WO2001060816A1
(en)
*
|
2000-02-17 |
2001-08-23 |
Amgen Inc. |
Kinase inhibitors
|
US7105530B2
(en)
*
|
2000-12-21 |
2006-09-12 |
Smithkline Beecham Corporation |
Pyrimidineamines as angiogenesis modulators
|
US7153871B2
(en)
|
2001-01-22 |
2006-12-26 |
Memory Pharmaceuticals Corporation |
Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
|
US7205320B2
(en)
|
2001-01-22 |
2007-04-17 |
Memory Pharmaceuticals Corp. |
Phosphodiesterase 4 inhibitors
|
AU2002316421B2
(en)
*
|
2001-06-26 |
2008-05-15 |
Bristol-Myers Squibb Company |
N-heterocyclic inhibitors of TNF-ALPHA expression
|
US7115617B2
(en)
|
2001-08-22 |
2006-10-03 |
Amgen Inc. |
Amino-substituted pyrimidinyl derivatives and methods of use
|
US6939874B2
(en)
*
|
2001-08-22 |
2005-09-06 |
Amgen Inc. |
Substituted pyrimidinyl derivatives and methods of use
|
CA2463989C
(en)
*
|
2001-10-17 |
2012-01-31 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Pyrimidine derivatives, pharmaceutical compositions containing these compounds, the use thereof and process for the preparation thereof
|
WO2003037877A1
(en)
*
|
2001-11-01 |
2003-05-08 |
Janssen Pharmaceutica N.V. |
AMINOBENZAMIDE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3β INHIBITORS
|
TWI329105B
(en)
*
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
EP1487824B1
(en)
|
2002-03-01 |
2007-06-20 |
SmithKline Beecham Corporation |
Diamino-pyrimidines and their use as angiogenesis inhibitors
|
PL374963A1
(en)
*
|
2002-06-17 |
2005-11-14 |
Smithkline Beecham Corporation |
Chemical process
|
ATE421505T1
(en)
*
|
2002-07-19 |
2009-02-15 |
Memory Pharmaceutical Corp |
4-AMINOBENZOFURAN COMPOUNDS AS PHOSPHODIESTERASE-4 INHIBITORS
|
AU2003256616B2
(en)
|
2002-07-19 |
2009-08-27 |
Memory Pharmaceuticals Corporation |
Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs
|
EP1534286B1
(en)
*
|
2002-07-29 |
2009-12-09 |
Rigel Pharmaceuticals, Inc. |
Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
|
US7189712B2
(en)
*
|
2002-10-10 |
2007-03-13 |
Smithkline Beecham Corporation |
1,3-Oxazole compounds for the treatment of cancer
|
JP2006508987A
(en)
|
2002-11-19 |
2006-03-16 |
メモリー・ファーマシューティカルズ・コーポレイション |
Phosphodiesterase 4 inhibitor
|
US7109337B2
(en)
|
2002-12-20 |
2006-09-19 |
Pfizer Inc |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
UA80767C2
(en)
*
|
2002-12-20 |
2007-10-25 |
Pfizer Prod Inc |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
ATE458731T1
(en)
|
2002-12-20 |
2010-03-15 |
Pfizer Prod Inc |
PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
|
US20040167132A1
(en)
*
|
2003-01-16 |
2004-08-26 |
Geetha Shankar |
Methods of treating conditions associted with an Edg-2 receptor
|
WO2004074244A2
(en)
|
2003-02-20 |
2004-09-02 |
Smithkline Beecham Corporation |
Pyrimidine compounds
|
PL1648998T3
(en)
|
2003-07-18 |
2015-03-31 |
Amgen Inc |
Specific binding agents to hepatocyte growth factor
|
DK1656372T3
(en)
|
2003-07-30 |
2013-07-01 |
Rigel Pharmaceuticals Inc |
2,4-PYRIMIDINE DIAMINE COMPOUNDS FOR USING TREATMENT OR PREVENTION OF AUTO-IMMUNE DISEASES
|
ES2365223T3
(en)
|
2003-08-07 |
2011-09-26 |
Rigel Pharmaceuticals, Inc. |
2,4-PYRIMIDINDIAMINE COMPOUNDS AND USES AS ANTIPROLIFERATIVE AGENTS.
|
ZA200603719B
(en)
*
|
2003-11-06 |
2007-09-26 |
Celgene Corp |
Methods of using and compositions comprising a JNK inhibitor for the treatment and management of asbestos-related diseases and disorders
|
US20070208023A1
(en)
*
|
2004-04-16 |
2007-09-06 |
Smithkline Beecham Corporation |
Cancer Treatment Method
|
BRPI0510963A
(en)
|
2004-05-14 |
2007-11-20 |
Pfizer Prod Inc |
pyrimidine derivatives for the treatment of abnormal cell growth
|
BRPI0510980A
(en)
|
2004-05-14 |
2007-11-27 |
Pfizer Prod Inc |
pyrimidine derivatives for the treatment of abnormal cell growth
|
MXPA06011658A
(en)
|
2004-05-14 |
2006-12-14 |
Pfizer Prod Inc |
Pyrimidine derivatives for the treatment of abnormal cell growth.
