FI990207A0 - Enantiomerically pure diazabicyclo (4.3.0) nonander derivatives - Google Patents

Enantiomerically pure diazabicyclo (4.3.0) nonander derivatives

Info

Publication number
FI990207A0
FI990207A0 FI990207A FI990207A FI990207A0 FI 990207 A0 FI990207 A0 FI 990207A0 FI 990207 A FI990207 A FI 990207A FI 990207 A FI990207 A FI 990207A FI 990207 A0 FI990207 A0 FI 990207A0
Authority
FI
Finland
Prior art keywords
nonander
diazabicyclo
derivatives
enantiomerically pure
enantiomerically
Prior art date
Application number
FI990207A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI110943B (en
FI990207A (en
Inventor
Uwe Petersen
Andreas Krebs
Thomas Schenke
Thomas Philipps
Klaus Grohe
Klaus-Dieter Bremm
Rainer Endermann
Karl-Georg Metzger
Ingo Haller
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27203290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI990207(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE4200414A external-priority patent/DE4200414A1/en
Priority claimed from DE4208792A external-priority patent/DE4208792A1/en
Priority claimed from DE4208789A external-priority patent/DE4208789A1/en
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI990207A0 publication Critical patent/FI990207A0/en
Publication of FI990207A publication Critical patent/FI990207A/en
Application granted granted Critical
Publication of FI110943B publication Critical patent/FI110943B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
FI990207A 1992-01-10 1999-02-03 Enantiomerically pure 2,8-diazabicyclo [4.3.0] nonane derivatives FI110943B (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE4200414 1992-01-10
DE4200414A DE4200414A1 (en) 1992-01-10 1992-01-10 New quinoline and naphthyridinone-carboxylic acid derivs.
DE4208792 1992-03-19
DE4208792A DE4208792A1 (en) 1992-03-19 1992-03-19 New quinoline and naphthyridinone-carboxylic acid derivs.
DE4208789A DE4208789A1 (en) 1992-03-19 1992-03-19 New quinoline and naphthyridinone-carboxylic acid derivs.
DE4208789 1992-03-19

Publications (3)

Publication Number Publication Date
FI990207A0 true FI990207A0 (en) 1999-02-03
FI990207A FI990207A (en) 1999-02-03
FI110943B FI110943B (en) 2003-04-30

Family

ID=27203290

Family Applications (3)

Application Number Title Priority Date Filing Date
FI930049A FI104174B1 (en) 1992-01-10 1993-01-07 A process for the preparation of a therapeutically useful nonane isomer of 1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 7- [S, S] -2,8-diazabicyclo [4.3.0]
FI990207A FI110943B (en) 1992-01-10 1999-02-03 Enantiomerically pure 2,8-diazabicyclo [4.3.0] nonane derivatives
FI20020059A FI113771B (en) 1992-01-10 2002-01-11 Enantiomerically pure (1S, 6S) -2-oxa-5,8-diazabicyclo [4.3.0] nonane

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI930049A FI104174B1 (en) 1992-01-10 1993-01-07 A process for the preparation of a therapeutically useful nonane isomer of 1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 7- [S, S] -2,8-diazabicyclo [4.3.0]

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20020059A FI113771B (en) 1992-01-10 2002-01-11 Enantiomerically pure (1S, 6S) -2-oxa-5,8-diazabicyclo [4.3.0] nonane

Country Status (16)

Country Link
EP (1) EP0550903A1 (en)
JP (3) JPH05271229A (en)
KR (1) KR100251886B1 (en)
CN (3) CN1043142C (en)
AU (1) AU669502B2 (en)
CA (1) CA2086914C (en)
CZ (1) CZ289076B6 (en)
FI (3) FI104174B1 (en)
HU (1) HU219488B (en)
MX (1) MX9207604A (en)
MY (1) MY115416A (en)
NO (1) NO301420B1 (en)
NZ (1) NZ245640A (en)
PL (1) PL174853B1 (en)
SK (3) SK282971B6 (en)
TW (1) TW209865B (en)

