DK202788A - NITROGEN CONTAINING CYCLIC LIGANDS, METAL COMPLEXS CREATED BY THESE LIGANDS, DIAGNOSTIC PREPARATIONS CONTAINING THESE COMPLEXES AND PROCEDURES FOR THE PREPARATION OF THE LIGANDS - Google Patents
NITROGEN CONTAINING CYCLIC LIGANDS, METAL COMPLEXS CREATED BY THESE LIGANDS, DIAGNOSTIC PREPARATIONS CONTAINING THESE COMPLEXES AND PROCEDURES FOR THE PREPARATION OF THE LIGANDSInfo
- Publication number
- DK202788A DK202788A DK202788A DK202788A DK202788A DK 202788 A DK202788 A DK 202788A DK 202788 A DK202788 A DK 202788A DK 202788 A DK202788 A DK 202788A DK 202788 A DK202788 A DK 202788A
- Authority
- DK
- Denmark
- Prior art keywords
- ligands
- complexes
- procedures
- created
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Paints Or Removers (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
Ligands and complexes of the title and the applications of these complexes in magnetic resonance imaging, in X-ray radiology and as in-vivo chemical shift agents.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8705288A FR2614020B1 (en) | 1987-04-14 | 1987-04-14 | NOVEL NITROGEN CYCLIC LIGANDS, METAL COMPLEXES FORMED BY SUCH LIGANDS, DIAGNOSTIC COMPOSITIONS CONTAINING THESE COMPLEXES AND PROCESS FOR PREPARING LIGANDS. |
FR8705288 | 1987-04-14 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK202788D0 DK202788D0 (en) | 1988-04-13 |
DK202788A true DK202788A (en) | 1988-10-15 |
DK170946B1 DK170946B1 (en) | 1996-03-25 |
Family
ID=9350106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK202788A DK170946B1 (en) | 1987-04-14 | 1988-04-13 | Nitrogen-containing cyclic ligands, metal complexes formed by these ligands, diagnostic compositions containing these complexes, and methods for preparing the ligands |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0287465B1 (en) |
JP (1) | JP2675058B2 (en) |
KR (1) | KR880012572A (en) |
CN (1) | CN1022411C (en) |
AT (1) | ATE85052T1 (en) |
AU (1) | AU606146B2 (en) |
DD (1) | DD293113A5 (en) |
DE (1) | DE3877799T2 (en) |
DK (1) | DK170946B1 (en) |
ES (1) | ES2053779T3 (en) |
FI (1) | FI93830C (en) |
FR (1) | FR2614020B1 (en) |
GR (1) | GR3007495T3 (en) |
HR (1) | HRP920514A2 (en) |
HU (1) | HU198501B (en) |
IE (1) | IE62582B1 (en) |
IL (1) | IL86059A (en) |
NO (1) | NO176839C (en) |
PT (1) | PT87216B (en) |
SI (1) | SI8810742A (en) |
YU (1) | YU46691B (en) |
ZA (1) | ZA882552B (en) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5064633A (en) * | 1984-06-04 | 1991-11-12 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes, their formulations and use |
US5059412A (en) * | 1984-06-04 | 1991-10-22 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors |
US5362476A (en) * | 1984-10-18 | 1994-11-08 | Board Of Regents, The University Of Texas System | Alkyl phosphonate polyazamacrocyclic cheates for MRI |
US5316757A (en) * | 1984-10-18 | 1994-05-31 | Board Of Regents, The University Of Texas System | Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups |
FR2637895B1 (en) * | 1988-10-14 | 1992-11-06 | Guerbet Sa | NOVEL NITROGEN CYCLIC LIGANDS, METAL COMPLEXES FORMED BY THESE LIGANDS, DIAGNOSTIC COMPOSITIONS CONTAINING THESE COMPLEXES AND PROCESS FOR THE PREPARATION OF LIGANDS |
AU617338B2 (en) * | 1987-07-16 | 1991-11-28 | Nycomed As | Aminopolycarboxylic acids and derivatives thereof |
US5531978A (en) * | 1987-07-16 | 1996-07-02 | Nycomed Imaging As | Aminopolycarboxylic acids and derivatives thereof |
US5198208A (en) * | 1987-07-16 | 1993-03-30 | Nycomed Imaging As | Aminopolycarboxylic acids and derivatives thereof |
GB8719042D0 (en) | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
AU620841B2 (en) * | 1987-12-24 | 1992-02-27 | Bracco International B.V. | Macrocyclic chelating agents and chelates thereof |
GB8801646D0 (en) * | 1988-01-26 | 1988-02-24 | Nycomed As | Chemical compounds |
ES2116291T3 (en) * | 1989-10-23 | 1998-07-16 | Nycomed Salutar Inc | CHELATING AGENTS OF METALS IN MULTIPLE SITES. |
US5446145A (en) * | 1990-01-19 | 1995-08-29 | Nycomed Salutar, Inc. | Polychelant compounds |
GB8923843D0 (en) * | 1989-10-23 | 1989-12-13 | Salutar Inc | Compounds |
US5021409A (en) * | 1989-12-21 | 1991-06-04 | Johnson Matthey Plc | Antiviral cyclic polyamines |
NZ236267A (en) * | 1989-12-22 | 1992-12-23 | Squibb & Sons Inc | 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane |
AU625529B2 (en) * | 1989-12-22 | 1992-07-16 | E.R. Squibb & Sons, Inc. | 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes |
US5679810A (en) * | 1990-01-19 | 1997-10-21 | Salutar, Inc. | Linear oligomeric polychelant compounds |
WO1992017215A1 (en) | 1990-03-28 | 1992-10-15 | Nycomed Salutar, Inc. | Contrast media |
GB9024208D0 (en) * | 1990-11-07 | 1990-12-19 | Salutar Inc | Compounds |
DE4035760A1 (en) * | 1990-11-08 | 1992-05-14 | Schering Ag | MONO-N-SUBSTITUTED 1,4,7,10-TETRAAZACYCLODODECAN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM |
CA2072934C (en) * | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
KR0145953B1 (en) * | 1991-07-19 | 1998-08-17 | 제임스 클리프튼 보올딩 | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
AU5019193A (en) * | 1992-08-19 | 1994-03-15 | Mallinckrodt Medical, Inc. | Ligands for ga-68 pet heart applications |
US6204259B1 (en) | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
DE69432105T2 (en) * | 1993-11-26 | 2003-10-09 | Dow Global Technologies, Inc. | METHOD FOR PRODUCING POLYAZAMACROCYLENE |
WO1995028968A1 (en) * | 1994-04-22 | 1995-11-02 | Monsanto Company | Diagnostic image analysis with metal complexes |
EP0844889A1 (en) * | 1995-08-17 | 1998-06-03 | Monsanto Company | Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands |
EP0846003A1 (en) | 1995-08-17 | 1998-06-10 | Monsanto Company | Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands |
EP1191948A2 (en) | 1999-06-11 | 2002-04-03 | Neorx Corporation | High dose radionuclide complexes for bone marrow suppression |
US7094885B2 (en) | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
FR2830253B1 (en) * | 2001-09-28 | 2005-02-04 | Air Liquide | NOVEL PROCESS FOR THE PREPARATION OF C-FUNCTIONALIZED NITROGEN MACROCYCLES AND NOVEL INTERMEDIATES OBTAINED |
FR2968999B1 (en) | 2010-12-20 | 2013-01-04 | Guerbet Sa | CHELATE NANOEMULSION FOR MRI |
WO2016145156A1 (en) | 2015-03-10 | 2016-09-15 | Emory University | Metal tricarbonyl complexes comprising substituted iminodiactic acid ligands and uses as radioisotope tracers |
US10709697B2 (en) | 2015-07-16 | 2020-07-14 | Emory University | Bis-amines, compositions, and uses related to CXCR4 inhibition |
CN106588925B (en) * | 2016-12-05 | 2018-03-30 | 天津羲泽润科技有限公司 | It is a kind of to prepare the luxuriant method of the pyridine ring of 1,4,7,10 4 azepine 2,6 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO149961C (en) * | 1981-06-01 | 1984-07-25 | Borregaard Ind | PROCEDURE FOR THE PREPARATION OF N- (2-HYDROXYethyl) DERIVATIVES OF MACROCYCLIC POLYAMINES, CONTAINING MULTIPLE 1.4 NITROGEN ATOMS IN THE RING |
NL194579C (en) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostic. |
DE3316703A1 (en) * | 1983-05-04 | 1984-11-08 | Schering AG, 1000 Berlin und 4709 Bergkamen | ORAL CONTRAST AGENT FOR MRI MRI AND THE PRODUCTION THEREOF |
