FI93609C - Use of a biodegradable detergent in contact lens care solutions, a treatment solution and a method for treating contact lenses - Google Patents

Use of a biodegradable detergent in contact lens care solutions, a treatment solution and a method for treating contact lenses Download PDF

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Publication number
FI93609C
FI93609C FI934199A FI934199A FI93609C FI 93609 C FI93609 C FI 93609C FI 934199 A FI934199 A FI 934199A FI 934199 A FI934199 A FI 934199A FI 93609 C FI93609 C FI 93609C
Authority
FI
Finland
Prior art keywords
contact lens
lens care
ethyl
treatment solution
glucoside
Prior art date
Application number
FI934199A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI93609B (en
FI934199A0 (en
Inventor
Olavi Nieminen
Original Assignee
Finnsusp Ab Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Finnsusp Ab Oy filed Critical Finnsusp Ab Oy
Priority to FI934199A priority Critical patent/FI93609C/en
Publication of FI934199A0 publication Critical patent/FI934199A0/en
Priority to PCT/FI1994/000392 priority patent/WO1995008352A1/en
Priority to EP94925504A priority patent/EP0728020A1/en
Priority to JP7509579A priority patent/JPH09503134A/en
Priority to AU75389/94A priority patent/AU7538994A/en
Priority to CA 2172043 priority patent/CA2172043A1/en
Publication of FI93609B publication Critical patent/FI93609B/en
Application granted granted Critical
Publication of FI93609C publication Critical patent/FI93609C/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/141—Biguanides, e.g. chlorhexidine
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/662—Carbohydrates or derivatives
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses

Description

9360993609

Biologisesti hajoavan detergentin käyttö piilolinssien hoitoliuoksissa, hoitoliuos ja menetelmä piilolinssien hoitamiseksi 5 Keksintö koskee biologisesti hajoavan detergentin, tarkemmin sanottuna etyyli-6-0-dodekanoyyli-glukosidin käyttöä piilolinssien hoitoliuoksissa, tällaista deter-genttiä sisältävää hoitoliuosta ja menetelmää piilolinssien hoitamiseksi.The invention relates to the use of a biodegradable detergent, in particular ethyl 6-O-dodecanoyl glucoside in contact lens care solutions, to a treatment solution containing such a detergent and to a method for treating such contact detergents.

10 Optimaalista piilolinssien desinfiointimenetelmää ei vielä ole kehitetty. Desinfiointiin on yleisesti käytetty vetyperoksidia, mutta mahdolliset toksiset vaikutukset ovat vähentäneet sen suosiota. On ehdotettu desin-fiointisysteemejä, joissa ei käytetä peroksidia, mutta 15 näiden systeemien on todettu vaativan huolellisia puhdistus- ja huuhtelutoimenpiteitä (ks. Shih et ai. CLAO-J, 1991, 17, 165-168). Lisäksi on havaittu, että enterobak-teerien muodostamat biofilmit estävät tehokkaan desinfioinnin (ks. Parment et ai. Acta Ophtalmol, 1986, 64, 20 456-462). Piilolinsseihin liityvien biofilmien tutkimuk sissa on todettu, että vetyperoksidi on tehokkaampi kuin muut desinfiointiaineet ja että ei-peroksidiaineet vaativat tehokkaan menetelmän biofilmin poistamiseksi (ks. Wilson et ai. Arch Ophtalmol, 1991, 109, 1155-1157).10 An optimal method for disinfecting contact lenses has not yet been developed. Hydrogen peroxide has been commonly used for disinfection, but its potential toxic effects have reduced its popularity. Peroxide-free disinfection systems have been proposed, but these systems have been found to require careful cleaning and rinsing procedures (see Shih et al. CLAO-J, 1991, 17, 165-168). In addition, biofilms formed by enterobacteria have been found to inhibit effective disinfection (see Parment et al. Acta Ophtalmol, 1986, 64, 20456-462). Studies of biofilms associated with contact lenses have shown that hydrogen peroxide is more effective than other disinfectants and that non-peroxide agents require an effective method of biofilm removal (see Wilson et al. Arch Ophtalmol, 1991, 109, 1155-1157).

