BE2014C050I2 - Circovirus sequences associated with piglet weight loss disease (PWD) - Google Patents

Circovirus sequences associated with piglet weight loss disease (PWD)

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Publication number
BE2014C050I2
BE2014C050I2 BE2014C050C BE2014C050C BE2014C050I2 BE 2014C050 I2 BE2014C050 I2 BE 2014C050I2 BE 2014C050 C BE2014C050 C BE 2014C050C BE 2014C050 C BE2014C050 C BE 2014C050C BE 2014C050 I2 BE2014C050 I2 BE 2014C050I2
Authority
BE
Belgium
Prior art keywords
pwd
circovirus
polypeptides
vectors
weight loss
Prior art date
Application number
BE2014C050C
Other languages
French (fr)
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Zoetis Services Llc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9514225&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2014C050(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc
Publication of BE2014C050I2 publication Critical patent/BE2014C050I2/en

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    • C12N2710/14011Baculoviridae
    • C12N2710/14111Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141Use of virus, viral particle or viral elements as a vector
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    • G01N2469/20Detection of antibodies in sample from host which are directed against antigens from microorganisms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract

The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
BE2014C050C 1997-12-05 2014-08-14 Circovirus sequences associated with piglet weight loss disease (PWD) BE2014C050I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9715396A FR2772047B1 (en) 1997-12-05 1997-12-05 GENOMIC SEQUENCE AND POLYPEPTIDES OF CIRCOVIRUS ASSOCIATED WITH PIGLET LOSS DISEASE (MAP), APPLICATIONS TO DIAGNOSIS AND TO PREVENTION AND / OR TREATMENT OF INFECTION
PCT/FR1998/002634 WO1999029871A2 (en) 1997-12-05 1998-12-04 Circovirus sequences related to piglet weight loss disease (pwd)

Publications (1)

Publication Number Publication Date
BE2014C050I2 true BE2014C050I2 (en) 2018-07-04

Family

ID=9514225

Family Applications (2)

Application Number Title Priority Date Filing Date
BE2014C050C BE2014C050I2 (en) 1997-12-05 2014-08-14 Circovirus sequences associated with piglet weight loss disease (PWD)
BE2014C049C BE2014C049I2 (en) 1997-12-05 2014-08-14 Circovirus sequences associated with piglet weight loss disease (PWD)

Family Applications After (1)

Application Number Title Priority Date Filing Date
BE2014C049C BE2014C049I2 (en) 1997-12-05 2014-08-14 Circovirus sequences associated with piglet weight loss disease (PWD)

Country Status (15)

