FR11C0038I1 - MACROCYCLIC ANALOGS, THEIR METHODS OF USE AND PREPARATION - Google Patents

MACROCYCLIC ANALOGS, THEIR METHODS OF USE AND PREPARATION

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Publication number
FR11C0038I1
FR11C0038I1 FR11C0038C FR11C0038I1 FR 11C0038 I1 FR11C0038 I1 FR 11C0038I1 FR 11C0038 C FR11C0038 C FR 11C0038C FR 11C0038 I1 FR11C0038 I1 FR 11C0038I1
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FR
France
Prior art keywords
preparation
methods
macrocyclic analogs
analogs
macrocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
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French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22219026&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR11C0038(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Publication of FR11C0038I1 publication Critical patent/FR11C0038I1/en
Application granted granted Critical
Publication of FR11C0038I2 publication Critical patent/FR11C0038I2/en
Active legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides a compound having the formula: that is useful as an intermediate in the preparation of certain pharmaceutically active halichondrin analogs.
FR11C0038C 1998-06-17 2011-09-09 MACROCYCLIC ANALOGS, THEIR METHODS OF USE AND PREPARATION Active FR11C0038I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8968298P 1998-06-17 1998-06-17
EP99928746A EP1087960B1 (en) 1998-06-17 1999-06-16 Macrocyclic analogs and methods of their use and preparation

Publications (2)

Publication Number Publication Date
FR11C0038I1 true FR11C0038I1 (en) 2011-10-14
FR11C0038I2 FR11C0038I2 (en) 2013-01-11

Family

ID=22219026

Family Applications (1)

Application Number Title Priority Date Filing Date
FR11C0038C Active FR11C0038I2 (en) 1998-06-17 2011-09-09 MACROCYCLIC ANALOGS, THEIR METHODS OF USE AND PREPARATION

Country Status (23)

Country Link
US (4) US6214865B1 (en)
EP (4) EP2272840B1 (en)
JP (1) JP4454151B2 (en)
KR (1) KR100798600B1 (en)
CN (1) CN1216051C (en)
AT (1) ATE502932T1 (en)
AU (1) AU762998B2 (en)
BE (1) BE2011C028I2 (en)
BR (1) BRPI9911326B8 (en)
CA (3) CA2632433C (en)
CY (2) CY1111516T1 (en)
DE (2) DE122011100031I1 (en)
DK (1) DK1087960T3 (en)
FR (1) FR11C0038I2 (en)
HK (1) HK1035534A1 (en)
HU (1) HU227912B1 (en)
IL (1) IL139960A0 (en)
LU (1) LU91854I2 (en)
NO (5) NO328280B1 (en)
NZ (1) NZ508597A (en)
PT (1) PT1087960E (en)
WO (1) WO1999065894A1 (en)
ZA (1) ZA200007159B (en)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1216051C (en) * 1998-06-17 2005-08-24 卫材株式会社 Macrocyclic analogs and methods of their use and preparation
US8097648B2 (en) * 1998-06-17 2012-01-17 Eisai R&D Management Co., Ltd. Methods and compositions for use in treating cancer
US6653341B1 (en) * 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
DE10037310A1 (en) 2000-07-28 2002-02-07 Asta Medica Ag New indole derivatives and their use as medicines
WO2003072754A2 (en) * 2002-02-27 2003-09-04 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
RU2342399C2 (en) 2002-03-22 2008-12-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Hemiasterlyn derivatives and application thereof for at cancer treatment
US20050075395A1 (en) * 2003-05-28 2005-04-07 Gary Gordon Continuous dosing regimen
MXPA05012814A (en) * 2003-05-29 2007-01-25 Abbott Lab Continuous dosing regimen with abt-751.
WO2005011589A2 (en) * 2003-07-29 2005-02-10 Eisai Co., Ltd. Drug delivery methods and devices
EP2949652B1 (en) 2004-06-03 2019-08-07 Eisai R&D Management Co., Ltd. Intermediates for the preparation of halichondrin B
CN1993342A (en) * 2004-06-03 2007-07-04 卫材株式会社 Intermediates for the preparation of halichondrin b
US20060045846A1 (en) * 2004-08-30 2006-03-02 Horstmann Thomas E Reagents and methods for labeling terminal olefins
EP1831697A4 (en) * 2004-12-09 2011-01-26 Eisai R&D Man Co Ltd Tubulin isotype screening in cancer therapy using halichondrin b analogs
MX2010003599A (en) 2007-10-03 2010-09-10 Eisai R&D Man Co Ltd Intermediates and methods for the synthesis of halichondrin b analogs.
US8598373B2 (en) 2008-04-04 2013-12-03 Eisai R&D Management Co., Ltd. Halichondrin B analogs
RU2476216C1 (en) * 2009-03-30 2013-02-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Liposomal composition
JP5622719B2 (en) 2009-03-30 2014-11-12 エーザイ・アール・アンド・ディー・マネジメント株式会社 Method for producing liposome composition
LT2415470T (en) 2009-03-30 2016-10-10 Eisai R&D Management Co., Ltd. Liposome composition
US8765974B2 (en) * 2009-04-14 2014-07-01 Nissan Chemical Industries, Ltd. Method for producing tetrahydropyran compound and intermediate thereof
CA2787919C (en) 2010-01-26 2018-07-31 Eisai R&D Management Co., Ltd. Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs
SG10201602147YA (en) 2011-03-18 2016-05-30 Eisai R&D Man Co Ltd Methods And Compositions For Predicting Response To Eribulin
WO2012147900A1 (en) 2011-04-28 2012-11-01 Eisai R&D Management Co., Ltd. Microreactor process for halichondrin b analog synthesis
ES2841809T3 (en) 2011-06-03 2021-07-09 Eisai R&D Man Co Ltd Biomarkers to predict and evaluate the degree of response of subjects with thyroid and kidney cancer to lenvatinib compounds
EP2785687B1 (en) 2011-11-30 2019-02-20 Sandoz AG Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene
AU2012350420A1 (en) 2011-12-16 2014-07-10 Alphora Research Inc. Process for preparation of 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl) propanol derivatives and intermediates useful thereof
SI2797945T1 (en) * 2011-12-29 2016-07-29 Alphora Research Inc. 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation
IN2014MN02106A (en) * 2012-03-30 2015-09-11 Alphora Res Inc
RU2689977C2 (en) 2012-12-04 2019-05-30 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Using eribulin for treating breast cancer
CA2909209A1 (en) 2013-05-15 2014-11-20 Alphora Research Inc. 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof
BR112015029386B1 (en) 2013-06-26 2023-11-14 Eisai R&D Management Co., Ltd. USE OF ERIBULIN AND LENVATINIB AS COMBINATION THERAPY AND KIT
WO2015000070A1 (en) 2013-07-03 2015-01-08 Alphora Research Inc. Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein including intermediates containing -so2-(p-tolyl) groups
CN103483352A (en) * 2013-10-18 2014-01-01 李友香 Medicinal bulk drug for resisting tumors
US9783549B2 (en) 2013-11-04 2017-10-10 Eisai R&D Management Co., Ltd. Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
MX370611B (en) 2013-12-06 2019-12-18 Eisai R&D Man Co Ltd Methods useful in the synthesis of halichondrin b analogs.
CN104860978A (en) * 2014-02-20 2015-08-26 正大天晴药业集团股份有限公司 Synthesis intermediates of halichondrin B analog
TW201617326A (en) * 2014-03-06 2016-05-16 Ａｌｐｈｏｒａ研發股份有限公司 Crystalline derivatives of (S)-1-((2R,3R,4S,5S)-5-allyl-3-methoxy-4-(tosylmethyl)tetrahydrofuran-2-yl)-3-aminopropan-2-ol
US20170100367A1 (en) 2014-05-28 2017-04-13 Eisai R&D Management Co., Ltd. Use of eribulin in the treatment of cancer
JP2017520586A (en) 2014-06-30 2017-07-27 プレジデント アンド フェローズ オブ ハーバード カレッジ Synthesis and use of halichondrin analogues
KR102512940B1 (en) 2014-08-28 2023-03-23 에자이 알앤드디 매니지먼트 가부시키가이샤 High-purity quinoline derivative and method for manufacturing same
WO2016038624A1 (en) 2014-09-09 2016-03-17 Cipla Limited "process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof"
CN105713031B (en) * 2014-12-05 2021-05-07 正大天晴药业集团股份有限公司 Intermediate for preparing eribulin and preparation method thereof
CA2976325C (en) 2015-02-25 2023-07-04 Eisai R&D Management Co., Ltd. Method for suppressing bitterness of quinoline derivative
KR102662228B1 (en) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 Combination of PD-1 antagonists and VEGFR/FGFR/RET tyrosine kinase inhibitors to treat cancer
AU2016226157B2 (en) 2015-03-04 2022-01-27 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and eribulin for treating cancer
WO2016176560A1 (en) 2015-04-30 2016-11-03 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
KR20180013943A (en) * 2015-05-07 2018-02-07 에자이 알앤드디 매니지먼트 가부시키가이샤 Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halicondrine markrolides
US10597401B2 (en) 2015-05-08 2020-03-24 Albany Molecular Research, Inc. Methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof
BR112017027227B1 (en) 2015-06-16 2023-12-12 Eisai R&D Management Co., Ltd ANTI-CANCER AGENT
KR20180107243A (en) * 2016-02-12 2018-10-01 에자이 알앤드디 매니지먼트 가부시키가이샤 Intermediates and related synthetic methods in the synthesis of eribulin
EP3449921B1 (en) 2016-04-28 2023-05-31 Eisai R&D Management Co., Ltd. Eribulin for inhibiting tumor growth
CN109415383A (en) * 2016-05-26 2019-03-01 雷迪博士实验室有限公司 Prepare the method and its intermediate of eribulin
MX2018016329A (en) 2016-06-30 2019-09-18 Eisai R&D Man Co Ltd Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof.
WO2018071792A1 (en) 2016-10-14 2018-04-19 Merck Sharp & Dohme Corp. Combination of a pd-1 antagonist and eribulin for treating urothelial cancer
JP6978758B2 (en) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ Palladium-mediated ketolization
WO2018096478A2 (en) 2016-11-23 2018-05-31 Dr. Reddy’S Laboratories Limited Process for preparation of eribulin and intermediates thereof
KR101991710B1 (en) 2017-12-14 2019-06-21 연성정밀화학(주) Intermediate for Preparing Eribulin Mesylate and Process for Preparing the Same
KR101880939B1 (en) 2017-01-02 2018-08-17 연성정밀화학(주) Intermediate for Preparing Eribulin Mesylate and Process for Preapring the Same
CN110139866B (en) * 2017-01-02 2022-05-17 研成精密化学株式会社 Intermediate for preparing eribulin mesylate and method for preparing same
CN108341828B (en) * 2017-01-24 2021-04-06 江苏恒瑞医药股份有限公司 Process for the preparation of eribulin and intermediates thereof
CN108341738B (en) * 2017-01-24 2022-10-21 江苏恒瑞医药股份有限公司 Process for the preparation of eribulin and intermediates thereof
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
MD3606928T2 (en) 2017-04-05 2022-12-31 Harvard College Macrocyclic compound and uses thereof
CA3211559A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College Synthesis of halichondrins
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
US20190046513A1 (en) 2017-08-10 2019-02-14 Huya Bioscience International, Llc Combination therapies of hdac inhibitors and tubulin inhibitors
CN109694379B (en) * 2017-10-24 2020-09-11 江苏恒瑞医药股份有限公司 Intermediate for preparing eribulin and preparation method thereof
CN111328328B (en) * 2017-11-09 2023-05-23 研成精密化学株式会社 Intermediate for preparing eribulin mesylate and preparation method thereof
CN117924310A (en) 2017-11-15 2024-04-26 哈佛大学的校长及成员们 Macrocyclic compounds and uses thereof
US11419856B2 (en) 2017-11-20 2022-08-23 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of neoplastic diseases
WO2019102490A1 (en) 2017-11-21 2019-05-31 Natco Pharma Limited Intermediates for the preparation of eribulin thereof
JP7469226B2 (en) 2018-01-03 2024-04-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 The Prins reaction and compounds useful for the synthesis of halichondrin macrolides and their analogues
WO2019211877A1 (en) 2018-05-03 2019-11-07 Cipla Limited Process for the preparation of macrocyclic ketone analogs of halichondrin b
WO2020008382A1 (en) * 2018-07-04 2020-01-09 Dr. Reddy’S Laboratories Limited Process for preparation of eribulin and intermediates thereof
EP3823973A4 (en) * 2018-07-20 2022-09-21 Dr. Reddy's Laboratories Limited Purification process for preparation of eribulin and intermediates thereof
WO2020075027A1 (en) * 2018-10-09 2020-04-16 Dr. Reddy's Laboratories Limited Process for preparation of eribulin and intermediates thereof
US11447499B2 (en) 2019-06-14 2022-09-20 Rk Pharma Inc. Process for the preparation of eribulin mesylate intermediate
WO2020255164A1 (en) 2019-06-21 2020-12-24 Council Of Scientific And Industrial Research A chemo-enzymatic process for the preparation of homopropargylic alcohol
US11083705B2 (en) 2019-07-26 2021-08-10 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
US12036204B2 (en) 2019-07-26 2024-07-16 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
MX2022005221A (en) 2019-11-07 2022-06-08 Eisai R&D Man Co Ltd Anti-mesothelin eribulin antibody-drug conjugates and methods of use.
CN113135876B (en) * 2020-01-16 2024-05-17 南通诺泰生物医药技术有限公司 Preparation method of eribulin and intermediate thereof
WO2021148003A1 (en) * 2020-01-22 2021-07-29 上海森辉医药有限公司 Drug conjugate of eribulin derivative, preparation method therefor and application thereof in medicine
KR102377262B1 (en) 2020-05-11 2022-03-22 연성정밀화학(주) Crystalline Eribulin Salt
IL279168B (en) * 2020-12-02 2022-04-01 Finetech Pharmaceutical Ltd Process for the preparation of eribulin
CN113354659B (en) 2021-06-08 2022-04-08 江苏慧聚药业股份有限公司 Synthesis of eribulin mesylate
CA3225975A1 (en) * 2021-07-22 2023-01-26 Shanghai Senhui Medicine Co., Ltd. Drug conjugate of eribulin derivative
WO2023212746A2 (en) * 2022-04-30 2023-11-02 William Marsh Rice University A unified strategy for the total syntheses of eribulin and a macrolactam analogue of halichondrin b
WO2024153123A1 (en) * 2023-01-17 2024-07-25 成都百利多特生物药业有限责任公司 Conjugate of eribulin drug