25 Erillisten puhdistus- ja desinfiointiaineiden käyt tö tekee piilolinssien hoidon hankalaksi. Näin ollen olisi erittäin toivottavaa saada aikaan yhdistelmäaine, joka on samalla sekä tehokas puhdistusaine että tehokas desinfiointiaine. Tähän asti puhdistusdetergentit ovat olleet 30 toksisia silmille, minkä vuoksi on ollut pakko käyttää erillistä huuhteluliuosta puhdistuksen jälkeen.25 The use of separate cleaning and disinfecting agents makes contact lens care difficult. Thus, it would be highly desirable to provide a combination agent that is both an effective cleaning agent and an effective disinfectant. Until now, cleansing detergents have been toxic to the eyes, which has forced the use of a separate rinsing solution after cleansing.

Nyt on yllättäen havaittu, että käyttämällä piilolinssien hoitoliuoksissa biologisesti hajoavaa detergent-tiä saadaan aikaan liuos, joka samanaikaisesti soveltuu 35 sekä piilolinssien puhdistukseen, huuhteluun, desinfiointiin että säilytykseen.It has now surprisingly been found that the use of a biodegradable detergent in contact lens care solutions provides a solution which is simultaneously suitable for cleaning, rinsing, disinfecting and storing contact lenses.

2 936092 93609

Keksintö koskee etyyli-6-0-dodekanoyyli-glukosidin käyttöä piilolinssien hoitoliuoksissa.The invention relates to the use of ethyl 6-O-dodecanoyl glucoside in contact lens care solutions.

Keksintö koskee myös piilolinssien hoitoliuosta, jolle on tunnusomaista, että se sisältää etyyli-6-0-dode-5 kanoyyli-glukosidia.The invention also relates to a contact lens care solution, characterized in that it contains ethyl 6-O-dode-5 canoyl glucoside.

Lisäksi keksintö koskee menetelmää piilolinssien hoitamiseksi. Menetelmälle on tunnusomaista, että piilolinssiä käsitellään etyyli-6-0-dodekanoyyli-glukosidia sisältävällä hoitoliuoksella.The invention further relates to a method of treating contact lenses. The method is characterized in that the contact lens is treated with a treatment solution containing ethyl 6-O-dodecanoyl glucoside.

10 Etyyli-6-0-dodekanoyyli-glukosidi on biologisesti hajoava detergentti, jota myy yhtiö Novo Nordisk kauppanimellä Biosurf™.10 Ethyl 6-O-dodecanoyl glucoside is a biodegradable detergent sold by Novo Nordisk under the trade name Biosurf®.

Biologisesti hajoavaa detergenttiä voidaan keksinnön mukaan käyttää kaiken tyyppisissä piilolinssien 15 hoitoliuoksissa. Edullisesti sitä kuitenkin käytetään hoitoliuoksissa, jotka sisältävät biguanidia, erityisesti klooriheksidiiniä. Klooriheksidiini on kationinen NXN5-substituoitu bibisguanidi, jolla on laaja antibakteerinen spektri. Biologisesti hajoavan detergentin edullisen vaik-20 utuksen oletetaan johtuvan siitä, että tällainen deter gentti, mahdollisen oman antibakteerisen vaikutuksensa lisäksi, tehostaa muiden aineiden, kuten klooriheksidii-nin, antibakteerista vaikutusta. Lisäksi biologisesti hajoavalla detergentillä on biofilmiä hajottava vaikutus, 25 mikä mahdollistaa sopivan mikroympäristön desinfioiville aineille.According to the invention, a biodegradable detergent can be used in all types of contact lens care solutions. Preferably, however, it is used in treatment solutions containing biguanide, especially chlorhexidine. Chlorhexidine is a cationic NXN5-substituted bibisguanide with a broad antibacterial spectrum. The beneficial effect of a biodegradable detergent is believed to be due to the fact that such a detergent, in addition to its possible antibacterial effect, enhances the antibacterial effect of other substances such as chlorhexidine. In addition, the biodegradable detergent has a biofilm-degrading effect, allowing a suitable microenvironment for disinfectants.

