赛医药科技有限公司 Preparation and application of novel kinase inhibitor
TWI696617B (en) 2015-04-28 2020-06-21 大陸商上海復尚慧創醫藥研究有限公司 Certain protein kinase inhibitor
PL3305785T3 (en) 2015-05-29 2021-12-27 Teijin Pharma Limited Pyrido[3,4-d]pyrimidine derivative and pharmaceutically acceptable salt thereof
CN105037236B (en) 2015-06-04 2017-07-28 苏州明锐医药科技有限公司 Rui Boxini intermediates and preparation method thereof
CN106336412A (en) * 2015-07-10 2017-01-18 南开大学 2-(N-oxidized aromatic ring-2 amino)-pyrrolopyrimidinyl and purines compound as CDK4/6 inhibitor
CN106699785A (en) * 2015-07-13 2017-05-24 南开大学 2-(N-oxide pyridine-2-ylamino)-pyrido[2,3-d]pyrimidin-7-one compound as CDK4/6 inhibitor
CN105130992B (en) * 2015-07-16 2018-02-09 苏州大学 Nitrogen-containing heterocycle compound, preparation method and purposes with kinase inhibiting activity
US20180222982A1 (en) 2015-07-29 2018-08-09 Novartis Ag Combination therapies comprising antibody molecules to pd-1
LT3317301T (en) 2015-07-29 2021-07-26 Novartis Ag Combination therapies comprising antibody molecules to lag-3
EP3316902A1 (en) 2015-07-29 2018-05-09 Novartis AG Combination therapies comprising antibody molecules to tim-3
EP3340987A1 (en) 2015-08-28 2018-07-04 Novartis AG Combination of ribociclib and dabrafenib for treating or preventing cancer
EP3340991A1 (en) 2015-08-28 2018-07-04 Novartis AG Combinations of the cdk4/6 inhibitor lee011 and the mek1/2 inhibitor trametinib, optionally further comprising the pi3k inhibitor byl719 to treat cancer
JP2018528952A (en) 2015-08-28 2018-10-04 ノバルティス アーゲー Pharmaceutical combination comprising PI3K inhibitor alpericib and CDK4 / 6 inhibitor ribocyclib and its use in the treatment / prevention of cancer
CN108348522A (en) 2015-08-28 2018-07-31 诺华股份有限公司 The pharmaceutical composition of (CDK4/6) the inhibitor LEE011 containing cyclin dependent kinase 4/6 (A) (=RIBOCICLIB) and (B) EGF-R ELISA (EGFR) inhibitor Tarceva, for treating or preventing cancer
EP3156406A1 (en) 2015-10-14 2017-04-19 ratiopharm GmbH Crystalline forms of ribociclib free base
AU2016347881A1 (en) 2015-11-02 2018-05-10 Novartis Ag Dosage regimen for a phosphatidylinositol 3-kinase inhibitor
JP2019500893A (en) 2015-11-03 2019-01-17 ヤンセン バイオテツク，インコーポレーテツド Antibodies that specifically bind to PD-1 and TIM-3 and uses thereof
MX2018005061A (en) 2015-11-12 2019-02-28 Siamab Therapeutics Inc Glycan-interacting compounds and methods of use.
CN106749259B (en) * 2015-11-19 2019-02-01 华东师范大学 A kind of synthetic method of cyclopenta pyrimido azoles
CN106831780A (en) * 2015-12-03 2017-06-13 南开大学 New type heterocycle derivative with CDK4/6 and HDAC inhibitory activity
US20180371093A1 (en) 2015-12-17 2018-12-27 Novartis Ag Antibody molecules to pd-1 and uses thereof
CN105541863B (en) * 2016-02-16 2017-09-05 安纳康科学股份有限公司 Thiophene [2,3 c] pyridine derivate and its purposes as CDK kinase inhibitors
WO2017156263A1 (en) 2016-03-09 2017-09-14 Memorial Sloan-Kettering Cancer Center Enigma and cdh18 as companion diagnostics for cdk4 inhibitors
WO2017161253A1 (en) 2016-03-18 2017-09-21 Tufts Medical Center Compositions and methods for treating and preventing metabolic disorders
TWI772291B (en) 2016-03-25 2022-08-01 大陸商正大天晴藥業集團股份有限公司 Substituted pyrrolopyrimidine CDK inhibitors, pharmaceutical compositions containing the same and uses thereof
CN107266451B (en) * 2016-04-07 2021-12-31 上海医药工业研究院 Preparation method of rebuximab intermediate
WO2017185031A1 (en) * 2016-04-22 2017-10-26 Dana-Farber Cancer Institute, Inc. Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use
MX2018013573A (en) 2016-05-07 2019-08-01 Shanghai Fochon Pharmaceutical Co Ltd Certain protein kinase inhibitors.
