FR14C0061I2 - SEQUENCES OF CIRCOVIRUS ASSOCIATED WITH PIGLE WASTING DISEASE (PAD) - Google Patents
SEQUENCES OF CIRCOVIRUS ASSOCIATED WITH PIGLE WASTING DISEASE (PAD)Info
- Publication number
- FR14C0061I2 FR14C0061I2 FR14C0061C FR14C0061C FR14C0061I2 FR 14C0061 I2 FR14C0061 I2 FR 14C0061I2 FR 14C0061 C FR14C0061 C FR 14C0061C FR 14C0061 C FR14C0061 C FR 14C0061C FR 14C0061 I2 FR14C0061 I2 FR 14C0061I2
- Authority
- FR
- France
- Prior art keywords
- nucleotide sequence
- polypeptide
- sequence
- nucleotide
- circovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 241001533384 Circovirus Species 0.000 title abstract 2
- 208000010399 Wasting Syndrome Diseases 0.000 title abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 14
- 239000002773 nucleotide Substances 0.000 abstract 13
- 229920001184 polypeptide Polymers 0.000 abstract 10
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 10
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 10
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 241000202347 Porcine circovirus Species 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- 230000000295 complement effect Effects 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 230000001939 inductive effect Effects 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 230000003612 virological effect Effects 0.000 abstract 2
- 208000005753 Circoviridae Infections Diseases 0.000 abstract 1
- 241000282887 Suidae Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 238000007423 screening assay Methods 0.000 abstract 1
Classifications
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- A61P31/04—Antibacterial agents
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/20—Antivirals for DNA viruses
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- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/10011—Circoviridae
- C12N2750/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12N2750/00011—Details
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- C12N2750/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10051—Methods of production or purification of viral material
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- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10061—Methods of inactivation or attenuation
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- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
Abstract
Nucleotide sequence comprising a 1759 bp genomic DNA sequence (I) of a porcine circovirus called MAP ("maladie de l'amaigrissement du porcelet"; piglet fatal wasting disease), is new. Also claimed are: (1) The nucleotide sequence of the porcine circovirus is: (a) a fragment of (I); (b) a nucleotide sequence homologous to the nucleotide sequence of (a); (c) a nucleotide sequence complementary to (I) or complementary to the nucleotide sequence of (a) or (b); (d) a nucleotide sequence capable of hybridizing under stringent conditions to the nucleotide sequence of (a), (b) or (c); (e) a nucleotide sequence comprising (I) or the nucleotide sequences of (a), (b), (c) or (d); (f) a modified nucleotide sequence comprising the nucleotide sequence of (a), (b), (c), (d) or (e). (2) polypeptide encoded by the nucleotide sequence of (1); (3) cloning and/or expression vectors containing the nucleotide sequences; (4) viral or pseudoviral particles generated from the vectors; (5) host cells transformed with the vectors or (pseudo)viral particles; (6) animals containing the transformed cells; (7) synthetic polypeptides obtained using the amino acid sequence of a polypeptide as in (1); (8) hybrid polypeptides comprising at least one sequence of a polypeptide as in (2) or (7) and a sequence of an immunogenic polypeptide; (9) nucleotide sequences encoding the hybrid polypeptides; (10) vectors containing a sequence as in (9); (11) a method for the detection of the porcine circovirus; (12) mono- or polyclonal antibodies or their fragments or chimeric antibodies capable of specifically recognising a polypeptide as in (2) or (7); and (13) compounds that are capable of binding to a polypeptide or nucleotide sequence as above or of recognising an antibody as in (12) and/or of modulating, inducing or inhibiting the expression of genes and/or of modifying the cellular replication of MAP circovirus or of inducing or inhibiting pathologies associated with MAP circovirus infection in pigs and are capable of being selected by a screening assay comprising contacting a compound with a polypeptide, nucleotide sequence or transformed cell as above or administering the compound to an animal as in (6) and determining the effect of the compound.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9715396A FR2772047B1 (en) | 1997-12-05 | 1997-12-05 | GENOMIC SEQUENCE AND POLYPEPTIDES OF CIRCOVIRUS ASSOCIATED WITH PIGLET LOSS DISEASE (MAP), APPLICATIONS TO DIAGNOSIS AND TO PREVENTION AND / OR TREATMENT OF INFECTION |
EP98958957A EP1036180B2 (en) | 1997-12-05 | 1998-12-04 | Vaccine prepared with circovirus type b sequences related to piglet weight loss disease (pwd) |
Publications (2)
Publication Number | Publication Date |
---|---|
FR14C0061I1 FR14C0061I1 (en) | 2014-10-10 |
FR14C0061I2 true FR14C0061I2 (en) | 2016-06-24 |
Family
ID=9514225
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9715396A Expired - Lifetime FR2772047B1 (en) | 1997-12-05 | 1997-12-05 | GENOMIC SEQUENCE AND POLYPEPTIDES OF CIRCOVIRUS ASSOCIATED WITH PIGLET LOSS DISEASE (MAP), APPLICATIONS TO DIAGNOSIS AND TO PREVENTION AND / OR TREATMENT OF INFECTION |
FR14C0062C Active FR14C0062I2 (en) | 1997-12-05 | 2014-08-19 | SEQUENCES OF CIRCOVIRUS ASSOCIATED WITH PIGLE WASTING DISEASE (PAD) |
FR14C0061C Active FR14C0061I2 (en) | 1997-12-05 | 2014-08-19 | SEQUENCES OF CIRCOVIRUS ASSOCIATED WITH PIGLE WASTING DISEASE (PAD) |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9715396A Expired - Lifetime FR2772047B1 (en) | 1997-12-05 | 1997-12-05 | GENOMIC SEQUENCE AND POLYPEPTIDES OF CIRCOVIRUS ASSOCIATED WITH PIGLET LOSS DISEASE (MAP), APPLICATIONS TO DIAGNOSIS AND TO PREVENTION AND / OR TREATMENT OF INFECTION |
FR14C0062C Active FR14C0062I2 (en) | 1997-12-05 | 2014-08-19 | SEQUENCES OF CIRCOVIRUS ASSOCIATED WITH PIGLE WASTING DISEASE (PAD) |
Country Status (15)
Country | Link |
---|---|
US (43) | US6703023B1 (en) |
EP (6) | EP1036180B2 (en) |
AT (1) | ATE412664T1 (en) |
AU (1) | AU1491699A (en) |
BE (2) | BE2014C049I2 (en) |
CY (6) | CY1115405T1 (en) |
DE (1) | DE69840174D1 (en) |
DK (5) | DK2316925T3 (en) |
ES (5) | ES2548146T3 (en) |
FR (3) | FR2772047B1 (en) |
HK (5) | HK1158254A1 (en) |
LU (2) | LU92524I2 (en) |
NL (2) | NL300686I2 (en) |
PT (5) | PT2316925E (en) |
WO (1) | WO1999029871A2 (en) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6517843B1 (en) | 1999-08-31 | 2003-02-11 | Merial | Reduction of porcine circovirus-2 viral load with inactivated PCV-2 |
AU2002302120B2 (en) * | 1997-10-03 | 2006-01-19 | Merial | Porcine circoviruses, vaccines and diagnostic reagents |
US6391314B1 (en) | 1997-10-03 | 2002-05-21 | Merial | Porcine circoviruses vaccines diagnostic reagents |
US7211379B2 (en) | 1997-10-03 | 2007-05-01 | Merial Sas | Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2 |
US7192594B2 (en) | 1997-10-03 | 2007-03-20 | Merial Limited | Postweaning multisystemic wasting syndrome and porcine circovirus from pigs |
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