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Priority claimed from US06/883,189external-prioritypatent/US4803280A/en
Application filed by American Cyanamid CofiledCriticalAmerican Cyanamid Co
Publication of FI923615A0publicationCriticalpatent/FI923615A0/en
Publication of FI923615ApublicationCriticalpatent/FI923615A/en
Application grantedgrantedCritical
Publication of FI91854BpublicationCriticalpatent/FI91854B/en
Publication of FI91854CpublicationCriticalpatent/FI91854C/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Hydrogenated Pyridines
(AREA)
Plural Heterocyclic Compounds
(AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members
(AREA)
Abstract
The invention relates to N3-thioacyl semicarbazides of the formula <IMAGE> wherein R1 is hydrogen, C1-6 alkyl, polyfluorinated C1-6 alkyl, phenyl, multisubstituted phenyl wherein the substituents are C1-6 alkyl, C1-3 alkoxy, chloro, fluoro and/or trifluoromethyl, naphthyl, thienyl, phenylthio, tetrahydropyranyl, benzyl or -COOC2H5, and R2 is amino or C1-3 alkoxy. Compounds according to the invention are useful intermediates in the preparation of 1,2,3-thiadiazole-4- thiolates. 1,2,3-thiadiazoles are themselves useful intermediates in the production of cephalosporins.
1-bromoethyl ethyl carbonate and its use in the preparation of 1'-ethoxy-carbonyloxyethyl esters of penicillins and novel intermediates, methods for its preparation and 1-bromoethylchloroformate and 1-bromoethylbromoformate obtained as intermediates