FI980341L - 2-Oxyindole derivatives - Google Patents

2-Oxyindole derivatives Download PDF

Info

Publication number
FI980341L
FI980341L FI980341A FI980341A FI980341L FI 980341 L FI980341 L FI 980341L FI 980341 A FI980341 A FI 980341A FI 980341 A FI980341 A FI 980341A FI 980341 L FI980341 L FI 980341L
Authority
FI
Finland
Prior art keywords
oxyindole derivatives
oxyindole
derivatives
Prior art date
Application number
FI980341A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI980341A7 (en
FI980341A0 (en
Inventor
Loic Foulon
Georges Garcia
Dino Nisato
Richard Roux
Claudine Serradeil-Legal
Gerard Valette
Jean Wagnon
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Priority to FI980341A priority Critical patent/FI980341A0/en
Publication of FI980341L publication Critical patent/FI980341L/en
Publication of FI980341A7 publication Critical patent/FI980341A7/en
Publication of FI980341A0 publication Critical patent/FI980341A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • C07D209/92—Naphthostyrils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI980341A 1992-01-30 1993-01-28 2-oxy-indole derivatives FI980341A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI980341A FI980341A0 (en) 1992-01-30 1993-01-28 2-oxy-indole derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9201034A FR2686878B1 (en) 1992-01-30 1992-01-30 DERIVATIVES OF N-SULFONYL OXO-2 INDOLE, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME.
PCT/FR1993/000093 WO1993015051A1 (en) 1992-01-30 1993-01-28 N-sulphonyl-2-oxoindole derivatives having affinity for vasopressin and/or ocytocin receptors
FI934274A FI934274A0 (en) 1992-01-30 1993-01-28 N-SULPHONYL-2-OXI-INDOLDERIVAT, DERAS FRAMSTAELLNING OCH DESSA INNEHAOLLANDE PHARMACEUTICAL COMPOSITION
FI980341A FI980341A0 (en) 1992-01-30 1993-01-28 2-oxy-indole derivatives

Publications (3)

Publication Number Publication Date
FI980341L true FI980341L (en) 1998-02-13
FI980341A7 FI980341A7 (en) 1998-02-13
FI980341A0 FI980341A0 (en) 1998-02-13

Family

ID=9426168

Family Applications (2)

Application Number Title Priority Date Filing Date
FI934274A FI934274A0 (en) 1992-01-30 1993-01-28 N-SULPHONYL-2-OXI-INDOLDERIVAT, DERAS FRAMSTAELLNING OCH DESSA INNEHAOLLANDE PHARMACEUTICAL COMPOSITION
FI980341A FI980341A0 (en) 1992-01-30 1993-01-28 2-oxy-indole derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI934274A FI934274A0 (en) 1992-01-30 1993-01-28 N-SULPHONYL-2-OXI-INDOLDERIVAT, DERAS FRAMSTAELLNING OCH DESSA INNEHAOLLANDE PHARMACEUTICAL COMPOSITION

Country Status (20)

