FI971702A - Hepatitis C virus asialoglycoproteins - Google Patents
Hepatitis C virus asialoglycoproteins Download PDFInfo
- Publication number
- FI971702A FI971702A FI971702A FI971702A FI971702A FI 971702 A FI971702 A FI 971702A FI 971702 A FI971702 A FI 971702A FI 971702 A FI971702 A FI 971702A FI 971702 A FI971702 A FI 971702A
- Authority
- FI
- Finland
- Prior art keywords
- virus
- proteins
- hepatitis
- cells
- hcv
- Prior art date
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Abstract
Two hepatitis C virus shell proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes or in mammalian cells in which a terminal glycosylation has been prevented yields, as the result, recombinant proteins which are similar to the natural HCV glycoproteins. By means of being isolated using GNA lectin affinity, the E1 and E2 proteins are aggregated into virus-like particles. Cells possessing a mannose receptor or an asialoglycoprotein receptor can be infected with HCV and these cells function as carriers when culturing the virus.
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61141990A | 1990-11-08 | 1990-11-08 | |
US61196590A | 1990-11-08 | 1990-11-08 | |
US61141990 | 1990-11-08 | ||
US61196590 | 1990-11-08 | ||
US75888091A | 1991-09-13 | 1991-09-13 | |
US75888091 | 1991-09-13 | ||
US9108272 | 1991-11-07 | ||
PCT/US1991/008272 WO1992008734A1 (en) | 1990-11-08 | 1991-11-07 | Hepatitis c virus asialoglycoproteins |
FI932025A FI107803B (en) | 1990-11-08 | 1993-05-05 | Method for producing hepatitis C virus asialoglycoproteins |
FI932025 | 1993-05-05 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI971702A true FI971702A (en) | 1997-04-21 |
FI971702A0 FI971702A0 (en) | 1997-04-21 |
FI107804B FI107804B (en) | 2001-10-15 |
Family
ID=27444224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI971702A FI107804B (en) | 1990-11-08 | 1997-04-21 | Hepatitis C virus asialoglycoproteins which are used in immunodeterminations |
Country Status (1)
Country | Link |
---|---|
FI (1) | FI107804B (en) |
-
1997
- 1997-04-21 FI FI971702A patent/FI107804B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI107804B (en) | 2001-10-15 |
FI971702A0 (en) | 1997-04-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Transfer of assignment of patent |
Owner name: NOVARTIS VACCINES AND DIAGNOSTICS, INC. Free format text: NOVARTIS VACCINES AND DIAGNOSTICS, INC. |
|
MA | Patent expired |