FR1602555A - A-furan steroids - Google Patents
A-furan steroidsInfo
- Publication number
- FR1602555A FR1602555A FR1602555DA FR1602555A FR 1602555 A FR1602555 A FR 1602555A FR 1602555D A FR1602555D A FR 1602555DA FR 1602555 A FR1602555 A FR 1602555A
- Authority
- FR
- France
- Prior art keywords
- residue
- uterotrophic
- cholane
- pregnane
- substd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A-oxasteroids (I) where S = an oestrane, pregnane, cholane, or cholestane residue, opt. substd. e.g. by OH, O acyl, alkylenedioxy, oxo, lower alkyl, lower alkenyl, lower alkynyl, opt. substd. NH2, CHO, CO2H, ether, ester, or lactone residues. and esp. (II) where X=C=O, CHOH, (where R = a (1-5C) hydrocarbon residue), -(1-11C) acyl, a ketal residue, or a pregnane, cholane or cholestane side chain. Anti-deciduomatogenic, anti-uterotrophic, anti-anabolic, anti-estrogenic, anti-androgenic, uterotrophic, contraceptic, and hypolipaemic. AlBui2 H (0.8 g.) in THF (4.7 ml.) was added to 17beta-acetoxy-3-oxa-A-noroestra-1 (10)-ene-2-one (517 mg.) in THF (14 ml.), at -20 to -25 deg. The mixture was stirred 20 mins., decompd. with 10% H2SO4 (a few drops), dild. with H2O, and extd. with CH2Cl2. The extract was washed, dried, and evapd., and the residue recryst. from Me2 CO-hexane, giving (I) (294 mg.), m.p. 137.5-139.5 deg.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5306367A GB1200640A (en) | 1967-11-22 | 1967-11-22 | A-furan oxasteroids and their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR1602555A true FR1602555A (en) | 1970-12-28 |
Family
ID=10466492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR1602555D Expired FR1602555A (en) | 1967-11-22 | 1968-11-21 | A-furan steroids |
Country Status (8)
| Country | Link |
|---|---|
| CH (1) | CH560187A5 (en) |
| DE (1) | DE1810477A1 (en) |
| DK (1) | DK123531B (en) |
| FR (1) | FR1602555A (en) |
| GB (1) | GB1200640A (en) |
| NL (1) | NL6816764A (en) |
| NO (1) | NO130190B (en) |
| SE (1) | SE346784B (en) |
-
1967
- 1967-11-22 GB GB5306367A patent/GB1200640A/en not_active Expired
-
1968
- 1968-11-18 DK DK560168A patent/DK123531B/en unknown
- 1968-11-21 SE SE1585568A patent/SE346784B/xx unknown
- 1968-11-21 FR FR1602555D patent/FR1602555A/en not_active Expired
- 1968-11-22 DE DE19681810477 patent/DE1810477A1/en active Pending
- 1968-11-22 CH CH1743968A patent/CH560187A5/xx not_active IP Right Cessation
- 1968-11-22 NL NL6816764A patent/NL6816764A/xx unknown
- 1968-11-22 NO NO466268A patent/NO130190B/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH560187A5 (en) | 1975-03-27 |
| GB1200640A (en) | 1970-07-29 |
| NO130190B (en) | 1974-07-22 |
| DE1810477A1 (en) | 1969-08-14 |
| SE346784B (en) | 1972-07-17 |
| DK123531B (en) | 1972-07-03 |
| NL6816764A (en) | 1969-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |