FI915135A - NYA CYCLOSPORINER. - Google Patents

NYA CYCLOSPORINER. Download PDF

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Publication number
FI915135A
FI915135A FI915135A FI915135A FI915135A FI 915135 A FI915135 A FI 915135A FI 915135 A FI915135 A FI 915135A FI 915135 A FI915135 A FI 915135A FI 915135 A FI915135 A FI 915135A
Authority
FI
Finland
Prior art keywords
cyclosporiner
nya
aids
cyclosporins
nonimmunosuppressive
Prior art date
Application number
FI915135A
Other languages
Finnish (fi)
Other versions
FI915135A0 (en
FI111730B (en
Inventor
Soo Young Ko
Hans Kobel
Brigitte Rosenwirth
Dieter Seebach
Rene P Traber
Roland Wenger
Pietro Bollinger
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27517009&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI915135(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB909023859A external-priority patent/GB9023859D0/en
Priority claimed from GB909023972A external-priority patent/GB9023972D0/en
Priority claimed from GB909023970A external-priority patent/GB9023970D0/en
Priority claimed from GB909023971A external-priority patent/GB9023971D0/en
Priority claimed from GB919116836A external-priority patent/GB9116836D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of FI915135A0 publication Critical patent/FI915135A0/en
Publication of FI915135A publication Critical patent/FI915135A/en
Application granted granted Critical
Publication of FI111730B publication Critical patent/FI111730B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Abstract

It has been found that nonimmunosuppressive, cyclophilin-binding cyclosporins are useful in the treatment and prevention of AIDS and AIDS-related disorders. Such cyclosporins include novel Ciclosporin derivatives modified at the 4- and/or 5-positions.
FI915135A 1990-11-02 1991-10-30 A process for the preparation of a non-immunosuppressive cyclosporin FI111730B (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB909023859A GB9023859D0 (en) 1990-11-02 1990-11-02 Chemical products
GB9023859 1990-11-02
GB9023970 1990-11-05
GB909023972A GB9023972D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB9023971 1990-11-05
GB909023970A GB9023970D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB909023971A GB9023971D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB9023972 1990-11-05
GB919116836A GB9116836D0 (en) 1991-08-05 1991-08-05 Organic compounds
GB9116836 1991-08-05

Publications (3)

Publication Number Publication Date
FI915135A0 FI915135A0 (en) 1991-10-30
FI915135A true FI915135A (en) 1992-05-03
FI111730B FI111730B (en) 2003-09-15

Family

ID=27517009

Family Applications (1)

Application Number Title Priority Date Filing Date
FI915135A FI111730B (en) 1990-11-02 1991-10-30 A process for the preparation of a non-immunosuppressive cyclosporin

Country Status (25)

Country Link
US (3) US5767069A (en)
EP (1) EP0484281B2 (en)
JP (1) JP2740775B2 (en)
KR (1) KR100203556B1 (en)
AT (1) ATE148469T1 (en)
AU (1) AU649277B2 (en)
CA (1) CA2054590C (en)
CY (1) CY2159B1 (en)
CZ (1) CZ280909B6 (en)
DE (1) DE69124459T3 (en)
DK (1) DK0484281T4 (en)
ES (1) ES2095926T5 (en)
FI (1) FI111730B (en)
GR (2) GR3022592T3 (en)
HK (1) HK1005741A1 (en)
HU (1) HU212674B (en)
IE (1) IE913824A1 (en)
IL (1) IL99912A (en)
MX (1) MX9101869A (en)
MY (1) MY134806A (en)
NZ (1) NZ240421A (en)
PL (1) PL168609B1 (en)
PT (1) PT99410B (en)
SA (1) SA92120344B1 (en)
SK (1) SK278808B6 (en)

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ATE423130T1 (en) 1997-10-08 2009-03-15 Isotechnika Inc DEUTERATED CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS
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Also Published As

Publication number Publication date
DE69124459D1 (en) 1997-03-13
DE69124459T3 (en) 2001-05-31
ES2095926T5 (en) 2001-02-16
AU8692391A (en) 1992-05-07
IL99912A (en) 1996-09-12
AU649277B2 (en) 1994-05-19
DK0484281T3 (en) 1997-02-17
FI915135A0 (en) 1991-10-30
EP0484281A3 (en) 1993-02-24
US5767069A (en) 1998-06-16
US6255100B1 (en) 2001-07-03
JP2740775B2 (en) 1998-04-15
HU913446D0 (en) 1992-01-28
ES2095926T3 (en) 1997-03-01
IL99912A0 (en) 1992-08-18
MY134806A (en) 2007-12-31
HU212674B (en) 1996-09-30
ATE148469T1 (en) 1997-02-15
DK0484281T4 (en) 2001-02-05
CA2054590C (en) 2003-09-16
CA2054590A1 (en) 1992-05-03
PL292248A1 (en) 1992-07-27
DE69124459T2 (en) 1997-07-10
MX9101869A (en) 1993-04-01
SK278808B6 (en) 1998-03-04
EP0484281A2 (en) 1992-05-06
PT99410A (en) 1992-09-30
PT99410B (en) 1999-04-30
CZ280909B6 (en) 1996-05-15
HK1005741A1 (en) 1999-01-22
EP0484281B2 (en) 2000-11-22
GR3035323T3 (en) 2001-04-30
JPH05208996A (en) 1993-08-20
CY2159B1 (en) 2002-08-23
PL168609B1 (en) 1996-03-29
FI111730B (en) 2003-09-15
EP0484281B1 (en) 1997-01-29
CS329791A3 (en) 1992-05-13
KR920009390A (en) 1992-06-25
KR100203556B1 (en) 1999-06-15
SA92120344B1 (en) 2004-01-24
HUT62337A (en) 1993-04-28
GR3022592T3 (en) 1997-05-31
US5981479A (en) 1999-11-09
IE913824A1 (en) 1992-05-22
NZ240421A (en) 1993-04-28

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