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Application filed by Icos CorporationfiledCriticalIcos Corporation
Priority claimed from PCT/EP1997/002277external-prioritypatent/WO1997043287A1/en
Publication of MD980248ApublicationCriticalpatent/MD980248A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Carboline derivatives of formula (I):(1)are strong inhibitors of phosphodiesterase specific to the cycloguanosine-3',5'-monophosphate and are used in different therapeutic fields where this inhibition is beneficial, including the treatment of cardiovascular affections.
2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives and pharmaceuticals thereof, useful for inhibiting leukocyte function and treating inflammatory conditions