FI98705B - Monoclonal antibody for selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids - Google Patents

Monoclonal antibody for selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids

Info

Publication number
FI98705B
FI98705B FI891953A FI891953A FI98705B FI 98705 B FI98705 B FI 98705B FI 891953 A FI891953 A FI 891953A FI 891953 A FI891953 A FI 891953A FI 98705 B FI98705 B FI 98705B
Authority
FI
Finland
Prior art keywords
type iii
procollagen
monoclonal antibody
peptide
body fluids
Prior art date
Application number
FI891953A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI98705C (en
FI891953A0 (en
FI891953L (en
Inventor
Dietrich Brocks
Volkmar Guenzler-Pukall
Henning Hachmann
Juergen Puenter
Rupert Timpl
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI891953A0 publication Critical patent/FI891953A0/en
Publication of FI891953L publication Critical patent/FI891953L/en
Application granted granted Critical
Publication of FI98705B publication Critical patent/FI98705B/en
Publication of FI98705C publication Critical patent/FI98705C/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The said peptide can be determined with great accuracy with the aid of a monoclonal antibody which is directed specifically against one epitope of amino-terminal procollagen peptide (type III) which is not present on the fragment Col 1 and of a second monoclonal or polyclonal antibody against an epitope of amino-terminal procollagen peptide (type III).
FI891953A 1988-04-27 1989-04-25 Monoclonal antibody for selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids FI98705C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3814216 1988-04-27
DE3814216 1988-04-27

Publications (4)

Publication Number Publication Date
FI891953A0 FI891953A0 (en) 1989-04-25
FI891953L FI891953L (en) 1989-10-28
FI98705B true FI98705B (en) 1997-04-30
FI98705C FI98705C (en) 1997-08-11

Family

ID=6353005

Family Applications (1)

Application Number Title Priority Date Filing Date
FI891953A FI98705C (en) 1988-04-27 1989-04-25 Monoclonal antibody for selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids

Country Status (12)

Country Link
EP (1) EP0339443B1 (en)
JP (1) JPH07110880B2 (en)
AT (1) ATE115963T1 (en)
CA (1) CA1338324C (en)
DE (1) DE58908787D1 (en)
DK (1) DK169571B1 (en)
ES (1) ES2065350T3 (en)
FI (1) FI98705C (en)
GR (1) GR3014957T3 (en)
IE (1) IE66320B1 (en)
NO (1) NO179107C (en)
PT (1) PT90369B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010862A (en) * 1987-11-06 2000-01-04 Washington Research Foundation Methods of detecting collagen type III degradation in vivo
DE4225038C2 (en) * 1992-07-29 1995-11-30 Boehringer Mannheim Gmbh Production and use of antibodies against collagen
ES2122231T3 (en) * 1993-07-28 1998-12-16 Boehringer Mannheim Gmbh IMMUNO ANALYSIS FOR THE DETECTION OF TYPE I COLLAGEN OR CORRESPONDING COLLAGEN FRAGMENTS.
GB9506050D0 (en) 1995-03-24 1995-05-10 Osteometer A S Assaying collagen fragments in body fluids
ATE199185T1 (en) 1994-10-17 2001-02-15 Osteometer Biotech As ASSESSMENT OF FRAGMENTATION PATTERNS OF COLLAGEN IN BODY FLUID AND DIAGNOSIS OF DISORDERS RELATED TO COLLAGEN METABOLISM
US6107047A (en) * 1996-03-21 2000-08-22 Osteometer Biotech A/S Assaying protein fragments in body fluids
GB9617616D0 (en) 1996-08-22 1996-10-02 Osteometer Biotech As Assaying protein fragments in body fluids
ATE202632T1 (en) 1996-12-09 2001-07-15 Osteometer Biotech As SANDWIGHT TEST FOR DETECTING COLLAGEN FRAGMENTS
US6117646A (en) * 1997-09-22 2000-09-12 Osteometer Biotech A/S Assaying protein fragments in body fluids
PT1086135E (en) 1998-05-28 2004-07-30 Bayer Healthcare Ag MONOCLONAL ANTIBODY AND ANALYSIS FOR PIIINP DETECTION
US6602980B1 (en) 1998-06-19 2003-08-05 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays
US6916903B2 (en) 1998-06-19 2005-07-12 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3209149A1 (en) * 1982-03-13 1983-10-06 Hoechst Ag METHOD FOR THE COMMON IMMUNOLOGICAL DETERMINATION OF PROCOLLAGEN PEPTIDE (TYPE III) AND PROCOLLAGEN PEPTIDE COL 1 (TYPE III) AND METHOD FOR THE PRODUCTION OF ANTI-PROCOLLAGEN PEPTIDE COL 1 (TYPE III) SERUM

Also Published As

Publication number Publication date
DK202189A (en) 1989-10-28
CA1338324C (en) 1996-05-14
FI98705C (en) 1997-08-11
DE58908787D1 (en) 1995-02-02
NO179107B (en) 1996-04-29
ATE115963T1 (en) 1995-01-15
IE66320B1 (en) 1995-12-27
FI891953A0 (en) 1989-04-25
GR3014957T3 (en) 1995-05-31
NO891732L (en) 1989-10-30
EP0339443A3 (en) 1990-05-09
PT90369B (en) 1994-08-31
DK169571B1 (en) 1994-12-05
NO179107C (en) 1996-08-07
EP0339443A2 (en) 1989-11-02
ES2065350T3 (en) 1995-02-16
JPH07110880B2 (en) 1995-11-29
NO891732D0 (en) 1989-04-26
DK202189D0 (en) 1989-04-26
EP0339443B1 (en) 1994-12-21
FI891953L (en) 1989-10-28
JPH0213396A (en) 1990-01-17
IE891372L (en) 1989-10-27
PT90369A (en) 1989-11-10

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Legal Events

Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH

PC Transfer of assignment of patent

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH

Free format text: SANOFI-AVENTIS DEUTSCHLAND GMBH

MA Patent expired