FI924640A - LAONGSAMT DOSERANDE SYNERESISK POLYMER LAEKEMEDELSDOSERINGSANORDNING - Google Patents

LAONGSAMT DOSERANDE SYNERESISK POLYMER LAEKEMEDELSDOSERINGSANORDNING Download PDF

Info

Publication number
FI924640A
FI924640A FI924640A FI924640A FI924640A FI 924640 A FI924640 A FI 924640A FI 924640 A FI924640 A FI 924640A FI 924640 A FI924640 A FI 924640A FI 924640 A FI924640 A FI 924640A
Authority
FI
Finland
Prior art keywords
vehicle
drug
delivery device
water
drug delivery
Prior art date
Application number
FI924640A
Other languages
Finnish (fi)
Other versions
FI924640A0 (en
Inventor
Terry Tsong-Pin Hsu
Alan S Michaels
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI924640A0 publication Critical patent/FI924640A0/en
Publication of FI924640A publication Critical patent/FI924640A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Materials For Photolithography (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

There is disclosed a slow release drug delivery device for the prolonged administration of topically active medicines which consists of a vehicle in which water is soluble and in which is dissolved the topically active drug which is formed into a stable organogel with a polymer matrix with a very low water absorbing capability. The organogel, in the presence of water or atmospheric water vapor, slowly imbibes such water into the vehicle and by doing so the vehicle becomes incompatible with the matrix and is slowly expelled therefrom. The vehicle dissolves the drug and the vehicle/drug combination is slowly pumped out of the polymeric matrix with substantially linear drug delivery occurring for periods in excess of 6 months. The drug delivery device may be used to administer drugs topically, as a collar or trans dermal patch, orally, as a slow delivery device, particularly as a ruminal bolus,, or as a suppository or a subcutaneous implant. The preferred form for the drug delivery device is as a flea and tick collar for household pets and the preferred active drug is selected from the avermectin and milbemycin families of active antiparasitic agents. <IMAGE>
FI924640A 1991-10-15 1992-10-14 LAONGSAMT DOSERANDE SYNERESISK POLYMER LAEKEMEDELSDOSERINGSANORDNING FI924640A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/776,913 US5411737A (en) 1991-10-15 1991-10-15 Slow release syneresing polymeric drug delivery device

Publications (2)

Publication Number Publication Date
FI924640A0 FI924640A0 (en) 1992-10-14
FI924640A true FI924640A (en) 1993-04-16

Family

ID=25108723

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924640A FI924640A (en) 1991-10-15 1992-10-14 LAONGSAMT DOSERANDE SYNERESISK POLYMER LAEKEMEDELSDOSERINGSANORDNING

Country Status (12)