WO2017211245A1 (en) * 2016-06-06 2017-12-14 深圳市塔吉瑞生物医药有限公司 Substituted pyrrolopyrimidine compound and application thereof
CN112250670B (en) 2016-06-07 2021-06-08 北京加科思新药研发有限公司 Novel heterocyclic derivatives useful as SHP2 inhibitors
KR102445288B1 (en) 2016-07-01 2022-09-19 쥐원 쎄라퓨틱스, 인크. Synthesis of N-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amine
EA201990187A1 (en) 2016-07-01 2019-07-31 Г1 Терапьютикс, Инк. PYRIMIDINE ANTIPROLIFERATION AGENTS
WO2018005863A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Pyrimidine-based compounds for the treatment of cancer
WO2018005533A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Antiproliferative pyrimidine-based compounds
US11098077B2 (en) 2016-07-05 2021-08-24 Chinook Therapeutics, Inc. Locked nucleic acid cyclic dinucleotide compounds and uses thereof
ES2966469T3 (en) 2016-08-23 2024-04-22 Eisai R&D Man Co Ltd Combination therapies for the treatment of hepatocellular carcinoma
WO2018051280A1 (en) * 2016-09-15 2018-03-22 Dr. Reddy’S Laboratories Limited Process for preparation of ribociclib, its acid addition salts
CN109715163B (en) 2016-09-19 2022-11-22 诺华股份有限公司 Therapeutic combination comprising a RAF inhibitor and an ERK inhibitor
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
ES2934846T3 (en) 2016-10-20 2023-02-27 Pfizer CDK inhibitors for PAH treatment
WO2018081211A1 (en) * 2016-10-26 2018-05-03 Li George Y Deuterated 7-cyclopentyl-n, n-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7h-pyrrolo[2,3-d]pyrimdine-6-carboxamide
EP3538148A1 (en) 2016-11-08 2019-09-18 Dana-Farber Cancer Institute Compositions and methods of modulating anti-tumor immunity
US11001586B2 (en) 2016-11-17 2021-05-11 The University Of North Carolina At Chapel Hill Alkyl pyrrolopyrimidine analogs and methods of making and using same
EP3541847A4 (en) 2016-11-17 2020-07-08 Seattle Genetics, Inc. Glycan-interacting compounds and methods of use
PL3546456T3 (en) 2016-11-28 2022-05-02 Teijin Pharma Limited Crystal of pyrido[3, 4-d]pyrimidine derivative or solvate thereof
EP3546458B1 (en) 2016-11-28 2021-01-06 Teijin Pharma Limited ((pyridin-2-yl)-amino)pyrido[3,4-d]pyrimidine and ((pyridazin-3-yl)-amino)pyrido[3,4-d]pyrimidine derivatives as cdk4/6 inhibitors for treating e.g. rheumatoid arthritis, arteriosclerosis, pulmonary fibrosis, cerebral infarction or cancer
IL303038B1 (en) 2016-12-05 2024-04-01 G1 Therapeutics Inc Preservation of immune response during chemotherapy regimens
BR112019013814A2 (en) 2017-01-06 2020-01-21 G1 Therapeutics Inc method for treating cancer or a tumor in an individual, pharmaceutical composition, combination, and, kit.
JP2020506904A (en) * 2017-01-27 2020-03-05 シグナルアールエックス ファーマシューティカルズ，インコーポレイテッド Thienopyranones and furanopyranones as kinases, bromodomains and checkpoint inhibitors
US11395821B2 (en) 2017-01-30 2022-07-26 G1 Therapeutics, Inc. Treatment of EGFR-driven cancer with fewer side effects
MX2019010202A (en) 2017-03-03 2019-10-02 Seattle Genetics Inc Glycan-interacting compounds and methods of use.