|
EP1763514A2
(en)
|
2004-05-18 |
2007-03-21 |
Rigel Pharmaceuticals, Inc. |
Cycloalkyl substituted pyrimidinediamine compounds and their uses
|
WO2006020564A1
(en)
*
|
2004-08-09 |
2006-02-23 |
Smithkline Beecham Corporation |
Pyrimidin derivatives for the treatment of multiple myeloma
|
PA8649401A1
(en)
*
|
2004-10-13 |
2006-09-22 |
Wyeth Corp |
ANILINO-PYRIMIDINE ANALOGS
|
GB2420559B
(en)
|
2004-11-15 |
2008-08-06 |
Rigel Pharmaceuticals Inc |
Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
|
CN100516049C
(en)
|
2004-11-16 |
2009-07-22 |
永信药品工业股份有限公司 |
Synthesis of N2 - (substituted arylmethyl) -3- (substituted phenyl) indazoles as anti-angiogenic agents
|
WO2006068770A1
(en)
|
2004-11-24 |
2006-06-29 |
Rigel Pharmaceuticals, Inc. |
Spiro-2, 4-pyrimidinediamine compounds and their uses
|
WO2006060318A2
(en)
|
2004-11-30 |
2006-06-08 |
Amgen Inc. |
Quinolines and quinazoline analogs and their use as medicaments for treating cancer
|
CA2591948C
(en)
|
2005-01-19 |
2013-11-12 |
Rigel Pharmaceuticals, Inc. |
Prodrugs of 2,4-pyrimidinediamine compounds and their uses
|
US8227455B2
(en)
|
2005-04-18 |
2012-07-24 |
Rigel Pharmaceuticals, Inc. |
Methods of treating cell proliferative disorders
|
WO2006129100A1
(en)
*
|
2005-06-03 |
2006-12-07 |
Glaxo Group Limited |
Novel compounds
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
JP5225079B2
(en)
|
2005-06-08 |
2013-07-03 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
Compositions and methods for inhibition of the JAK pathway
|
US8986650B2
(en)
|
2005-10-07 |
2015-03-24 |
Guerbet |
Complex folate-NOTA-Ga68
|
EP1940841B9
(en)
|
2005-10-07 |
2017-04-19 |
Guerbet |
Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
|
EP2380572A1
(en)
|
2005-11-29 |
2011-10-26 |
Glaxosmithkline LLC |
Cancer treatment method
|
PL1968594T3
(en)
*
|
2005-11-29 |
2011-03-31 |
Glaxosmithkline Llc |
Treatment of ocular neovascular disorders such as macular degeneration, angiod streaks, uveitis and macular edema
|
US20080108664A1
(en)
|
2005-12-23 |
2008-05-08 |
Liu Belle B |
Solid-state form of AMG 706 and pharmaceutical compositions thereof
|
TW200736232A
(en)
*
|
2006-01-26 |
2007-10-01 |
Astrazeneca Ab |
Pyrimidine derivatives
|
AR059066A1
(en)
|
2006-01-27 |
2008-03-12 |
Amgen Inc |
COMBINATIONS OF THE ANGIOPOYETINE INHIBITOR -2 (ANG2) AND THE VASCULAR ENDOTELIAL GROWTH FACTOR INHIBITOR (VEGF)
|
ES2353482T3
(en)
|
2006-02-10 |
2011-03-02 |
Amgen, Inc |
HYGRATE FORMS OF AMG706.
|
EP1991532B1
(en)
|
2006-02-24 |
2017-01-11 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
WO2007143483A2
(en)
*
|
2006-06-01 |
2007-12-13 |
Smithkline Beecham Corporation |
Combination of pazopanib and lapatinib for treating cancer
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
PE20080403A1
(en)
|
2006-07-14 |
2008-04-25 |
Amgen Inc |
FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE
|
DE602007012363D1
(en)
|
2006-10-19 |
2011-03-17 |
Rigel Pharmaceuticals Inc |
2,4-pyridimediamine derivatives as inhibitors of JAK KINASES for the treatment of autoimmune diseases
|
AU2007338792B2
(en)
|
2006-12-20 |
2012-05-31 |
Amgen Inc. |
Substituted heterocycles and methods of use
|
ES2449482T3
(en)
|
2007-01-09 |
2014-03-19 |
Amgen Inc. |
Bis-aryl-amide derivatives useful for cancer treatment
|
FR2911604B1
(en)
|
2007-01-19 |
2009-04-17 |
Sanofi Aventis Sa |
N- (HETEROARYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
|
MX2009008531A
(en)
|
2007-02-16 |
2009-08-26 |
Amgen Inc |
Nitrogen-containing heterocyclyl ketones and methods of use.