Country Link
EP (1) EP0581939B1 (en)
JP (1) JPH06507182A (en)
AT (1) ATE180773T1 (en)
AU (1) AU662960B2 (en)
BR (1) BR9303993A (en)
CA (1) CA2107348A1 (en)
CZ (1) CZ203793A3 (en)
DE (1) DE69325130D1 (en)
FI (2) FI934274A0 (en)
FR (1) FR2686878B1 (en)
HU (1) HUT68642A (en)
IL (1) IL104559A0 (en)
MX (1) MX9300498A (en)
NO (1) NO180538C (en)
NZ (1) NZ249158A (en)
RU (1) RU2135469C1 (en)
SK (1) SK105393A3 (en)
TW (1) TW239126B (en)
WO (1) WO1993015051A1 (en)
ZA (1) ZA93649B (en)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2708605A1 (en) * 1993-07-30 1995-02-10 Sanofi Sa N-sulfonylindol-2-one derivatives, their preparation, pharmaceutical compositions containing them.
US5686624A (en) * 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
US5849780A (en) * 1992-01-30 1998-12-15 Sanofi 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
FR2708606B1 (en) * 1993-07-30 1995-10-27 Sanofi Sa N-phenylalkylindol-2-one derivatives, their preparation, pharmaceutical compositions containing them.
FR2708608B1 (en) * 1993-07-30 1995-10-27 Sanofi Sa N-sulfonylbenzimidazolone derivatives, their preparation, pharmaceutical compositions containing them.
FR2714378B1 (en) * 1993-12-24 1996-03-15 Sanofi Sa Indol-2-one derivatives substituted in 3 with a nitrogen group, their preparation, pharmaceutical compositions containing them.
FR2722190B1 (en) * 1994-07-05 1996-10-04 Sanofi Sa 1-BENZYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO1996036611A1 (en) * 1995-05-19 1996-11-21 Chiroscience Limited 3,4-disubstituted-phenylsulphonamides and their therapeutic use
FR2740136B1 (en) * 1995-10-24 1998-01-09 Sanofi Sa INDOLIN-2-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5756497A (en) * 1996-03-01 1998-05-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
ATE264330T1 (en) 1999-07-21 2004-04-15 Astrazeneca Ab LINKS
GB9918684D0 (en) 1999-08-09 1999-10-13 Novartis Ag Organic compounds
WO2002070478A1 (en) 2001-03-06 2002-09-12 Astrazeneca Ab Indolone derivatives having vascular-damaging activity
SE0200979D0 (en) * 2002-03-28 2002-03-28 Astrazeneca Ab New compounds
DE10222034A1 (en) * 2002-05-17 2003-11-27 Bayer Ag New 2-benzenesulfonyl-3,4-dihydro-2(1H)-isoquinoline derivatives, are PPAR-delta activators useful e.g. for treating coronary heart disease, dyslipidemia or restenosis
DE60317333T2 (en) * 2002-06-21 2008-08-28 Suven Life Sciences Ltd. TETRACYCLIC ARYLSULFONYLINDOLE WITH AFFINITY TO THE SEROTONIN RECEPTOR
RU2259999C2 (en) * 2003-08-26 2005-09-10 ООО "Исследовательский институт химического разнообразия" 1-sulfonyl-1,3-dihydroindole-2-ones, pharmaceutical compositions (variants), method for their preparing and applying
US20050070718A1 (en) 2003-09-30 2005-03-31 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US8580842B2 (en) 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US7414052B2 (en) 2004-03-30 2008-08-19 Wyeth Phenylaminopropanol derivatives and methods of their use
US7517899B2 (en) 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
JP2008526702A (en) * 2004-12-31 2008-07-24 アボット ゲーエムベーハー ウント カンパニー カーゲー Substituted oxindole derivatives, drugs containing the derivatives and uses thereof
WO2006080574A1 (en) * 2005-01-28 2006-08-03 Taisho Pharmaceutical Co., Ltd. 1,3-dihydro-2h-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle
DE102005014904A1 (en) * 2005-03-26 2007-02-01 Abbott Gmbh & Co. Kg New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders
EP1861392A2 (en) 2005-03-24 2007-12-05 Abbott GmbH & Co. KG Substituted oxindol derivatives, drugs containing said derivatives and the use thereof
DE102005015957A1 (en) * 2005-03-31 2006-10-05 Abbott Gmbh & Co. Kg New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders
DE102005014936A1 (en) 2005-03-24 2006-12-14 Abbott Gmbh & Co. Kg New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders
AR053710A1 (en) 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc SPIROHETEROCICLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS
MY144968A (en) 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
US8193208B2 (en) 2005-09-09 2012-06-05 Purdue Pharma L.P. Fused and spirocycle compounds and the use thereof