IL269357B1 (en) 2017-03-16 2024-06-01 Eisai R&D Man Co Ltd A combination of ER? inhibitor and CDK 4/6 inhibitor for use in a method of treating breast cancer
SG11201908820VA (en) 2017-03-23 2019-10-30 Jacobio Pharmaceuticals Co Ltd Novel heterocyclic derivatives useful as shp2 inhibitors
UY37695A (en) 2017-04-28 2018-11-30 Novartis Ag BIS 2’-5’-RR- (3’F-A) (3’F-A) CYCLE DINUCLEOTIDE COMPOUND AND USES OF THE SAME
ES2952265T3 (en) 2017-05-02 2023-10-30 Novartis Ag Combination therapy comprising a Raf inhibitor and trametinib
CN106946880B (en) * 2017-05-06 2019-04-26 南京焕然生物科技有限公司 A method of preparing Rui Boxini intermediate
CN107118215B (en) * 2017-05-06 2019-04-05 上海耀大生物科技有限公司 A kind of preparation method for treating breast cancer medicines Rui Boxini intermediate
CN107267481A (en) * 2017-05-09 2017-10-20 上海交通大学医学院附属新华医院 CDK5 epitope peptides and its application
CN108929312A (en) * 2017-05-22 2018-12-04 南开大学 Novel benzheterocycle with CDK or HDAC inhibitory activity joins pyrimidine inhibitors
CN108929324A (en) * 2017-05-22 2018-12-04 南开大学 The preparation and application of novel 1,1- cyclopropyl diamide derivatives
TW201906818A (en) * 2017-05-31 2019-02-16 美商５１１製藥公司 Novel erbium-substituted positron emission tomography (PET) developer and its pharmacological application
EP3642240A1 (en) 2017-06-22 2020-04-29 Novartis AG Antibody molecules to cd73 and uses thereof
AU2018291026B2 (en) 2017-06-29 2022-09-01 G1 Therapeutics, Inc. Morphic forms of GIT38 and methods of manufacture thereof
CN110996962A (en) 2017-08-03 2020-04-10 诺华股份有限公司 Therapeutic combinations of third generation EGFR tyrosine kinase inhibitors and cyclin D kinase inhibitors
US11155545B2 (en) 2017-08-25 2021-10-26 Sicor—Societa Italiana Corticosteroid s.r.l. Ribociclib salts and solid state forms thereof
EP3676404A1 (en) 2017-08-31 2020-07-08 Novartis AG Methods of selecting a treatment for cancer patients
CN111164085B (en) * 2017-09-29 2023-04-04 杭州领业医药科技有限公司 Eutectic of rebamipillin and eutectic of rebamipillin monosuccinate, preparation method, composition and application thereof
KR20200057705A (en) 2017-10-27 2020-05-26 프레세니어스 카비 온콜로지 리미티드 Improved method for preparing ribociclib and salts thereof
US11179365B2 (en) 2017-11-16 2021-11-23 Novartis Ag Pharmaceutical combination comprising LSZ102 and ribociclib
KR20200089286A (en) 2017-11-16 2020-07-24 노파르티스 아게 Combination therapy
US11111250B2 (en) 2017-12-22 2021-09-07 Shilpa Meicare Limited Polymorphs of Ribociclib mono succinate
MX2020006587A (en) 2017-12-22 2020-12-10 Ravenna Pharmaceuticals Inc Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors.