|
PL2154967T3
(en)
*
|
2007-04-16 |
2014-08-29 |
Hutchison Medipharma Entpr Ltd |
Pyrimidine derivatives
|
RS56743B1
(en)
|
2007-08-21 |
2018-03-30 |
Amgen Inc |
Human c-fms antigen binding proteins
|
EP2058307A1
(en)
|
2007-11-12 |
2009-05-13 |
Cellzome Ag |
Methods for the identification of JAK kinase interacting molecules and for the purification of JAK kinases
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
VN29259A1
(en)
|
2008-04-16 |
2012-04-25 |
Portola Pharm Inc |
2, 6-diamino- pyrimidin- 5-yl-carboxamides as syk or JAK kinases inhibitors
|
PT2323993E
(en)
|
2008-04-16 |
2015-10-12 |
Portola Pharm Inc |
2,6-diamino- pyrimidin- 5-yl-carboxamides as syk or jak kinases inhibitors
|
WO2009131687A2
(en)
|
2008-04-22 |
2009-10-29 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
US9273077B2
(en)
|
2008-05-21 |
2016-03-01 |
Ariad Pharmaceuticals, Inc. |
Phosphorus derivatives as kinase inhibitors
|
MX2010012703A
(en)
|
2008-05-21 |
2010-12-21 |
Ariad Pharma Inc |
Phosphorous derivatives as kinase inhibitors.
|
WO2010003084A2
(en)
*
|
2008-07-02 |
2010-01-07 |
Memory Pharmaceuticals Corporation |
Phosphodiesterase 4 inhibitors
|
US20110301113A1
(en)
*
|
2008-09-26 |
2011-12-08 |
Concert Pharmaceuticals Inc. |
Pyridineamine derivatives
|
FR2942227B1
(en)
|
2009-02-13 |
2011-04-15 |
Guerbet Sa |
USE OF BUFFERS FOR RADIONUCLEID COMPLEXATION
|
WO2011039648A1
(en)
|
2009-09-30 |
2011-04-07 |
Glaxo Wellcome Manufacturing Pte Ltd. |
Methods of administration and treatment
|
EP2490536A4
(en)
*
|
2009-10-23 |
2013-04-17 |
Glaxo Wellcome Mfg Pte Ltd |
Compositions and processes
|
WO2011058179A1
(en)
|
2009-11-16 |
2011-05-19 |
Ratiopharm Gmbh |
5- (4- (n- (2, 3 -dimethyl- 2h- indazol- 6 -yl) -n-methylamino) pyrimidin- 2 -ylamino) -2 -methylbenzenesulfonamide
|
WO2011069053A1
(en)
|
2009-12-04 |
2011-06-09 |
Teva Pharmaceutical Industries Ltd. |
Process for the preparation of pazopanip hcl and crystalline forms of pazopanib hcl
|
UY33164A
(en)
*
|
2010-01-06 |
2011-08-31 |
Glaxo Wellcome Mfg Pte Ltd |
TREATMENT METHOD
|
US10166142B2
(en)
|
2010-01-29 |
2019-01-01 |
Forsight Vision4, Inc. |
Small molecule delivery with implantable therapeutic device
|
US8598156B2
(en)
|
2010-03-25 |
2013-12-03 |
Glaxosmithkline Llc |
Chemical compounds
|
WO2011144742A1
(en)
|
2010-05-21 |
2011-11-24 |
Chemilia Ab |
Novel pyrimidine derivatives
|
EP2575460A4
(en)
*
|
2010-05-26 |
2013-10-16 |
Glaxosmithkline Llc |
Combination
|
EP3075730B1
(en)
|
2010-06-04 |
2018-10-24 |
Genentech, Inc. |
Aminopyrimidine derivatives as lrrk2 modulators
|
WO2011161217A2
(en)
|
2010-06-23 |
2011-12-29 |
Palacký University in Olomouc |
Targeting of vegfr2
|
JP5903433B2
(en)
|
2010-08-26 |
2016-04-13 |
ノバルティス アーゲー |
Pharmaceutical combination of VEGFR inhibitor and MEK inhibitor useful for the treatment of cancer
|
JP6185839B2
(en)
*
|
2010-09-14 |
2017-08-23 |
ノバルティス アーゲー |
Combination of BRAF inhibitor and VEGF inhibitor