JPS60202869A (en) * | 1984-03-26 | 1985-10-14 | Ajinomoto Co Inc | Macrocyclic polyamine derivative and its use |
US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
DE3772785D1 (en) * | 1986-01-23 | 1991-10-17 | Squibb & Sons Inc | 1-SUBSTITUTED-4,7,10-TRISCARBOXYMETHYL-1,4,7,10-TETRAAZACYCLODODECAN AND ANALOG. |
GB8603537D0 (en) * | 1986-02-13 | 1986-03-19 | Parker D | Conjugate compound |
DE3625417C2 (en) * | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecane derivatives |
GB8719042D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
GB8719041D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
-
1987
- 1987-04-14 FR FR8705288A patent/FR2614020B1/en not_active Expired
-
1988
- 1988-04-12 DD DD88314659A patent/DD293113A5/en not_active IP Right Cessation
- 1988-04-12 PT PT87216A patent/PT87216B/en not_active IP Right Cessation
- 1988-04-12 NO NO881567A patent/NO176839C/en unknown
- 1988-04-12 ZA ZA882552A patent/ZA882552B/en unknown
- 1988-04-13 DK DK202788A patent/DK170946B1/en not_active IP Right Cessation
- 1988-04-13 HU HU881897A patent/HU198501B/en not_active IP Right Cessation
- 1988-04-13 IE IE111488A patent/IE62582B1/en not_active IP Right Cessation
- 1988-04-13 ES ES88400895T patent/ES2053779T3/en not_active Expired - Lifetime
- 1988-04-13 YU YU74288A patent/YU46691B/en unknown
- 1988-04-13 SI SI8810742A patent/SI8810742A/en unknown
- 1988-04-13 FI FI881708A patent/FI93830C/en not_active IP Right Cessation
- 1988-04-13 AT AT88400895T patent/ATE85052T1/en not_active IP Right Cessation
- 1988-04-13 EP EP88400895A patent/EP0287465B1/en not_active Expired - Lifetime
- 1988-04-13 KR KR1019880004187A patent/KR880012572A/en not_active Application Discontinuation
- 1988-04-13 JP JP63089189A patent/JP2675058B2/en not_active Expired - Lifetime
- 1988-04-13 DE DE8888400895T patent/DE3877799T2/en not_active Expired - Fee Related
- 1988-04-13 IL IL86059A patent/IL86059A/en not_active IP Right Cessation
- 1988-04-14 CN CN88102139A patent/CN1022411C/en not_active Expired - Fee Related
- 1988-04-14 AU AU14611/88A patent/AU606146B2/en not_active Ceased
-
1992
- 1992-09-26 HR HRP920514AA patent/HRP920514A2/en not_active Application Discontinuation
-
1993
- 1993-03-30 GR GR930400681T patent/GR3007495T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK202788A (en) | NITROGEN CONTAINING CYCLIC LIGANDS, METAL COMPLEXS CREATED BY THESE LIGANDS, DIAGNOSTIC PREPARATIONS CONTAINING THESE COMPLEXES AND PROCEDURES FOR THE PREPARATION OF THE LIGANDS | |
ES2087938T3 (en) | USE OF CHELATED COMPLEXES. | |
NO874971D0 (en) | IMPROVED METAL CONTAINING DIAGNOSTIC AGENT. | |
DK0417870T3 (en) | Chelating agents for complex binding of radioactive isotopes, their metal complexes and their use for diagnostics and therapy | |
NO923739D0 (en) | CONTRAST MEDIA | |
ES8504668A1 (en) | Metal complex salts and their use in diagnostic preparations | |
EP0235361A3 (en) | Ferrioxamine paramagnetic contrast agents for mr imaging | |
DK169086A (en) | Device for position determination of transition zones between at least two different enclosing media | |
DE69330494D1 (en) | RADIOACTIVELY MARKED SOMATOSTATIN | |
GB8919488D0 (en) | New cores for technetium radiopharmaceuticals | |
DE3862843D1 (en) | CATIONIC 99M TECHNOLOGY COMPLEXES. | |
EP0230027A3 (en) | Magnet shimming using information derived from chemical shift imaging | |
ATE122665T1 (en) | CYCLIC NITROGEN CONTAINING LIGANDS, THEIR METAL COMPLEXES, DIAGNOSTIC AGENTS CONTAINING THEM AND METHOD FOR PRODUCING THE LIGANDS. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PBP | Patent lapsed |