FI915136A0 - CYCLISKA IMINODERIVAT, DESSA FOERENINGAR INNEHAOLLANDE LAEKEMEDE OCH FOERFARANDE FOER DERAS FRAMSTAELLNING. - Google Patents

CYCLISKA IMINODERIVAT, DESSA FOERENINGAR INNEHAOLLANDE LAEKEMEDE OCH FOERFARANDE FOER DERAS FRAMSTAELLNING.

Info

Publication number
FI915136A0
FI915136A0 FI915136A FI915136A FI915136A0 FI 915136 A0 FI915136 A0 FI 915136A0 FI 915136 A FI915136 A FI 915136A FI 915136 A FI915136 A FI 915136A FI 915136 A0 FI915136 A0 FI 915136A0
Authority
FI
Finland
Prior art keywords
laekemede
iminoderivat
cycliska
foerfarande foer
och foerfarande
Prior art date
Application number
FI915136A
Other languages
Finnish (fi)
Other versions
FI107606B (en
FI915136L (en
Inventor
Frank Himmelsbach
Volkhard Austel
Helmut Pieper
Wolfgang Eisert
Thomas Mueller
Johannes Weisenberger
Guenter Linz
Gerd Krueger
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of FI915136A0 publication Critical patent/FI915136A0/en
Publication of FI915136L publication Critical patent/FI915136L/en
Application granted granted Critical
Publication of FI107606B publication Critical patent/FI107606B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Detergent Compositions (AREA)

Abstract

The invention relates to cyclic imino derivatives of the general formula B - X - A - Y - E (I> in which A, B, E, X and Y are as defined in Claim 1, their geometrical isomers and their addition salts, in particular their physiologically tolerable addition salts with inorganic or organic acids or bases which, inter alia, have useful pharmacological properties, preferably aggregation-inhibiting effects, a process for their preparation and drugs containing these compounds.
FI915136A 1990-11-02 1991-10-31 Process for the preparation of pharmaceutically valuable 1-, 3-, 5-substituted pyrrolidin-2-ones FI107606B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4035961 1990-11-02
DE4035961A DE4035961A1 (en) 1990-11-02 1990-11-02 CYCLIC IMINODERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF

Publications (3)

Publication Number Publication Date
FI915136A0 true FI915136A0 (en) 1991-10-31
FI915136L FI915136L (en) 1992-05-03
FI107606B FI107606B (en) 2001-09-14

Family

ID=6418111

Family Applications (1)

Application Number Title Priority Date Filing Date
FI915136A FI107606B (en) 1990-11-02 1991-10-31 Process for the preparation of pharmaceutically valuable 1-, 3-, 5-substituted pyrrolidin-2-ones

Country Status (24)

