FI960628A0 - Amidine derivatives with nitric oxide synthetase activities - Google Patents
Amidine derivatives with nitric oxide synthetase activitiesInfo
- Publication number
- FI960628A0 FI960628A0 FI960628A FI960628A FI960628A0 FI 960628 A0 FI960628 A0 FI 960628A0 FI 960628 A FI960628 A FI 960628A FI 960628 A FI960628 A FI 960628A FI 960628 A0 FI960628 A0 FI 960628A0
- Authority
- FI
- Finland
- Prior art keywords
- nitric oxide
- oxide synthetase
- amidine derivatives
- synthetase activities
- activities
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Furan Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
The present invention relates to methods and compositions useful for treating and preventing conditions in which inhibition of nitric oxide synthetase is beneficial. These conditions include stroke, schizophrenia, anxiety, and pain.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939316806A GB9316806D0 (en) | 1993-08-12 | 1993-08-12 | Pharmaceutically active compounds |
GB939319835A GB9319835D0 (en) | 1993-09-25 | 1993-09-25 | Pharmaceutically active compounds |
GB939325410A GB9325410D0 (en) | 1993-12-11 | 1993-12-11 | Pharmaceutically active compounds |
GB9401580A GB9401580D0 (en) | 1994-01-27 | 1994-01-27 | Pharmaceutically active compounds |
GB9411700A GB9411700D0 (en) | 1994-06-10 | 1994-06-10 | Pharmceutically active compounds |
PCT/GB1994/001767 WO1995005363A1 (en) | 1993-08-12 | 1994-08-12 | Amidine derivatives with nitric oxide synthetase activities |
Publications (2)
Publication Number | Publication Date |
---|---|
FI960628A0 true FI960628A0 (en) | 1996-02-12 |
FI960628A FI960628A (en) | 1996-02-12 |
Family
ID=27517202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI960628A FI960628A (en) | 1993-08-12 | 1996-02-12 | Amidine derivatives with nitric oxide synthetase activities |
Country Status (18)
Country | Link |
---|---|
US (2) | US5807885A (en) |
EP (1) | EP0713483B1 (en) |
JP (1) | JPH09501918A (en) |
AT (1) | ATE231126T1 (en) |
AU (1) | AU682381B2 (en) |
BR (1) | BR9407515A (en) |
CA (1) | CA2169280A1 (en) |
CZ (1) | CZ29996A3 (en) |
DE (1) | DE69432019T2 (en) |
FI (1) | FI960628A (en) |
HU (1) | HUT75876A (en) |
IL (1) | IL110643A (en) |
NO (1) | NO306459B1 (en) |
NZ (1) | NZ269571A (en) |
PL (1) | PL180081B1 (en) |
RU (1) | RU2130017C1 (en) |
SK (1) | SK16396A3 (en) |
WO (1) | WO1995005363A1 (en) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2173468A1 (en) | 1993-10-21 | 1995-04-27 | Donald W. Hansen, Jr. | Amidino derivatives useful as nitric oxide synthase inhibitors |
ATE182889T1 (en) * | 1994-05-07 | 1999-08-15 | Astra Ab | BICYCLIC AMIDEINE DERIVATIVES AS NO-SYNTHETASE INHIBITORS |
SI0758890T1 (en) | 1994-05-11 | 2005-08-31 | Jes Olesen | |
GB9418912D0 (en) * | 1994-09-20 | 1994-11-09 | Fisons Corp | Pharmaceutically active compounds |
WO1996021445A1 (en) * | 1995-01-13 | 1996-07-18 | The General Hospital Corporation | Methods of inhibiting neurodegenerative diseases |
TW397812B (en) * | 1995-02-11 | 2000-07-11 | Astra Ab | Bicyclic isothiourea derivatives useful in therapy |
ES2206571T3 (en) * | 1995-04-20 | 2004-05-16 | G.D. SEARLE & CO. | CYCLING AMIDINO AGENTS USED AS INHIBITORS OF NITRICO SINTASA OXIDE. |
KR970706272A (en) * | 1995-08-10 | 1997-11-03 | 클래스 빌헬름슨 | Bicyclic Amidine Derivatives Useful in Therapy < RTI ID = 0.0 > |