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DE4121214A1 (en) * 1991-06-27 1993-01-14 Bayer Ag 7-AZAISOINDOLINYL CHINOLONE AND NAPHTHYRIDONE CARBONIC ACID DERIVATIVES
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DE4301246A1 (en) * 1993-01-19 1994-07-21 Bayer Ag Quinolone and naphthyridonecarboxylic acid derivatives
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DE4329600A1 (en) * 1993-09-02 1995-03-09 Bayer Ag Pyrido [1,2,3-d, e] [1,3,4] benzoxadiazine derivatives
KR950018003A (en) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 Novel quinolone derivatives and methods for their preparation
DE4342186A1 (en) * 1993-12-10 1995-06-14 Bayer Ag One-pot process for the production of 3-quinolonecarboxylic acid derivatives
DE4418510A1 (en) * 1994-05-27 1995-11-30 Bayer Ag 1,9-bridged thiazolol [3,4-a] quinoline derivatives
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DE19652239A1 (en) * 1996-12-16 1998-06-18 Bayer Ag Use of 7- (2-oxa-5,8-diazabicyclo [4.3.0] non-8-yl) -quinolone and naphthyridonecarboxylic acid derivatives for the therapy of Helicobacter pylori infections and the associated gastroduodenal diseases
DE19735198A1 (en) * 1997-08-14 1999-02-18 Bayer Ag Optical resolution of cis- or trans-pyrrolo:piperidine derivatives
PL192273B1 (en) * 1997-09-25 2006-09-29 Bayer Ag Therapeutic agent preparation of controllable active substance release
DE19751948A1 (en) * 1997-11-24 1999-05-27 Bayer Ag Rapid preparation of 8-alkoxy-quinolone-carboxylic acid derivative antibacterial agent, e.g. gatifloxacin, in high purity
DE19821039A1 (en) 1998-05-11 1999-11-18 Bayer Ag Production of (S,S)-8-benzyl-2,8-diazabicyclo(4.3.0)nonane useful as intermediate for antibiotic moxifloxacin
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
US6716830B2 (en) 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
AR020661A1 (en) * 1998-09-30 2002-05-22 Alcon Lab Inc A PHARMACEUTICAL COMPOSITION TOPICA OFTALMICA, OTICA OR NASAL AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
HU229065B1 (en) * 1998-11-10 2013-07-29 Bayer Ip Gmbh Pharmaceutical moxifloxacin compositions
CN1343128B (en) 1999-03-17 2010-04-21 第一制药株式会社 Medicinal compositions
DE19927412A1 (en) * 1999-06-16 2000-12-21 Bayer Ag Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo [4.3.0] nonane
DE19931115A1 (en) 1999-07-06 2001-01-11 Bayer Ag Racemization of R, S-dioxo-benzylpyrrolopiperidine
DE19962470A1 (en) 1999-12-22 2001-07-12 Schulz Hans Herrmann Use of chemotherapy drugs
DE10226923A1 (en) * 2002-06-17 2003-12-24 Bayer Ag Process for the enantiomer enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo [4.3.0] nonane
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US7759362B2 (en) 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
CN1244582C (en) * 2004-04-21 2006-03-08 中国医学科学院医药生物技术研究所 Compound of quinolone carboxylic acid, preparation method and medicinal usage
ES2284380B1 (en) * 2006-03-10 2008-11-01 Quimica Sintetica S.A. PROCEDURE FOR THE PREPARATION OF MOXIFLOXACINO AND MOXIFLOXACINO CHLORHYDRATE.
EP2032521B1 (en) 2006-06-27 2009-10-28 Sandoz AG New method for salt preparation
AU2007320997B2 (en) 2006-11-13 2012-11-08 Cipla Limited Process for the synthesis of moxifloxacin hydrochloride
WO2008059521A2 (en) * 2006-11-14 2008-05-22 Msn Laboratories Limited Novel process for the preparation of moxifloxacin hydrochloride and a novel polymorph of moxifloxacin
US7692015B2 (en) 2007-01-05 2010-04-06 Zheqing Wang Economical process for preparing (S, S)-2, 8-diazabicyclo[4.3.0]nonane and its enantiomer
WO2008102188A1 (en) 2007-02-22 2008-08-28 Tibor Nagy Procedure to manufacture and use beer and other types liquids treated with neodimium magnet
EP2083010A1 (en) 2008-01-08 2009-07-29 Chemo Ibérica, S.A. Polymorphic Forms of Moxifloxacin hydrochloride and processes for preparation thereof
EP2154137A1 (en) 2008-08-04 2010-02-17 Chemo Ibérica, S.A. Crystalline form of moxifloxacin base
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WO2010122774A1 (en) * 2009-04-20 2010-10-28 株式会社カネカ Processes for producing (1s,6s)- or (1r,6r)-cis-2,8-diazabicyclo[4.3.0]nonane and intermediate thereof
IT1398952B1 (en) * 2010-03-19 2013-03-28 F S I Fabbrica Italiana Sint PROCESS OF PREPARATION OF MOXIFLOXACINE AND ITS SALTS
CN101941969B (en) * 2010-09-30 2012-05-23 江苏正大丰海制药有限公司 Preparation method of moxifloxacin hydrochloride
CN102675307A (en) * 2011-03-17 2012-09-19 苏州中科天马肽工程中心有限公司 Method for preparing chiral compound 8-phenethyl-2,8-diazabicyclo[4.3.0]nonane
CN102675308A (en) * 2011-03-17 2012-09-19 苏州中科天马肽工程中心有限公司 Method for preparing 8-benzyl-2,8-diazabicyclo(4.3.0) nonane
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CN103044418B (en) * 2011-10-14 2015-02-04 上海朴颐化学科技有限公司 Asymmetric synthesis method, relevant raw materials and preparation method of (S,S)-2,8-diazabicyclo[4,3,0] nonane
CN102408427B (en) * 2011-10-22 2012-12-12 浙江普洛康裕制药有限公司 Preparation method for moxifloxacin intermediate (1S, 6R)-8-benzyl-7, 9-dioxy-2, 8-diazabicyclo [4.3.0] nonane
BRPI1106900A2 (en) 2011-12-26 2013-11-05 Ems Sa SOLID PHARMACEUTICAL COMPOSITION UNDERSTANDING ANTIBOTH FAMILY OF QUINOLONES AND THE PROCESS OF OBTAINING THEM
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CN103012452B (en) * 2012-12-25 2015-12-02 浙江新和成股份有限公司 The preparation method of a kind of Moxifloxacin and hydrochloride thereof
UA106556C2 (en) 2013-05-13 2014-09-10 Наталья Николаевна Деркач Method of obtaining (1-cyclopropyl -6- fluoro-1,4-dihydro methoxy -8 -7 - [(4as, 7as) - oktahydro -6n- pyrrolo [3,4-pyridine bsch - 6- yl] -4-oxo-3-hinolinkarbonovoyi acid
CN103724262B (en) * 2013-12-10 2016-05-18 广东省第二人民医院 A kind of fluoquinolone silver compound and its production and use
CN104860944A (en) * 2015-06-09 2015-08-26 内蒙古东北六药集团有限公司 Production method of moxifloxacin hydrochloride
CN108872413B (en) * 2018-04-27 2021-06-08 山东齐都药业有限公司 Method for detecting enantiomer content in (S, S) -2, 8-diazabicyclo [4,3,0] nonane
CN110627768B (en) * 2018-06-22 2021-11-09 扬子江药业集团有限公司 Preparation method of moxifloxacin degradation impurity J
CN110183445B (en) * 2019-06-28 2021-08-24 昆明学院 Synthetic method of moxifloxacin and derivatives thereof
RU2713932C1 (en) * 2019-10-31 2020-02-11 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Fluoroquinolone compounds based on pyridoxine derivatives, having antibacterial properties
CN112939849B (en) * 2019-12-11 2022-05-03 浙江新和成股份有限公司 (S, S) -2, 8-diazabicyclo [4.3.0] nonane intermediate and preparation method and application thereof
CN110981874A (en) * 2020-03-05 2020-04-10 北京四环生物制药有限公司 Preparation method of moxifloxacin hydrochloride
CN112409352B (en) * 2020-11-20 2022-05-24 华南理工大学 Moxifloxacin drug derivatives and preparation method and application thereof
CN112574197B (en) * 2020-12-07 2021-12-31 泰安汉威集团有限公司 Chiral purification method of compound C