Country Link
US (2) US5541343A (en)
EP (1) EP0483667B1 (en)
JP (1) JP2937589B2 (en)
KR (1) KR100223135B1 (en)
AT (1) ATE163008T1 (en)
BG (1) BG62025B2 (en)
BR (1) BR1100445A (en)
CA (1) CA2054850C (en)
DE (2) DE4035961A1 (en)
DK (1) DK0483667T3 (en)
EE (1) EE03099B1 (en)
ES (1) ES2113867T3 (en)
FI (1) FI107606B (en)
GR (1) GR3026508T3 (en)
HU (2) HUT67288A (en)
IE (1) IE913822A1 (en)
IL (1) IL99926A (en)
MX (1) MX9203677A (en)
NO (1) NO174806B (en)
NZ (1) NZ240463A (en)
PT (1) PT99402B (en)
RU (1) RU2040519C1 (en)
SG (1) SG81852A1 (en)
ZA (1) ZA918734B (en)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4127404A1 (en) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K CYCLIC IMINODERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
AU646966B2 (en) * 1991-08-23 1994-03-10 Takeda Chemical Industries Ltd. 2-piperazinone compounds, their production and use
DE4213919A1 (en) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K CYCLIC IMINODERIVATES, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENTS CONTAINING SUCH COMPOUNDS
DE4213931A1 (en) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K CYCLIC IMINODERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE59303178D1 (en) * 1992-04-28 1996-08-14 Thomae Gmbh Dr K Tritiated fibrinogen receptor antagonists, their use and methods for their preparation
DE4219158A1 (en) * 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenyl derivatives, pharmaceutical compositions containing them and processes for their preparation
DE4241632A1 (en) * 1992-12-10 1994-06-16 Thomae Gmbh Dr K Carboxylic acid derivatives, medicaments containing these compounds and process for their preparation
US5314902A (en) * 1993-01-27 1994-05-24 Monsanto Company Urea derivatives useful as platelet aggregation inhibitors
DK0691953T3 (en) * 1993-03-31 2000-09-04 Searle & Co 1-amidinophenyl pyrrolidones / piperidinones as platelet aggregating inhibitors
US6169107B1 (en) 1993-04-28 2001-01-02 Sumitomo Pharmaceutical Co., Ltd. Indoloylguanidine derivatives
DE4424975A1 (en) * 1994-07-15 1996-01-18 Thomae Gmbh Dr K 2-Piperidinones, medicaments containing these compounds and process for their preparation
EE9700141A (en) * 1994-12-23 1997-12-15 Dr. Karl Thomae Gmbh Piperazine derivatives, medicinal products containing them, their use and method of preparation
WO1996033982A1 (en) * 1995-04-26 1996-10-31 Takeda Chemical Industries, Ltd. Piperazinones useful as inhibitors of platelet aggregation
DE19515500A1 (en) * 1995-04-27 1996-10-31 Thomae Gmbh Dr K Substituted phenylamidines, pharmaceutical compositions containing these compounds and processes for their preparation
US5719296A (en) * 1995-10-30 1998-02-17 Merck & Co., Inc. Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
DE19604191A1 (en) * 1996-02-06 1997-08-07 Hoechst Schering Agrevo Gmbh 2,4-diamino-1,3,5-triazines, process for their preparation and their use as herbicides and plant growth regulators
US5942544A (en) * 1996-02-22 1999-08-24 Dupont Pharmaceuticals Company α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors
DE19621482A1 (en) 1996-05-29 1997-12-04 Hoechst Ag Substituted 1-naphthoylguanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
DE19621483A1 (en) * 1996-05-29 1997-12-04 Hoechst Ag Substituted 2-naphthoylguanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
AU4064597A (en) * 1996-08-16 1998-03-06 Du Pont Pharmaceuticals Company Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
US6057342A (en) * 1996-08-16 2000-05-02 Dupont Pharmaceutical Co. Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
EP1009758B1 (en) * 1997-08-29 2005-06-01 Tularik Limited Meta-benzamidine derivatives as serine protease inhibitors
US6740682B2 (en) 1997-08-29 2004-05-25 Tularik Limited Meta-benzamidine derivatives as serine protease inhibitors
NZ502866A (en) 1997-09-08 2001-12-21 Univ Georgetown Substituted 2-pyrrolidinone activators of PKC
WO1999026919A1 (en) 1997-11-20 1999-06-03 Teijin Limited Biphenylamidine derivatives
CA2333927A1 (en) 1998-04-01 1999-10-07 Dupont Pharmaceuticals Company Pyrimidines and triazines as integrin antagonists
AU3406599A (en) * 1998-04-09 1999-11-01 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
KR100416111B1 (en) 1998-04-10 2004-01-31 니뽄 다바코 산교 가부시키가이샤 Amidine compounds
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
JP2002512224A (en) * 1998-04-23 2002-04-23 アボット・ラボラトリーズ Pyrrolidine as an inhibitor of neuraminidase
WO2000005234A1 (en) 1998-07-22 2000-02-03 Suntory Limited NF-λB INHIBITORS CONTAINING INDAN DERIVATIVES AS THE ACTIVE INGREDIENT
