FI903701A0 - RENINHAEMMANDE AMINO-OLIGOHYDROXIDERIVAT. - Google Patents

RENINHAEMMANDE AMINO-OLIGOHYDROXIDERIVAT.

Info

Publication number
FI903701A0
FI903701A0 FI903701A FI903701A FI903701A0 FI 903701 A0 FI903701 A0 FI 903701A0 FI 903701 A FI903701 A FI 903701A FI 903701 A FI903701 A FI 903701A FI 903701 A0 FI903701 A0 FI 903701A0
Authority
FI
Finland
Prior art keywords
reninhaemmande
oligohydroxiderivat
amino
medicines
compounds
Prior art date
Application number
FI903701A
Other languages
Finnish (fi)
Inventor
Heinz-Werner Kleemann
Hansjoerg Urbach
Adalbert Wagner
Dieter Ruppert
Wolfgang Linz
Werner Kramer
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3924506A external-priority patent/DE3924506A1/en
Priority claimed from DE19893932817 external-priority patent/DE3932817A1/en
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI903701A0 publication Critical patent/FI903701A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Abstract

The present invention relates to compounds of the formula I <IMAGE> in which A, R<2>, R<3>, R<4> and n are defined as indicated in the description, to processes for the preparation thereof, to the use thereof as medicines and to pharmaceutical compositions containing these.
FI903701A 1989-07-25 1990-07-23 RENINHAEMMANDE AMINO-OLIGOHYDROXIDERIVAT. FI903701A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3924506A DE3924506A1 (en) 1989-07-25 1989-07-25 New poly:hydroxy:amide derivs.
DE19893932817 DE3932817A1 (en) 1989-09-30 1989-09-30 New poly:hydroxy:amide derivs.

Publications (1)

Publication Number Publication Date
FI903701A0 true FI903701A0 (en) 1990-07-23

Family

ID=25883333

Family Applications (1)

Application Number Title Priority Date Filing Date
FI903701A FI903701A0 (en) 1989-07-25 1990-07-23 RENINHAEMMANDE AMINO-OLIGOHYDROXIDERIVAT.

Country Status (20)

Country Link
EP (1) EP0410278B1 (en)
JP (1) JPH0366652A (en)
KR (1) KR910002776A (en)
CN (1) CN1049164A (en)
AT (1) ATE100463T1 (en)
AU (1) AU639246B2 (en)
CA (1) CA2021822A1 (en)
CS (1) CS368890A3 (en)
DE (1) DE59004292D1 (en)
DK (1) DK0410278T3 (en)
ES (1) ES2062214T3 (en)
FI (1) FI903701A0 (en)
HU (1) HU205140B (en)
IE (1) IE902686A1 (en)
IL (1) IL95166A0 (en)
MA (1) MA21913A1 (en)
NO (1) NO903291L (en)
NZ (1) NZ234608A (en)
PL (1) PL286188A1 (en)
PT (1) PT94798A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW209870B (en) * 1990-01-18 1993-07-21 Pfizer
IE68045B1 (en) * 1990-05-11 1996-05-15 Abbott Lab Renin inhibitors
JPH06500561A (en) * 1990-08-24 1994-01-20 ジ・アップジョン・カンパニー Aminopolyol-containing peptides as transition state mimetics
EP0483403A1 (en) * 1990-10-31 1992-05-06 Hoechst Aktiengesellschaft Derivatives of amino acids as inhibitors of renin, methods for their preparation, medicaments containing them and their use
AU4686401A (en) * 2000-04-10 2001-10-23 Yuichi Ishida Hypotensors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK34086A (en) * 1985-01-23 1986-07-24 Abbott Lab PEPTIDYLAMINODIOLS
NZ218937A (en) * 1986-01-16 1990-03-27 Abbott Lab Functionalised peptidyl aminodiols and -triols as renin inhibitors and pharmaceutical compositions
US4863905A (en) * 1987-02-04 1989-09-05 Warner-Lambert Company Renin inhibitors II

Also Published As

Publication number Publication date
NO903291L (en) 1991-01-28
PT94798A (en) 1991-03-20
HU205140B (en) 1992-03-30
MA21913A1 (en) 1991-04-01
CA2021822A1 (en) 1991-01-26
NO903291D0 (en) 1990-07-24
DK0410278T3 (en) 1994-05-24
AU5971990A (en) 1991-01-31
DE59004292D1 (en) 1994-03-03
EP0410278A1 (en) 1991-01-30
CS368890A3 (en) 1992-02-19
PL286188A1 (en) 1991-04-22
JPH0366652A (en) 1991-03-22
IE902686A1 (en) 1991-02-27
CN1049164A (en) 1991-02-13
ES2062214T3 (en) 1994-12-16
IL95166A0 (en) 1991-06-10
AU639246B2 (en) 1993-07-22
HU904582D0 (en) 1990-12-28
EP0410278B1 (en) 1994-01-19
ATE100463T1 (en) 1994-02-15
NZ234608A (en) 1991-12-23
KR910002776A (en) 1991-02-26
HUT55033A (en) 1991-04-29

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Legal Events

Date Code Title Description
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Owner name: HOECHST AKTIENGESELLSCHAFT