FI935728A0 - Substituent 4-phenylpyridone and 4-phenyl-2-alkoxypyridine - Google Patents

Substituent 4-phenylpyridone and 4-phenyl-2-alkoxypyridine

Info

Publication number
FI935728A0
FI935728A0 FI935728A FI935728A FI935728A0 FI 935728 A0 FI935728 A0 FI 935728A0 FI 935728 A FI935728 A FI 935728A FI 935728 A FI935728 A FI 935728A FI 935728 A0 FI935728 A0 FI 935728A0
Authority
FI
Finland
Prior art keywords
phenyl
alkoxypyridine
phenylpyridone
substituent
phenylpyridones
Prior art date
Application number
FI935728A
Other languages
Finnish (fi)
Other versions
FI935728A (en
Inventor
Rolf Angerbauer
Peter Fey
Walter Huebsch
Thomas Philipps
Hilmar Bischoff
Hans-Peter Krause
Gehr Joerg Petersen-Von
Delf Schmidt
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4321421A external-priority patent/DE4321421A1/en
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI935728A0 publication Critical patent/FI935728A0/en
Publication of FI935728A publication Critical patent/FI935728A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Substituted 4-phenylpyridones and 4-phenyl-2-alkoxypyridines are prepared by reducing corresponding 4-phenylpyridone derivatives and 4-phenyl-2-alkoxypyridine derivatives, respectively. The substituted 4-phenylpyridones and 4-phenyl-2-alkoxypyridines may be employed as active compounds in drugs (medicaments, pharmaceuticals, medicines), in particular for the treatment of hyperlipoproteinaemia.
FI935728A 1992-12-21 1993-12-20 Substituted 4-phenylpyridones and 4-phenyl-2-alkoxypyridines FI935728A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4243278 1992-12-21
DE4321421A DE4321421A1 (en) 1992-12-21 1993-06-28 Substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridines

Publications (2)

Publication Number Publication Date
FI935728A0 true FI935728A0 (en) 1993-12-20
FI935728A FI935728A (en) 1994-06-22

Family

ID=25921579

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935728A FI935728A (en) 1992-12-21 1993-12-20 Substituted 4-phenylpyridones and 4-phenyl-2-alkoxypyridines

Country Status (21)