|
BR112013008816A2
(en)
*
|
2010-10-14 |
2016-06-28 |
Ariad Pharma Inc |
a method of treating egfr cancer targeted to erlotinib or gefitinib resistant or using a pharmaceutically acceptable salt in an individual
|
WO2012061415A1
(en)
|
2010-11-01 |
2012-05-10 |
Portola Pharmaceuticals, Inc. |
Oxypyrimidines as syk modulators
|
EP2635556B1
(en)
|
2010-11-01 |
2017-06-21 |
Portola Pharmaceuticals, Inc. |
Benzamides and nicotinamides as syk modulators
|
US9102625B2
(en)
|
2010-11-01 |
2015-08-11 |
Portola Pharmaceuticals, Inc. |
Nicotinamides as JAK kinase modulators
|
TW201302733A
(en)
|
2010-11-10 |
2013-01-16 |
Hoffmann La Roche |
Pyrazole aminopyrimidine derivatives as LRRK2 modulators
|
CA2818612C
(en)
|
2010-11-19 |
2020-12-29 |
Forsight Vision4, Inc. |
Therapeutic agent formulations for implanted devices
|
EP2646431B1
(en)
|
2010-11-29 |
2016-04-06 |
Hetero Research Foundation |
A process for the preparation of pazopanib using novel intermediate
|
CN102060848B
(en)
*
|
2010-12-09 |
2013-09-18 |
天津药物研究院 |
Preparation and application of aromatic amine substituted pyrimidine derivatives
|
CN102093340B
(en)
*
|
2010-12-09 |
2013-07-17 |
天津药物研究院 |
Preparation method and application of 2-methylindazole derivatives
|
CN102093339B
(en)
*
|
2010-12-09 |
2013-06-12 |
天津药物研究院 |
Preparation method and application of pyrimidine derivatives
|
JP6013359B2
(en)
|
2010-12-17 |
2016-10-25 |
ノバルティス アーゲー |
combination
|
FR2968999B1
(en)
|
2010-12-20 |
2013-01-04 |
Guerbet Sa |
CHELATE NANOEMULSION FOR MRI
|
EP2672969A4
(en)
|
2011-02-01 |
2014-07-16 |
Glaxosmithkline Intellectual Property Ltd |
Combination
|
CA2830516C
(en)
|
2011-03-23 |
2017-01-24 |
Amgen Inc. |
Fused tricyclic dual inhibitors of cdk 4/6 and flt3
|
AU2012230229A1
(en)
|
2011-03-24 |
2013-10-10 |
Noviga Research Ab |
Novel pyrimidine derivatives
|
CA2833288A1
(en)
*
|
2011-04-19 |
2012-10-26 |
Bayer Intellectual Property Gmbh |
Substituted 4-aryl-n-phenyl-1,3,5-triazin-2-amines
|
AU2012250517B2
(en)
|
2011-05-04 |
2016-05-19 |
Takeda Pharmaceutical Company Limited |
Compounds for inhibiting cell proliferation in EGFR-driven cancers
|
TW201636330A
(en)
|
2011-05-24 |
2016-10-16 |
拜耳知識產權公司 |
4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group
|
US9745288B2
(en)
|
2011-08-16 |
2017-08-29 |
Indiana University Research And Technology Corporation |
Compounds and methods for treating cancer by inhibiting the urokinase receptor
|
ES2588102T3
(en)
*
|
2011-09-16 |
2016-10-28 |
Bayer Intellectual Property Gmbh |
Substituted 5-fluoro-pyrimidine derivatives containing a sulfoximin group
|
FR2980364B1
(en)
|
2011-09-26 |
2018-08-31 |
Guerbet |
NANOEMULSIONS AND THEIR USE AS CONTRAST AGENTS
|
WO2013066616A1
(en)
|
2011-10-31 |
2013-05-10 |
Glaxo Wellcome Manufacturing Pte Ltd |
Pazopanib formulation
|
MX363551B
(en)
|
2011-11-23 |
2019-03-27 |
Portola Pharmaceuticals Inc Star |
Pyrazine kinase inhibitors.