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US (43) US6703023B1 (en)
EP (6) EP2000535B1 (en)
AT (1) ATE412664T1 (en)
AU (1) AU1491699A (en)
BE (2) BE2014C050I2 (en)
CY (6) CY1115405T1 (en)
DE (1) DE69840174D1 (en)
DK (5) DK1992696T3 (en)
ES (5) ES2456959T3 (en)
FR (3) FR2772047B1 (en)
HK (5) HK1158694A1 (en)
LU (2) LU92523I2 (en)
NL (2) NL300686I2 (en)
PT (5) PT2330188E (en)
WO (1) WO1999029871A2 (en)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002302120B2 (en) * 1997-10-03 2006-01-19 Merial Porcine circoviruses, vaccines and diagnostic reagents
US7192594B2 (en) 1997-10-03 2007-03-20 Merial Limited Postweaning multisystemic wasting syndrome and porcine circovirus from pigs
AU2003248395B2 (en) * 1997-10-03 2006-03-16 Merial Porcine CircoViruses, vaccines and diagnostic reagents
UA78180C2 (en) * 1997-10-03 2007-03-15 Меріаль Porcine circovirus, vaccines and diagnostic reagents
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
US7211379B2 (en) 1997-10-03 2007-05-01 Merial Sas Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2
US6391314B1 (en) 1997-10-03 2002-05-21 Merial Porcine circoviruses vaccines diagnostic reagents
FR2772047B1 (en) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E GENOMIC SEQUENCE AND POLYPEPTIDES OF CIRCOVIRUS ASSOCIATED WITH PIGLET LOSS DISEASE (MAP), APPLICATIONS TO DIAGNOSIS AND TO PREVENTION AND / OR TREATMENT OF INFECTION
CA2313806A1 (en) * 1997-12-11 1999-06-17 University Of Saskatchewan Postweaning multisystemic wasting syndrome virus from pigs
EP1816200B1 (en) * 1997-12-11 2016-03-09 Merial Postweaning multisystemic wasting syndrome virus for pigs
WO1999045956A1 (en) * 1998-03-13 1999-09-16 University Of Georgia Research Foundation, Inc. Vaccines against circovirus infections
US6943152B1 (en) * 1999-06-10 2005-09-13 Merial DNA vaccine-PCV
ES2170622B1 (en) * 1999-12-03 2004-05-16 Consejo Superior De Investigaciones Cientificas CLONES AND INFECTIVE VECTORS DERIVED FROM CORONAVIRUS AND ITS APPLICATIONS.
AU2001238535A1 (en) 2000-02-16 2001-08-27 Large Scale Biology Corporation Rolling circle replicon expression vectors
US6794163B2 (en) 2001-03-27 2004-09-21 University Of Saskatchewan Methods to culture circovirus
US7279166B2 (en) 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US7276353B2 (en) 2001-12-12 2007-10-02 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
UA95602C2 (en) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Pcv2 immunogenic compositions and methods of producing such compositions
US7700285B1 (en) 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
US7833707B2 (en) 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
AU2011253941B2 (en) * 2004-12-30 2015-01-29 Boehringer Ingelheim Animal Health USA Inc. PCV2 immunogenic compositions and methods of producing such compositions
DK1833992T3 (en) 2004-12-30 2015-06-08 Boehringer Ingelheim Vetmed PCV2 immunogenic compositions and methods for preparing such compositions
ITBO20050123A1 (en) 2005-03-07 2005-06-06 Alfa Wassermann Spa GASTRORESISTIC PHARMACEUTICAL FORMULATIONS CONTAINING RIFAXIMINA
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
TW200643171A (en) * 2005-06-07 2006-12-16 Temasek Life Sciences Lab Ltd Porcine circovirus type 2 vaccines
JP5106398B2 (en) * 2005-09-09 2012-12-26 インターベツト・インターナシヨナル・ベー・ベー PCV-2 vaccine
PL1968630T3 (en) 2005-12-29 2018-08-31 Boehringer Ingelheim Vetmedica, Inc. Multivalent pcv2 immunogenic compositions
HUE029552T2 (en) 2005-12-29 2017-03-28 Boehringer Ingelheim Vetmedica Inc Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs
US20100136060A1 (en) * 2006-11-22 2010-06-03 Boehringer Ingelheim Vetmedica, Inc. Methods of reducing porcine circovirus-associated disease outbreaks
US20100129397A1 (en) * 2006-12-11 2010-05-27 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
BRPI0721083A2 (en) * 2006-12-15 2014-02-25 Boehringer Ingelheim Vetmed PCV2 ANTIGEN PIG TREATMENT
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
US8518696B2 (en) * 2007-05-11 2013-08-27 Temasek Life Sciences Laboratory Limited Production of homogeneous cell line highly permissive to porcine circovirus type 2 (PCV2) infection
US7829274B2 (en) 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
CL2008003813A1 (en) * 2007-12-21 2009-03-20 Zoetis W Llc Porcine circovirus; nucleic acid molecule that encodes it; immunogenic composition comprising it; method to immunize a pig against viral infection or to prevent post-weaning syndrome of multi-system wasting (pmsw), and method to determine if a mammal has or is at risk of developing pmsw.