WO2007063123A1 (en) 2005-12-02 2007-06-07 Abbott Gmbh & Co. Kg Substituted oxindol-derivatives, medicaments containing said derivatives and use thereof
DE102006040915A1 (en) 2006-08-26 2008-03-20 Abbott Gmbh & Co. Kg New oxindole derivatives useful for treating vasopressin- or oxytocin-dependent diseases
EP2061769A1 (en) 2006-08-26 2009-05-27 Abbott GmbH & Co. KG Substituted benzimidazolone derivatives, medicaments comprising them and their use
AU2007299822A1 (en) * 2006-09-22 2008-03-27 Janssen Pharmaceutica N.V. Spiro benzazepines as vasopressin antagonists
PL2078022T3 (en) * 2006-09-22 2012-04-30 Janssen Pharmaceutica Nv Spiro benzazepines used as vasopressin antagonists
US8466188B2 (en) 2006-10-12 2013-06-18 Xenon Pharmaceuticals Inc. Use of spiro-oxindole compounds as therapeutic agents
FR2909668B1 (en) * 2006-12-12 2009-01-23 Sanofi Aventis Sa 5-ALKYLOXY-INDOLIN-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS
US20080167286A1 (en) 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
US8486979B2 (en) 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
UY30846A1 (en) 2006-12-30 2008-07-31 Abbott Gmbh & Amp OXINDOL DERIVATIVES REPLACED, MEDICINES THAT UNDERSTAND AND USE THEMSELVES
US9023854B2 (en) 2007-12-07 2015-05-05 AbbVie Deutschland GmbH & Co. KG 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressin-dependent diseases
JP5645217B2 (en) 2007-12-07 2014-12-24 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー 5,6-disubstituted oxindole derivatives and their use to treat vasopressin-dependent diseases
US8703774B2 (en) 2007-12-07 2014-04-22 AbbVie Deutschland GmbH & Co. KG Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
MX2010006202A (en) 2007-12-07 2011-03-04 Abbott Gmbh & Co Kg Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses.
KR101570996B1 (en) 2007-12-27 2015-11-23 아비에 도이치란트 게엠베하 운트 콤파니 카게 Substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
FR2927625B1 (en) 2008-02-19 2010-03-12 Sanofi Aventis NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2930249B1 (en) * 2008-04-21 2010-05-14 Sanofi Aventis NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF
US8101647B2 (en) 2008-10-17 2012-01-24 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
PT2350090E (en) 2008-10-17 2015-11-13 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their use as therapeutic agents
WO2010138600A2 (en) 2009-05-29 2010-12-02 Abbott Laboratories Pharmaceutical compositions for the treatment of pain
AR077252A1 (en) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc ESPIROOXINDOL COMPOUND ENANTIOMERS AND THEIR USES AS THERAPEUTIC AGENTS
PE20121350A1 (en) 2009-10-14 2012-10-20 Xenon Pharmaceuticals Inc SYNTHETIC METHODS FOR SPIRO-OXOINDOL COMPOUNDS
NZ601667A (en) 2010-02-26 2014-10-31 Xenon Pharmaceuticals Inc Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
EP2881391A1 (en) 2013-12-05 2015-06-10 Bayer Pharma Aktiengesellschaft Spiroindoline carbocycle derivatives and pharmaceutical compositions thereof
US9682033B2 (en) 2015-02-05 2017-06-20 Teva Pharmaceuticals International Gmbh Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
WO2017127409A1 (en) * 2016-01-20 2017-07-27 Chemocentryx, Inc. 2-oxindole compounds
CN114702448A (en) * 2021-09-30 2022-07-05 西南大学 Synthetic method of trifluoromethylated tandem cyclized spiro compounds of cycloalkenes
CN119019312B (en) * 2024-10-24 2025-01-28 苏州宜联生物医药有限公司 Indol-2-one derivative, antibody drug conjugate thereof and application thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2540057A (en) 1947-07-02 1951-01-30 Gen Aniline & Film Corp Aromatic and heterocyclic diazosulfones
US3838167A (en) * 1972-08-01 1974-09-24 Lilly Co Eli Process for preparing indoles
DK167393B1 (en) 1985-12-30 1993-10-25 Roussel Uclaf 1-SULPHONYL-2-OXO-PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEREOF
US4863437A (en) * 1986-03-20 1989-09-05 Clarke Ellis W Means for fluid administration
US4803217A (en) * 1986-12-24 1989-02-07 Merck & Co., Inc. Hapalindolinone compounds as vassopressin antagonists
EP0303418A3 (en) * 1987-08-11 1990-11-07 Smithkline Beecham Laboratoires Pharmaceutiques Substituted indolones, useful in the treatment of heart or asthmatic diseases
ES2110965T3 (en) * 1989-07-25 1998-03-01 Taiho Pharmaceutical Co Ltd DERIVED FROM OXOINDOL.

