FI900226A0 - NYTT FOERFARANDE FOER FRAMSTAELLNING AV ETT FENYLPROPIONDERIVAT. - Google Patents

NYTT FOERFARANDE FOER FRAMSTAELLNING AV ETT FENYLPROPIONDERIVAT.

Info

Publication number
FI900226A0
FI900226A0 FI900226A FI900226A FI900226A0 FI 900226 A0 FI900226 A0 FI 900226A0 FI 900226 A FI900226 A FI 900226A FI 900226 A FI900226 A FI 900226A FI 900226 A0 FI900226 A0 FI 900226A0
Authority
FI
Finland
Prior art keywords
fenylpropionderivat
ett
acids
foerfarande foer
foer framstaellning
Prior art date
Application number
FI900226A
Other languages
Finnish (fi)
Other versions
FI101960B (en
FI101960B1 (en
Inventor
Claude Perrin
Original Assignee
Bouchara Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bouchara Sa filed Critical Bouchara Sa
Publication of FI900226A0 publication Critical patent/FI900226A0/en
Application granted granted Critical
Publication of FI101960B publication Critical patent/FI101960B/en
Publication of FI101960B1 publication Critical patent/FI101960B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
    • C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The invention relates to the field of organic chemistry, and more specifically to the synthesis of phenylpropionic acids. Its specific subject is a new process for the preparation of 2-[4-(R-amino)phenyl]propionic acids of general formula I <IMAGE> which consists in subjecting a 2-(4-aminophenyl)propionic derivative of formula II <IMAGE> in which R1 is hydrogen or a C1-C6 alkyl radical, to the action of an alkylating agent in a heterogeneous phase in the presence of a phase transfer catalyst and a basic agent in an aqueous medium. The acids obtained are active principles of medicaments.
FI900226A 1989-01-16 1990-01-15 Process for the preparation of a phenylpropionic acid derivative FI101960B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8900522A FR2642752B1 (en) 1989-01-16 1989-01-16 NEW PROCESS FOR OBTAINING A PROPIONIC PHENYL ACID
FR8900522 1989-01-16

Publications (3)

Publication Number Publication Date
FI900226A0 true FI900226A0 (en) 1990-01-15
FI101960B FI101960B (en) 1998-09-30
FI101960B1 FI101960B1 (en) 1998-09-30

Family

ID=9377804

Family Applications (1)

Application Number Title Priority Date Filing Date
FI900226A FI101960B1 (en) 1989-01-16 1990-01-15 Process for the preparation of a phenylpropionic acid derivative

Country Status (12)

Country Link
EP (1) EP0379423B1 (en)
JP (1) JP2852393B2 (en)
KR (1) KR0177151B1 (en)
CN (1) CN1042330C (en)
AT (1) ATE90934T1 (en)
DE (1) DE69002011T2 (en)
DK (1) DK0379423T3 (en)
ES (1) ES2058828T3 (en)
FI (1) FI101960B1 (en)
FR (1) FR2642752B1 (en)
IE (1) IE65258B1 (en)
PT (1) PT92873B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102206150A (en) * 2011-04-11 2011-10-05 启东东岳药业有限公司 Method for purifying 2-phenylpropionic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH538449A (en) * 1967-07-22 1973-06-30 Merck Patent Gmbh Process for the preparation of aminophenylacetic acid derivatives
DE1913742A1 (en) * 1968-03-27 1969-10-09 Ciba Geigy Tertiary aliphatic amino acids
FR2137211B1 (en) 1971-05-17 1974-08-02 Bouchara Emile
FR2193579A2 (en) * 1972-07-25 1974-02-22 Bouchara Emile Para amino phenyl acetic acids - analgesics and antiinflammatories, prepd. by alkylation of prim amino acid

Also Published As

Publication number Publication date
EP0379423A1 (en) 1990-07-25
PT92873A (en) 1990-07-31
JP2852393B2 (en) 1999-02-03
EP0379423B1 (en) 1993-06-23
DK0379423T3 (en) 1993-11-15
IE900164L (en) 1990-07-16
ATE90934T1 (en) 1993-07-15
IE65258B1 (en) 1995-10-18
ES2058828T3 (en) 1994-11-01
DE69002011D1 (en) 1993-07-29
KR0177151B1 (en) 1999-04-15
FI101960B (en) 1998-09-30
FR2642752A1 (en) 1990-08-10
KR900011712A (en) 1990-08-02
JPH02262547A (en) 1990-10-25
PT92873B (en) 1995-12-29
CN1042330C (en) 1999-03-03
DE69002011T2 (en) 1993-12-23
FI101960B1 (en) 1998-09-30
CN1058206A (en) 1992-01-29
FR2642752B1 (en) 1991-04-12

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: BOUCHARA S.A.