FI96743C - Use of a cysteine proteinase inhibitor in oral hygiene and confectionery products - Google Patents

Description

96743

USE OF CYSTEUN PROTEINASE INHIBITOR IN ORAL HYGIENE AND CONFECTIONERY PRODUCTS

The concentration of the acid cysteine proteinase inhibitor is decreased or disappeared from the mouth of a patient with stomatitis or dental rot compared to a normal individual. In this case, the physiological ability of the mouth to resist pathogens in organisms is reduced. Toothpaste, mouthwash, and confectionery are used to apply ACPI to the mouth from the outside to correct the disturbed in-inhibitor balance in the mouth to prevent pathological processes in the mouth.

The invention relates to: 10

is 1) toothpaste, 2) mouthwash and 3) confectionery products all mixed with a cysteine proteinase inhibitor, acid cysteine Proteinase inhibitor = ACPI = cystatin A

,, Properties of ACPI: purified in human liver, nialuriasis and skin -oral squamous epithelium abundant -inormal saliva lgg / 1 and is thus one of the salivary soluble predominant proteins (fluoroimmunoassay / Wallac Oy, Turku; result not published) 20 In the salivary mucosa of the affected mouth, only small amounts of the inhibitor can be measured by a sensitive method (fluoroimmunoassay / Wallac Oy, Turku, result not published) - the molecular weight is 12000 D

25 - withstands heat + 100 ° C

-isoelectric point is 4.8 and 5 0 2 96743 -inhibits all known mammalian cysteine proteinases such as cathepsins B, H, I. and S as well as plant cysteine proteinases such as papain, ficin and bromelain (result partially published; other groups and me) 5 postulate on function: presumed function is non-specific protective function of the body, especially in mucous membranes containing stratified squamous epithelium such as in the mouth

Purpose of the product: 10 In inflamed and decayed mouth, the normal inhibitor balance is disturbed either primary or secondary and this disturbance is corrected by external administration of toothpaste, mouthwash and / or confectionery products, e.g. chewing gum, physiological situation which in turn defends and prevents the progression of the pathological process 1 f The product is also used as a prophylactic for these diseases

Products:

The cysteine proteinase inhibitor can be mixed with, for example, 1) toothpaste, 2) mouthwash and 3) confectionery products.

For example, of the composition of the toothpaste: 1. abrasives and polishes, e.g. calcium carbonate or tricalcium phosphate, n 50% 2. binders, e.g. aqueous silica or sodium carboxymethylcellulose, n 3% 3. foam-forming non-soap-based 2% detergent, n. soap-based detergent, approx. 8% 5. humectants, e.g. sorbitol or glycerol, approx. 30% 6. perfumes and flavors, e.g. saccharin or xylitol (according to the current form of salmia) approx. 1% 30 7. 0.001% cysteine proteinase- inhibitor 8. the remainder of the water.

il S * j 340 I f -? S |

Claims (2)

96743 Λ J. A cysteine proteinase inhibitor is produced 1. by biochemical purification from the body 2. by molecular biological means or 3. by physicochemical means (synthetic cysteine proteinase inhibitor with a lower molecular weight of 5). The toothpaste is packaged in either a tube or single-dose vacuum packs. Mouthwash in bottles and disposables, respectively 10 CLAIMS Use of ACPI (acid cysteine Proteinase inhibitor) in oral hygiene and confectionery products to balance the physiological cysteine proteinase inhibitor state of the mouth. Development of ACPI (acid cysteine Proteinase Inhibitor) in the health and ocular scaffolds for balancing with other physiological cysteine protein inhibitors