Country Link
US (1) US5411737A (en)
EP (1) EP0537998B1 (en)
JP (1) JP2649002B2 (en)
KR (1) KR930007438A (en)
AT (1) ATE147621T1 (en)
AU (1) AU656815B2 (en)
CA (1) CA2080574A1 (en)
DE (1) DE69216755T2 (en)
FI (1) FI924640A (en)
IL (1) IL103363A0 (en)
NO (1) NO923986L (en)
ZA (1) ZA927908B (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR970100096A (en) * 1996-03-29 1997-11-28 Merial External device against cattle parasites based on n-phenylpyrazol, ear rings
GR1002899B (en) * 1996-03-29 1998-05-11 Rhone Merieux Collar against fleas and ticks for dogs and cats using n-phenylpyrazol
US5861174A (en) * 1996-07-12 1999-01-19 University Technology Corporation Temperature sensitive gel for sustained delivery of protein drugs
IL121286A0 (en) 1997-07-11 1998-01-04 Pets N People Ltd Apparatus and methods for dispensing pet care substances
WO1999015166A1 (en) * 1997-09-23 1999-04-01 Pfizer Limited Parasiticidal formulations
WO1999018797A1 (en) 1997-10-09 1999-04-22 Emory University Method and devices for transdermal delivery of lithium
US6524602B1 (en) * 1998-10-13 2003-02-25 Craig G. Burkhart Polymer delivery system in treatments for parasitic skin diseases
GB9825402D0 (en) † 1998-11-19 1999-01-13 Pfizer Ltd Antiparasitic formulations
NL1011336C2 (en) * 1999-02-18 2001-06-26 Beaphar B V Collar for a cat or dog in which certain active substances are incorporated in the material of the collar and a method for the manufacture of such a collar.
US20040047910A1 (en) * 2000-07-07 2004-03-11 Christian Beckett Suppository and composition comprising at least one polyethylene glycol
US6627613B2 (en) 2001-07-23 2003-09-30 Michael A. Strobel Application of water and organic solvent soluble ivermectin for topical and oral use
US20050009762A1 (en) 2003-06-06 2005-01-13 Strobel Michael Albert Application of water and organic solvent soluble ivermectin for topical and oral use
DE10157755A1 (en) * 2001-11-27 2003-06-12 Henkel Kgaa Gel capsules containing active ingredient and their use
GB0229804D0 (en) * 2002-12-20 2003-01-29 Syngenta Participations Ag Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position
CN101091695B (en) * 2003-02-03 2011-01-19 诺瓦提斯公司 Pharmaceutical formulation
WO2005120173A2 (en) * 2004-05-12 2005-12-22 Kishore Madhukar Paknikar Anti-microbial activity of biologically stabilized silver nano particles
DE102004031325A1 (en) * 2004-06-29 2006-01-19 Bayer Healthcare Ag Active substance-containing solid shaped articles for external use against parasites on animals
KR100914426B1 (en) * 2004-08-06 2009-08-27 닛뽕소다 가부시키가이샤 Agricultural-chemical preparation having controlled releasability
ES2264894B1 (en) * 2005-07-07 2008-02-01 Europea Del Hogar Y La Limpieza Eurolar, S.L. PROCESS OF PREPARATION OF A SOLID ANTIPOLILLA PRODUCT FOR CLOTHING AND ITS CONTAINER.
US20070224233A1 (en) * 2005-08-05 2007-09-27 Nippon Soda Co., Ltd Controlled-Release Agricultural Chemical Formulation
EP1931417A2 (en) * 2005-09-30 2008-06-18 Transcutaneous Technologies Inc. Transdermal drug delivery systems, devices, and methods employing novel pharmaceutical vehicles
WO2007079193A2 (en) 2005-12-30 2007-07-12 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
PL1982590T3 (en) * 2006-02-06 2017-11-30 Nippon Soda Co., Ltd. Pesticide-containing resin compositions controlled in dissolution, process for production thereof, and pesticide preparations
US20070259029A1 (en) * 2006-05-08 2007-11-08 Mcentire Edward Enns Water-dispersible patch containing an active agent for dermal delivery
US7879942B2 (en) * 2006-10-05 2011-02-01 Eastman Chemical Company Switchable adhesive article for attachment to skin and method of using the same
JP5383497B2 (en) 2006-12-01 2014-01-08 Ｔｔｉ・エルビュー株式会社 System and device for powering and / or controlling a device, for example a transdermal delivery device
NL1033350C2 (en) * 2007-02-07 2008-08-11 Ver Bedrijven Beaphar B V Animal collar containing insecticide, comprises band with cavity in one side for housing insecticide strip
US20080260823A1 (en) * 2007-04-20 2008-10-23 Sciele Pharma, Inc. Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea
AU2007251891B8 (en) * 2007-06-29 2014-03-06 Y-Tex Corporation Pesticidal ear tag
FR2921541B1 (en) 2007-10-02 2012-04-27 Ab7 Ind REPELLENT DEVICE AGAINST PESTS OF DOMESTIC ANIMALS
US8529790B2 (en) * 2007-12-28 2013-09-10 Council Of Scientific & Industrial Research White light emitting organogel and process thereof
GB0805535D0 (en) * 2008-03-27 2008-04-30 Univ Leicester Scar prevention
CN102271672B (en) 2008-11-19 2015-02-04 梅里亚有限公司 Compositions comprising 1-arylpyrazoles, alone or in combination with formamidines, for the treatment of parasitic infections
UA108641C2 (en) 2010-04-02 2015-05-25 PARASITICID COMPOSITION CONTAINING FOUR ACTIVE AGENTS AND METHOD OF APPLICATION
WO2012013791A1 (en) * 2010-07-30 2012-02-02 Ceva Sante Animale Compositions for treating heartworm infestation
BR112013002177B8 (en) * 2010-07-30 2019-03-06 Ceva Sante Animale composition of a veterinary drug for use in the control of heart worm infestations in a non-human animal subject, and kit for treatment and / or prevention of heart worm parasitic infestation in a non-human animal subject
CN103889434B (en) 2011-06-21 2017-02-15 Bvw控股公司 Medical device comprising boswellic acid
US8586527B2 (en) 2011-10-20 2013-11-19 Jaipal Singh Cerivastatin to treat pulmonary disorders
JP6249568B2 (en) 2011-11-17 2017-12-20 メリアル インコーポレイテッド Composition comprising arylpyrazole and substituted imidazole, method of use thereof
NZ627781A (en) 2012-01-23 2016-10-28 Sage Therapeutics Inc Neuroactive steroid formulations and methods of treating cns disorders
FR3002232B1 (en) 2013-02-15 2015-03-27 Ab7 Innovation POLYMERIC SUPPORT FOR DISPENSING NATURALLY CRYSTALLINE SUBSTANCE AND PROCESS FOR OBTAINING SAME
ITTO20130284A1 (en) * 2013-04-09 2014-10-10 Fond Istituto Italiano Di Tecnologia PROCEDURE FOR THE PRODUCTION OF SHAPED POLYMERIC MICROPARTELS
MX2016013573A (en) 2014-04-17 2017-02-13 Merial Inc Use of malononitrile compounds for protecting animals from parasites.
ES2566577B1 (en) * 2014-10-13 2017-01-31 Javier CATALÁN GUTIERREZ Multi-component antiparasitic collar for livestock
WO2019157241A1 (en) 2018-02-08 2019-08-15 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof
US10900927B2 (en) * 2018-03-21 2021-01-26 University Of South Carolina Graphene field effect transistors for detection of ions
WO2021005606A1 (en) 2019-07-09 2021-01-14 Solano S.P. Ltd. Slow release flea and tick collar
FR3107203B1 (en) 2020-02-14 2023-11-24 Ab7 Innovation SOLID COMPOSITE MATRIX FOR PROLONGED DELIVERY OF ACTIVES
EP3872170A1 (en) 2020-02-25 2021-09-01 University of Georgia Research Foundation, Inc. Chemically-stabilized allosteric modulators of leucine-rich repeat kinase 2 (lrrk2)
WO2023205649A1 (en) * 2022-04-18 2023-10-26 Massachusetts Institute Of Technology Crosslinked organogels for drug delivery