US6284796B1 (en) * 1998-08-06 2001-09-04 Abbott Laboratories Ukokinase inhibitors
DE19844787A1 (en) * 1998-09-30 2000-04-13 Boehringer Ingelheim Pharma Disubstituted pyrrolidinones, medicaments containing them and their use and their preparation
WO2000051609A1 (en) * 1999-03-02 2000-09-08 Merck & Co., Inc. 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity
US6372764B1 (en) 1999-03-02 2002-04-16 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
EP1159273A1 (en) 1999-03-02 2001-12-05 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cathepsin s
US6362201B1 (en) 1999-03-02 2002-03-26 Merck & Co., Inc. 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
RU2177317C1 (en) * 2000-10-24 2001-12-27 Московский научно-исследовательский институт медицинской экологии (МНИИМЭ) Quinoline derivatives for correction of hemostasis system, pharmaceutical composition, agent for hemostasis correction
FR2817257B1 (en) * 2000-11-30 2009-03-20 Sanofi Synthelabo CYCLOHEXYL (ALKYL) -PROPANOLAMINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2436774A1 (en) * 2001-01-30 2002-08-08 R. Michael Lawrence Sulfonamide lactam inhibitors of factor xa
DE10121003A1 (en) * 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilic acid amides, processes for their preparation, their use as medicaments and pharmaceutical preparations containing them
GB0114004D0 (en) 2001-06-08 2001-08-01 Glaxo Group Ltd Chemical compounds
GB0114005D0 (en) 2001-06-08 2001-08-01 Glaxo Group Ltd Chemical compounds
TWI224101B (en) * 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
DE60221391T2 (en) * 2001-06-20 2008-04-17 Wyeth SUBSTITUTED INDOLESE DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1)
EP1569900B1 (en) * 2002-12-10 2006-06-28 Wyeth Substituted 3-carbonyl-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
DK1569899T3 (en) * 2002-12-10 2006-10-23 Wyeth Corp Substituted 3-alkyl and 3-arylalkyl-1H-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
UA80453C2 (en) * 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
EP1569901B1 (en) * 2002-12-10 2008-10-15 Wyeth ARYL, ARYLOXY, AND ALKYLOXY SUBSTITUTED i 1H /i -INDOL-3-YL GLYOXYLIC ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1)
CN1747734A (en) * 2003-02-07 2006-03-15 贝林格尔·英格海姆国际有限公司 Use of dipyridamole or monopiper dipyridamole in the treatment and prevention of MMP-9-dependent diseases
JP2006524203A (en) 2003-04-24 2006-10-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Use of dipyridamole or mopidamol for the treatment and prevention of thromboembolic diseases and disorders caused by thrombin over-formation and / or increased expression of thrombin receptor
NZ542797A (en) * 2003-05-16 2007-12-21 Merck Sharp & Dohme Cyclohexyl sulfones comprising an additional fused ring cyclic sulfonamide group suitable for inhibition of gamma-secretase
US7442805B2 (en) * 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7411083B2 (en) * 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7420083B2 (en) * 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7342039B2 (en) * 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
US7351726B2 (en) * 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7332521B2 (en) * 2003-09-25 2008-02-19 Wyeth Substituted indoles
US7163954B2 (en) * 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7446201B2 (en) * 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7265148B2 (en) * 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7582773B2 (en) * 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7141592B2 (en) * 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7534894B2 (en) 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
WO2005035495A2 (en) 2003-10-08 2005-04-21 Nicholas Piramal India Limited Fibrinogen receptor antagonists and their use
JP2007519707A (en) * 2004-02-02 2007-07-19 ファイザー・プロダクツ・インク Histamine-3 receptor modulator
CN101001836B (en) * 2004-05-07 2010-12-22 詹森药业有限公司 Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
CA2577846A1 (en) 2004-08-23 2006-03-02 Wyeth Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1
JP2008510814A (en) * 2004-08-23 2008-04-10 ワイス Pyrrolo-naphthylic acid as a PAI-1 inhibitor
BRPI0514544A (en) * 2004-08-23 2008-06-17 Wyeth Corp oxazol-naphthyl acids as modulators of plasminogen activator inhibitor type-1 (pai-1)
ES2338441T3 (en) * 2004-08-30 2010-05-07 Janssen Pharmaceutica Nv N-2-ADAMANTIL-2-PHENOXY-ACETAMIDE DERIVATIVES AS INHIBITORS OF 11-BETAHYDROXIESTEROID-DEHYDROGENASE.
