FI943570A0 - 1-Benzenesulfonyl-1,3-dihydroindole-2-undivate, their preparation and drugs containing them - Google Patents
1-Benzenesulfonyl-1,3-dihydroindole-2-undivate, their preparation and drugs containing themInfo
- Publication number
- FI943570A0 FI943570A0 FI943570A FI943570A FI943570A0 FI 943570 A0 FI943570 A0 FI 943570A0 FI 943570 A FI943570 A FI 943570A FI 943570 A FI943570 A FI 943570A FI 943570 A0 FI943570 A0 FI 943570A0
- Authority
- FI
- Finland
- Prior art keywords
- undivate
- dihydroindole
- benzenesulfonyl
- preparation
- drugs containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
- C07D209/92—Naphthostyrils
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9309404A FR2708605A1 (en) | 1993-07-30 | 1993-07-30 | N-sulfonylindol-2-one derivatives, their preparation, pharmaceutical compositions containing them. |
Publications (2)
Publication Number | Publication Date |
---|---|
FI943570A0 true FI943570A0 (en) | 1994-07-29 |
FI943570A FI943570A (en) | 1995-01-31 |
Family
ID=9449794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI943570A FI943570A (en) | 1993-07-30 | 1994-07-29 | 1-Benzenesulfonyl-1,3-dihydroindole-2-undivate, their preparation and drugs containing them |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0636608A1 (en) |
JP (1) | JPH07247269A (en) |
KR (1) | KR950003271A (en) |
CN (1) | CN1107467A (en) |
CA (1) | CA2129215A1 (en) |
FI (1) | FI943570A (en) |
FR (1) | FR2708605A1 (en) |
HU (1) | HUT70408A (en) |
IL (1) | IL110482A (en) |
NO (1) | NO301824B1 (en) |
NZ (1) | NZ264122A (en) |
RU (1) | RU2141476C1 (en) |
TW (1) | TW375609B (en) |
ZA (1) | ZA945656B (en) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2740136B1 (en) * | 1995-10-24 | 1998-01-09 | Sanofi Sa | INDOLIN-2-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US5756497A (en) * | 1996-03-01 | 1998-05-26 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
US5880137A (en) * | 1996-04-19 | 1999-03-09 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
TW397821B (en) * | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
FR2757157B1 (en) * | 1996-12-13 | 1999-12-31 | Sanofi Sa | INDOLIN-2-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US6291449B1 (en) | 1998-09-23 | 2001-09-18 | Children's Medical Center Corporation | Use of 11-phenyl-dibenzazepine compounds to treat diarrhea or scours |
BR9815617A (en) | 1997-11-20 | 2001-10-16 | Harvard College | Substituted 11-phenyl-dibenzazepine compounds, pharmaceutical composition based on said compounds, and methods for inhibiting the proliferation of mammalian cells and for treating or preventing a disorder caused by abnormal cell proliferation |
WO1999026611A1 (en) * | 1997-11-20 | 1999-06-03 | President And Fellows Of Harvard College | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation |
US6992079B2 (en) | 1997-11-20 | 2006-01-31 | President Fellows of Harvard College | Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation |
US6800658B2 (en) | 1997-11-20 | 2004-10-05 | Children's Medical Center Corporation | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation |
EP1050308A4 (en) | 1998-01-28 | 2002-09-04 | Senju Pharma Co | Preventives or remedies for vision disorders |
US6069153A (en) * | 1998-05-12 | 2000-05-30 | American Home Products Corporation | Indenoindoles and benzocarbazoles as estrogenic agents |
US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
WO1999065525A1 (en) * | 1998-06-19 | 1999-12-23 | Wakamoto Pharmaceutical Co., Ltd. | Ocular tension lowering agents and phosphoric ester derivatives |