|
CN103159742B
(en)
*
|
2011-12-16 |
2015-08-12 |
北京韩美药品有限公司 |
5-chloropyrimide compounds and the application as EGFR tyrosine kinase inhibitor thereof
|
AR090263A1
(en)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
COMBINED ANTIBODY THERAPY AGAINST HUMAN CSF-1R AND USES OF THE SAME
|
CN103373989B
(en)
*
|
2012-04-28 |
2016-04-13 |
上海医药工业研究院 |
The preparation method of the intermediate of pazopanib hydrochloride
|
AU2013204563B2
(en)
|
2012-05-05 |
2016-05-19 |
Takeda Pharmaceutical Company Limited |
Compounds for inhibiting cell proliferation in EGFR-driven cancers
|
US9505749B2
(en)
|
2012-08-29 |
2016-11-29 |
Amgen Inc. |
Quinazolinone compounds and derivatives thereof
|
WO2014058921A2
(en)
|
2012-10-08 |
2014-04-17 |
Portola Pharmaceuticals, Inc. |
Substituted pyrimidinyl kinase inhibitors
|
ES2595222T3
(en)
|
2012-10-18 |
2016-12-28 |
Bayer Pharma Aktiengesellschaft |
5-Fluoro-N- (pyridin-2-yl) pyridin-2-amine derivatives containing a sulfone group
|
WO2014060493A2
(en)
|
2012-10-18 |
2014-04-24 |
Bayer Pharma Aktiengesellschaft |
N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfone group
|
TW201418243A
(en)
|
2012-11-15 |
2014-05-16 |
Bayer Pharma AG |
N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfoximine group
|
CN105102444B
(en)
|
2012-11-15 |
2017-08-01 |
拜耳医药股份有限公司 |
The amine derivative of 5 fluorine N (base of pyridine 2) pyridine 2 of the imido grpup containing sulphur
|
CN103864764A
(en)
*
|
2012-12-11 |
2014-06-18 |
齐鲁制药有限公司 |
Indazole-substituted pyrimidinamine derivative, and preparation method and use thereof
|
US9802923B2
(en)
*
|
2012-12-17 |
2017-10-31 |
Sun Pharmaceutical Industries Limited |
Process for the preparation of pazopanib or salts thereof
|
WO2014097152A1
(en)
|
2012-12-17 |
2014-06-26 |
Ranbaxy Laboratories Limited |
Process for the preparation of pazopanib or salts thereof
|
CN103910716A
(en)
*
|
2013-01-07 |
2014-07-09 |
华东理工大学 |
2,4-disubstituted-cycloalkyl[d]pyrimidine compound and its use
|
JP2016504409A
(en)
|
2013-01-09 |
2016-02-12 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー2、リミテッドGlaxosmithkline Intellectual Property No.2 Limited |
combination
|
FR3001154B1
(en)
|
2013-01-23 |
2015-06-26 |
Guerbet Sa |
MAGNETO-EMULSION VECTORIZED
|
AU2014236455B2
(en)
|
2013-03-14 |
2018-07-12 |
Forsight Vision4, Inc. |
Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
|
US9611283B1
(en)
|
2013-04-10 |
2017-04-04 |
Ariad Pharmaceuticals, Inc. |
Methods for inhibiting cell proliferation in ALK-driven cancers
|
CN103214467B
(en)
*
|
2013-04-26 |
2015-09-30 |
中国人民解放军军事医学科学院微生物流行病研究所 |
5-[[4-[(2,3-dimethyl-2H-indazole-6-base) methylamino-]-2 pyrimidyl] are amino]-2-methyl-benzenesulfonyl sulfonamide derivatives and preparation method thereof and application
|
JP6371385B2
(en)
|
2013-07-04 |
2018-08-08 |
バイエル ファーマ アクチエンゲゼルシャフト |
Sulfoximine substituted 5-fluoro-N- (pyridin-2-yl) pyridin-2-amine derivatives and their use as CDK9 kinase inhibitors
|
WO2015031604A1
(en)
|
2013-08-28 |
2015-03-05 |
Crown Bioscience, Inc. |
Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same
|
WO2015056180A1
(en)
|
2013-10-15 |
2015-04-23 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Indoline derivatives as inhibitors of perk
|
WO2015068175A2
(en)
*
|
2013-11-05 |
2015-05-14 |
Laurus Labs Private Limited |
An improved process for the preparation of pazopanib or a pharmaceutically acceptable salt thereof
|
CN103739550B
(en)
*
|
2014-01-02 |
2016-06-01 |
中国药科大学 |
2,3-dimethyl-6-urea-2H-indazole compounds and its preparation method and application
|
CN104829542B
(en)
*
|
2014-02-10 |
2018-02-02 |
中国科学院上海药物研究所 |
Aniline pyrimidine class compound, its preparation method and medical usage
|
JP2017507967A
(en)
|
2014-03-11 |
2017-03-23 |
グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited |
Compounds acting as PERK inhibitors
|
US9856242B2
(en)
|
2014-03-13 |
2018-01-02 |
Bayer Pharma Aktiengesellscaft |
5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
|
CN106414412B
(en)
|
2014-04-01 |
2019-06-21 |
拜耳医药股份有限公司 |
Disubstituted 5-FU derivative containing sulphonyl diimine group
|
AP2016009483A0
(en)
|
2014-04-11 |
2016-10-31 |
Bayer Pharma AG |
Novel macrocyclic compounds
|
WO2015166370A1
(en)
|
2014-04-28 |
2015-11-05 |
Pfizer Inc. |