Country Link
US (1) US5418243A (en)
EP (1) EP0603649B1 (en)
JP (1) JPH06234741A (en)
CN (1) CN1117965A (en)
AT (1) ATE140226T1 (en)
AU (1) AU660132B2 (en)
CA (1) CA2111778A1 (en)
CZ (1) CZ284093A3 (en)
DE (1) DE59303195D1 (en)
DK (1) DK0603649T3 (en)
ES (1) ES2089687T3 (en)
FI (1) FI935728A (en)
GR (1) GR3020668T3 (en)
HU (1) HUT70150A (en)
IL (1) IL108071A0 (en)
MX (1) MX9308013A (en)
NO (1) NO934706L (en)
NZ (1) NZ250500A (en)
PH (1) PH29953A (en)
PL (1) PL301582A1 (en)
SK (1) SK144893A3 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19627420A1 (en) * 1996-07-08 1998-01-15 Bayer Ag 6- (hydroxymethyl-ethyl) pyridine
JP2005126340A (en) * 2003-10-22 2005-05-19 Kureha Chem Ind Co Ltd Method for producing substituted pyridone compounds, raw material compound thereof and method for producing the same
AR059898A1 (en) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv DERIVATIVES OF 3-CIANO-PIRIDONA 1,4-DISUSTITUTED AND ITS USE AS ALLOSTERIC MODULATORS OF MGLUR2 RECEIVERS
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
NZ584145A (en) 2007-09-14 2012-03-30 Ortho Mcneil Janssen Pharm 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1,4'] bipyridinyl-2'-ones
EA019085B1 (en) * 2007-09-14 2014-01-30 Янссен Фармасьютикалз, Инк. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
EP2205565B1 (en) * 2007-09-14 2013-04-17 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
MX2010005110A (en) * 2007-11-14 2010-09-09 Ortho Mcneil Janssen Pharm Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors.
ES2439291T3 (en) 2008-09-02 2014-01-22 Janssen Pharmaceuticals, Inc. 3-Azabicyclo [3.1.0] hexyl derivatives as modulators of metabotropic glutamate receptors
US8697689B2 (en) 2008-10-16 2014-04-15 Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
MX2011005242A (en) 2008-11-28 2011-09-06 Ortho Mcneil Janssen Pharm Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors.
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY161325A (en) 2009-05-12 2017-04-14 Janssen Pharmaceuticals Inc 1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
CA2760259C (en) 2009-05-12 2018-05-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2536433T3 (en) 2010-11-08 2015-05-25 Janssen Pharmaceuticals, Inc. 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
JP5852664B2 (en) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of the mGluR2 receptor
CN103298809B (en) 2010-11-08 2016-08-31 杨森制药公司 1,2,4-triazol [4,3-a] pyridine derivate and the purposes of the positive allosteric modulators as MGLUR2 acceptor thereof
JO3368B1 (en) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3367B1 (en) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
ME03518B (en) 2014-01-21 2020-04-20 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
WO2015110435A1 (en) 2014-01-21 2015-07-30 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
CN104370806B (en) * 2014-06-17 2017-07-07 中国海洋大学 A kind of pyridone alkaloid compound and its production and use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154838A (en) * 1975-07-31 1979-05-15 Smith Kline & French Laboratories Limited Alkoxy pyridine
GB1564502A (en) * 1975-07-31 1980-04-10 Smith Kline French Lab Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives
US4684477A (en) * 1985-03-06 1987-08-04 Chisso Corporation Pyridine derivatives and their use in liquid crystals
US4906624A (en) * 1987-09-08 1990-03-06 Warner-Lambert Company 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
EP0339342A1 (en) * 1988-04-23 1989-11-02 Bayer Ag N-substituted N-amino pyrroles
US4916239A (en) * 1988-07-19 1990-04-10 Merck & Co., Inc. Process for the lactonization of mevinic acids and analogs thereof
US5032602A (en) * 1988-12-14 1991-07-16 Bayer Aktiengesellschaft Inhibiting HMG-CoA reductase with novel substituted 2-pyridones and pyrid-2-thiones
DE3909378A1 (en) * 1989-03-22 1990-09-27 Bayer Ag SUBSTITUTED BIPHENYLE
DE3925636A1 (en) * 1989-08-03 1991-02-07 Bayer Ag IMINO-SUBSTITUTED PYRIDINE

Also Published As

Publication number Publication date
EP0603649B1 (en) 1996-07-10
PH29953A (en) 1996-09-16
DK0603649T3 (en) 1996-11-04
EP0603649A1 (en) 1994-06-29
CA2111778A1 (en) 1994-06-22
NO934706D0 (en) 1993-12-20
US5418243A (en) 1995-05-23
ES2089687T3 (en) 1996-10-01
CN1117965A (en) 1996-03-06
NZ250500A (en) 1996-02-27
AU5195593A (en) 1994-06-30
HU9303675D0 (en) 1994-04-28
PL301582A1 (en) 1994-06-27
ATE140226T1 (en) 1996-07-15
DE59303195D1 (en) 1996-08-14
MX9308013A (en) 1994-08-31
HUT70150A (en) 1995-09-28
FI935728A (en) 1994-06-22
IL108071A0 (en) 1994-04-12
NO934706L (en) 1994-06-22
GR3020668T3 (en) 1996-10-31
JPH06234741A (en) 1994-08-23
AU660132B2 (en) 1995-06-08
CZ284093A3 (en) 1994-07-13
SK144893A3 (en) 1995-02-08

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