EP0759984A4 - Modulator of tnf/ngf superfamily receptors and soluble oligomeric tnf/ngf superfamily receptors - Google Patents

Modulator of tnf/ngf superfamily receptors and soluble oligomeric tnf/ngf superfamily receptors

Info

Publication number
EP0759984A4
EP0759984A4 EP95919787A EP95919787A EP0759984A4 EP 0759984 A4 EP0759984 A4 EP 0759984A4 EP 95919787 A EP95919787 A EP 95919787A EP 95919787 A EP95919787 A EP 95919787A EP 0759984 A4 EP0759984 A4 EP 0759984A4
Authority
EP
European Patent Office
Prior art keywords
tnf
superfamily receptors
ngf superfamily
modulator
ngf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95919787A
Other languages
German (de)
French (fr)
Other versions
EP0759984A1 (en
Inventor
David Wallach
Mark Boldin
Igor Mett
Eugene Varfolomeev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL109632A external-priority patent/IL109632A/en
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Publication of EP0759984A1 publication Critical patent/EP0759984A1/en
Publication of EP0759984A4 publication Critical patent/EP0759984A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Transmitters (AREA)
  • Circuits Of Receivers In General (AREA)
EP95919787A 1994-05-11 1995-05-11 Modulator of tnf/ngf superfamily receptors and soluble oligomeric tnf/ngf superfamily receptors Withdrawn EP0759984A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IL10963294 1994-05-11
IL109632A IL109632A (en) 1994-05-11 1994-05-11 Modulators of the function of tnf receptors
IL11112594 1994-10-02
IL11112594A IL111125A0 (en) 1994-05-11 1994-10-02 Soluble oligomeric tnf/ngf super family ligand receptors and their use
PCT/US1995/005854 WO1995031544A1 (en) 1994-05-11 1995-05-11 Modulator of tnf/ngf superfamily receptors and soluble oligomeric tnf/ngf superfamily receptors

Publications (2)

Publication Number Publication Date
EP0759984A1 EP0759984A1 (en) 1997-03-05
EP0759984A4 true EP0759984A4 (en) 2002-06-26

Family

ID=26322830

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95919787A Withdrawn EP0759984A4 (en) 1994-05-11 1995-05-11 Modulator of tnf/ngf superfamily receptors and soluble oligomeric tnf/ngf superfamily receptors

Country Status (10)

Country Link
EP (1) EP0759984A4 (en)
JP (1) JP3966387B2 (en)
KR (1) KR100404737B1 (en)
CN (2) CN1329512C (en)
AU (1) AU703919B2 (en)
CA (1) CA2189983A1 (en)
FI (1) FI964509A (en)
IL (1) IL111125A0 (en)
NO (1) NO321514B1 (en)
WO (1) WO1995031544A1 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663070A (en) * 1993-11-15 1997-09-02 Lxr Biotechnology Inc. Recombinant production of a soluble splice variant of the Fas (Apo-1) antigen, fas TM
US5847099A (en) * 1994-10-19 1998-12-08 Genetics Institute, Inc. TNF receptor death domain ligand proteins
US5852173A (en) * 1994-10-19 1998-12-22 Genetics Institute, Inc. TNF receptor death ligand proteins and inhibitors of ligand binding
US5712381A (en) * 1994-10-19 1998-01-27 Genetics Institute, Inc. MADD, a TNF receptor death domain ligand protein
US5849501A (en) * 1994-10-19 1998-12-15 Genetics Institute, Inc. TNF receptor death domain ligand proteins and method to identify inhibitors of ligand binding
IL114615A0 (en) 1995-07-16 1995-11-27 Yeda Res & Dev Modulators of the function of fas receptors and other proteins
US7097972B1 (en) 1995-02-13 2006-08-29 Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6060238A (en) * 1995-02-13 2000-05-09 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6015665A (en) * 1995-02-13 2000-01-18 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
JP3860608B2 (en) * 1995-02-22 2006-12-20 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド Regulatory protein modulator
US6355780B1 (en) 1995-02-22 2002-03-12 Yeda Research And Development Co. Ltd. Antibodies to the death domain motifs of regulatory proteins
US6747138B1 (en) 1995-04-03 2004-06-08 Regents Of The University Of Michigan Methods and compositions for regulating Fas-associated apoptosis
US7807783B1 (en) * 1995-04-03 2010-10-05 The Regents Of The University Of Michigan Methods and compositions for regulating FAS-associated apoptosis
US6399327B1 (en) 1995-07-16 2002-06-04 Yeda Research And Development Co. Ltd. Modulators of the function of FAS receptors and other proteins
US6030945A (en) * 1996-01-09 2000-02-29 Genentech, Inc. Apo-2 ligand
US6998116B1 (en) 1996-01-09 2006-02-14 Genentech, Inc. Apo-2 ligand
AU706504B2 (en) * 1996-02-20 1999-06-17 Merck Serono Sa Hybrid proteins which form heterodimers
EP1541689B1 (en) 1996-02-20 2012-09-05 Merck Serono SA Hybrid proteins which form heterodimers
US6469144B1 (en) 1996-04-01 2002-10-22 Genentech, Inc. Apo-2LI and Apo-3 polypeptides
WO1998006839A1 (en) * 1996-07-15 1998-02-19 Human Genome Sciences, Inc. Cd44-like protein
US6462176B1 (en) 1996-09-23 2002-10-08 Genentech, Inc. Apo-3 polypeptide
WO1998020038A1 (en) * 1996-11-05 1998-05-14 Board Of Regents, The University Of Texas System Compositions and uses for sentrin, a cell-death protecting protein
US6593456B1 (en) 1996-11-06 2003-07-15 The Regents Of The University Of California Tumor necrosis factor receptor releasing enzyme
US6930084B1 (en) 1996-11-06 2005-08-16 The Regents Of The University Of California Treating arthritis with TNF receptor releasing enzyme
ATE403714T1 (en) 1996-11-06 2008-08-15 Univ California TUMOR NECROSIS FACTOR RECEPTOR SEPARATING ENZYME, PREPARATIONS AND USES THEREOF
US5858990A (en) * 1997-03-04 1999-01-12 St. Elizabeth's Medical Center Fas ligand compositions for treatment of proliferative disorders
US6342369B1 (en) 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
DK1015477T3 (en) * 1997-05-30 2011-02-07 Human Genome Sciences Inc 32 human secreted proteins
US7001992B2 (en) 1997-05-30 2006-02-21 Human Genome Sciences, Inc. Antibodies to secreted protein HEMCM42
IL121746A0 (en) * 1997-06-05 1998-02-22 Yeda Res & Dev Modulators of intracellular cell death and cell survival pathways
US6051385A (en) * 1997-10-22 2000-04-18 The Regents Of The University Of Michigan Compositions and methods for identifying and testing therapeutics against HSV infection
WO1999028465A2 (en) * 1997-11-28 1999-06-10 The Regents Of The University Of California Pias molecules that recognize and bind stat proteins and uses thereof
EP1045906B1 (en) 1998-01-15 2008-10-15 Genentech, Inc. Apo-2 ligand
US6207422B1 (en) 1998-04-17 2001-03-27 The Metrohealth System Protein that enhances expression of potassium channels on cell surfaces and nucleic acids that encode the same
EP1022027A1 (en) * 1999-01-22 2000-07-26 Applied Research Systems ARS Holding N.V. Tumor necrosis factor antagonists and their use in endometriosis
JP2001078776A (en) * 1999-09-14 2001-03-27 Inst Of Physical & Chemical Res Nade-binding protein
EP2406636B1 (en) 2008-12-10 2018-11-07 Joslin Diabetes Center, Inc. Methods of diagnosing and predicting renal disease
WO2014127835A1 (en) 2013-02-22 2014-08-28 Christian-Albrechts-Universität Zu Kiel Plant-derived resistance gene

