FR15C0028I2 - MANUFACTURE OF TIACUMICIN - Google Patents

MANUFACTURE OF TIACUMICIN

Info

Publication number
FR15C0028I2
FR15C0028I2 FR15C0028C FR15C0028C FR15C0028I2 FR 15C0028 I2 FR15C0028 I2 FR 15C0028I2 FR 15C0028 C FR15C0028 C FR 15C0028C FR 15C0028 C FR15C0028 C FR 15C0028C FR 15C0028 I2 FR15C0028 I2 FR 15C0028I2
Authority
FR
France
Prior art keywords
tiacumicin
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR15C0028C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Optimer Pharmaceuticals LLC
Original Assignee
Optimer Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Optimer Pharmaceuticals LLC filed Critical Optimer Pharmaceuticals LLC
Publication of FR15C0028I1 publication Critical patent/FR15C0028I1/fr
Application granted granted Critical
Publication of FR15C0028I2 publication Critical patent/FR15C0028I2/en
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
FR15C0028C 2002-07-29 2015-03-27 MANUFACTURE OF TIACUMICIN Active FR15C0028I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39995602P 2002-07-29 2002-07-29
PCT/US2003/021977 WO2004014295A2 (en) 2002-07-29 2003-07-15 Tiacumicin production

Publications (2)

Publication Number Publication Date
FR15C0028I1 FR15C0028I1 (en) 2015-05-15
FR15C0028I2 true FR15C0028I2 (en) 2015-11-13

Family

ID=31715689

Family Applications (1)

Application Number Title Priority Date Filing Date
FR15C0028C Active FR15C0028I2 (en) 2002-07-29 2015-03-27 MANUFACTURE OF TIACUMICIN

Country Status (18)