WO2019133864A1 (en) 2017-12-29 2019-07-04 Accutar Biotechnology DUAL INHIBITORS OF PARP1 and CDK
CN107936029B (en) * 2018-01-08 2020-06-30 南京奇可药业有限公司 Method for synthesizing Ribociclib
EP3738084A4 (en) 2018-01-08 2021-11-17 G1 Therapeutics, Inc. G1t38 superior dosage regimes
EP3746072B1 (en) * 2018-01-29 2023-04-12 Beta Pharma, Inc. 2h-indazole derivatives as cdk4 and cdk6 inhibitors and therapeutic uses thereof
BR112020015431A2 (en) 2018-02-15 2020-12-08 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS
WO2019167068A1 (en) 2018-03-01 2019-09-06 Cipla Limited Novel polymorphs of ribociclib succinate
WO2019195959A1 (en) 2018-04-08 2019-10-17 Cothera Biosciences, Inc. Combination therapy for cancers with braf mutation
US10723739B2 (en) 2018-05-14 2020-07-28 Apotex Inc. Processes for the preparation of Ribociclib and intermediates thereof
WO2019222521A1 (en) * 2018-05-16 2019-11-21 G1 Therapeutics, Inc. Cdk inhibitors for the treatment of neoplastic disorders
CN108558745A (en) * 2018-05-17 2018-09-21 苏州莱克施德药业有限公司 A kind of pa wins the synthetic method of XiLin intermediate
TW202015726A (en) 2018-05-30 2020-05-01 瑞士商諾華公司 Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
AR116109A1 (en) 2018-07-10 2021-03-31 Novartis Ag DERIVATIVES OF 3- (5-AMINO-1-OXOISOINDOLIN-2-IL) PIPERIDINE-2,6-DIONA AND USES OF THE SAME
KR20210049847A (en) 2018-08-24 2021-05-06 쥐원 쎄라퓨틱스, 인크. Improved synthesis of 1,4-diazaspiro[5.5]undecan-3-one
CN112888690B (en) * 2018-09-13 2022-04-12 正大天晴药业集团股份有限公司 Salts of substituted pyrrolopyrimidine CDK inhibitors, crystals thereof and use thereof
WO2020084389A1 (en) 2018-10-23 2020-04-30 Lupin Limited Ribociclib intermediate and process for preparation thereof
CN113227089B (en) 2018-10-31 2024-07-05 吉利德科学公司 Substituted 6-azabenzimidazole compounds as HPK1 inhibitors
WO2020092528A1 (en) 2018-10-31 2020-05-07 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
CN113271945A (en) 2018-12-20 2021-08-17 诺华股份有限公司 Dosing regimens and pharmaceutical combinations comprising 3- (1-oxoisoindolin-2-yl) piperidine-2, 6-dione derivatives
CN109400612A (en) * 2018-12-24 2019-03-01 重庆三圣实业股份有限公司 A kind of preparation method of Rui Boxini and products thereof and purposes
US20230065740A1 (en) * 2018-12-28 2023-03-02 Spv Therapeutics Inc. Cyclin-dependent kinase inhibitors
US20220056037A1 (en) * 2018-12-28 2022-02-24 Spv Therapeutics Inc. Cyclin-dependent kinase inhibitors
KR20210119444A (en) 2019-01-23 2021-10-05 노파르티스 아게 Novel of succinate of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-D]pyrimidine-6-carboxylic acid dimethylamide crystalline form
BR112021015632A2 (en) 2019-02-12 2021-10-05 Novartis Ag PHARMACEUTICAL COMBINATION INCLUDING TNO155 AND RIBOCICLIB
EA202192029A1 (en) 2019-02-15 2021-10-27 Новартис Аг SUBSTITUTED DERIVATIVES OF 3- (1-OXOISOINDOLIN-2-YL) PIPERIDINE-2,6-DIONE AND VARIANTS OF THEIR APPLICATION
KR20210129671A (en) 2019-02-15 2021-10-28 노파르티스 아게 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
WO2020225827A1 (en) 2019-05-08 2020-11-12 Mylan Laboratories Limited Novel polymorphs of ribociclib succinate
MX2021014094A (en) 2019-05-20 2022-02-11 Novartis Ag Mcl-1 inhibitor antibody-drug conjugates and methods of use.