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417563A2 (en) * 1989-09-12 1991-03-20 F. Hoffmann-La Roche Ag TNF-binding proteins
EP0418014A1 (en) * 1989-09-11 1991-03-20 Immunex Corporation Tumor necrosis factor-alpha and -beta receptors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2067031C (en) * 1991-04-26 2003-02-18 Shigekazu Nagata Dna coding for human cell surface antigen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0418014A1 (en) * 1989-09-11 1991-03-20 Immunex Corporation Tumor necrosis factor-alpha and -beta receptors
EP0417563A2 (en) * 1989-09-12 1991-03-20 F. Hoffmann-La Roche Ag TNF-binding proteins

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CLEMENT M-V ET AL: "FAS AND TUMOR NECROSIS FACTOR RECEPTOR-MEDIATED CELL DEATH: SIMILARITIES AND DISTINCTIONS", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 180, no. 2, 1 August 1994 (1994-08-01), pages 557 - 567, XP000983917, ISSN: 0022-1007 *
EVANS T J ET AL: "PROTECTIVE EFFECT OF 55- BUT NOT 75-KF SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR-IMMUNOGLOBULIN G FUSION PROTEINS IN AN ANIMAL MODELOF GRAM-NEGATIVE SEPSIS", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 180, 1 December 1994 (1994-12-01), pages 2173 - 2179, XP000615869, ISSN: 0022-1007 *
HSU K C ET AL: "DIFFERENTIAL EXPRESSION AND LIGAND BINDING PROPERTIES OF TUMOR NECROSIS FACTOR RECEPTOR CHIMERIC MUTANTS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 268, no. 22, 5 August 1993 (1993-08-05), pages 16430 - 16436, XP000942148, ISSN: 0021-9258 *
MORIMOTO H ET AL: "OVERCOMING TUMOR NECROSIS FACTOR AND DRUG RESISTANCE OF HUMAN TUMORCELL LINES BY COMBINATION TREATMENT WITH ANTI-FAS ANTIBODY AND DRUGS OR TOXINS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 53, no. 11, 1 June 1993 (1993-06-01), pages 2591 - 2596, XP000942154, ISSN: 0008-5472 *
See also references of WO9531544A1 *
SUDA T ET AL: "MOLECULAR CLONING AND EXPRESSION OF THE FAS LIGAND, A NOVEL MEMBER OF THE TUMOR NECROSIS FACTOR FAMILY", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 75, 17 December 1993 (1993-12-17), pages 1169 - 1178, XP000579690, ISSN: 0092-8674 *
TARTAGLIA L A ET AL: "TUMOR NECROSIS FACTOR RECEPTOR SIGNALING", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 267, no. 7, 5 March 1992 (1992-03-05), pages 4304 - 4307, XP002056559, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
NO321514B1 (en) 2006-05-15
KR970703419A (en) 1997-07-03
JP3966387B2 (en) 2007-08-29
NO964741D0 (en) 1996-11-08
CN1173033C (en) 2004-10-27
CN1329512C (en) 2007-08-01
CN1616661A (en) 2005-05-18
JPH10500568A (en) 1998-01-20
CA2189983A1 (en) 1995-11-23
FI964509A (en) 1997-01-09
AU703919B2 (en) 1999-04-01
NO964741L (en) 1997-01-09
CN1152937A (en) 1997-06-25
AU2546995A (en) 1995-12-05
IL111125A0 (en) 1994-12-29
EP0759984A1 (en) 1997-03-05
FI964509A0 (en) 1996-11-08
WO1995031544A1 (en) 1995-11-23
KR100404737B1 (en) 2004-05-03

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