Country Link
US (4) US7507564B2 (en)
EP (2) EP1539977B1 (en)
JP (3) JP2005534332A (en)
KR (1) KR100972542B1 (en)
CN (1) CN100519757C (en)
AU (1) AU2003251902B2 (en)
BE (1) BE2015C017I2 (en)
CA (1) CA2494742C (en)
CY (1) CY2015015I1 (en)
DK (1) DK1539977T3 (en)
ES (1) ES2527052T3 (en)
FR (1) FR15C0028I2 (en)
HU (1) HUS1500016I1 (en)
LU (1) LU92684I2 (en)
NL (1) NL300727I2 (en)
PT (1) PT1539977E (en)
SI (1) SI1539977T1 (en)
WO (1) WO2004014295A2 (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006085838A1 (en) * 2005-01-31 2006-08-17 Optimer Pharmaceuticals, Inc. 18-membered macrocycles and analogs thereof
US20070105791A1 (en) * 2002-07-29 2007-05-10 Optimer Pharmaceuticals, Inc. Method of treating clostridium difficile-associated diarrhea
WO2004014295A2 (en) * 2002-07-29 2004-02-19 Optimer Pharmaceuticals, Inc. Tiacumicin production
US20070173462A1 (en) * 2004-05-14 2007-07-26 Optimer Pharmaceuticals, Inc. Treatment of diseases associated with the use of antibiotics
US7906489B2 (en) 2004-05-14 2011-03-15 Optimer Pharmaceuticals, Inc. 18-membered macrocycles and analogs thereof
US7378508B2 (en) * 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
AU2012200784B2 (en) * 2005-01-31 2013-07-11 Merck Sharp & Dohme Llc 18-membered macrocycles and analogs thereof
CA2626698C (en) * 2005-10-21 2015-12-01 Optimer Pharmaceuticals, Inc. Method of treating clostridium difficile-associated diarrhea
US20080176927A1 (en) * 2007-01-19 2008-07-24 Optimer Pharmaceuticals, Inc. Compositions of stable tiacumicins
KR100891313B1 (en) * 2007-08-17 2009-03-31 (주) 제노텍 Method of extraction and yield-up of tricyclo compounds by adding a solid adsorbent resin as their carrier in fermentation medium
TWI326284B (en) * 2007-10-26 2010-06-21 Echem Hightech Co Ltd Derivatives of tiacumicin b as anti-cancer agents
TWI523654B (en) 2007-11-27 2016-03-01 默沙東藥廠 Antibiotic macrocycle compounds and methods of manufacture and use thereof
AU2011215616A1 (en) * 2010-02-15 2012-09-06 Transition Therapeutics Ireland Limited Process for the preparation of scyllo-Inositol
AU2011316540A1 (en) 2010-10-13 2014-04-10 Elan Pharmaceuticals, Inc. Methods of synthesis of scyllitol and related compounds
CN102115757B (en) * 2010-12-14 2015-10-28 中国科学院南海海洋研究所 Platform hooks biological synthesis gene cluster and the application thereof of mycin
ITMI20120559A1 (en) * 2012-04-05 2013-10-06 Olon Spa IMPROVED PROCEDURE FOR THE PRODUCTION OF TIACUMICINA B
ITMI20120560A1 (en) 2012-04-05 2013-10-06 Olon Spa PROCEDURE FOR THE PURIFICATION OF TIACUMICINA B
CN104768963A (en) * 2012-05-10 2015-07-08 特瓦制药厂有限公司 Solid state forms of fidaxomycin and processes for preparation thereof
ITMI20121406A1 (en) * 2012-08-07 2014-02-08 Olon Spa PROCEDURE FOR THE PRODUCTION OF TIACUMICINA B
WO2014023616A1 (en) 2012-08-07 2014-02-13 Olon Spa Procedure for the production of tiacumicin b
ITMI20130856A1 (en) * 2013-05-27 2014-11-28 Olon Spa PROCEDURE FOR THE PRODUCTION OF TIACUMICINA B
CN102993251B (en) * 2012-12-17 2016-03-16 苏州纳微科技有限公司 A kind of method of high-efficient liquid phase chromatogram purification TCM B
JO3464B1 (en) 2013-01-15 2020-07-05 Astellas Pharma Europe Ltd Compositions of Tiacumicin Compounds
WO2014174528A2 (en) * 2013-04-23 2014-10-30 Concord Biotech Limited An improved process for the preparation of fidaxomicin
CN103275152B (en) * 2013-05-29 2015-11-18 华北制药集团新药研究开发有限责任公司 A kind of preparation method of high-purity fidaxomicin
CN103275153B (en) * 2013-06-27 2016-03-23 华北制药集团新药研究开发有限责任公司 A kind of preparation method of fidaxomicin crystal
CN104418925B (en) * 2013-09-05 2018-09-28 重庆乾泰生物医药有限公司 A method of preparing high-purity fidaxomicin
CN104513286B (en) * 2013-09-27 2018-08-17 博瑞生物医药（苏州）股份有限公司 A method of isolating and purifying Fei Da meter stars
CN104560766B (en) 2013-10-16 2017-07-28 浙江海正药业股份有限公司 A kind of Actinoplanes bacteria strain and its application
CN104561198B (en) * 2013-10-18 2019-04-12 重庆乾泰生物医药有限公司 A kind of method of fermenting and producing feldamycin
DK3083976T3 (en) * 2013-12-20 2020-09-07 Xellia Pharmaceuticals Aps PROCEDURE FOR THE PREPARATION OF THIACUMICIN B
CN104846044B (en) * 2014-02-17 2019-02-01 上海医药工业研究院 A kind of fermentation medium improving feldamycin yield
WO2015127955A1 (en) 2014-02-25 2015-09-03 Olon S.P.A. A new polymorph of tiacumicin b and process for preparation thereof
JP2017507994A (en) 2014-03-18 2017-03-23 クセリア ファーマシューティカルズ エーピーエスＸｅｌｌｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ ＡｐＳ New polymorph and new solid state of thiacomycin B
CN103880904B (en) * 2014-03-28 2016-08-24 华北制药集团新药研究开发有限责任公司 Feldamycin crystal formation I and preparation method thereof
CN104946708B (en) * 2014-03-28 2018-06-12 上海医药工业研究院 A kind of fermentation medium and fermentation process for producing feldamycin
EP3139932B1 (en) 2014-05-09 2018-08-01 Astellas Pharma Europe Ltd. Treatment regimen for tiacumicin compound
CN104098637B (en) * 2014-07-09 2017-01-04 浙江海正药业股份有限公司 A kind of method of purification feldamycin
JP2018519344A (en) 2015-07-03 2018-07-19 アステラス ファーマ ユーロープ リミテッド A novel dosing regimen for thiamycin compounds
IL251499B (en) * 2017-04-02 2019-02-28 Efraty Avi Hydraulic-arm aided closed circuit batch-ro desalination apparatus of low energy and high recovery prospects
CN107236686B (en) * 2017-06-21 2019-10-15 杭州华东医药集团新药研究院有限公司 A kind of dactylosporangium aurantiacum and its application in regulating microorganism metabolism object feldamycin
CN114084964B (en) * 2020-08-24 2023-02-24 中国石油化工股份有限公司 Aromatic organic compound wastewater biological treatment accelerant and preparation method and application thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3000792A (en) 1957-05-21 1961-09-19 Merck & Co Inc Antibiotic adsorption process
GB1458512A (en) 1973-11-22 1976-12-15 Lepetit Spa Antibiotic substance
US4632902A (en) * 1981-08-20 1986-12-30 Becton, Dickinson And Company Method for detecting biological activity in a body fluid
US4843008A (en) * 1984-12-24 1989-06-27 Yamanouchi Pharmaceutical Co., Ltd. Novel microorganisms and a novel process for producing antibiotics
US4918174A (en) * 1986-09-26 1990-04-17 Abbott Laboratories Tiacumicin compounds
US5242815A (en) * 1990-01-24 1993-09-07 Shin-Etsu Chemical Co., Ltd. Process for preparation of streptovaricin
CA2384514C (en) * 1991-03-04 2006-07-25 Bayer Corporation Automated analyzer
US5767096A (en) * 1996-07-12 1998-06-16 Abbott Laboratories Bromotiacumicin compounds
DK1367057T3 (en) * 1996-11-18 2009-01-19 Biotechnolog Forschung Gmbh Epothilones E and F
JP2000072760A (en) * 1998-06-19 2000-03-07 Ajinomoto Co Inc New cystothiazole analogue
JP2000053514A (en) * 1998-08-06 2000-02-22 Aquas Corp Microbicidal substance produced by legionella bacterium, microbicide, water treatment agent and slime inhibitor using the same, and their production
JP2000239266A (en) * 1999-02-17 2000-09-05 Ajinomoto Co Inc New polyene-based antibiotic
IL151960A0 (en) * 2000-04-28 2003-04-10 Kosan Biosciences Inc Production of polyketides
WO2004014295A2 (en) * 2002-07-29 2004-02-19 Optimer Pharmaceuticals, Inc. Tiacumicin production