Also Published As

Publication number Publication date
JPH06507182A (en) 1994-08-11
FR2686878A1 (en) 1993-08-06
FI934274L (en) 1993-09-29
WO1993015051A1 (en) 1993-08-05
FI934274A7 (en) 1993-09-29
IL104559A0 (en) 1993-05-13
NZ249158A (en) 1996-02-27
CA2107348A1 (en) 1993-07-31
FI934274A0 (en) 1993-09-29
FI980341A7 (en) 1998-02-13
NO180538C (en) 1997-05-07
NO180538B (en) 1997-01-27
ZA93649B (en) 1993-09-02
AU3504393A (en) 1993-09-01
BR9303993A (en) 1994-08-02
NO933482L (en) 1993-11-29
TW239126B (en) 1995-01-21
ATE180773T1 (en) 1999-06-15
EP0581939B1 (en) 1999-06-02
SK105393A3 (en) 1994-08-10
FR2686878B1 (en) 1995-06-30
EP0581939A1 (en) 1994-02-09
NO933482D0 (en) 1993-09-29
DE69325130D1 (en) 1999-07-08
FI980341A0 (en) 1998-02-13
MX9300498A (en) 1994-07-29
HUT68642A (en) 1995-07-28
CZ203793A3 (en) 1994-04-13
AU662960B2 (en) 1995-09-21
RU2135469C1 (en) 1999-08-27
HU9302762D0 (en) 1993-12-28

Similar Documents

Publication Publication Date Title
FI930208L (en) QUINAZOLE DERIVATIVES
FI935431A7 (en) Kianzoline derivatives
FI980341L (en) 2-Oxyindole derivatives
ATA75293A (en) INDOLDER DERIVATIVES
FI933037A7 (en) THIAZOLOLYLPHENYL DERIVATIVES
FI941423A7 (en) 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives
DE69208877D1 (en) CHINUCLIDINE DERIVATIVES
FI924160A7 (en) BENZANE DERIVATIVES
FI935726A7 (en) Azanorbornane derivatives
FI924159L (en) BENZANE DERIVATIVES
NO922182D0 (en) CRYSTALLINIC OXATATOLAN DERIVATIVES
FI943976A7 (en) 5-arylindole derivatives
DE69330497D1 (en) CHINAZOLIN DERIVATIVES
FI925763A0 (en) FUNGICIDA 2-IMIDAZOLIN-5-ON-OCH 2-IMIDAZOLINE-5-THION DERIVATIVES
FI923726L (en) SULFATERADE GLYCOSAMINOGLYCANOID DERIVATIVES
FI20010214L (en) Acylaminoindole derivatives
DE59308714D1 (en) CYCLOBUTANE-BENZENE DERIVATIVES
FI20002460L (en) 4-diphenylmethylpiperidine derivatives
FI942444A7 (en) Terahydropyran derivatives
FI943885L (en) Penaam derivatives
FI935243L (en) PYRIDONECARBOXYL DERIVATIVES
FI944044L (en) Phenylalkanolamine derivatives
FI920394A7 (en) 3-quinuclidine derivatives
NO952288D0 (en) Benzazepinon derivatives
DE69313890D1 (en) 5-aminoflavone derivatives