KR20100103535A (en) * 2007-12-31 2010-09-27 베링거잉겔하임베트메디카인코퍼레이티드 Pcv2 orf2 virus like particle with foreign amino acid insertion
US20090317423A1 (en) 2008-01-23 2009-12-24 Boehringer Ingelheim Vetmedica, Inc. Pcv2 mycoplasma hyopneumoniae immunogenic compositions and methods of producing such compositions
US20110033495A1 (en) * 2008-02-15 2011-02-10 Boehringer Ingelheim Vetmedica, Inc. Methods and compositions for reducing the impact of enteric diseases
CA2739469A1 (en) * 2008-10-16 2010-04-22 Pfizer Inc. Torque teno virus (ttv) isolates and compositions
US20100150959A1 (en) * 2008-12-15 2010-06-17 Vectogen Pty Ltd. PCV 2-Based Methods and Compositions for the Treatment of Pigs
TWI627281B (en) 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 Methods of reducing viricidal activity in pcv-2 compositions and pcv-2 compositions with an improved immunogenicity
US20110252505A1 (en) 2009-10-02 2011-10-13 Pioneer Hi-Bred International, Inc. Down-Regulation of ACC Synthase for Improved Plant Performance
CN103865955A (en) * 2009-10-16 2014-06-18 佐蒂斯有限责任公司 Infectious clones of Torque teno virus
US8846388B2 (en) 2009-10-16 2014-09-30 Zoetis Llc Infectious clones of torque teno virus
CA2777159A1 (en) * 2009-10-22 2011-04-28 Universitat Leipzig Detection of a circovirus in calves suffering from bovine neonatal pancytopenia
WO2011091389A2 (en) * 2010-01-25 2011-07-28 Blood Systems, Inc. Cyclovirus and method of use
KR20110090711A (en) * 2010-02-04 2011-08-10 녹십자수의약품(주) Novel porcine circovirus type 2 and use thereof
TWI508974B (en) 2010-12-22 2015-11-21 Sbc Virbac Ltd Porcine circovirus type 2, immunogenic composition containing the same, test kit, and application thereof
BR112013027860A2 (en) 2011-04-29 2016-11-29 Pioneer Hi Bred Int isolated nucleic acid, plant or plant cell, method for increasing drain capacity, accelerating remobilization and / or grain senescence and drying in a plant, method for increasing drought tolerance in the absence of a productivity penalty under conditions without drought, expression cassette and method for reducing zmme293 expression or zmme293 activity in a plant
HUP1100470A2 (en) 2011-08-30 2013-03-28 Mezoegazdasagi Biotechnologiai Kutatokoezpont Nanoparticle-based veterinary vaccine
EP2564869A1 (en) 2011-09-02 2013-03-06 Ceva Sante Animale Synthetic capsid proteins and uses thereof
UA113192C2 (en) * 2011-12-06 2016-12-26 IMMUNOGENIC COMPOSITION AGAINST PIG TYPE 2 (PCV2) CIRCULOSIS
US9120859B2 (en) 2012-04-04 2015-09-01 Zoetis Services Llc Mycoplasma hyopneumoniae vaccine
UA114503C2 (en) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс PCV AND MYCOPLASMA HYOPNEUMONIA COMBINED VACCINE
DK2961766T3 (en) * 2013-03-01 2019-07-15 Boehringer Ingelheim Animal Health Usa Inc QUANTIFICATION OF VACCINE COMPOSITIONS
KR102217387B1 (en) * 2013-03-11 2021-02-19 주식회사 중앙백신연구소 Porcine circovirus2 vaccine using recombinant yeast whole cell and manufacturing thereof
EP2789346A1 (en) 2013-04-11 2014-10-15 CEVA Santé Animale SA Fusion polypeptides and vaccines
WO2014182872A1 (en) 2013-05-08 2014-11-13 Protatek International, Inc. Vaccine for pcv2 and mycoplasma
EP4091629A1 (en) 2013-09-25 2022-11-23 Zoetis Services LLC Pcv2b divergent vaccine composition and methods of use
EP3052516B1 (en) 2013-10-02 2020-01-01 Boehringer Ingelheim Animal Health USA Inc. Pcv2 orf2 protein variant and virus like particles composed thereof
EP3034609A1 (en) 2014-12-19 2016-06-22 Ceva Sante Animale Recombinant swinepox virus and vaccines
EP3254692A1 (en) 2016-06-10 2017-12-13 Ceva Sante Animale Multivalent recombinant spv
WO2019032830A1 (en) 2017-08-09 2019-02-14 Dreamwell, Ltd. Adjustable foundation
WO2019110822A1 (en) 2017-12-08 2019-06-13 Ceva Sante Animale Recombinant swinepox virus and vaccines
CA3091982A1 (en) 2018-03-26 2019-10-03 Boehringer Ingelheim Animal Health USA Inc. Method of producing an immunogenic composition
EP3801609A1 (en) 2018-06-11 2021-04-14 Ceva Santé Animale Vaccination against porcine circoviruses
WO2022076614A1 (en) * 2020-10-06 2022-04-14 Materials and Machines Corporation of America Method for detection of rna or dna from biological samples
WO2023192936A2 (en) * 2022-03-30 2023-10-05 Fred Hutchinson Cancer Center Systems and methods to produce b cells that express selected antibodies and gene products
CN114736310B (en) * 2022-06-10 2022-10-28 北京华夏兴洋生物科技有限公司 Protein and biological material for producing circovirus type 2 virus-like particles and application