Also Published As

Publication number Publication date
AU2003251902B2 (en) 2008-03-06
JP2005534332A (en) 2005-11-17
US20130123477A1 (en) 2013-05-16
JP2010178760A (en) 2010-08-19
CN1688707A (en) 2005-10-26
EP1539977A2 (en) 2005-06-15
DK1539977T3 (en) 2014-11-17
NL300727I2 (en) 2016-05-17
US8728796B2 (en) 2014-05-20
WO2004014295A2 (en) 2004-02-19
EP2860241A1 (en) 2015-04-15
KR20050053598A (en) 2005-06-08
PT1539977E (en) 2015-01-14
BE2015C017I2 (en) 2022-09-22
CA2494742C (en) 2015-05-12
WO2004014295A3 (en) 2005-04-14
EP1539977B1 (en) 2014-10-08
JP2013208131A (en) 2013-10-10
EP1539977A4 (en) 2006-10-11
FR15C0028I1 (en) 2015-05-15
US20100028970A1 (en) 2010-02-04
SI1539977T1 (en) 2015-01-30
ES2527052T3 (en) 2015-01-20
US20060257981A1 (en) 2006-11-16
US20140296498A1 (en) 2014-10-02
LU92684I2 (en) 2015-11-02
CY2015015I1 (en) 2020-05-29
JP5729919B2 (en) 2015-06-03
AU2003251902A1 (en) 2004-02-25
CN100519757C (en) 2009-07-29
JP5907931B2 (en) 2016-04-26
CA2494742A1 (en) 2004-02-19
US7507564B2 (en) 2009-03-24
KR100972542B1 (en) 2010-07-28
HUS1500016I1 (en) 2017-10-30

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