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3318769A (en) * 1963-05-31 1967-05-09 Shell Oil Co Resin compositions comprising organo-phosphorus pesticides
US3852416A (en) * 1971-05-27 1974-12-03 L Grubb Tick and flea collar of solid solution plasticized vinylic resin-carbamate insecticide
US3944662A (en) * 1972-04-17 1976-03-16 Shell Oil Company Non-volatile slow-release pesticidal generators
US3921636A (en) * 1973-01-15 1975-11-25 Alza Corp Novel drug delivery device
US4127127A (en) * 1977-05-23 1978-11-28 Alza Corporation Therapeutic systems made from certain segmented copolyesters
US4348321A (en) * 1980-11-14 1982-09-07 Zoecon Corporation Recrystallization of phosmet
CA1185173A (en) * 1982-03-25 1985-04-09 Johannes T. Bouman Slow release pesticidal composition and control device, its preparation and its use
DE3586713T2 (en) * 1984-11-15 1993-05-13 Hercon Lab DEVICE FOR THE CONTROLLED DELIVERY OF DRUG ACTIVE SUBSTANCES.
US4717718A (en) * 1985-08-09 1988-01-05 Alza Corporation Device for the controlled delivery of a beneficial agent
DE3538688A1 (en) * 1985-10-31 1987-05-07 Bayer Ag METHOD FOR COMBATING PARASITOSIS IN BEES
EP0334516A3 (en) * 1988-03-21 1991-07-03 Pfizer Inc. Method for enhancing the unrolling of a rolled matrix device
US4861596A (en) * 1988-03-21 1989-08-29 Pfizer Inc. Rolled matrix device having enhanced ability to unroll and method for its production