Keksinnön mukainen hoitoliuos voi biologisesti hajoavan detergentin, veden ja antibakteeristen aineiden lisäksi sisältää tavanomaisia lisäaineita, kuten etyleeni-30 diamiinitetraetikkahappoa (EDTA) ja puskuria. Keksinnön ’ mukainen hoitoliuos sisältää tyypillisesti 0,001 - 0,1 paino-%, edullisesti noin 0,005 paino-%, biologisesti hajoavaa detergenttiä.In addition to the biodegradable detergent, water and antibacterial agents, the treatment solution of the invention may contain conventional additives such as ethylene diamine tetraacetic acid (EDTA) and a buffer. The treatment solution of the invention typically contains 0.001 to 0.1% by weight, preferably about 0.005% by weight, of a biodegradable detergent.

Keksintöä valaistaan yksityiskohtaisemmin seuraa- 35 vassa.The invention is illustrated in more detail below.

lii 3 93609lii 3 93609

EsimerkkiExample

Valmistettiin 1 1 piilolinssien hoitoliuosta, joka sisälsi ionivaihdettua vettä jaA 1 L contact lens care solution containing deionized water and

Klooriheksidiiniasetaattia 0,00025 paino-% 5 EDTArta 0,091 paino-%Chlorhexidine acetate 0.00025% by weight 5 EDTA 0.091% by weight

NaCl 0,472 paino-%NaCl 0.472% by weight

Na-tetraboraattidekahydraattia 0,14 paino-%Na tetraborate decahydrate 0.14% by weight

Etyyli-6-0-dodekanoyyli-gluko- sidia 0,005 paino-% 10 Aineosien sekoittamisen jälkeen pH säädettiin arvoon 7,8 - 8,0 väkevällä suolahapolla.Ethyl 6-O-dodecanoyl glucoside 0.005% by weight After mixing the ingredients, the pH was adjusted to 7.8 to 8.0 with concentrated hydrochloric acid.

Claims (7)

1. Användning av etyl-6-O-dodekanoyl-glukosid i skötsellösningar för kontaktlinser.1. Use of ethyl 6-O-dodecanoyl glucoside in contact lens care solutions. 2. Användning enligt patentkravet 1, känne- t e c k n a d därav, att mängden etyl-6-O-dodekanoyl-glu-kosid är 0,001 - 0,1 vikt-%, beräknat pä skötsellösningen.Use according to claim 1, characterized in that the amount of ethyl 6-O-dodecanoyl-glucoside is 0.001 - 0.1% by weight, calculated on the maintenance solution. 3. Användning enligt patentkravet 2, känne- t e c k n a d därav, att mängden etyl-6-0-dodekanoyl-glu-10 kosid är ca 0,005 vikt-%, beräknat pä skötsellösningen.Use according to claim 2, characterized in that the amount of ethyl-6-O-dodecanoyl-glucoside is about 0.005% by weight, calculated on the maintenance solution. 4. Skötsellösning för kontaktlinser, känne- t e c k n a d därav, att den innehäller etyl-6-0-dodeka-noyl-glukosid.4. Contact lens care solution, characterized in that it contains ethyl 6-O-dodecanoyl glucoside. 5. Skötsellösning enligt patentkravet 4, känne-15 tecknad därav, att den innehäller 0,001 - 0,1 vikt-% etyl-6-0-dodekanoyl-glukosid.5. A care solution according to claim 4, characterized in that it contains 0.001 - 0.1% by weight of ethyl 6 - 0 - dodecanoyl glucoside. 6. Skötsellösning enligt patentkravet 5, känne-tecknad därav, att den innehäller ca 0,005 vikt-% etyl-6-0-dodekanoyl-glukosid. 206. A care solution according to claim 5, characterized in that it contains about 0.005% by weight of ethyl 6-O-dodecanoyl glucoside. 20 7. Förfarande för skötsel av kontaktlinser, k ä n - netecknat därav, att kotaktlinsen behandlas med en skötsellösning enligt nägot av patentkraven 4-6. «7. Method of maintaining contact lenses, characterized in that the cotact lens is treated with a care solution according to any of claims 4-6. «
FI934199A 1993-09-24 1993-09-24 Use of a biodegradable detergent in contact lens care solutions, a treatment solution and a method for treating contact lenses FI93609C (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FI934199A FI93609C (en) 1993-09-24 1993-09-24 Use of a biodegradable detergent in contact lens care solutions, a treatment solution and a method for treating contact lenses
PCT/FI1994/000392 WO1995008352A1 (en) 1993-09-24 1994-09-05 Contact lens care solutions
EP94925504A EP0728020A1 (en) 1993-09-24 1994-09-05 Contact lens care solutions
JP7509579A JPH09503134A (en) 1993-09-24 1994-09-05 Contact lens protection solution
AU75389/94A AU7538994A (en) 1993-09-24 1994-09-05 Contact lens care solutions
CA 2172043 CA2172043A1 (en) 1993-09-24 1994-09-05 Contact lens care solutions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI934199 1993-09-24
FI934199A FI93609C (en) 1993-09-24 1993-09-24 Use of a biodegradable detergent in contact lens care solutions, a treatment solution and a method for treating contact lenses

