FI93830B - Nitrogen-containing cyclic ligands, processes for their preparation and their use for the preparation of metal complexes and diagnostic compositions containing these complexes - Google Patents

Nitrogen-containing cyclic ligands, processes for their preparation and their use for the preparation of metal complexes and diagnostic compositions containing these complexes

Info

Publication number
FI93830B
FI93830B FI881708A FI881708A FI93830B FI 93830 B FI93830 B FI 93830B FI 881708 A FI881708 A FI 881708A FI 881708 A FI881708 A FI 881708A FI 93830 B FI93830 B FI 93830B
Authority
FI
Finland
Prior art keywords
preparation
complexes
nitrogen
processes
diagnostic compositions
Prior art date
Application number
FI881708A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI881708A (en
FI93830C (en
FI881708A0 (en
Inventor
Michel Schaefer
Didier Doucet
Bruno Bonnemain
Dominique Meyer
Original Assignee
Guerbet Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet Sa filed Critical Guerbet Sa
Publication of FI881708A0 publication Critical patent/FI881708A0/en
Publication of FI881708A publication Critical patent/FI881708A/en
Publication of FI93830B publication Critical patent/FI93830B/en
Application granted granted Critical
Publication of FI93830C publication Critical patent/FI93830C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Abstract

Ligands and complexes of the title and the applications of these complexes in magnetic resonance imaging, in X-ray radiology and as in-vivo chemical shift agents.
FI881708A 1987-04-14 1988-04-13 Nitrogen-containing cyclic ligands, processes for their preparation and their use for the preparation of metal complexes and diagnostic compositions containing these complexes FI93830C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8705288 1987-04-14
FR8705288A FR2614020B1 (en) 1987-04-14 1987-04-14 NOVEL NITROGEN CYCLIC LIGANDS, METAL COMPLEXES FORMED BY SUCH LIGANDS, DIAGNOSTIC COMPOSITIONS CONTAINING THESE COMPLEXES AND PROCESS FOR PREPARING LIGANDS.

Publications (4)

Publication Number Publication Date
FI881708A0 FI881708A0 (en) 1988-04-13
FI881708A FI881708A (en) 1988-10-15
FI93830B true FI93830B (en) 1995-02-28
FI93830C FI93830C (en) 1995-06-12

Family

ID=9350106

Family Applications (1)

Application Number Title Priority Date Filing Date
FI881708A FI93830C (en) 1987-04-14 1988-04-13 Nitrogen-containing cyclic ligands, processes for their preparation and their use for the preparation of metal complexes and diagnostic compositions containing these complexes

Country Status (22)

Country Link
EP (1) EP0287465B1 (en)
JP (1) JP2675058B2 (en)
KR (1) KR880012572A (en)
CN (1) CN1022411C (en)
AT (1) ATE85052T1 (en)
AU (1) AU606146B2 (en)
DD (1) DD293113A5 (en)
DE (1) DE3877799T2 (en)
DK (1) DK170946B1 (en)
ES (1) ES2053779T3 (en)
FI (1) FI93830C (en)
FR (1) FR2614020B1 (en)
GR (1) GR3007495T3 (en)
HR (1) HRP920514A2 (en)
HU (1) HU198501B (en)
IE (1) IE62582B1 (en)
IL (1) IL86059A (en)
NO (1) NO176839C (en)
PT (1) PT87216B (en)
SI (1) SI8810742A (en)
YU (1) YU46691B (en)
ZA (1) ZA882552B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US5362476A (en) * 1984-10-18 1994-11-08 Board Of Regents, The University Of Texas System Alkyl phosphonate polyazamacrocyclic cheates for MRI
US5316757A (en) * 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
FR2637895B1 (en) * 1988-10-14 1992-11-06 Guerbet Sa NOVEL NITROGEN CYCLIC LIGANDS, METAL COMPLEXES FORMED BY THESE LIGANDS, DIAGNOSTIC COMPOSITIONS CONTAINING THESE COMPLEXES AND PROCESS FOR THE PREPARATION OF LIGANDS
AU617338B2 (en) * 1987-07-16 1991-11-28 Nycomed As Aminopolycarboxylic acids and derivatives thereof
EP0466200B1 (en) * 1987-07-16 1996-04-24 Nycomed Imaging As Aminocarboxylic acids and derivatives thereof
US5531978A (en) * 1987-07-16 1996-07-02 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
AU620841B2 (en) * 1987-12-24 1992-02-27 Bracco International B.V. Macrocyclic chelating agents and chelates thereof
GB8801646D0 (en) * 1988-01-26 1988-02-24 Nycomed As Chemical compounds
GB8923843D0 (en) * 1989-10-23 1989-12-13 Salutar Inc Compounds
US5446145A (en) * 1990-01-19 1995-08-29 Nycomed Salutar, Inc. Polychelant compounds
DE69032374T2 (en) * 1989-10-23 1998-12-17 Nycomed Salutar Inc MULTI-TEED METAL CHELATING COMPOUNDS
US5021409A (en) * 1989-12-21 1991-06-04 Johnson Matthey Plc Antiviral cyclic polyamines
AU625529B2 (en) * 1989-12-22 1992-07-16 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes
NZ236267A (en) * 1989-12-22 1992-12-23 Squibb & Sons Inc 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane
US5679810A (en) * 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
WO1992017215A1 (en) 1990-03-28 1992-10-15 Nycomed Salutar, Inc. Contrast media
GB9024208D0 (en) * 1990-11-07 1990-12-19 Salutar Inc Compounds
DE4035760A1 (en) * 1990-11-08 1992-05-14 Schering Ag MONO-N-SUBSTITUTED 1,4,7,10-TETRAAZACYCLODODECAN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
CA2072934C (en) * 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
KR0145953B1 (en) * 1991-07-19 1998-08-17 제임스 클리프튼 보올딩 Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
WO1994004485A1 (en) * 1992-08-19 1994-03-03 Mallinckrodt Medical, Inc. LIGANDS FOR Ga-68 PET HEART APPLICATIONS
US6204259B1 (en) 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
ATE232220T1 (en) * 1993-11-26 2003-02-15 Dow Global Technologies Inc METHOD FOR PRODUCING POLYAZAMACROCYLENE
HUT76318A (en) * 1994-04-22 1997-08-28 Searle & Co Diagnostic image analysis with metal complexes
WO1997006830A1 (en) 1995-08-17 1997-02-27 Monsanto Company Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
CA2229777A1 (en) * 1995-08-17 1997-02-27 Monsanto Company Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands
CA2371728C (en) 1999-06-11 2009-06-02 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
FR2830253B1 (en) * 2001-09-28 2005-02-04 Air Liquide NOVEL PROCESS FOR THE PREPARATION OF C-FUNCTIONALIZED NITROGEN MACROCYCLES AND NOVEL INTERMEDIATES OBTAINED
FR2968999B1 (en) 2010-12-20 2013-01-04 Guerbet Sa CHELATE NANOEMULSION FOR MRI
US10633404B2 (en) 2015-03-10 2020-04-28 Emory University Metal tricarbonyl complexes comprising substituted iminodiactic acid ligands and uses as radioisotope tracers
WO2017011517A1 (en) 2015-07-16 2017-01-19 Emory University Bis-amines, compositions, and uses related to cxcr4 inhibition
CN106588925B (en) * 2016-12-05 2018-03-30 天津羲泽润科技有限公司 It is a kind of to prepare the luxuriant method of the pyridine ring of 1,4,7,10 4 azepine 2,6