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US69750A (en) * 1867-10-15 Henry bean
US69233A (en) * 1867-09-24 Joseph r
FR2422956A1 (en) 1978-04-13 1979-11-09 Pasteur Institut METHOD OF DETECTION AND CHARACTERIZATION OF A NUCLEIC ACID OR OF A SEQUENCE OF THE SAME, AND ENZYMATIC REAGENT FOR THE IMPLEMENTATION OF THIS PROCESS
FR2464269B1 (en) 1979-08-30 1986-04-18 Anvar NUCLEOTIDE SEQUENCE ENCODING HEPATITIS B VIRUS SURFACE ANTIGEN, PROCESS FOR OBTAINING SAME AND ANTIGEN OBTAINED
FR2518755B1 (en) 1981-12-23 1986-04-11 Pasteur Institut PROBE CONTAINING MODIFIED NUCLEIC ACID RECOGNIZABLE BY SPECIFIC ANTIBODIES AND USE OF THE SAME TO DETECT AND CHARACTERIZE A HOMOLOGATED DNA SEQUENCE
US5833975A (en) 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
US4745051A (en) 1983-05-27 1988-05-17 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4946787A (en) 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5545412A (en) 1985-01-07 1996-08-13 Syntex (U.S.A.) Inc. N-[1, (1-1)-dialkyloxy]-and N-[1, (1-1)-dialkenyloxy]-alk-1-yl-n,n,n-tetrasubstituted ammonium lipids and uses therefor
US5106733A (en) 1987-06-25 1992-04-21 Immunex Corporation Bovine granulocyte-macrophage colony stimulating factor
SU1538305A1 (en) 1987-07-21 1994-12-15 Всесоюзный государственный научно-контрольный институт ветеринарных препаратов Госагропрома СССР Associated vaccine against peptospirosis and parvovirus infection of pigs
US5069901A (en) 1988-02-03 1991-12-03 Jones Elaine V Preparation of a recombinant subunit vaccine against pseudorabies infection
EP0454735B1 (en) 1989-01-23 1996-05-22 Auspharm International Limited Vaccine composition
US5811103A (en) 1989-03-19 1998-09-22 Akzo Nobel N.V. Hog cholera virus vaccine and diagnostic
ES2200016T3 (en) 1989-03-21 2004-03-01 Vical Incorporated EXPRESSION OF EXECUTIVE POLINUCLEOTIDIC SEQUENCES IN A VERTEBRATE.
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
WO1991018627A1 (en) 1990-05-29 1991-12-12 Smithkline Beecham Corporation Swine pneumonia vaccine and method for the preparation thereof
US5565205A (en) * 1990-08-16 1996-10-15 Solvay Animal Health, Inc. Inactivated Mycoplasma hypopneumoniae bacterin and method of use thereof
WO1992005255A1 (en) 1990-09-13 1992-04-02 Commonwealth Scientific And Industrial Research Organisation Ovine cytokine genes
GB9023111D0 (en) * 1990-10-24 1990-12-05 Wellcome Found Expression system
DK0555366T3 (en) 1990-11-01 2000-08-28 Univ Iowa State Res Found Inc Method of bacterial attenuation and vaccine
EP0575491B1 (en) 1991-03-07 2003-08-13 Virogenetics Corporation Genetically engineered vaccine strain
ES2026827A6 (en) 1991-03-26 1992-05-01 Ercros Sa Method for producing a subunit vaccine against porcine parvovirus.
US5580557A (en) * 1991-10-09 1996-12-03 Iowa State University Research Foundation, Inc. Live, avirulent salmonella choleraesuis vaccine used for inducing an immune response in animals
US6033904A (en) 1992-01-13 2000-03-07 Syntro Corporation Recombinant swinepox virus
US5382425A (en) 1992-01-13 1995-01-17 Syntro Corporation Recombinant swinepox virus
US5338543A (en) * 1992-02-27 1994-08-16 Ambico, Inc. Thimerosal inactivated mycoplasma hyopneumoniae vaccine