Heteroaromatic compounds and their use as dopamine d1 ligands
|
AU2015301054B2
(en)
|
2014-08-08 |
2020-05-14 |
Forsight Vision4, Inc. |
Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
|
WO2016055935A1
(en)
|
2014-10-06 |
2016-04-14 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Combination of lysine-specific demethylase 1 inhibitor and thrombopoietin agonist
|
JP2017531003A
(en)
|
2014-10-16 |
2017-10-19 |
バイエル ファーマ アクチエンゲゼルシャフト |
Benzofuranyl-pyrimidine derivatives containing sulfonic groups
|
US9884849B2
(en)
|
2014-10-16 |
2018-02-06 |
Bayer Pharma Aktiengesellschaft |
Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group
|
US11083755B2
(en)
|
2015-01-08 |
2021-08-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
Factors and cells that provide for induction of bone, bone marrow, and cartilage
|
US20180000771A1
(en)
|
2015-01-13 |
2018-01-04 |
Kyoto University |
Agent for preventing and/or treating amyotrophic lateral sclerosis
|
KR101705980B1
(en)
*
|
2015-06-12 |
2017-02-13 |
중앙대학교 산학협력단 |
Novel pazopanib derivatives and pharmaceutical composition comprising the same
|
CN105237523B
(en)
*
|
2015-10-08 |
2018-06-01 |
深圳市博圣康生物科技有限公司 |
Pyrimidine derivatives and preparation method thereof, purposes
|
WO2017098421A1
(en)
|
2015-12-08 |
2017-06-15 |
Glaxosmithkline Intellectual Property Development Limited |
Benzothiadiazine compounds
|
WO2017153952A1
(en)
|
2016-03-10 |
2017-09-14 |
Glaxosmithkline Intellectual Property Development Limited |
5-sulfamoyl-2-hydroxybenzamide derivatives
|
EP3228630A1
(en)
|
2016-04-07 |
2017-10-11 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Combination of an apelin antagonist and an angiogenesis inhibitor for the treatment of cancer
|
RU2018146946A
(en)
|
2016-06-08 |
2020-07-10 |
Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед |
CHEMICAL COMPOUNDS
|
WO2017212425A1
(en)
|
2016-06-08 |
2017-12-14 |
Glaxosmithkline Intellectual Property Development Limited |
Chemical compounds as atf4 pathway inhibitors
|
WO2018015879A1
(en)
|
2016-07-20 |
2018-01-25 |
Glaxosmithkline Intellectual Property Development Limited |
Isoquinoline derivatives as perk inhibitors
|
US20190365710A1
(en)
|
2016-12-01 |
2019-12-05 |
Glaxosmithkline Intellectual Property Development Limited |
Methods of treating cancer
|
EP4001269A1
(en)
|
2016-12-22 |
2022-05-25 |
Amgen Inc. |
Benzoisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer
|
US11426406B2
(en)
|
2017-02-09 |
2022-08-30 |
Georgetown University |
Compositions and methods for treating lysosomal storage disorders
|
PL3601253T3
(en)
|
2017-03-28 |
2022-01-17 |
Bayer Aktiengesellschaft |
Novel ptefb inhibiting macrocyclic compounds
|
CA3057891A1
(en)
|
2017-03-28 |
2018-10-04 |
Bayer Aktiengesellschaft |
Novel ptefb inhibiting macrocyclic compounds
|
WO2018195084A1
(en)
|
2017-04-17 |
2018-10-25 |
Yale University |
Compounds, compositions and methods of treating or preventing acute lung injury
|
JOP20190272A1
(en)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
Kras g12c inhibitors and methods of using the same
|
WO2018225093A1
(en)
|
2017-06-07 |
2018-12-13 |
Glaxosmithkline Intellectual Property Development Limited |
Chemical compounds as atf4 pathway inhibitors
|
CN110896634A
(en)
|
2017-07-03 |
2020-03-20 |
葛兰素史密斯克莱知识产权发展有限公司 |
2- (4-chlorophenoxy) -N- ((1- (2- (4-chlorophenoxy) ethynylazetidin-3-yl) methyl) acetamide derivatives and related compounds as ATF4 inhibitors for the treatment of cancer and other diseases
|
JP2020525513A
(en)
|
2017-07-03 |
2020-08-27 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited |
N-(3-(2-(4-chlorophenoxy)acetamidobicyclo[1.1.1]pentan-1-yl)-2-cyclobutane-1 as an ATF4 inhibitor for treating cancer and other diseases -Carboxamide derivatives and related compounds
|
WO2019021208A1
(en)
|
2017-07-27 |
2019-01-31 |
Glaxosmithkline Intellectual Property Development Limited |
Indazole derivatives useful as perk inhibitors
|
CN107619407B
(en)
*
|
2017-08-10 |
2019-05-24 |
山东大学 |
Bis- target spot inhibitor of HDAC and VEGFR based on pazopanib structure and its preparation method and application
|
UY37866A
(en)
|
2017-09-07 |
2019-03-29 |
Glaxosmithkline Ip Dev Ltd |
NEW SUBSTITUTED BENZOIMIDAZOL COMPOUNDS THAT REDUCE MYC PROTEIN (C-MYC) IN THE CELLS AND INHIBIT THE HISTONE ACETYLTRANSPHERASE OF P300 / CBP.
