FI910894A - Process for the preparation of therapeutically useful N-cycloalkylalkylamines - Google Patents

Process for the preparation of therapeutically useful N-cycloalkylalkylamines Download PDF

Info

Publication number
FI910894A
FI910894A FI910894A FI910894A FI910894A FI 910894 A FI910894 A FI 910894A FI 910894 A FI910894 A FI 910894A FI 910894 A FI910894 A FI 910894A FI 910894 A FI910894 A FI 910894A
Authority
FI
Finland
Prior art keywords
cycloalkylalkylamines
preparation
therapeutically useful
lower alkyl
thienyl
Prior art date
Application number
FI910894A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI910894A0 (en
FI97384B (en
FI97384C (en
Inventor
Gilbert Aubard
Alain Calvet
Jean-Pierre Defaux
Claude-Jean Gouret
Agnes Grouhel
James Hudspeth
Henri Jacobelli
Jean-Louis Junien
Xavier Pascaud
Francois Roman
Lin Yuan
Original Assignee
Jouveinal Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/484,403 external-priority patent/US5034419A/en
Priority claimed from FR9002494A external-priority patent/FR2658822A1/en
Application filed by Jouveinal Sa filed Critical Jouveinal Sa
Publication of FI910894A0 publication Critical patent/FI910894A0/en
Publication of FI910894A publication Critical patent/FI910894A/en
Publication of FI97384B publication Critical patent/FI97384B/en
Application granted granted Critical
Publication of FI97384C publication Critical patent/FI97384C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

N-Cycloalkylalkylamines of general formula (I) <IMAGE> in which: R1 is a furyl or thienyl radical or is a phenyl radical, provided that Q denotes a 1,2-cyclopropanediyl group, R2 is lower alkyl, R3 is hydrogen or lower alkyl, m has the value 1 or 2, R4 is cycloalkyl -CH(CH2)n, in which n is an integer from 2 to 5, R5 is optionally substituted phenyl or thienyl, Q is 1,2-ethylenediyl or 1,2-cyclopropanediyl, and their addition salts with acids. These amines are psychotropic medications and are also useful in gastroenterology.
FI910894A 1990-02-26 1991-02-25 Process for the preparation of therapeutically useful N-cycloalkylalkylamines FI97384C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US48440390 1990-02-26
US07/484,403 US5034419A (en) 1988-09-01 1990-02-26 N-cycloalkylalkylamines, process for their preparation, their use as medicament and their synthesis intermediates
FR9002494A FR2658822A1 (en) 1990-02-28 1990-02-28 N-Cycloalkylalkylamines, process for their preparation, their use as medicaments and their synthetic intermediates
FR9002494 1990-02-28

Publications (4)

Publication Number Publication Date
FI910894A0 FI910894A0 (en) 1991-02-25
FI910894A true FI910894A (en) 1991-08-27
FI97384B FI97384B (en) 1996-08-30
FI97384C FI97384C (en) 1996-12-10

Family

ID=26227891

Family Applications (1)

Application Number Title Priority Date Filing Date
FI910894A FI97384C (en) 1990-02-26 1991-02-25 Process for the preparation of therapeutically useful N-cycloalkylalkylamines

Country Status (14)

Country Link
EP (1) EP0445013B1 (en)
JP (1) JP2899429B2 (en)
AT (1) ATE106879T1 (en)
AU (1) AU633695B2 (en)
CA (1) CA2037114C (en)
DE (1) DE69102309T2 (en)
DK (1) DK0445013T3 (en)
ES (1) ES2054452T3 (en)
FI (1) FI97384C (en)
HU (1) HU215430B (en)
IE (1) IE66180B1 (en)
IL (1) IL97354A (en)
NZ (1) NZ237224A (en)
PT (1) PT96885B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849760A (en) * 1993-12-09 1998-12-15 Institut De Recherche Jouveinal 2-(arylalkenyl)azacycloalkane derivatives as ligands for sigma receptors
GB9405392D0 (en) * 1994-03-18 1994-05-04 Secr Defence Microorganism detection apparatus and method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS584748A (en) * 1981-06-30 1983-01-11 Takasago Corp Preparation of enamine or imine
IL86740A (en) * 1987-06-30 1992-11-15 Tanabe Seiyaku Co Thiphene derivatives,their preparation and pharmaceutical compositions containing them
JPS6416778A (en) * 1987-07-09 1989-01-20 Tanabe Seiyaku Co Thiophene derivative

Also Published As

Publication number Publication date
JP2899429B2 (en) 1999-06-02
HU215430B (en) 1999-09-28
DE69102309T2 (en) 1994-09-15
HUT62284A (en) 1993-04-28
FI910894A0 (en) 1991-02-25
DE69102309D1 (en) 1994-07-14
FI97384B (en) 1996-08-30
AU633695B2 (en) 1993-02-04
IE910620A1 (en) 1991-08-28
IL97354A (en) 1995-12-08
EP0445013A1 (en) 1991-09-04
EP0445013B1 (en) 1994-06-08
AU7134091A (en) 1991-08-29
CA2037114A1 (en) 1991-08-27
PT96885A (en) 1991-10-31
NZ237224A (en) 1992-05-26
FI97384C (en) 1996-12-10
CA2037114C (en) 2003-09-09
HU910625D0 (en) 1991-09-30
IE66180B1 (en) 1995-12-13
ES2054452T3 (en) 1994-08-01
DK0445013T3 (en) 1994-07-11
JPH0616598A (en) 1994-01-25
IL97354A0 (en) 1992-05-25
ATE106879T1 (en) 1994-06-15
PT96885B (en) 1998-07-31

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Legal Events

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BB Publication of examined application