ZA934890B (en) 1992-07-08 1994-04-14 Schering Corp Use of Gm-CSF as a vaccine adjuvant
JP3149116B2 (en) * 1992-10-28 2001-03-26 信越化学工業株式会社 Epitope-related peptide of human parvovirus
AU675269B2 (en) * 1992-11-09 1997-01-30 Zonagen, Inc. Materials and methods for immunocontraception
EP0683816B1 (en) 1993-02-08 2000-11-02 Bayer Corporation Process for growing porcine reproductive and respiratory syndrome virus and its use in vaccines
IL108915A0 (en) 1993-03-18 1994-06-24 Merck & Co Inc Polynucleotide vaccine against influenza virus
WO1994027238A1 (en) 1993-05-14 1994-11-24 Mds Health Group Ltd. Electronic worksheet system for microbiology testing and reporting
JPH09500013A (en) 1993-06-01 1997-01-07 ライフ・テクノロジーズ・インコーポレイテッド Gene immunity with cationic lipids
DE69434447T2 (en) 1993-06-07 2006-05-18 Vical, Inc., San Diego PLASMIDE FOR GENE THERAPY
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
FR2711670B1 (en) 1993-10-22 1996-01-12 Pasteur Institut Nucleotide vector, composition containing it and vaccine for immunization against hepatitis.
GB2285766B (en) 1994-01-21 1997-07-23 Ecc Int Ltd Ceramic casting composition
KR0121105B1 (en) * 1994-02-04 1997-11-10 문정환 Fifo memory bus appurtenance
EP0804249A2 (en) 1994-03-15 1997-11-05 Brown University Research Foundation Polymeric gene delivery system
CA2188447C (en) 1994-04-29 2002-10-22 Falko-Gunter Falkner Recombinant poxviruses with foreign polynucleotides in essential regions
EP0968722B1 (en) * 1994-05-10 2007-06-20 Wyeth Improved modified live BRSV vaccine
GB2289279B (en) 1994-05-13 1998-09-16 Iberica Cyanamid Diagnostic kits and vaccines containing recombinant PRRSV proteins
US5719131A (en) 1994-12-09 1998-02-17 Genzyme Corporation Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules
US5840306A (en) * 1995-03-22 1998-11-24 Merck & Co., Inc. DNA encoding human papillomavirus type 18
US6043232A (en) 1997-07-23 2000-03-28 Nitromed, Inc. Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
CA2214029A1 (en) 1995-04-25 1996-10-31 Magda Marquet Single-vial formulations of dna/lipid complexes
US5681658A (en) * 1995-05-30 1997-10-28 Aluminum Company Of America Gelation-resistant alumina
US5885823A (en) 1995-06-05 1999-03-23 Nobl Laboratories, Inc. Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents
US5705385A (en) 1995-06-07 1998-01-06 Inex Pharmaceuticals Corporation Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US5820869A (en) 1995-06-07 1998-10-13 American Home Products Corporation Recombinant raccoon pox viruses and their use as an effective vaccine against feline immunodeficiency virus infection
US6019980A (en) 1995-06-07 2000-02-01 Connaught Laboratories Limited Nucleic acid respiratory syncytial virus vaccines
WO1996040931A1 (en) 1995-06-07 1996-12-19 Aesculaap B.V. Neutralizing conformational epitopes of chicken anemia virus
US5795872A (en) 1995-09-19 1998-08-18 Pharmadigm, Inc. DNA construct for immunization
FR2751224B1 (en) 1996-07-19 1998-11-20 Rhone Merieux POLYNUCLEOTIDE VACCINE FORMULA AGAINST BREATHING AND PIG REPRODUCTIVE CONDITIONS
PT835930E (en) 1996-10-09 2001-06-29 Akzo Nobel Nv EUROPEAN VACCINE VIRUSES OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV)