TWI826690B (en) 2019-05-23 2023-12-21 美商基利科學股份有限公司 Substituted eneoxindoles and uses thereof
CN114008039B (en) * 2019-06-04 2024-01-16 斯泰普制药股份公司 Compounds as human CTPS1 inhibitors for the treatment of proliferative diseases
TW202112767A (en) 2019-06-17 2021-04-01 美商佩特拉製藥公司 Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
CN112094272A (en) 2019-06-18 2020-12-18 北京睿熙生物科技有限公司 CDK kinase inhibitors
WO2021038590A1 (en) 2019-08-30 2021-03-04 Mylan Laboratories Limited Novel polymorph of ribociclib succinate
JP2022548881A (en) 2019-09-18 2022-11-22 ノバルティス アーゲー ENTPD2 Antibodies, Combination Therapy and Methods of Using Antibodies and Combination Therapy
US20230015914A1 (en) * 2019-11-07 2023-01-19 Crinetics Pharmaceuticals, Inc. Melanocortin subtype-2 receptor (mc2r) antagonists and uses thereof
EP4077331A4 (en) 2019-12-16 2023-12-27 Lunella Biotech, Inc. Selective cdk4/6 inhibitor cancer therapeutics
EP4076660A1 (en) 2019-12-20 2022-10-26 Novartis AG Uses of anti-tgf-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases
CA3161892A1 (en) 2019-12-23 2021-07-01 Jie Fan Combinations of estrogen receptor degraders and cyclin-dependent kinase inhibitors for treating cancer
WO2021190637A1 (en) * 2020-03-27 2021-09-30 Jiangsu Alphamab Biopharmaceuticals Co., Ltd. Combination of anti-her2 antibody and cdk inhibitior for tumor treatment
JP7406008B2 (en) * 2020-05-12 2023-12-26 蘇州阿尓脈生物科技有限公司 Polycyclic amide derivatives as CDK9 inhibitors, their preparation methods and uses
CN115551509A (en) 2020-05-12 2022-12-30 诺华股份有限公司 Therapeutic combinations comprising CRAF inhibitors
EP4140997A4 (en) * 2020-05-12 2023-09-06 Suzhou Alphama Biotechnology Co., Ltd. Pyridine acetamide derivative serving as cdk inhibitor, and preparation method therefor and use thereof
IL298294A (en) 2020-05-19 2023-01-01 G1 Therapeutics Inc Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof
MX2022015852A (en) 2020-06-23 2023-01-24 Novartis Ag Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6- dione derivatives.
US20230271940A1 (en) 2020-08-03 2023-08-31 Novartis Ag Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
CN112375081B (en) * 2020-11-23 2022-04-12 中国医学科学院医药生物技术研究所 Pyrrole [2,3-d ] pyrimidine derivative with CDK4, 6 or 9 inhibiting activity and preparation method and application thereof
KR20230138444A (en) 2020-11-24 2023-10-05 노파르티스 아게 MCL-1 inhibitor antibody-drug conjugate and methods of use
EP4251648A2 (en) 2020-11-24 2023-10-04 Novartis AG Anti-cd48 antibodies, antibody drug conjugates, and uses thereof
WO2022162122A1 (en) 2021-01-29 2022-08-04 Biotx.Ai Gmbh Genetically verified netosis inhibitor for use in the treatment of a sars-cov2 infection
EP4288434A1 (en) 2021-02-02 2023-12-13 Les Laboratoires Servier Selective bcl-xl protac compounds and methods of use
EP4313987A2 (en) 2021-04-01 2024-02-07 KRKA, d.d., Novo mesto Process for the preparation of ribociclib and pharmaceutically acceptable salts thereof
TW202304979A (en) 2021-04-07 2023-02-01 瑞士商諾華公司 USES OF ANTI-TGFβ ANTIBODIES AND OTHER THERAPEUTIC AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
EP4333847A1 (en) 2021-05-05 2024-03-13 Novartis AG Compounds and compositions for the treatment of mpnst
AR125874A1 (en) 2021-05-18 2023-08-23 Novartis Ag COMBINATION THERAPIES
