ES2127133A1 - Use of 2,5-dihydroxybenzenesulphonic derivatives for the manufacture of drugs intended for the treatment and prevention of Alzheimer's disease - Google Patents
Use of 2,5-dihydroxybenzenesulphonic derivatives for the manufacture of drugs intended for the treatment and prevention of Alzheimer's diseaseInfo
- Publication number
- ES2127133A1 ES2127133A1 ES09700827A ES9700827A ES2127133A1 ES 2127133 A1 ES2127133 A1 ES 2127133A1 ES 09700827 A ES09700827 A ES 09700827A ES 9700827 A ES9700827 A ES 9700827A ES 2127133 A1 ES2127133 A1 ES 2127133A1
- Authority
- ES
- Spain
- Prior art keywords
- dihydroxybenzenesulphonic
- alzheimer
- disease
- derivatives
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Use of 2,5-dihydroxybenzenesulphonic derivatives of general formula I, in which R represents H or SO-3 B represents Ca++ or H2N+ (C2H5)2 n represents 1 or 2 and m represents 1 or 2, for the manufacture of drugs intended to prevent the formation of the amyloid protein associated with Alzheimer's disease.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9604181 | 1996-04-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2127133A1 true ES2127133A1 (en) | 1999-04-01 |
ES2127133B1 ES2127133B1 (en) | 1999-12-01 |
Family
ID=9490864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9700827A Expired - Fee Related ES2127133B1 (en) | 1996-04-03 | 1997-04-03 | USE OF 2,5-DIHYDROXYBENZENOSPHONE DERIVATIVES FOR THE MANUFACTURE OF MEDICINES INTENDED FOR THE TREATMENT AND PREVENTION OF ALZHEIMER DISEASE. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2127133B1 (en) |
-
1997
- 1997-04-03 ES ES9700827A patent/ES2127133B1/en not_active Expired - Fee Related
Non-Patent Citations (5)
Title |
---|
FRASER et al. Effects of sulfate ions on Alzheimer beta/A4 Peptide Assemblies: Implications for Amyloid Fibril-Proteoglycan Interactions. Journal of Neurochemistry, 1992, Vol. 59, no 4, paginas 1531-1540. * |
KISILEVSKY et al. Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease. Nature Medicine, Vol. 1, no 2, Febrero 1995, paginas 143-148, resumen y discusion. * |
LEVEUGLE et al. Binding of heparan sulfate glycosaminoglycan to beta-amyloid peptide: inhibition by potentially therapeutic polysulfated compounds. Neuroreport, Vol. 5, no 11, 27 Junio 1994, paginas 1389-1392. * |
NARINDRASORASAK et al. High Affinity Interactions between the Alzheimer's beta-amyloid precursor proteins and the basement Membrane form of heparan sulfate proteoglycan. Journal of Biological Chemistry, Vol. 266, no 20, 1991, paginas 12878-12883. * |
SNOW et al. Proteoglycans in the Pathogenesis of Alzheimer's Disease and other Amyloidoses. Neurobiology of Aging, Vol. 10, 1989, paginas 481-497. * |
Also Published As
Publication number | Publication date |
---|---|
ES2127133B1 (en) | 1999-12-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19990401 Kind code of ref document: A1 Effective date: 19990401 |
|
FD1A | Patent lapsed |
Effective date: 20020401 |