DE602005017159D1 (en) 2004-08-30 2009-11-26 Janssen Pharmaceutica Nv OXYSTEROID DEHYDROGENASE INHIBITORS
KR101197672B1 (en) * 2004-08-30 2012-11-07 얀센 파마슈티카 엔.브이. Tricyclic Lactam Derivatives as 11-Beta Hydroxysteroid Dehydrogenase Inhibitors
WO2006114096A1 (en) * 2005-04-25 2006-11-02 Danmarks Tekniske Universitet Pyrrolidinone dipeptide analogs and use thereof as artificial sweeteners
BRPI0614340A2 (en) * 2005-08-17 2011-04-12 Wyeth Corp replaced indoles and methods of use
CN101889017B (en) 2007-10-05 2013-11-27 奥克塞拉有限公司 Alkoxylates for the treatment of diseases
NZ585103A (en) * 2007-10-23 2012-04-27 Allergan Inc Substituted lactams derivatives and their uses for glaucoma and ocullar hypertension
EP2448569B1 (en) 2009-07-02 2021-10-27 Acucela, Inc. Pharmacology of visual cycle modulators
US8822679B2 (en) 2011-06-24 2014-09-02 California Institute Of Technology Quaternary heteroatom containing compounds
US20130267699A1 (en) 2011-06-24 2013-10-10 California Institute Of Technology Quaternary heteroatom containing compounds
US9518034B2 (en) 2013-10-14 2016-12-13 California Institute Of Technology Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof
CA2931313C (en) 2013-11-21 2022-04-05 Marquette University Substituted (4'-hydroxyphenyl)cycloalkane compounds and uses thereof as selective agonists of the estrogen receptor beta isoform
US10421696B2 (en) 2014-12-18 2019-09-24 California Institute Of Technology Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation
WO2016160579A1 (en) 2015-03-27 2016-10-06 Stoltz Brian M Asymmetric catalytic decarboxylative alkyl alkylation using low catalyst concentrations and a robust precatalyst
WO2017156239A1 (en) 2016-03-11 2017-09-14 California Institute Of Technology Compositions and methods for acylating lactams
EP3480190B1 (en) 2017-11-01 2023-01-04 California Institute of Technology Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols
EP3699173A1 (en) 2018-10-18 2020-08-26 California Institute of Technology Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247466A (en) * 1979-07-05 1981-01-27 American Cyanamid Company Lactone metabolites of 3-(4-biphenylylcarbonyl)propionic acid
EP0194548A3 (en) * 1985-03-12 1988-08-17 Dr. Karl Thomae GmbH Sulfonylaminoethyl compounds, medicines containing these compounds and process for their preparation
IL78157A (en) * 1985-03-16 1989-08-15 Wellcome Found Aryl derivatives,their preparation and pharmaceutical compositions containing them
DE3823299A1 (en) * 1988-07-07 1990-01-11 Schering Ag SUBSTITUTED PHENYL-PYRROLIDIN-2-ONE, -OXAZOLIDIN-2-ONE AND -IMIDAZOLIDIN-2-ONE, THEIR PRODUCTION AND USE IN MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
HU913455D0 (en) 1992-01-28
JP2937589B2 (en) 1999-08-23
AU8692691A (en) 1992-05-07
IE913822A1 (en) 1992-05-22
HU211563A9 (en) 1995-12-28
IL99926A0 (en) 1992-08-18
US5541343A (en) 1996-07-30
US5591769A (en) 1997-01-07
DE59108930D1 (en) 1998-03-12
GR3026508T3 (en) 1998-07-31
IL99926A (en) 1996-06-18
EE03099B1 (en) 1998-06-15
EP0483667B1 (en) 1998-02-04
SG81852A1 (en) 2001-07-24
NO174806B (en) 1994-04-05
KR100223135B1 (en) 1999-10-15
HK1008742A1 (en) 1999-05-14
MX9203677A (en) 1992-07-01
ES2113867T3 (en) 1998-05-16
DE4035961A1 (en) 1992-05-07
NO174806C (en) 1994-07-13
PT99402B (en) 1999-04-30
FI107606B (en) 2001-09-14
NO914294D0 (en) 1991-11-01
NZ240463A (en) 1997-04-24
DK0483667T3 (en) 1998-09-23
HUT67288A (en) 1995-03-28
PT99402A (en) 1992-09-30
JPH04264068A (en) 1992-09-18
EP0483667A2 (en) 1992-05-06
CA2054850A1 (en) 1992-05-03
NO914294L (en) 1992-05-04
BR1100445A (en) 2000-07-18
BG62025B2 (en) 1998-12-30
EP0483667A3 (en) 1992-09-16
ZA918734B (en) 1993-05-04
KR920009793A (en) 1992-06-25
CA2054850C (en) 2001-01-02
FI915136L (en) 1992-05-03
RU2040519C1 (en) 1995-07-25
AU650488B2 (en) 1994-06-23
ATE163008T1 (en) 1998-02-15

Similar Documents

Publication Publication Date Title
FI915136A0 (en) CYCLISKA IMINODERIVAT, DESSA FOERENINGAR INNEHAOLLANDE LAEKEMEDE OCH FOERFARANDE FOER DERAS FRAMSTAELLNING.
FI923691A0 (en) CYCLISKA IMINODERIVAT, DESSA FOERENINGAR INNEHAOLLANDE PHARMACEUTICAL BLANDNINGAR OCH FOERFARANDE FOER DERAS FRAMSTAELLNING.
FI931880A0 (en) CYCLIC IMINODERIVAT, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE CEE
TW257753B (en)
NO178137C (en) Process for the preparation of a polyprenyl-containing pharmaceutical composition in the form of hard capsules
DE69011174D1 (en) Catecholamine ester.

Legal Events

Date Code Title Description
MA Patent expired