Also Published As

Publication number Publication date
JP2649002B2 (en) 1997-09-03
FI924640A0 (en) 1992-10-14
US5411737A (en) 1995-05-02
JPH05194187A (en) 1993-08-03
AU2701792A (en) 1993-04-22
KR930007438A (en) 1993-05-20
DE69216755T2 (en) 1997-07-24
NO923986L (en) 1993-04-16
ZA927908B (en) 1993-07-14
ATE147621T1 (en) 1997-02-15
DE69216755D1 (en) 1997-02-27
IL103363A0 (en) 1993-03-15
EP0537998B1 (en) 1997-01-15
EP0537998A1 (en) 1993-04-21
CA2080574A1 (en) 1993-04-16
AU656815B2 (en) 1995-02-16
NO923986D0 (en) 1992-10-14

Similar Documents

Publication Publication Date Title
FI924640A (en) LAONGSAMT DOSERANDE SYNERESISK POLYMER LAEKEMEDELSDOSERINGSANORDNING
US7560120B2 (en) Vehicles for delivery of biologically active substances
EP1484033B1 (en) Liquid polymeric compositions for controlled release of bioactive substances
Roseman et al. Monolithic polymer devices
US4859696A (en) Precutaneous absorption accelerator and preparation containing same
NO884474L (en) IMPLANT, BIOLOGICAL DEGRADABLE ACTIVE SUBSTANCE RELEASE SYSTEM.
KR880013586A (en) Dosage device comprising a removable substrate with a solid state property
DE69331906D1 (en) GRANULATED PHARMACEUTICAL COMPOSITION
KR910009240A (en) Transport system of pharmaceutical or therapeutically active agent
ES2056915T5 (en) DRUG SUPPLY SYSTEM AND METHOD OF MANUFACTURING THEM.
ES2081352T3 (en) SOLID MATRIX SYSTEM FOR TRANSDERMIC DRUG ADMINISTRATION.
ES2113906T3 (en) POLYMERIC COMPOSITIONS USEFUL AS IMPLANTS WITH CONTROLLED ADMINISTRATION.
AR065073A2 (en) A MEDICAMENT FORMULATION OF A MATRIX SYSTEM THAT HAS CONTROLLED RELEASE OF AN ACTIVE COMPOUND
PT706401E (en) SYSTEM FOR ADMINISTRATION OF DRUGS
ITMI922603A1 (en) PHARMACEUTICAL COMPOSITIONS INCLUDING A DRUG, A CROSS-LINKED POLYMERIC SUBSTANCE, AN OIL AND A SURFACTIVE AGENT
DK0950403T3 (en) Emulsions for in-situ delivery systems
JP2010195823A (en) Injectable veterinary composition for small animals
KR910009241A (en) Sustained release compositions for treatment of periodontal disease
JPH05246893A (en) Long-acting antiparasitic injectable formulation containing hydrogenated castor oil
SI9420028A (en) Pour-on medical formulations containing avermectin compound as a medical active agent, polymeric material, glycols and glycerides
AR018691A1 (en) PELLET IMPLANT PROVISION FOR IMMEDIATE RELEASE AND DELAYED ANTIPARASITARY DRUGS
ES2241269T3 (en) SULFUROPENTAFLUOROFENILPIRAZOLES FOR THE CONTROL OF INFESTATIONS BY ECTOPARASITOS.
KR970705402A (en) DISEASE AND CONDITIONS ASSOCIATED WITH MACROPHAGE IN INFILTRATION IN PARTICULAR STROKE AND MYOCARDIAL INFARCTION.
US5124152A (en) Parenteral formulation of metolazone
JP4829405B2 (en) Liquid polymer composition for controlled release of bioactive substances

Legal Events

Date Code Title Description
FD Application lapsed