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Also Published As

Publication number Publication date
NO301420B1 (en) 1997-10-27
EP0550903A1 (en) 1993-07-14
CN1074218A (en) 1993-07-14
FI113771B (en) 2004-06-15
JP4111431B2 (en) 2008-07-02
KR930016421A (en) 1993-08-26
CN1061351C (en) 2001-01-31
SK396692A3 (en) 2002-09-10
FI20020059A (en) 2002-01-11
FI930049A0 (en) 1993-01-07
FI930049A (en) 1993-07-11
JP2003048890A (en) 2003-02-21
SK2212000A3 (en) 2006-05-04
CA2086914C (en) 2005-03-15
PL174853B1 (en) 1998-09-30
JPH05271229A (en) 1993-10-19
SK285223B6 (en) 2006-09-07
TW209865B (en) 1993-07-21
FI110943B (en) 2003-04-30
SK285155B6 (en) 2006-07-07
AU3105493A (en) 1993-07-15
CN1192440A (en) 1998-09-09
MX9207604A (en) 1993-10-01
NO924978D0 (en) 1992-12-22
KR100251886B1 (en) 2000-07-01
NO924978L (en) 1993-07-12
FI990207A (en) 1999-02-03
CA2086914A1 (en) 1993-07-11
CN1043142C (en) 1999-04-28
HU9300034D0 (en) 1993-04-28
JP2003026574A (en) 2003-01-29
SK2232000A3 (en) 2006-05-04
NZ245640A (en) 1995-03-28
AU669502B2 (en) 1996-06-13
HU219488B (en) 2001-04-28
CN1075499C (en) 2001-11-28
HUT64065A (en) 1993-11-29
CZ289076B6 (en) 2001-10-17
CZ396692A3 (en) 1993-08-11
MY115416A (en) 2003-06-30
FI104174B (en) 1999-11-30
CN1212256A (en) 1999-03-31
SK282971B6 (en) 2003-01-09
FI104174B1 (en) 1999-11-30
PL297338A1 (en) 1993-09-06

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