US6159959A (en) | 1999-05-06 | 2000-12-12 | American Home Products Corporation | Combined estrogen and antiestrogen therapy |
US6673790B1 (en) | 2000-04-03 | 2004-01-06 | Sanofi-Synthelabo | Indolin-2-one derivatives, preparation and their use as ocytocin receptor ligands |
FR2807038B1 (en) * | 2000-04-03 | 2002-08-16 | Sanofi Synthelabo | NOVEL INDOLIN-2-ONE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
MXPA03000135A (en) * | 2000-07-05 | 2005-02-17 | Johnson & Johnson | Nonpeptide substituted spirobenzoazepines as vasopressin antagonists. |
WO2002070478A1 (en) | 2001-03-06 | 2002-09-12 | Astrazeneca Ab | Indolone derivatives having vascular-damaging activity |
DE10222034A1 (en) * | 2002-05-17 | 2003-11-27 | Bayer Ag | New 2-benzenesulfonyl-3,4-dihydro-2(1H)-isoquinoline derivatives, are PPAR-delta activators useful e.g. for treating coronary heart disease, dyslipidemia or restenosis |
DE10229777A1 (en) * | 2002-07-03 | 2004-01-29 | Bayer Ag | Indoline-phenylsulfonamide derivatives |
DE10300099A1 (en) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Indole-phenylsulfonamide derivatives |
AU2004281257C1 (en) | 2003-06-17 | 2010-07-01 | Janssen Pharmaceutica N.V. | Substituted spirobenzazepines |
DE10335449A1 (en) * | 2003-08-02 | 2005-02-17 | Bayer Healthcare Ag | New 2-((indoline-1-sulfonyl)-tetralinyl or indanyl)-alkanoic acid derivatives, are PPAR-delta activators useful e.g. for treating or preventing stroke, arteriosclerosis, coronary heart disease or dyslipidemia |
US7414052B2 (en) | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US7517899B2 (en) | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US7514466B2 (en) | 2004-04-27 | 2009-04-07 | Wyeth | Purification of progesterone receptor modulators |
FR2875499B1 (en) * | 2004-09-20 | 2006-10-27 | Sanofi Aventis Sa | NOVEL INDOLIN-2-ONE PYRIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF |
BRPI0519013A2 (en) | 2004-12-13 | 2009-11-03 | Lilly Co Eli | single compound or stereoisomers, mixtures of pharmaceutically acceptable stereoisomers, salts, tautomers or prodrugs thereof, pharmaceutical composition, and use of a compound |
US20120115842A1 (en) * | 2004-12-31 | 2012-05-10 | Wilfried Lubisch | Substituted Oxindole Derivatives, Medicaments Containing Said Derivatives and Use Thereof |
DE102005014936A1 (en) * | 2005-03-24 | 2006-12-14 | Abbott Gmbh & Co. Kg | New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders |
MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
MY145694A (en) | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
TWI315304B (en) * | 2006-08-31 | 2009-10-01 | Univ Taipei Medical | Indoline-sulfonamides compounds |
PT2078022E (en) * | 2006-09-22 | 2012-01-11 | Janssen Pharmaceutica Nv | Spiro benzazepines used as vasopressin antagonists |
US7825111B2 (en) | 2006-09-22 | 2010-11-02 | Janssen Pharmaceutica Nv | Substituted spiroheterocycles |
CL2007002950A1 (en) | 2006-10-12 | 2008-02-01 | Xenon Pharmaceuticals Inc | USE OF COMPOUNDS DERIVED FROM ESPIRO-OXINDOL IN THE TREATMENT OF HYPERCHOLESTEROLEMIA, BENIGNA HYPERPLASIA DE PROSTATA, PRURITIS, CANCER |
FR2930249B1 (en) * | 2008-04-21 | 2010-05-14 | Sanofi Aventis | NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF |
EP2280001B1 (en) * | 2008-04-24 | 2014-10-15 | Msd K.K. | Long-chain fatty acid elongation enzyme inhibitor comprising arylsulfonyl derivative as active ingredient |
