FI943100A - Ansamycin derivatives as anthionogenic and anti-cancer agents - Google Patents

Ansamycin derivatives as anthionogenic and anti-cancer agents Download PDF

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Publication number
FI943100A
FI943100A FI943100A FI943100A FI943100A FI 943100 A FI943100 A FI 943100A FI 943100 A FI943100 A FI 943100A FI 943100 A FI943100 A FI 943100A FI 943100 A FI943100 A FI 943100A
Authority
FI
Finland
Prior art keywords
anthionogenic
cancer agents
ansamycin derivatives
ansamycin
derivatives
Prior art date
Application number
FI943100A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI943100A0 (en
Inventor
Randall James Gallaschun
Mikel Paul Moyer
Rodney Caughren Schnur
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI943100A0 publication Critical patent/FI943100A0/en
Publication of FI943100A publication Critical patent/FI943100A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D225/00Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
FI943100A 1993-06-29 1994-06-28 Ansamycin derivatives as anthionogenic and anti-cancer agents FI943100A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8506593A 1993-06-29 1993-06-29

Publications (2)

Publication Number Publication Date
FI943100A0 FI943100A0 (en) 1994-06-28
FI943100A true FI943100A (en) 1994-12-30

Family

ID=22189242

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943100A FI943100A (en) 1993-06-29 1994-06-28 Ansamycin derivatives as anthionogenic and anti-cancer agents

Country Status (5)

Country Link
EP (1) EP0706516A1 (en)
JP (1) JP2794342B2 (en)
CA (1) CA2166320A1 (en)
FI (1) FI943100A (en)
WO (1) WO1995001342A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU764603B2 (en) 1998-07-17 2003-08-21 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Water-soluble drugs and methods for their production
WO2000061578A1 (en) * 1999-04-09 2000-10-19 Sloan-Kettering Institute For Cancer Research Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases
WO2002036574A1 (en) * 2000-11-06 2002-05-10 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Geldanamycin derivatives useful for the treatment of cancer
SI21369A (en) * 2001-03-30 2004-06-30 The United States Of America, Represented By The Secretary, Geldanamycin derivative and method of treating cancer using same
WO2003013430A2 (en) * 2001-08-06 2003-02-20 Kosan Biosciences, Inc. Benzoquinone ansamycins
EP1923061A1 (en) 2001-09-24 2008-05-21 Conforma Therapeutic Corporation Process for preparing 17-Allyl amino geldanamycin (17-AAG) and other ansamycins
CN100378079C (en) * 2001-09-24 2008-04-02 康福玛医药公司 Process for preparing 17-allyl amino geldanamycin (17-AAG) and other ansamycins
AU2003217393B8 (en) 2002-02-08 2009-06-25 Conforma Therapeutics Corporation Ansamycins having improved pharmacological and biological properties
JP2006514994A (en) * 2003-03-13 2006-05-18 コンフォーマ・セラピューティクス・コーポレイション Pharmaceutical formulations with long and medium chain triglycerides
US6875863B1 (en) 2003-11-12 2005-04-05 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6870049B1 (en) 2003-11-12 2005-03-22 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6855705B1 (en) 2003-11-12 2005-02-15 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6887993B1 (en) 2003-11-12 2005-05-03 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US20060019941A1 (en) * 2003-12-23 2006-01-26 Infinity Pharmaceuticals, Inc. Analogs of benzoquinone-containing ansamycins and methods of use thereof
ES2409351T3 (en) 2003-12-23 2013-06-26 Infinity Discovery, Inc. Ansamycin analogs containing benzoquinone for cancer treatment
PE20081506A1 (en) * 2006-12-12 2008-12-09 Infinity Discovery Inc ANSAMYCIN FORMULATIONS
KR20110090925A (en) 2008-10-15 2011-08-10 인피니티 파마슈티컬스, 인코포레이티드 Ansamycin hydroquinone compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595955A (en) * 1969-03-26 1971-07-27 Upjohn Co Geldanamycin and process for producing same
US3987035A (en) * 1974-04-05 1976-10-19 University Of Illinois Foundation Biologically active compounds
US4261989A (en) * 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
JPH06510913A (en) * 1992-01-06 1994-12-08 フアイザー・インコーポレイテツド Production and use of 4,5-dihydrogeldanamycin and its hydroquinone

Also Published As

Publication number Publication date
EP0706516A1 (en) 1996-04-17
CA2166320A1 (en) 1995-01-12
FI943100A0 (en) 1994-06-28
JP2794342B2 (en) 1998-09-03
JPH08506356A (en) 1996-07-09
WO1995001342A1 (en) 1995-01-12

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