|
SG11202001499WA
(en)
|
2017-09-08 |
2020-03-30 |
Amgen Inc |
Inhibitors of kras g12c and methods of using the same
|
WO2019053617A1
(en)
|
2017-09-12 |
2019-03-21 |
Glaxosmithkline Intellectual Property Development Limited |
Chemical compounds
|
JP7280286B2
(en)
|
2018-02-13 |
2023-05-23 |
バイエル アクチェンゲゼルシャフト |
5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(S-methylsulfonimidoyl)methyl]pyridine-2- for treating diffuse large B-cell lymphoma Use of yl}pyridin-2-amine
|
WO2019193541A1
(en)
|
2018-04-06 |
2019-10-10 |
Glaxosmithkline Intellectual Property Development Limited |
Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors
|
WO2019193540A1
(en)
|
2018-04-06 |
2019-10-10 |
Glaxosmithkline Intellectual Property Development Limited |
Heteroaryl derivatives of formula (i) as atf4 inhibitors
|
WO2019053500A1
(en)
|
2018-04-17 |
2019-03-21 |
Alvogen Malta Operations (Row) Ltd |
Pharmaceutical composition of solid dosage form containing pazopanib and process for its preparation
|
EP3788038B1
(en)
|
2018-05-04 |
2023-10-11 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
WO2019213526A1
(en)
|
2018-05-04 |
2019-11-07 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
EP3790886B1
(en)
|
2018-05-10 |
2024-06-26 |
Amgen Inc. |
Kras g12c inhibitors for the treatment of cancer
|
WO2019232419A1
(en)
|
2018-06-01 |
2019-12-05 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
US20190375749A1
(en)
|
2018-06-11 |
2019-12-12 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
EP3807276A2
(en)
|
2018-06-12 |
2021-04-21 |
Amgen Inc. |
Kras g12c inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer
|
JP7409696B2
(en)
|
2018-06-15 |
2024-01-09 |
ハンダ ファーマシューティカルズ インコーポレイテッド |
Kinase inhibitor salts and compositions thereof
|
WO2020007822A1
(en)
|
2018-07-02 |
2020-01-09 |
Conservatoire National Des Arts Et Metiers (Cnam) |
Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof
|
BR112021000332A2
(en)
|
2018-07-09 |
2021-04-06 |
Glaxosmithkline Intellectual Property Development Limited |
CHEMICAL COMPOUNDS
|
WO2020031107A1
(en)
|
2018-08-08 |
2020-02-13 |
Glaxosmithkline Intellectual Property Development Limited |
Chemical compounds
|
JP2020090482A
(en)
|
2018-11-16 |
2020-06-11 |
アムジエン・インコーポレーテツド |
Improved synthesis of key intermediate of kras g12c inhibitor compound
|
JP7377679B2
(en)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
Combination therapy comprising a KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancer
|
EP3883565A1
(en)
|
2018-11-19 |
2021-09-29 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
EP4342473A3
(en)
|
2018-11-30 |
2024-05-15 |
GlaxoSmithKline Intellectual Property Development Limited |
Compounds useful in hiv therapy
|
AU2019401495A1
(en)
|
2018-12-20 |
2021-06-24 |
Amgen Inc. |
Heteroaryl amides useful as KIF18A inhibitors
|
PE20211475A1
(en)
|
2018-12-20 |
2021-08-05 |
Amgen Inc |
KIF18A INHIBITORS
|
US20220073504A1
(en)
|
2018-12-20 |
2022-03-10 |
Amgen Inc. |
Kif18a inhibitors
|
US20220056015A1
(en)
|
2018-12-20 |
2022-02-24 |
Amgen Inc. |
Kif18a inhibitors
|
TW202038957A
(en)
|
2018-12-21 |
2020-11-01 |
日商第一三共股份有限公司 |
Combination of antibody-drug conjugate and kinase inhibitor
|
MX2021010319A
(en)
|
2019-03-01 |
2021-12-10 |
Revolution Medicines Inc |
Bicyclic heteroaryl compounds and uses thereof.