RU2011119626A (en) | 2008-10-17 | 2012-11-27 | Ксенон Фармасьютикалз Инк. | SPIROOXINDOL COMPOUNDS AND THEIR APPLICATION AS A THERAPEUTIC |
WO2010045197A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals, Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
EP2246326A1 (en) | 2009-05-02 | 2010-11-03 | Bayer CropScience AG | Method for producing oxindoles and ortho-substituted anilines and their use as intermediate products for syntheses |
AR077252A1 (en) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | ESPIROOXINDOL COMPOUND ENANTIOMERS AND THEIR USES AS THERAPEUTIC AGENTS |
RU2015103694A (en) | 2009-10-14 | 2015-06-27 | Ксенон Фармасьютикалз Инк. | METHODS FOR SYNTHESIS OF SPIRO-OXINDOL COMPOUNDS |
CN102946859B (en) | 2010-02-26 | 2016-03-02 | 泽农医药公司 | For the pharmaceutical composition of the spiral shell-oxindole compounds of topical and the purposes as therapeutic agent thereof |
TWI499583B (en) * | 2010-05-10 | 2015-09-11 | Bayer Ip Gmbh | Process for preparing substituted 1,3-dihydro-2h-indol-2-ones |
WO2012028162A1 (en) | 2010-09-01 | 2012-03-08 | Bayer Cropscience Ag | Process for preparing oxindoles and ortho-substituted anilines and the use thereof as intermediates for syntheses |
TW201636017A (en) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
CN114213396B (en) * | 2022-01-27 | 2023-03-24 | 深圳市乐土生物医药有限公司 | Indole-2-ketone compound and preparation method and application thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4803217A (en) * | 1986-12-24 | 1989-02-07 | Merck & Co., Inc. | Hapalindolinone compounds as vassopressin antagonists |
CA2037287A1 (en) * | 1990-03-02 | 1991-09-03 | Ben E. Evans | Spirocyclic oxytocin antagonists |
FR2686878B1 (en) * | 1992-01-30 | 1995-06-30 | Sanofi Elf | DERIVATIVES OF N-SULFONYL OXO-2 INDOLE, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME. |
-
1993
- 1993-07-30 FR FR9309404A patent/FR2708605A1/en active Pending
-
1994
- 1994-07-28 EP EP94401737A patent/EP0636608A1/en not_active Withdrawn
- 1994-07-28 NZ NZ264122A patent/NZ264122A/en unknown
- 1994-07-28 IL IL11048294A patent/IL110482A/en not_active IP Right Cessation
- 1994-07-29 HU HU9402232A patent/HUT70408A/en unknown
- 1994-07-29 RU RU94027576A patent/RU2141476C1/en active
- 1994-07-29 CA CA002129215A patent/CA2129215A1/en not_active Abandoned
- 1994-07-29 NO NO942834A patent/NO301824B1/en not_active IP Right Cessation
- 1994-07-29 FI FI943570A patent/FI943570A/en unknown
- 1994-07-29 ZA ZA945656A patent/ZA945656B/en unknown
- 1994-07-29 TW TW083107081A patent/TW375609B/en active
- 1994-07-30 KR KR1019940018912A patent/KR950003271A/en not_active Application Discontinuation
- 1994-07-30 CN CN94114900A patent/CN1107467A/en active Pending
- 1994-08-01 JP JP6199069A patent/JPH07247269A/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
NO942834L (en) | 1995-01-31 |
TW375609B (en) | 1999-12-01 |
AU684791B2 (en) | 1998-01-08 |
NZ264122A (en) | 1996-07-26 |
EP0636608A1 (en) | 1995-02-01 |
NO301824B1 (en) | 1997-12-15 |
IL110482A0 (en) | 1994-10-21 |
CN1107467A (en) | 1995-08-30 |
KR950003271A (en) | 1995-02-16 |
FR2708605A1 (en) | 1995-02-10 |
AU6878994A (en) | 1995-02-09 |
CA2129215A1 (en) | 1995-01-31 |
NO942834D0 (en) | 1994-07-29 |
RU2141476C1 (en) | 1999-11-20 |
ZA945656B (en) | 1995-03-09 |
JPH07247269A (en) | 1995-09-26 |
FI943570A (en) | 1995-01-31 |
HU9402232D0 (en) | 1994-09-28 |
HUT70408A (en) | 1995-10-30 |
IL110482A (en) | 1999-04-11 |
RU94027576A (en) | 1996-05-27 |
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