EP4376848A1 (en) 2021-07-26 2024-06-05 Celcuity Inc. 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea (gedatolisib) and its combinations for use in the treatment of cancer
KR20240041340A (en) * 2021-07-27 2024-03-29 보로노이 주식회사 Pyrrolopyrimidine derivative compounds and uses thereof
WO2023144684A1 (en) 2022-01-25 2023-08-03 Novartis Ag Ribociclib pharmaceutical compositions
CN114456180B (en) * 2022-02-18 2023-07-25 贵州大学 Compounds and pharmaceutical formulations for the treatment and/or prophylaxis of malignant tumors and use thereof
WO2023196518A1 (en) * 2022-04-08 2023-10-12 Biolexis Therapeutics, Inc. Cdk9 inhibitors
US20230322792A1 (en) * 2022-04-08 2023-10-12 Biolexis Therapeutics, Inc. Cdk9 inhibitors
WO2023225336A1 (en) 2022-05-20 2023-11-23 Novartis Ag Met bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
WO2023225320A1 (en) 2022-05-20 2023-11-23 Novartis Ag Epha2 bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
WO2024049926A1 (en) 2022-08-31 2024-03-07 Arvinas Operations, Inc. Dosage regimens of estrogen receptor degraders
WO2024086361A1 (en) * 2022-10-21 2024-04-25 Novartis Ag Molecular glue degrader compounds and uses thereof
WO2024100236A1 (en) 2022-11-11 2024-05-16 Astrazeneca Ab Combination therapies for the treatment of cancer
WO2024115680A1 (en) 2022-12-01 2024-06-06 Krka, D.D., Novo Mesto Ribociclib salts and formulations thereof
CN117069663B (en) * 2023-08-31 2023-12-26 四川维亚本苑生物科技有限公司 Synthesis method of rebaudinib intermediate V and synthesis method of rebaudinib

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US6218529B1 (en) 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
CA2744096C (en) 1996-07-31 2013-07-30 Laboratory Corporation Of America Holdings Biomarkers and targets for diagnosis, prognosis and management of prostate disease
PL220952B1 (en) * 2002-01-22 2016-01-29 Warner Lambert Co 2-(Pyridin-2-ylamino) pyrido [2,3-d] pyrimidin -7-ones
ES2314224T3 (en) 2002-03-07 2009-03-16 F. Hoffmann-La Roche Ag BIRCINAL PYRIMIDINE AND PYRIDINE INHIBITORS OF P38 QUINASA.
NZ539165A (en) 2002-09-04 2008-03-28 Schering Corp Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
EP1590341B1 (en) * 2003-01-17 2009-06-17 Warner-Lambert Company LLC 2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation
JP2007504271A (en) 2003-09-05 2007-03-01 ニューロジェン・コーポレーション Heteroaryl-fused pyridines, pyrazines and pyrimidines which are CRF1 receptor ligands
MXPA06002853A (en) 2003-09-11 2006-06-14 Kemia Inc Cytokine inhibitors.
US7319102B1 (en) * 2003-12-09 2008-01-15 The Procter & Gamble Company Pyrrolo[2,3-d]pyrimidine cytokine inhibitors
JP4989233B2 (en) 2004-02-14 2012-08-01 アイアールエム・リミテッド・ライアビリティ・カンパニー Compounds and compositions as protein kinase inhibitors
RU2006135120A (en) 2004-03-05 2008-04-10 Тайсо Фармасьютикал Ко. Pyrrolopyrimidine derivatives
WO2005107760A1 (en) 2004-04-30 2005-11-17 Irm Llc Compounds and compositions as inducers of keratinocyte differentiation
EP1781647A2 (en) * 2004-07-22 2007-05-09 Astex Therapeutics Limited Thiazole and isothiazole derivatives as protein kinase inhibitors
US7906528B2 (en) 2004-10-05 2011-03-15 Novartis International Pharmaceutical Ltd. Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds
MX2007005159A (en) 2004-10-29 2007-06-26 Tibotec Pharm Ltd Hiv inhibiting bicyclic pyrimidine derivatives.