WO1998040499A1 (en) 1997-03-10 1998-09-17 Heather Lynn Davis Gene delivery to mucosal epithelium for immunization or therapeutic purposes
US5990091A (en) 1997-03-12 1999-11-23 Virogenetics Corporation Vectors having enhanced expression, and methods of making and uses thereof
US6004777A (en) 1997-03-12 1999-12-21 Virogenetics Corporation Vectors having enhanced expression, and methods of making and uses thereof
US20030215445A1 (en) * 1997-05-23 2003-11-20 Ginette Serrero Methods and compositions for inhibiting the growth of hematopoietic malignant cells
FR2769321B1 (en) 1997-10-03 2001-10-26 Merial Sas NEW PIG CIRCOVIRUSES, VACCINES AND DIAGNOSTIC REAGENTS
US6143334A (en) * 1997-10-03 2000-11-07 Sargento Foods Inc. Pasta filata method for manufacturing Swiss-type cheeses
UA78180C2 (en) 1997-10-03 2007-03-15 Меріаль Porcine circovirus, vaccines and diagnostic reagents
FR2781159B1 (en) 1998-07-06 2000-10-06 Merial Sas CIRCOVIRUS VACCINE AND PIG PARVOVIRUS
FR2769322B1 (en) 1997-10-03 2002-03-08 Merial Sas NEW PORCINE CIRCOVIRUSES, VACCINES AND DIAGNOSTIC REAGENTS
US6391314B1 (en) * 1997-10-03 2002-05-21 Merial Porcine circoviruses vaccines diagnostic reagents
US7211379B2 (en) 1997-10-03 2007-05-01 Merial Sas Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2
US7192594B2 (en) * 1997-10-03 2007-03-20 Merial Limited Postweaning multisystemic wasting syndrome and porcine circovirus from pigs
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
US6165493A (en) 1997-10-22 2000-12-26 New York Blood Center, Inc. "Methods and compositions for decreasing the frequency of HIV, herpesvirus and sexually transmitted bacterial infections"
FR2772047B1 (en) * 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E GENOMIC SEQUENCE AND POLYPEPTIDES OF CIRCOVIRUS ASSOCIATED WITH PIGLET LOSS DISEASE (MAP), APPLICATIONS TO DIAGNOSIS AND TO PREVENTION AND / OR TREATMENT OF INFECTION
US20040062775A1 (en) 1997-12-05 2004-04-01 Agence Francaise De Securite Sanitaire Des Aliments Circovirus sequences associated with piglet weight loss disease (PWD)
CA2313806A1 (en) * 1997-12-11 1999-06-17 University Of Saskatchewan Postweaning multisystemic wasting syndrome virus from pigs
WO1999045956A1 (en) * 1998-03-13 1999-09-16 University Of Georgia Research Foundation, Inc. Vaccines against circovirus infections
US6294176B1 (en) * 1998-07-10 2001-09-25 Schering-Plough Veterinary Corp. Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species
WO2000024428A2 (en) 1998-10-23 2000-05-04 Heska Corporation Cationic lipid-mediated enhancement of nucleic acid immunization of cats
US6143333A (en) 1998-11-13 2000-11-07 Purina Mills, Inc. Method of preparing a packaged fish attractant block
FR2789695B1 (en) 1999-02-11 2003-03-07 Merial Sas VIRAL VACCINES AND VACCINES BASED ON RECOMBINANT AND REPLICATIVE SWINE ADENOVIRUSES
US6943152B1 (en) * 1999-06-10 2005-09-13 Merial DNA vaccine-PCV
US6497883B1 (en) * 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
US6139179A (en) 1999-09-03 2000-10-31 Davis-Standard Corporation Extruder screw having multi-channeled barrier section
US6179461B1 (en) 1999-09-03 2001-01-30 Davis-Standard Corporation Extruder screw
