FI964509A - TNF / NGF superfamily receptor transformers and soluble, oligomeric superfamily receptors - Google Patents

TNF / NGF superfamily receptor transformers and soluble, oligomeric superfamily receptors Download PDF

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Publication number
FI964509A
FI964509A FI964509A FI964509A FI964509A FI 964509 A FI964509 A FI 964509A FI 964509 A FI964509 A FI 964509A FI 964509 A FI964509 A FI 964509A FI 964509 A FI964509 A FI 964509A
Authority
FI
Finland
Prior art keywords
superfamily
oligomeric
transformers
tnf
soluble
Prior art date
Application number
FI964509A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI964509A0 (en
Inventor
David Wallach
Mark Boldin
Igor Mett
Eugene Varfolomeev
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL109632A external-priority patent/IL109632A/en
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of FI964509A0 publication Critical patent/FI964509A0/en
Publication of FI964509A publication Critical patent/FI964509A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transmitters (AREA)
  • Circuits Of Receivers In General (AREA)
  • Mobile Radio Communication Systems (AREA)
FI964509A 1994-05-11 1996-11-08 TNF / NGF superfamily receptor transformers and soluble, oligomeric superfamily receptors FI964509A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL109632A IL109632A (en) 1994-05-11 1994-05-11 Modulators of the function of tnf receptors
IL11112594A IL111125A0 (en) 1994-05-11 1994-10-02 Soluble oligomeric tnf/ngf super family ligand receptors and their use
PCT/US1995/005854 WO1995031544A1 (en) 1994-05-11 1995-05-11 Modulator of tnf/ngf superfamily receptors and soluble oligomeric tnf/ngf superfamily receptors

Publications (2)

Publication Number Publication Date
FI964509A0 FI964509A0 (en) 1996-11-08
FI964509A true FI964509A (en) 1997-01-09

Family

ID=26322830

Family Applications (1)

Application Number Title Priority Date Filing Date
FI964509A FI964509A (en) 1994-05-11 1996-11-08 TNF / NGF superfamily receptor transformers and soluble, oligomeric superfamily receptors

Country Status (10)