US7521446B2 (en) 2005-01-13 2009-04-21 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
US7723340B2 (en) 2005-01-13 2010-05-25 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
AU2006205851A1 (en) * 2005-01-14 2006-07-20 Janssen Pharmaceutica N.V. 5-membered annelated heterocyclic pyrimidines as kinase inhibitors
WO2006091737A1 (en) 2005-02-24 2006-08-31 Kemia, Inc. Modulators of gsk-3 activity
JP2006241089A (en) 2005-03-04 2006-09-14 Astellas Pharma Inc Pyrroloprymidine derivative or its salt
US20070225304A1 (en) 2005-09-06 2007-09-27 Pharmacopeia Drug Discovery, Inc. Aminopurine derivatives for treating neurodegenerative diseases
GB0520164D0 (en) 2005-10-04 2005-11-09 Novartis Ag Organic compounds
WO2007058990A2 (en) 2005-11-14 2007-05-24 Kemia, Inc. Therapy using cytokine inhibitors
GB0526246D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
JP2009524589A (en) * 2005-12-22 2009-07-02 ワイス Substituted isoquinoline-1,3 (2H, 4H) -dione, 1-thioxo-1,4-dihydro-2H-isoquinolin-3-one derivatives, and 1,4-dihydro-3 (2H) -isoquinolone, and Their use as kinase inhibitors
US7951803B2 (en) 2006-03-09 2011-05-31 Pharmacopeia, Llc 8-heteroarylpurine MNK2 inhibitors for treating metabolic disorders
WO2007125405A2 (en) 2006-05-01 2007-11-08 Pfizer Products Inc. Substituted 2-amino-fused heterocyclic compounds
JO3235B1 (en) * 2006-05-26 2018-03-08 Astex Therapeutics Ltd Pyrrolopyrimidine compounds and their uses
JP5537439B2 (en) * 2007-12-19 2014-07-02 アムジエン・インコーポレーテツド Condensed pyridine, pyrimidine and triazine compounds as cell cycle inhibitors
MX2010008719A (en) 2008-02-06 2010-09-24 Novartis Ag Pyrrolo [2, 3-d] pyridines and use thereof as tyrosine kinase inhibitors.
US8685980B2 (en) 2008-08-22 2014-04-01 Novartis Ag Pyrrolopyrimidine compounds and their uses
GB0819105D0 (en) 2008-10-17 2008-11-26 Chroma Therapeutics Ltd Pyrrolo-pyrimidine compounds
UY33227A (en) 2010-02-19 2011-09-30 Novartis Ag PIRROLOPIRIMIDINE COMPOUNDS AS INHIBITORS OF THE CDK4 / 6
UY33226A (en) 2010-02-19 2011-09-30 Novartis Ag PIRROLOPIRIMIDINE COMPUTERS DEUTERATED AS INHIBITORS OF THE CDK4 / 6
CN102869358B (en) 2010-04-13 2016-03-23 诺华股份有限公司 Be used for the treatment of the combination comprising cell cycle protein dependent kinase 4 or cell cycle protein dependent kinase 6 (CDK4/6) inhibitor and mTOR inhibitors of cancer

Also Published As

Publication number Publication date
TW201014858A (en) 2010-04-16
US20240043428A1 (en) 2024-02-08
EP2331547A1 (en) 2011-06-15
KR20110052713A (en) 2011-05-18
ME01282B (en) 2013-06-20
CY2017042I2 (en) 2018-04-04
RS53574B1 (en) 2015-02-27
LUC00048I2 (en) 2018-01-10
DK2331547T3 (en) 2014-11-03
LTC2331547I2 (en) 2018-09-10
AU2009284098A1 (en) 2010-02-25
AR073116A1 (en) 2010-10-13
US20100105653A1 (en) 2010-04-29
SMT201500017B (en) 2015-03-05
NO2017059I1 (en) 2017-11-13
PL2331547T3 (en) 2015-01-30
EP2331547B1 (en) 2014-07-30
US9416136B2 (en) 2016-08-16
CU24062B1 (en) 2014-12-26
AR111763A2 (en) 2019-08-14
MY150560A (en) 2014-01-30
CU20110040A7 (en) 2011-12-28
KR20130140222A (en) 2013-12-23
WO2010020675A1 (en) 2010-02-25
