FI972744A - Amino acid compositions and their use in clinical nutrition - Google Patents
Amino acid compositions and their use in clinical nutrition Download PDFInfo
- Publication number
- FI972744A FI972744A FI972744A FI972744A FI972744A FI 972744 A FI972744 A FI 972744A FI 972744 A FI972744 A FI 972744A FI 972744 A FI972744 A FI 972744A FI 972744 A FI972744 A FI 972744A
- Authority
- FI
- Finland
- Prior art keywords
- tnf
- amino acid
- diminution
- levels
- acid compositions
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 235000016709 nutrition Nutrition 0.000 title abstract 2
- 230000035764 nutrition Effects 0.000 title 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 7
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000013632 homeostatic process Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/13—Nucleic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pediatric Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides the use of at least one amino acid selected from the group consisting of glycine, alanine and serine, or the physiologically acceptable salts thereof, in the preparation of a medicament or nutritional formulation for the diminution of tumor necrosis factor (TNF) levels in patients in whom said levels are elevated beyond those which mediate physiological homeostasis and local inflammation. Such diminution of TNF levels can i.a. be achieved by inhibition or diminution of: (i) tumor necrosis factor (TNF) production by macrophage-type cells; (ii) the release of TNF from macrophage-type cells; and/or (iii) the binding of TNF by TNF receptors.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08392694 US5656608B1 (en) | 1995-02-23 | 1995-02-23 | Amino acid compositions and methods of treatment using same |
GBGB9512100.0A GB9512100D0 (en) | 1995-06-14 | 1995-06-14 | Improvements in or relating to organic compounds |
PCT/EP1996/000739 WO1996025861A1 (en) | 1995-02-23 | 1996-02-22 | Amino acid compositions and use thereof in clinical nutrition |
Publications (2)
Publication Number | Publication Date |
---|---|
FI972744A0 FI972744A0 (en) | 1997-06-25 |
FI972744A true FI972744A (en) | 1997-08-22 |
Family
ID=26307213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI972744A FI972744A (en) | 1995-02-23 | 1997-06-25 | Amino acid compositions and their use in clinical nutrition |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0810829B1 (en) |
JP (1) | JPH11501301A (en) |
KR (1) | KR19980702436A (en) |
CN (1) | CN1175887A (en) |
AT (1) | ATE191615T1 (en) |
AU (1) | AU710527B2 (en) |
BR (1) | BR9607336A (en) |
CA (1) | CA2210499A1 (en) |
CZ (1) | CZ266797A3 (en) |
DE (1) | DE69607750T2 (en) |
DK (1) | DK0810829T3 (en) |
ES (1) | ES2145997T3 (en) |
FI (1) | FI972744A (en) |
HU (1) | HUP9800049A3 (en) |
NO (1) | NO973884L (en) |
PL (1) | PL182205B1 (en) |
PT (1) | PT810829E (en) |
WO (1) | WO1996025861A1 (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9512100D0 (en) * | 1995-06-14 | 1995-08-09 | Sandoz Nutrition Ltd | Improvements in or relating to organic compounds |
US6096785A (en) * | 1996-07-30 | 2000-08-01 | Novartis Nutrition Ag | Amino acid compositions and use thereof in treating renal dysfunction |
JP2000515874A (en) * | 1996-07-30 | 2000-11-28 | ノバルテイス・ニユートリシヨン・アクチエンゲゼルシヤフト | Amino acid compositions and their use in treating tumor growth and metastasis |
GB9701674D0 (en) * | 1997-01-28 | 1997-03-19 | Novartis Nutrition Ag | Use of organic compounds |
EP0882451B1 (en) * | 1997-06-05 | 2004-05-12 | Novartis Nutrition AG | Glycine for prevention or treatment of transplant rejection |
US6310097B1 (en) * | 1997-07-28 | 2001-10-30 | Riken | Protecting and survival promoting agent for central nervous cell |
US6143786A (en) * | 1999-02-02 | 2000-11-07 | Novartis Nutrition Ag | Oral arginine and insulin secretion |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
US7364736B2 (en) | 2001-06-26 | 2008-04-29 | Amgen Inc. | Antibodies to OPGL |
NL1019368C2 (en) | 2001-11-14 | 2003-05-20 | Nutricia Nv | Preparation for improving receptor performance. |
DE10257360A1 (en) * | 2002-12-09 | 2004-07-08 | Fresenius Kabi Deutschland Gmbh | Gastrointestinally administrable formulation and its use |
EP1665940A4 (en) | 2003-09-02 | 2011-01-19 | Bbk Bio Corp | Diet food |
EP1591118A1 (en) | 2004-04-27 | 2005-11-02 | Nutri-Fit GmbH & Co. KG | Use of melatonin in preventing postoperative complications |
KR100555904B1 (en) * | 2004-05-19 | 2006-03-03 | 주식회사 오스코텍 | A herbal mixture extract of Pleurotus eryngii and Acanthopanacis Cortex and composition comprising the same for prevention and treatment of osteoporosis |