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436238A (en) 1992-03-12 1995-07-25 President And Fellows Of Harvard College Halichondrins and related compounds
US5338865A (en) * 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
GB9206244D0 (en) * 1992-03-23 1992-05-06 Pharma Mar Sa Cytotoxic compound from a marine sponge
US5426194A (en) * 1993-01-19 1995-06-20 Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University Isolation and structure of Halistatin 1
CN1216051C (en) * 1998-06-17 2005-08-24 卫材株式会社 Macrocyclic analogs and methods of their use and preparation
US6653341B1 (en) * 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
EP2949652B1 (en) 2004-06-03 2019-08-07 Eisai R&D Management Co., Ltd. Intermediates for the preparation of halichondrin B
MX2010003599A (en) 2007-10-03 2010-09-10 Eisai R&D Man Co Ltd Intermediates and methods for the synthesis of halichondrin b analogs.
MX2010005340A (en) 2007-11-16 2010-12-21 Eisai R&D Man Co Ltd Novel intermediate for halichondrin b analog synthesis and novel desulfonylation reaction used for the intermediate.
US8598373B2 (en) 2008-04-04 2013-12-03 Eisai R&D Management Co., Ltd. Halichondrin B analogs
CA2787919C (en) * 2010-01-26 2018-07-31 Eisai R&D Management Co., Ltd. Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs

