FR1505112A - 1-alkylidène-3-indényl-propylamines et leur procédé de préparation - Google Patents

1-alkylidène-3-indényl-propylamines et leur procédé de préparation

Info

Publication number
FR1505112A
FR1505112A FR87619A FR87619A FR1505112A FR 1505112 A FR1505112 A FR 1505112A FR 87619 A FR87619 A FR 87619A FR 87619 A FR87619 A FR 87619A FR 1505112 A FR1505112 A FR 1505112A
Authority
FR
France
Prior art keywords
propylamines
indenyl
alkylidene
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR87619A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to FR98737A priority Critical patent/FR7139M/fr
Application granted granted Critical
Publication of FR1505112A publication Critical patent/FR1505112A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
    • C07C49/67—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having two rings, e.g. tetralones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR87619A 1965-12-30 1966-12-15 1-alkylidène-3-indényl-propylamines et leur procédé de préparation Expired FR1505112A (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR98737A FR7139M (fr) 1965-12-30 1967-03-14

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51784165A 1965-12-30 1965-12-30

Publications (1)

Publication Number Publication Date
FR1505112A true FR1505112A (fr) 1967-12-08

Family

ID=24061448

Family Applications (2)

Application Number Title Priority Date Filing Date
FR87619A Expired FR1505112A (fr) 1965-12-30 1966-12-15 1-alkylidène-3-indényl-propylamines et leur procédé de préparation
FR98737A Expired FR7139M (fr) 1965-12-30 1967-03-14

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR98737A Expired FR7139M (fr) 1965-12-30 1967-03-14

Country Status (7)

Country Link
US (1) US3532752A (fr)
BR (1) BR6685475D0 (fr)
CH (1) CH495322A (fr)
DE (1) DE1593133A1 (fr)
FR (2) FR1505112A (fr)
GB (1) GB1154506A (fr)
NL (1) NL6618446A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0769940A1 (fr) * 1994-07-21 1997-05-02 Eli Lilly And Company COMPOSES D'INDENE UTILES POUR INHIBER sPLA 2?

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642785A (en) * 1969-08-11 1972-02-15 Merck & Co Inc Indenyl-3-aliphatic amines
US3759987A (en) * 1970-05-01 1973-09-18 Merck & Co Inc Preparation of 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-3-indenyl acetic acid
JPS5623982B2 (fr) * 1972-12-07 1981-06-03
US4007225A (en) * 1973-08-11 1977-02-08 Takeda Chemical Industries, Ltd. 4-Benzoylindan-1-carboxamide and derivatives thereof
US3998875A (en) * 1974-10-02 1976-12-21 Merck & Co., Inc. Process of preparing 5-fluoro-2-methyl-1-(paramethylsulfinylbenzylidene)-indenyl-3-acetic acid
JPS5740132B2 (fr) * 1975-02-19 1982-08-25
EP0000825B1 (fr) * 1977-08-05 1982-04-14 Kabi AB Dérivés de l'indène à deux substituants géminaux, leurs procédés de préparation et compositions pharmaceutiques les contenant
US4656190A (en) * 1983-11-14 1987-04-07 Merck & Co., Inc. Indene derivatives and their use as PAF-antagonists
US5001255A (en) * 1984-12-04 1991-03-19 Sandoz Pharm. Corp. Idene analogs of mevalonolactone and derivatives thereof
US5245028A (en) * 1990-08-09 1993-09-14 Warner-Lambert Company Process for preparing tetracyclic amines useful as cerebrovascular agents
US5292736A (en) * 1993-02-26 1994-03-08 Sterling Winthrop Inc. Morpholinoalkylindenes as antiglaucoma agents
US6121321A (en) * 1996-06-13 2000-09-19 Cell Pathways, Inc. Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions
US6063818A (en) * 1996-06-13 2000-05-16 Cell Pathways Inc. Substituted benzylidene indenyl formamides, acetamides and propionamides
US5998477A (en) * 1996-06-13 1999-12-07 Cell Pathways Inc. Substituted methoxy benzylidene indenyl-acetic and propionic acids for treating patients with precancerous lesions
US5965619A (en) * 1996-06-13 1999-10-12 Cell Pathways Inc. Method for treating patients having precancerous lesions with substituted indene derivatives
US5948779A (en) * 1997-12-12 1999-09-07 Cell Pathways, Inc. Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes
US6028116A (en) * 1998-04-03 2000-02-22 Cell Pathways, Inc. Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia
DE60032114T2 (de) * 1999-01-29 2007-06-06 Osi Pharmaceuticals, Inc. Behandlungsmethode von aknepatienten durch verabreichung von hemmern der cyclischen gmp pde
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
AU2012236275B2 (en) * 2011-04-01 2016-09-08 Southern Research Institute Derivatives of sulindac, use thereof and preparation thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2798888A (en) * 1952-08-12 1957-07-09 Ciba Pharm Prod Inc Indene and indane compounds and their production
US2886589A (en) * 1957-08-05 1959-05-12 Merck & Co Inc 8-methyl-5-oxyphenyl hexahydroindan compounds
US3072716A (en) * 1959-03-18 1963-01-08 Ciba Geigy Corp Substituted indenes
US3164607A (en) * 1961-01-10 1965-01-05 Upjohn Co 2-phenyl-3-(tertiary amino alkoxy) phenyl-indenes
NL282517A (fr) * 1961-08-31
DE1470055A1 (de) * 1963-12-07 1969-07-17 Merck Ag E Verfahren zur Herstellung von Piperidinderivaten

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0769940A1 (fr) * 1994-07-21 1997-05-02 Eli Lilly And Company COMPOSES D'INDENE UTILES POUR INHIBER sPLA 2?
EP0769940A4 (fr) * 1994-07-21 1997-06-11

Also Published As

Publication number Publication date
US3532752A (en) 1970-10-06
BR6685475D0 (pt) 1973-12-27
DE1593133A1 (de) 1970-07-16
FR7139M (fr) 1969-07-28
CH495322A (de) 1970-08-31
GB1154506A (en) 1969-06-11
NL6618446A (fr) 1967-07-03

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