WO2001017556A1 (en) 1999-09-07 2001-03-15 Shionogi & Co., Ltd. Vaccine preparations for mucosal administration
GB9921147D0 (en) 1999-09-07 1999-11-10 Smithkline Beecham Biolog Novel composition
GB9921146D0 (en) 1999-09-07 1999-11-10 Smithkline Beecham Biolog Novel composition
DE50009644D1 (en) * 1999-11-10 2005-04-07 Rodenstock Gmbh HETEROCYCLICALLY ANNELATED INDENOCHROMENE DERIVATIVES
US6366601B1 (en) * 1999-11-17 2002-04-02 Motorola, Inc. Variable rate spread spectrum communication method and apparatus
US7233407B1 (en) * 2000-02-02 2007-06-19 Xerox Corporation Document production system for capturing web page content
JP3363419B2 (en) * 1999-12-24 2003-01-08 住友ゴム工業株式会社 Radial tires for heavy loads
AU2001266940A1 (en) 2000-06-15 2001-12-24 Purdue Research Foundation Vaccine for congenital tremors in pigs
JP4768106B2 (en) 2000-07-31 2011-09-07 スリーエム イノベイティブ プロパティズ カンパニー Adhesive composition and adhesive structure for easy thermal peeling
DE10044646A1 (en) 2000-09-08 2002-04-04 Horsch Maschinen Gmbh Spray boom guidance
DE10044648A1 (en) * 2000-09-08 2002-03-21 Aventis Behring Gmbh Process for the propagation or removal of Cirocoviruses from biological material
DE10051562A1 (en) * 2000-10-18 2002-04-25 Emitec Emissionstechnologie Electrically heated honeycomb body used for removing hydrocarbons or nitrogen oxides from I.C. engine exhaust gases comprises two zones with different coatings arranged behind each other in the flow direction
US6572081B2 (en) * 2000-12-27 2003-06-03 Nkf Kabel B.V. Installation of guide tubes in a protective duct
US6794163B2 (en) * 2001-03-27 2004-09-21 University Of Saskatchewan Methods to culture circovirus
AUPR567401A0 (en) 2001-06-14 2001-07-12 University Of Melbourne, The Circovirus vaccines
US7276353B2 (en) * 2001-12-12 2007-10-02 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US7279166B2 (en) * 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US20030215455A1 (en) * 2002-05-14 2003-11-20 Bailey Reynolds Vaccine stabilizer and method of use
EP1914831B1 (en) * 2002-11-28 2014-07-02 BlackBerry Limited Multiple-band antenna with patch and slot structures
US7288529B2 (en) * 2003-04-24 2007-10-30 New York University ALK protein tyrosine kinase, cells and methods embodying and using same
ES2333334T5 (en) * 2003-07-25 2018-08-06 Boehringer Ingelheim Vetmedica, Inc. Lawsonia intracellularis of European origin and vaccines, diagnostic agents and methods of use thereof
US20050279889A1 (en) 2004-06-08 2005-12-22 Safe Flight Instrument Corporation Variable wing spacecraft
US7833707B2 (en) * 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
CN101189027A (en) * 2005-01-13 2008-05-28 贝林格尔·英格海姆维特梅迪卡有限公司 Prrs vaccines
ME02683B (en) * 2005-04-13 2017-06-20 Method for porcine circovirus production
HUE029552T2 (en) 2005-12-29 2017-03-28 Boehringer Ingelheim Vetmedica Inc Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs
US8377070B2 (en) * 2007-05-17 2013-02-19 Michael T. Gauthier Compressor distractor tool
US8214576B2 (en) 2009-03-03 2012-07-03 Vmware, Inc. Zero copy transport for target based storage virtual appliances

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