LUC00048I1 (en) 2017-11-15
HK1156625A1 (en) 2012-06-15
JP5882371B2 (en) 2016-03-09
IL211164A (en) 2016-09-29
HUS1700051I1 (en) 2017-12-28
US8685980B2 (en) 2014-04-01
NL300909I1 (en) 2017-11-10
NZ591176A (en) 2012-11-30
JO2924B1 (en) 2015-09-15
CN102186856A (en) 2011-09-14
SI2331547T1 (en) 2014-11-28
IL211164A0 (en) 2011-04-28
EA201100355A1 (en) 2011-10-31
ECSP11010843A (en) 2011-05-31
NI201100042A (en) 2011-08-09
JP5560496B2 (en) 2014-07-30
US20210253578A1 (en) 2021-08-19
NL300909I2 (en) 2017-12-19
FR17C1059I1 (en) 2018-02-16
CN102186856B (en) 2014-09-24
CA2734802A1 (en) 2010-02-25
DOP2011000057A (en) 2015-11-15
GEP20135785B (en) 2013-03-11
ES2522346T3 (en) 2014-11-14
MX2011001879A (en) 2011-03-29
LTPA2017039I1 (en) 2017-12-11
CO6341561A2 (en) 2011-11-21
HN2011000542A (en) 2013-10-17
EA201100355A8 (en) 2013-09-30
US20170183352A1 (en) 2017-06-29
US20130184285A1 (en) 2013-07-18
TN2011000062A1 (en) 2012-09-05
US20110152244A1 (en) 2011-06-23
US20140135312A1 (en) 2014-05-15
JP2012500785A (en) 2012-01-12
KR101353857B1 (en) 2014-01-21
JP2014129361A (en) 2014-07-10
CR20110101A (en) 2011-06-09
CA2734802E (en) 2010-02-25
TWI468409B (en) 2015-01-11
PE20110419A1 (en) 2011-07-13
CA2734802C (en) 2016-05-31
US8415355B2 (en) 2013-04-09
BRPI0917791B1 (en) 2022-03-22
EA019094B1 (en) 2014-01-30
UA103628C2 (en) 2013-11-11
NO2017059I2 (en) 2017-11-13
CL2011000306A1 (en) 2011-06-24
UY32067A (en) 2010-03-26
PT2331547E (en) 2014-10-29
CY2017042I1 (en) 2018-04-04
CN103788100A (en) 2014-05-14
CY1115703T1 (en) 2017-01-25
US20180155351A1 (en) 2018-06-07
AU2009284098B2 (en) 2012-03-29
MA32555B1 (en) 2011-08-01
US8962630B2 (en) 2015-02-24
ZA201100994B (en) 2011-12-28
BRPI0917791A2 (en) 2019-08-13
UY38935A (en) 2020-12-31
EP2716643A1 (en) 2014-04-09
HRP20141018T1 (en) 2015-02-13

Similar Documents

Publication Publication Date Title
FR17C1059I2 (en) PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES
BRPI0907231A2 (en) pyrrolpyrimidines and pyrrolpyridines
BRPI0920450A2 (en) Pyrrolobenzodiazepines
BRPI0815914A2 (en) DYNAMIC INSTANT COMMENTS
DK2528625T3 (en) Pyrrolobenzodiazepines and their conjugates
DK2361059T3 (en) EXTERNAL STENT
DE112009005514A5 (en) Two-way Dampers
DE112009000964A5 (en) tampon
FR2942476B1 (en) PYRIDOCARBAZOLE COMPOUNDS AND THEIR APPLICATIONS
FR2943345B1 (en) TEMPORIN-SHA ANALOGUES AND USES THEREOF
FR2957596B1 (en) NOVEL ESTERAMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
DK2370341T3 (en) ROLLED VEHICLES
FI20080124L (en) Near-Josephson detector
FR2955741B1 (en) HERBICIDE COMPOSITION AND USES
BRPI0922008A2 (en) compounds and their preparation methods
BRPI0910456A2 (en) prion immunogenic petids and their repetitions
FR2912170B1 (en) ISOLOIR DEMONTABLE AND MODULABLE.
FR2955122B1 (en) ORGANOSPECIFIC FELINE ENDOTHELIAL CELLS AND USES THEREOF.
TH0901003793A (en) Pyrrolopyrimidine compounds and their uses
TH96904B (en) diaper
FIU20080155U0 (en) Diaper
FIU20080019U0 (en) Floorball corner
ES1069539Y (en) PAPIROFLEXIA OBJECT IN LAMINA.
FI20080489A0 (en) Salmiac jam and salmiac jam
ITBO20080105A1 (en) TASTY TOOTHPROOF