EP2032170B1 (en) * | 2006-06-14 | 2012-11-28 | N.V. Nutricia | Anti-inflammatory composition comprising glycine and lactoferrin and the use thereof |
JP5979816B2 (en) | 2008-01-04 | 2016-08-31 | ネステク ソシエテ アノニム | Compositions containing unsaturated fatty acids and nitric oxide releasing compounds and their use to enhance cognitive function and related functions |
US20100179089A1 (en) * | 2009-01-13 | 2010-07-15 | Deutz Nicolaas E P | Compositions and Methods to Manage the Inflammatory Basis of Chronic Disease Conditions and Maintain an Optimal Immune Response in Elderly |
NZ615091A (en) * | 2009-06-08 | 2015-03-27 | Ucl Business Plc | Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate |
KR101213825B1 (en) * | 2010-07-16 | 2012-12-18 | 서울대학교산학협력단 | Composition for the prevention and treatment of fatty liver diseases containing serine as an active ingredient |
KR101758424B1 (en) | 2010-09-24 | 2017-07-14 | 유니버시티 오브 플로리다 리서치 파운데이션, 인크. | Materials and methods for improving gastrointestinal function |
JP6378307B2 (en) | 2013-03-11 | 2018-08-22 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | Substances and methods for improving lung function and for preventing and / or treating radiation-induced lung complications |
BR112017010832A2 (en) | 2014-11-24 | 2017-12-26 | Entrinsic Health Solutions Llc | amino acid compositions for treating disease symptoms |
EP3355878A1 (en) | 2015-10-02 | 2018-08-08 | N.V. Nutricia | Glycine for use in tolerance induction in allergic patients |
FR3041882B1 (en) * | 2015-10-06 | 2019-04-12 | Universite D'angers | PHARMACEUTICAL PREPARATION FOR THE PREVENTIVE TREATMENT OF LESIONS D'ISCHENIE REPERFUSION |
MX2019003821A (en) | 2016-10-04 | 2019-12-18 | Univ Florida | Amino acid compositions and uses thereof. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2591893B1 (en) * | 1985-12-19 | 1988-11-10 | Centre Nat Rech Scient | METHIONINE-DEFECTED NUTRITIONAL COMPOSITIONS FOR INHIBITING THE DEVELOPMENT AND DISSEMINATION OF MALIGNANT TUMORS IN MAMMALS |
US4988724A (en) * | 1988-12-09 | 1991-01-29 | Board Of Regents, The University Of Texas System | Methods and improved formulations for the determination and treatment of malignant disease in patients |
ATE174794T1 (en) * | 1991-09-27 | 1999-01-15 | Univ Texas | PREPARATIONS CONTAINING AMINO ACIDS FOR PARENTERAL APPLICATION TO COMBAT HYPOTENSION AND RELATED PATHOLOGIES |
US5571783A (en) * | 1993-03-09 | 1996-11-05 | Clintec Nutrition Company | Composition and method for treating patients with hepatic disease |
-
1996
- 1996-02-22 DE DE69607750T patent/DE69607750T2/en not_active Expired - Fee Related
- 1996-02-22 HU HU9800049A patent/HUP9800049A3/en unknown
- 1996-02-22 CZ CZ972667A patent/CZ266797A3/en unknown
- 1996-02-22 CN CN96192066A patent/CN1175887A/en active Pending
- 1996-02-22 BR BR9607336A patent/BR9607336A/en not_active Application Discontinuation
- 1996-02-22 WO PCT/EP1996/000739 patent/WO1996025861A1/en not_active Application Discontinuation
- 1996-02-22 AU AU48795/96A patent/AU710527B2/en not_active Ceased
- 1996-02-22 AT AT96904849T patent/ATE191615T1/en not_active IP Right Cessation
- 1996-02-22 KR KR1019970705835A patent/KR19980702436A/en not_active Application Discontinuation
- 1996-02-22 JP JP8525404A patent/JPH11501301A/en active Pending
- 1996-02-22 CA CA002210499A patent/CA2210499A1/en not_active Abandoned
- 1996-02-22 PT PT96904849T patent/PT810829E/en unknown
- 1996-02-22 ES ES96904849T patent/ES2145997T3/en not_active Expired - Lifetime
- 1996-02-22 PL PL96321238A patent/PL182205B1/en unknown
- 1996-02-22 EP EP96904849A patent/EP0810829B1/en not_active Expired - Lifetime
- 1996-02-22 DK DK96904849T patent/DK0810829T3/en active
-
1997
- 1997-06-25 FI FI972744A patent/FI972744A/en unknown
- 1997-08-22 NO NO973884A patent/NO973884L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JPH11501301A (en) | 1999-02-02 |
DK0810829T3 (en) | 2000-08-28 |
HUP9800049A2 (en) | 1998-05-28 |
DE69607750T2 (en) | 2000-08-31 |
FI972744A0 (en) | 1997-06-25 |
EP0810829A1 (en) | 1997-12-10 |
ES2145997T3 (en) | 2000-07-16 |
MX9706140A (en) | 1997-11-29 |
PL182205B1 (en) | 2001-11-30 |
HUP9800049A3 (en) | 1999-01-28 |
NO973884L (en) | 1997-10-17 |
AU710527B2 (en) | 1999-09-23 |
PL321238A1 (en) | 1997-11-24 |
ATE191615T1 (en) | 2000-04-15 |
CA2210499A1 (en) | 1996-08-29 |
NO973884D0 (en) | 1997-08-22 |
DE69607750D1 (en) | 2000-05-18 |
WO1996025861A1 (en) | 1996-08-29 |
KR19980702436A (en) | 1998-07-15 |
AU4879596A (en) | 1996-09-11 |
EP0810829B1 (en) | 2000-04-12 |
CN1175887A (en) | 1998-03-11 |
PT810829E (en) | 2000-08-31 |
BR9607336A (en) | 1997-11-25 |
CZ266797A3 (en) | 1998-03-18 |
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