Also Published As

Publication number Publication date
JP4454151B2 (en) 2010-04-21
NO2011026I1 (en) 2012-01-09
IL139960A0 (en) 2002-02-10
NO20006316L (en) 2001-02-15
AU4573999A (en) 2000-01-05
NO2011018I1 (en) 2011-09-26
CN1312804A (en) 2001-09-12
US20110172446A1 (en) 2011-07-14
PT1087960E (en) 2011-06-17
US8148554B2 (en) 2012-04-03
US6469182B1 (en) 2002-10-22
EP2272839B1 (en) 2012-08-22
BR9911326B1 (en) 2015-01-06
NO2022019I1 (en) 2022-06-03
EP2272840A1 (en) 2011-01-12
US6365759B1 (en) 2002-04-02
WO1999065894A1 (en) 1999-12-23
HUP0103357A2 (en) 2002-01-28
DE122011100031I1 (en) 2011-12-15
US6214865B1 (en) 2001-04-10
CY2011010I1 (en) 2014-04-09
EP1087960A1 (en) 2001-04-04
EP1087960B1 (en) 2011-03-23
DK1087960T3 (en) 2011-06-14
CA2335300A1 (en) 1999-12-23
NO20006316D0 (en) 2000-12-12
EP2277873A1 (en) 2011-01-26
CA2632433A1 (en) 1999-12-23
CN1216051C (en) 2005-08-24
EP2277873B1 (en) 2012-05-30
DE69943296D1 (en) 2011-05-05
EP2272840B1 (en) 2012-08-22
CY1111516T1 (en) 2014-04-09
LU91854I2 (en) 2011-10-17
CA2335300C (en) 2008-10-07
EP2272839A1 (en) 2011-01-12
KR100798600B1 (en) 2008-01-28
CY2011010I2 (en) 2014-04-09
HU227912B1 (en) 2012-05-29
ZA200007159B (en) 2001-12-04
CA2632433C (en) 2012-02-07
JP2002518384A (en) 2002-06-25
AU762998B2 (en) 2003-07-10
HUP0103357A3 (en) 2002-10-28
KR20010083050A (en) 2001-08-31
NO20093217L (en) 2001-02-15
NO331183B1 (en) 2011-10-24
EP1087960A4 (en) 2004-12-01
NO328280B1 (en) 2010-01-25
NZ508597A (en) 2004-01-30
BE2011C028I2 (en) 2018-08-24
HK1035534A1 (en) 2001-11-30
NO2011026I2 (en) 2012-06-11
CA2755266C (en) 2014-08-12
BR9911326A (en) 2001-04-03
RU2245335C2 (en) 2005-01-27
BRPI9911326B8 (en) 2021-05-25
FR11C0038I2 (en) 2013-01-11
ATE502932T1 (en) 2011-04-15
CA2755266A1 (en) 1999-12-23
AU762998C (en) 2000-01-05

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