FI982268A - Novel pro-drugs of non-steroidal anti-inflammatory carboxylic acids, their preparation and use - Google Patents

Novel pro-drugs of non-steroidal anti-inflammatory carboxylic acids, their preparation and use Download PDF

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Publication number
FI982268A
FI982268A FI982268A FI982268A FI982268A FI 982268 A FI982268 A FI 982268A FI 982268 A FI982268 A FI 982268A FI 982268 A FI982268 A FI 982268A FI 982268 A FI982268 A FI 982268A
Authority
FI
Finland
Prior art keywords
drugs
preparation
carboxylic acids
steroidal anti
novel pro
Prior art date
Application number
FI982268A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI982268A0 (en
Inventor
Tomi Jaervinen
Jarkko Rautio
Tapio Nevalainen
Hannu Taipale
Jouko Vepsaelaeinen
Jukka Gynther
Original Assignee
Tomi Jaervinen
Jarkko Rautio
Tapio Nevalainen
Hannu Taipale
Jouko Vepsaelaeinen
Jukka Gynther
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tomi Jaervinen, Jarkko Rautio, Tapio Nevalainen, Hannu Taipale, Jouko Vepsaelaeinen, Jukka Gynther filed Critical Tomi Jaervinen
Priority to FI982268A priority Critical patent/FI982268A/en
Publication of FI982268A0 publication Critical patent/FI982268A0/en
Priority to PCT/FI1999/000855 priority patent/WO2000023419A1/en
Priority to AU63436/99A priority patent/AU6343699A/en
Publication of FI982268A publication Critical patent/FI982268A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI982268A 1998-10-20 1998-10-20 Novel pro-drugs of non-steroidal anti-inflammatory carboxylic acids, their preparation and use FI982268A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FI982268A FI982268A (en) 1998-10-20 1998-10-20 Novel pro-drugs of non-steroidal anti-inflammatory carboxylic acids, their preparation and use
PCT/FI1999/000855 WO2000023419A1 (en) 1998-10-20 1999-10-18 Novel prodrugs of non-steroidal anti-inflammatory carboxylic acids, their preparation and use
AU63436/99A AU6343699A (en) 1998-10-20 1999-10-18 Novel prodrugs of non-steroidal anti-inflammatory carboxylic acids, their preparation and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI982268A FI982268A (en) 1998-10-20 1998-10-20 Novel pro-drugs of non-steroidal anti-inflammatory carboxylic acids, their preparation and use

Publications (2)

Publication Number Publication Date
FI982268A0 FI982268A0 (en) 1998-10-20
FI982268A true FI982268A (en) 2000-04-21

Family

ID=8552742

Family Applications (1)

Application Number Title Priority Date Filing Date
FI982268A FI982268A (en) 1998-10-20 1998-10-20 Novel pro-drugs of non-steroidal anti-inflammatory carboxylic acids, their preparation and use

Country Status (3)

Country Link
AU (1) AU6343699A (en)
FI (1) FI982268A (en)
WO (1) WO2000023419A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9805655D0 (en) 1998-03-16 1998-05-13 Celltech Therapeutics Ltd Chemical compounds
WO2001079173A2 (en) 2000-04-17 2001-10-25 Celltech R & D Limited Enamine derivatives as cell adhesion molecules
US6429223B1 (en) * 2000-06-23 2002-08-06 Medinox, Inc. Modified forms of pharmacologically active agents and uses therefor
GB0028844D0 (en) 2000-11-27 2001-01-10 Celltech Chiroscience Ltd Chemical compounds
PT1370531E (en) 2001-02-22 2007-04-30 Celltech R&D Ltd Phenylalanine enamide derivatives possessing a cyclobutene group, for use as integrin inhibitors
WO2003011815A1 (en) 2001-07-26 2003-02-13 Celltech R & D Limited Bicyclic heteroaromatic alanines
AU2015281799B2 (en) 2014-06-26 2019-11-28 Central Adelaide Local Health Network Incorporated Enzyme interacting agents
US20220274970A1 (en) 2019-07-24 2022-09-01 Cincera Therapeutics Pty Ltd Inhibitor compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199994B (en) * 1983-04-11 1989-01-05 Lancet Ind Farmaceutica S R L DERIVATIVES OF D-2- (6-METHOXY-2-NAFTIL) -PROPIONIC ACID THERAPEUTIC ACTIVITY, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO1991009831A1 (en) * 1989-12-26 1991-07-11 Nova Pharmaceutical Corporation Prodrug anhydrides of asprin, indomethacin and ibuprofen, their preparation, compositions, and anti-inflammatory method of use
US5607966A (en) * 1994-12-23 1997-03-04 Alcon Laboratories, Inc. Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs

Also Published As

Publication number Publication date
FI982268A0 (en) 1998-10-20
AU6343699A (en) 2000-05-08
WO2000023419A1 (en) 2000-04-27

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