|
SG11202109422WA
(en)
|
2019-03-01 |
2021-09-29 |
Revolution Medicines Inc |
Bicyclic heterocyclyl compounds and uses thereof
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
CN114144414A
(en)
|
2019-05-21 |
2022-03-04 |
美国安进公司 |
Solid state form
|
WO2021018941A1
(en)
|
2019-07-31 |
2021-02-04 |
Glaxosmithkline Intellectual Property Development Limited |
Methods of treating cancer
|
JP2022542392A
(en)
|
2019-08-02 |
2022-10-03 |
アムジエン・インコーポレーテツド |
Pyridine derivatives as KIF18A inhibitors
|
AU2020324406A1
(en)
|
2019-08-02 |
2022-03-17 |
Amgen Inc. |
KIF18A inhibitors
|
WO2021026101A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
MX2022001295A
(en)
|
2019-08-02 |
2022-02-22 |
Amgen Inc |
Kif18a inhibitors.
|
CN110746402B
(en)
*
|
2019-09-21 |
2021-01-15 |
温州医科大学 |
2-N-aryl-4-N-aryl-5-fluoropyrimidine compound and preparation method and application thereof
|
EP4048671A1
(en)
|
2019-10-24 |
2022-08-31 |
Amgen Inc. |
Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer
|
EP4055028A1
(en)
|
2019-11-04 |
2022-09-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
MX2022005357A
(en)
|
2019-11-04 |
2022-06-02 |
Revolution Medicines Inc |
Ras inhibitors.
|
AU2020379734A1
(en)
|
2019-11-04 |
2022-05-05 |
Revolution Medicines, Inc. |
Ras inhibitors
|
MX2022005525A
(en)
|
2019-11-08 |
2022-06-08 |
Revolution Medicines Inc |
Bicyclic heteroaryl compounds and uses thereof.
|
WO2021097207A1
(en)
|
2019-11-14 |
2021-05-20 |
Amgen Inc. |
Improved synthesis of kras g12c inhibitor compound
|
US20230192681A1
(en)
|
2019-11-14 |
2023-06-22 |
Amgen Inc. |
Improved synthesis of kras g12c inhibitor compound
|
CN114980976A
(en)
|
2019-11-27 |
2022-08-30 |
锐新医药公司 |
Covalent RAS inhibitors and uses thereof
|
TW202140011A
(en)
|
2020-01-07 |
2021-11-01 |
美商銳新醫藥公司 |
Shp2 inhibitor dosing and methods of treating cancer
|
CA3179187A1
(en)
|
2020-05-22 |
2021-11-25 |
Qx Therapeutics Inc. |
Compositions and methods for treating lung injuries associated with viral infections
|
CN115916194A
(en)
|
2020-06-18 |
2023-04-04 |
锐新医药公司 |
Methods for delaying, preventing and treating acquired resistance to RAS inhibitors
|
WO2022040446A1
(en)
|
2020-08-19 |
2022-02-24 |
Nanocopoeia, Llc |
Amorphous pazopanib particles and pharmaceutical compositions thereof
|
MX2023002248A
(en)
|
2020-09-03 |
2023-05-16 |
Revolution Medicines Inc |
Use of sos1 inhibitors to treat malignancies with shp2 mutations.
|
JP2023541916A
(en)
|
2020-09-15 |
2023-10-04 |
レボリューション メディシンズ インコーポレイテッド |
Indole derivatives as RAS inhibitors in the treatment of cancer
|
EP4267250A1
(en)
|
2020-12-22 |
2023-11-01 |
Qilu Regor Therapeutics Inc. |
Sos1 inhibitors and uses thereof
|
CA3217393A1
(en)
|
2021-05-05 |
2022-11-10 |
Elena S. Koltun |
Ras inhibitors
|
CN117500811A
(en)
|
2021-05-05 |
2024-02-02 |
锐新医药公司 |
Covalent RAS inhibitors and uses thereof
|
KR20240017811A
(en)
|
2021-05-05 |
2024-02-08 |
레볼루션 메디슨즈, 인크. |
RAS inhibitors for the treatment of cancer
|
AR127308A1
(en)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
RAS INHIBITORS
|
WO2023081923A1
(en)
|
2021-11-08 |
2023-05-11 |
Frequency Therapeutics, Inc. |
Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
|
WO2023114954A1
(en)
|
2021-12-17 |
2023-06-22 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
WO2023172940A1
(en)
|
2022-03-08 |
2023-09-14 |
Revolution Medicines, Inc. |
Methods for treating immune refractory lung cancer
|
WO2023228095A1
(en)
|
2022-05-24 |
2023-11-30 |
Daiichi Sankyo Company, Limited |
Dosage regimen of an anti-cdh6 antibody-drug conjugate
|
WO2023230541A1
(en)
|
2022-05-27 |
2023-11-30 |
Viiv Healthcare Company |
Piperazine derivatives useful in hiv therapy
|
WO2023240263A1
(en)
|
2022-06-10 |
2023-12-14 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
WO2024081916A1
(en)
|
2022-10-14 |
2024-04-18 |
Black Diamond Therapeutics, Inc. |
Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives
|