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO149961C (en) * 1981-06-01 1984-07-25 Borregaard Ind PROCEDURE FOR THE PREPARATION OF N- (2-HYDROXYethyl) DERIVATIVES OF MACROCYCLIC POLYAMINES, CONTAINING MULTIPLE 1.4 NITROGEN ATOMS IN THE RING
NL194579C (en) * 1983-01-21 2002-08-05 Schering Ag Diagnostic.
DE3316703A1 (en) * 1983-05-04 1984-11-08 Schering AG, 1000 Berlin und 4709 Bergkamen ORAL CONTRAST AGENT FOR MRI MRI AND THE PRODUCTION THEREOF
JPS60202869A (en) * 1984-03-26 1985-10-14 Ajinomoto Co Inc Macrocyclic polyamine derivative and its use
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
DE3772785D1 (en) * 1986-01-23 1991-10-17 Squibb & Sons Inc 1-SUBSTITUTED-4,7,10-TRISCARBOXYMETHYL-1,4,7,10-TETRAAZACYCLODODECAN AND ANALOG.
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound
DE3625417C2 (en) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecane derivatives
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
GB8719041D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds

Also Published As

Publication number Publication date
EP0287465A1 (en) 1988-10-19
FR2614020B1 (en) 1989-07-28
HUT47075A (en) 1989-01-30
CN88102139A (en) 1988-10-26
IE62582B1 (en) 1995-02-08
IE881114L (en) 1988-10-14
DK202788D0 (en) 1988-04-13
JP2675058B2 (en) 1997-11-12
DD293113A5 (en) 1991-08-22
NO881567D0 (en) 1988-04-12
IL86059A0 (en) 1988-09-30
NO176839B (en) 1995-02-27
NO881567L (en) 1988-10-17
AU1461188A (en) 1988-10-20
HU198501B (en) 1989-10-30
FI881708A (en) 1988-10-15
IL86059A (en) 1993-01-14
FI93830C (en) 1995-06-12
GR3007495T3 (en) 1993-07-30
FI881708A0 (en) 1988-04-13
SI8810742A (en) 1996-08-31
YU46691B (en) 1994-04-05
DE3877799D1 (en) 1993-03-11
DK202788A (en) 1988-10-15
PT87216A (en) 1988-05-01
DE3877799T2 (en) 1993-07-22
AU606146B2 (en) 1991-01-31
EP0287465B1 (en) 1993-01-27
KR880012572A (en) 1988-11-28
NO176839C (en) 1995-06-14
FR2614020A1 (en) 1988-10-21
ES2053779T3 (en) 1994-08-01
ZA882552B (en) 1988-09-27
PT87216B (en) 1992-07-31
CN1022411C (en) 1993-10-13
YU74288A (en) 1990-04-30
HRP920514A2 (en) 1994-04-30
JPH01211573A (en) 1989-08-24
DK170946B1 (en) 1996-03-25
ATE85052T1 (en) 1993-02-15

Similar Documents

Publication Publication Date Title
FI93830B (en) Nitrogen-containing cyclic ligands, processes for their preparation and their use for the preparation of metal complexes and diagnostic compositions containing these complexes
DE69019584T2 (en) Macrocyclic nitrogen ligands, process for their preparation, their metal complexes, diagnostic and therapeutic agents containing them.
ES2087938T3 (en) USE OF CHELATED COMPLEXES.
NO923739D0 (en) CONTRAST MEDIA
FI102892B (en) Chelating agents for the complexation of radioactive isotopes, their metal complexes and their use in diagnostics
GB8919488D0 (en) New cores for technetium radiopharmaceuticals
DE68922686T2 (en) Cyclic, nitrogen-containing ligands, their metal complexes, diagnostic agents containing them and methods for producing the ligands.
ES2021944A6 (en) New derivatives of 1,3,5-triamino-2,4,6-triiodobenzene and method for the preparation thereof

Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: GUERBET S.A.