Publications (3)

Publication Number Publication Date
FI934199A0 FI934199A0 (en) 1993-09-24
FI93609B FI93609B (en) 1995-01-31
FI93609C true FI93609C (en) 1995-05-10

Family

ID=8538656

Family Applications (1)

Application Number Title Priority Date Filing Date
FI934199A FI93609C (en) 1993-09-24 1993-09-24 Use of a biodegradable detergent in contact lens care solutions, a treatment solution and a method for treating contact lenses

Country Status (6)

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EP (1) EP0728020A1 (en)
JP (1) JPH09503134A (en)
AU (1) AU7538994A (en)
CA (1) CA2172043A1 (en)
FI (1) FI93609C (en)
WO (1) WO1995008352A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2762849B1 (en) * 1997-05-05 1999-06-18 Essilor Int AQUEOUS SOLUTION FOR MAINTAINING CONTACT LENSES
CN104138856B (en) * 2014-07-16 2016-08-24 北京卫星制造厂 The wiping arrangement in-orbit of a kind of mechanism seals circle and wiping method

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3169105D1 (en) * 1980-12-18 1985-03-28 Smith & Nephew Ass Lens sterilising solutions and their use
DE3626082A1 (en) * 1986-07-31 1988-02-11 Henkel Kgaa DISINFECTANT AND CLEANER SYSTEM FOR CONTACT LENSES
CA2009118C (en) * 1989-02-21 1996-02-27 Mary F. Mowrey-Mckee Method and composition for cleaning and disinfecting contact lenses
GB8922593D0 (en) * 1989-10-06 1989-11-22 Unilever Plc Detergent composition
KR0127768B1 (en) * 1990-12-27 1997-12-26 마틴 에이. 보에트 Method and composition for disinfecting contact lenses
IE920838A1 (en) * 1991-03-18 1992-09-23 Allergan Inc Contact lens disinfecting compositions
US5523012A (en) * 1991-07-19 1996-06-04 Ciba-Geigy Corporation Hydrogen peroxide disinfection solutions

Also Published As

Publication number Publication date
FI93609B (en) 1995-01-31
CA2172043A1 (en) 1995-03-30
AU7538994A (en) 1995-04-10
JPH09503134A (en) 1997-03-31
WO1995008352A1 (en) 1995-03-30
FI934199A0 (en) 1993-09-24
EP0728020A1 (en) 1996-08-28

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