Country Link
EP (1) EP0759984A4 (en)
JP (1) JP3966387B2 (en)
KR (1) KR100404737B1 (en)
CN (2) CN1173033C (en)
AU (1) AU703919B2 (en)
CA (1) CA2189983A1 (en)
FI (1) FI964509A (en)
IL (1) IL111125A0 (en)
NO (1) NO321514B1 (en)
WO (1) WO1995031544A1 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663070A (en) * 1993-11-15 1997-09-02 Lxr Biotechnology Inc. Recombinant production of a soluble splice variant of the Fas (Apo-1) antigen, fas TM
US5852173A (en) * 1994-10-19 1998-12-22 Genetics Institute, Inc. TNF receptor death ligand proteins and inhibitors of ligand binding
US5849501A (en) * 1994-10-19 1998-12-15 Genetics Institute, Inc. TNF receptor death domain ligand proteins and method to identify inhibitors of ligand binding
US5847099A (en) * 1994-10-19 1998-12-08 Genetics Institute, Inc. TNF receptor death domain ligand proteins
US5712381A (en) 1994-10-19 1998-01-27 Genetics Institute, Inc. MADD, a TNF receptor death domain ligand protein
IL114615A0 (en) 1995-07-16 1995-11-27 Yeda Res & Dev Modulators of the function of fas receptors and other proteins
US6015665A (en) * 1995-02-13 2000-01-18 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6060238A (en) * 1995-02-13 2000-05-09 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
US7097972B1 (en) 1995-02-13 2006-08-29 Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6355780B1 (en) 1995-02-22 2002-03-12 Yeda Research And Development Co. Ltd. Antibodies to the death domain motifs of regulatory proteins
ES2242195T3 (en) * 1995-02-22 2005-11-01 YEDA RESEARCH & DEVELOPMENT COMPANY, LTD. REGULATORY PROTEIN MODULATORS.
US6747138B1 (en) 1995-04-03 2004-06-08 Regents Of The University Of Michigan Methods and compositions for regulating Fas-associated apoptosis
US7807783B1 (en) * 1995-04-03 2010-10-05 The Regents Of The University Of Michigan Methods and compositions for regulating FAS-associated apoptosis
US6399327B1 (en) 1995-07-16 2002-06-04 Yeda Research And Development Co. Ltd. Modulators of the function of FAS receptors and other proteins
US6998116B1 (en) 1996-01-09 2006-02-14 Genentech, Inc. Apo-2 ligand
US6030945A (en) * 1996-01-09 2000-02-29 Genentech, Inc. Apo-2 ligand
EP1557432B1 (en) 1996-02-20 2013-08-21 Merck Serono SA Hybrid proteins which form heterodimers
ATE295887T1 (en) 1996-02-20 2005-06-15 Applied Research Systems HETERODIMERE-FORMING HYBRID PROTEINS
AU735200B2 (en) 1996-04-01 2001-07-05 Genentech Inc. APO-2LI and APO-3 apoptosis polypeptides
WO1998006839A1 (en) * 1996-07-15 1998-02-19 Human Genome Sciences, Inc. Cd44-like protein
US6462176B1 (en) 1996-09-23 2002-10-08 Genentech, Inc. Apo-3 polypeptide
EP0960126A4 (en) * 1996-11-05 2004-05-19 Univ Texas Compositions and uses for sentrin, a cell-death protecting protein
ATE403714T1 (en) 1996-11-06 2008-08-15 Univ California TUMOR NECROSIS FACTOR RECEPTOR SEPARATING ENZYME, PREPARATIONS AND USES THEREOF
US6930084B1 (en) 1996-11-06 2005-08-16 The Regents Of The University Of California Treating arthritis with TNF receptor releasing enzyme
US6593456B1 (en) 1996-11-06 2003-07-15 The Regents Of The University Of California Tumor necrosis factor receptor releasing enzyme
US5858990A (en) * 1997-03-04 1999-01-12 St. Elizabeth's Medical Center Fas ligand compositions for treatment of proliferative disorders
US6342369B1 (en) 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
US7001992B2 (en) 1997-05-30 2006-02-21 Human Genome Sciences, Inc. Antibodies to secreted protein HEMCM42
CA2291221A1 (en) * 1997-05-30 1998-12-03 Human Genome Sciences, Inc. 32 human secreted proteins
IL121746A0 (en) * 1997-06-05 1998-02-22 Yeda Res & Dev Modulators of intracellular cell death and cell survival pathways
US6051385A (en) * 1997-10-22 2000-04-18 The Regents Of The University Of Michigan Compositions and methods for identifying and testing therapeutics against HSV infection
WO1999028465A2 (en) * 1997-11-28 1999-06-10 The Regents Of The University Of California Pias molecules that recognize and bind stat proteins and uses thereof
EP1045906B1 (en) 1998-01-15 2008-10-15 Genentech, Inc. Apo-2 ligand
US6207422B1 (en) * 1998-04-17 2001-03-27 The Metrohealth System Protein that enhances expression of potassium channels on cell surfaces and nucleic acids that encode the same
EP1022027A1 (en) * 1999-01-22 2000-07-26 Applied Research Systems ARS Holding N.V. Tumor necrosis factor antagonists and their use in endometriosis
JP2001078776A (en) 1999-09-14 2001-03-27 Inst Of Physical & Chemical Res Nade-binding protein
DK2406636T3 (en) 2008-12-10 2019-02-18 Joslin Diabetes Center Inc PROCEDURES FOR DIAGNOSTICATION AND PREVENTION OF RENAL DISEASE
WO2014127835A1 (en) 2013-02-22 2014-08-28 Christian-Albrechts-Universität Zu Kiel Plant-derived resistance gene

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395760A (en) * 1989-09-05 1995-03-07 Immunex Corporation DNA encoding tumor necrosis factor-α and -β receptors
EP1132471A3 (en) * 1989-09-12 2001-11-28 F. Hoffmann-La Roche Ag TNF-binding proteins
CA2067031C (en) * 1991-04-26 2003-02-18 Shigekazu Nagata Dna coding for human cell surface antigen

Also Published As

Publication number Publication date
KR970703419A (en) 1997-07-03
NO964741L (en) 1997-01-09
CN1329512C (en) 2007-08-01
CN1173033C (en) 2004-10-27
WO1995031544A1 (en) 1995-11-23
EP0759984A1 (en) 1997-03-05
FI964509A0 (en) 1996-11-08
CN1616661A (en) 2005-05-18
IL111125A0 (en) 1994-12-29
AU703919B2 (en) 1999-04-01
NO321514B1 (en) 2006-05-15
AU2546995A (en) 1995-12-05
EP0759984A4 (en) 2002-06-26
JP3966387B2 (en) 2007-08-29
CA2189983A1 (en) 1995-11-23
CN1152937A (en) 1997-06-25
JPH10500568A (en) 1998-01-20
KR100404737B1 (en) 2004-05-03
NO964741D0 (en) 1996-11-08

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