WO1997009982A1 (en) * | 1995-09-14 | 1997-03-20 | Nippon Kayaku Kabushiki Kaisha | Nitrogen monoxide synthetase inhibitor comprising 2-aminopyridines as active ingredient |
TW458978B (en) * | 1995-11-07 | 2001-10-11 | Astra Ab | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase |
US6140322A (en) * | 1995-11-07 | 2000-10-31 | Astra Aktiebolag | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase |
WO1997046515A1 (en) * | 1996-06-04 | 1997-12-11 | Chugai Seiyaku Kabushiki Kaisha | Substituted benzenes having nos inhibitory effects |
US5929085A (en) * | 1996-11-06 | 1999-07-27 | Astra Aktiebolag | Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase |
KR100559816B1 (en) * | 1996-12-24 | 2006-03-10 | 쥬가이 세이야쿠 가부시키가이샤 | Aromatic amine derivatives having nos inhibitory effect |
FR2761066B1 (en) * | 1997-03-24 | 2000-11-24 | Sod Conseils Rech Applic | NOVEL 2- (IMINOMETHYL) AMINO-PHENYL DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
FR2764889B1 (en) * | 1997-06-20 | 2000-09-01 | Sod Conseils Rech Applic | NOVEL 2- (IMINOMETHYL) AMINO-PHENYL DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US6809088B2 (en) * | 1997-03-24 | 2004-10-26 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them |
US6335445B1 (en) * | 1997-03-24 | 2002-01-01 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them |
GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
EP0980362B1 (en) | 1997-05-02 | 2006-08-16 | Schering Aktiengesellschaft | Substituted heterocycles and their use in medicaments |
SE9701681D0 (en) | 1997-05-05 | 1997-05-05 | Astra Ab | New compounds |
SE9701682D0 (en) * | 1997-05-05 | 1997-05-05 | Astra Ab | Compounds |
AU726861B2 (en) | 1997-07-03 | 2000-11-23 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Novel nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same |
US5981556A (en) * | 1997-07-22 | 1999-11-09 | G.D. Searle & Co. | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors |
TW460460B (en) | 1997-11-04 | 2001-10-21 | Chugai Pharmaceutical Co Ltd | Heterocyclic compounds having NOS inhibitory activities |
GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
CA2333691A1 (en) | 1998-06-10 | 1999-12-16 | G.D. Searle & Co. | Heterobicyclic and tricyclic nitric oxide synthase inhibitors |
FR2783519B1 (en) * | 1998-09-23 | 2003-01-24 | Sod Conseils Rech Applic | NOVEL AMIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
FR2784678B1 (en) * | 1998-09-23 | 2002-11-29 | Sod Conseils Rech Applic | NOVEL N- (IMINOMETHYL) AMINE DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US7115557B2 (en) | 1998-09-25 | 2006-10-03 | Sciaticon Ab | Use of certain drugs for treating nerve root injury |
SE9803710L (en) | 1998-09-25 | 2000-03-26 | A & Science Invest Ab | Use of certain substances for the treatment of nerve root damage |
JP2002527433A (en) | 1998-10-08 | 2002-08-27 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotics) |
FR2801053B1 (en) * | 1999-11-16 | 2004-06-25 | Sod Conseils Rech Applic | NOVEL AMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS |
SE9904676D0 (en) * | 1999-12-20 | 1999-12-20 | Astra Ab | Novel compounds |
SE9904677D0 (en) * | 1999-12-20 | 1999-12-20 | Astra Ab | Novel compounds |
KR20010068667A (en) * | 2000-01-07 | 2001-07-23 | 박선호 | Novel aliphatic amide having anticancer property |
EP1264820A4 (en) * | 2000-03-14 | 2004-09-15 | Fujisawa Pharmaceutical Co | Novel amide compounds |
EP1265891B1 (en) * | 2000-03-16 | 2004-12-29 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Novel lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines |
FR2812198B1 (en) | 2000-07-28 | 2008-07-18 | Sod Conseils Rech Applic | AMIDINE DERIVATIVES INHIBITORS OF PHOSPHATASES cdc25 |
US6344473B1 (en) | 2000-08-07 | 2002-02-05 | G.D. Searle & Co. | Imidazoles useful as nitric oxide synthase inhibitors |
US6770636B2 (en) * | 2000-08-18 | 2004-08-03 | Boehringer Ingelheim Pharma Kg | Phenyl-and phenylalkyl-substituted ethanolamines and ethylenediamines |
DZ3415A1 (en) | 2000-08-31 | 2002-03-07 | Chiron Corp | GUANIDINOBENZAMIDES AS MC4-R AGONISTS. |
AU2001282829A1 (en) * | 2000-09-05 | 2002-03-22 | Astrazeneca Ab | Amidine derivatives which are inhibitors of nitric oxide synthase |
UA75093C2 (en) | 2000-10-06 | 2006-03-15 | Dimensional Pharm Inc | Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors |
EP1767525A1 (en) * | 2001-04-09 | 2007-03-28 | Novartis Vaccines and Diagnostics, Inc. | Guanidino compounds as melanocortin-4 receptor (MC4-R) agonists |
US6514960B1 (en) | 2001-08-27 | 2003-02-04 | Hedonist Biochemical Technologies Co., Ltd. | Use of bismuth subgallate in inhibition of production of nitric oxide synthase |
DE10162114A1 (en) * | 2001-12-12 | 2003-06-26 | Schering Ag | New N-phenyl (hetero)aryl-carboximidamides are potent nitrogen monoxide synthase inhibitors, useful e.g. for treating neurodegenerative, cardiovascular, autoimmune and/or inflammatory diseases |
US20050124652A1 (en) * | 2002-02-04 | 2005-06-09 | Rustum Boyce | Guanidino compounds |
US20030207814A1 (en) * | 2002-02-04 | 2003-11-06 | Chiron Corporation | Novel guanidinyl derivatives |
US20030195187A1 (en) * | 2002-02-04 | 2003-10-16 | Chiron Corporation | Guanidino compounds |
US20030229025A1 (en) * | 2002-02-25 | 2003-12-11 | Chiron Corporation | Intranasal administration of MC4-R agonists |
US7858631B2 (en) * | 2002-05-23 | 2010-12-28 | Novartis Vaccines And Diagnostics, Inc. | Substituted pyrido [2,3-d] pyrimidinone compounds |
FR2842808B1 (en) * | 2002-07-25 | 2004-09-10 | Sod Conseils Rech Applic | NOVEL ARYLIMIDAZOLA DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATIONS |
CA2523015A1 (en) * | 2003-05-23 | 2004-12-29 | Chiron Corporation | Guanidino-substituted quinazolinone compounds as mc4-r agonists |
MXPA06005736A (en) * | 2003-11-19 | 2006-12-14 | Chiron Corp | Quinazolinone compounds with reduced bioaccumulation. |
US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
EP1848430B1 (en) | 2004-12-31 | 2017-08-02 | Dr. Reddy's Laboratories Ltd. | Novel benzylamine derivatives as cetp inhibitors |
US7914705B2 (en) * | 2005-01-10 | 2011-03-29 | Robert Eliot Sisson | Flowable electrical conductive liquid |
WO2013024358A2 (en) | 2011-08-18 | 2013-02-21 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors |
WO2013046045A1 (en) | 2011-09-27 | 2013-04-04 | Dr. Reddy's Laboratories, Ltd. | 5 - benzylaminomethyl - 6 - aminopyrazolo [3, 4 -b] pyridine derivatives as cholesteryl ester -transfer protein (cetp) inhibitors useful for the treatment of atherosclerosis |
RU2480452C1 (en) * | 2012-01-11 | 2013-04-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная химико-фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СПХФА Минздрава России) | Method of producing n-4-nitrophenylbenzamidine |
US8735606B2 (en) * | 2012-08-30 | 2014-05-27 | Northwestern University | Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors |
EP2740474A1 (en) | 2012-12-05 | 2014-06-11 | Instituto Europeo di Oncologia S.r.l. | Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a |
EP3277659A1 (en) | 2015-03-30 | 2018-02-07 | University of Innsbruck | Diphenethylamine derivatives which are inter alia useful as analgesics and methods for their production |
RU2684117C1 (en) * | 2018-10-29 | 2019-04-04 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Method for producing n-(naphthalene-2-yl)benzamidine |
RU2694263C1 (en) * | 2019-02-14 | 2019-07-11 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Analgesic and anti-inflammatory agent with antimicrobial activity |
EP4009972A4 (en) * | 2019-08-09 | 2023-03-08 | University of Utah Research Foundation | "trpswitch" - a step function chemo-optogenetic ligand |
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US3299081A (en) * | 1963-09-13 | 1967-01-17 | Merck & Co Inc | Chemical processes for preparing nu-substituted amidines |
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GB1188956A (en) * | 1967-07-14 | 1970-04-22 | Delalande Sa | N-Substituted Aromatic Amidines and process for obtaining same |
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-
1994
- 1994-08-12 CA CA002169280A patent/CA2169280A1/en not_active Abandoned
- 1994-08-12 AT AT94923776T patent/ATE231126T1/en not_active IP Right Cessation
- 1994-08-12 CZ CZ96299A patent/CZ29996A3/en unknown
- 1994-08-12 HU HU9600310A patent/HUT75876A/en unknown
- 1994-08-12 US US08/586,761 patent/US5807885A/en not_active Expired - Fee Related
- 1994-08-12 EP EP94923776A patent/EP0713483B1/en not_active Expired - Lifetime
- 1994-08-12 SK SK163-96A patent/SK16396A3/en unknown
- 1994-08-12 RU RU96104356A patent/RU2130017C1/en active
- 1994-08-12 JP JP7506814A patent/JPH09501918A/en not_active Ceased
- 1994-08-12 AU AU73875/94A patent/AU682381B2/en not_active Ceased
- 1994-08-12 DE DE69432019T patent/DE69432019T2/en not_active Expired - Fee Related
- 1994-08-12 PL PL94312961A patent/PL180081B1/en unknown
- 1994-08-12 WO PCT/GB1994/001767 patent/WO1995005363A1/en active IP Right Grant
- 1994-08-12 BR BR9407515A patent/BR9407515A/en not_active Application Discontinuation
- 1994-08-12 NZ NZ269571A patent/NZ269571A/en unknown
- 1994-08-12 IL IL11064394A patent/IL110643A/en not_active IP Right Cessation
-
1996
- 1996-02-09 NO NO960534A patent/NO306459B1/en not_active IP Right Cessation
- 1996-02-12 FI FI960628A patent/FI960628A/en unknown
-
1998
- 1998-07-08 US US09/111,926 patent/US6030985A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
BR9407515A (en) | 1997-01-07 |
NO960534L (en) | 1996-04-11 |
NO306459B1 (en) | 1999-11-08 |
RU2130017C1 (en) | 1999-05-10 |
IL110643A (en) | 1998-07-15 |
US6030985A (en) | 2000-02-29 |
PL180081B1 (en) | 2000-12-29 |
DE69432019D1 (en) | 2003-02-20 |
DE69432019T2 (en) | 2003-11-27 |
HUT75876A (en) | 1997-05-28 |
NZ269571A (en) | 1996-11-26 |
EP0713483A1 (en) | 1996-05-29 |
WO1995005363A1 (en) | 1995-02-23 |
CZ29996A3 (en) | 1996-09-11 |
IL110643A0 (en) | 1994-11-11 |
HU9600310D0 (en) | 1996-04-29 |
EP0713483B1 (en) | 2003-01-15 |
ATE231126T1 (en) | 2003-02-15 |
JPH09501918A (en) | 1997-02-25 |
PL312961A1 (en) | 1996-05-27 |
AU682381B2 (en) | 1997-10-02 |
NO960534D0 (en) | 1996-02-09 |
FI960628A (en) | 1996-02-12 |
AU7387594A (en) | 1995-03-14 |
CA2169280A1 (en) | 1995-02-23 |
SK16396A3 (en) | 1996-09-04 |
US5807885A (en) | 1998-09-15 |
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