FI895288A0 - 1,2,3,4-tetrahydro-1,9-akridinaminer, foerfarande foer deras framstaellning och deras anvaendning som laekemedel. - Google Patents
1,2,3,4-tetrahydro-1,9-akridinaminer, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.Info
- Publication number
- FI895288A0 FI895288A0 FI895288A FI895288A FI895288A0 FI 895288 A0 FI895288 A0 FI 895288A0 FI 895288 A FI895288 A FI 895288A FI 895288 A FI895288 A FI 895288A FI 895288 A0 FI895288 A0 FI 895288A0
- Authority
- FI
- Finland
- Prior art keywords
- deras
- acridinaminer
- tetrahydro
- arylloweralkyl
- loweralkyl
- Prior art date
Links
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000007074 memory dysfunction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/269,038 US4868177A (en) | 1988-11-09 | 1988-11-09 | 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI895288A0 true FI895288A0 (fi) | 1989-11-07 |
Family
ID=23025549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI895288A FI895288A0 (fi) | 1988-11-09 | 1989-11-07 | 1,2,3,4-tetrahydro-1,9-akridinaminer, foerfarande foer deras framstaellning och deras anvaendning som laekemedel. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4868177A (fr) |
| EP (1) | EP0368188B1 (fr) |
| JP (1) | JPH03153667A (fr) |
| KR (1) | KR900007808A (fr) |
| AT (1) | ATE111899T1 (fr) |
| AU (1) | AU623701B2 (fr) |
| CA (1) | CA2002531A1 (fr) |
| DE (1) | DE68918402T2 (fr) |
| DK (1) | DK166620B1 (fr) |
| ES (1) | ES2059677T3 (fr) |
| FI (1) | FI895288A0 (fr) |
| HU (1) | HU208530B (fr) |
| IE (1) | IE64499B1 (fr) |
| IL (1) | IL92233A0 (fr) |
| NO (1) | NO894445L (fr) |
| NZ (1) | NZ231293A (fr) |
| PT (1) | PT92234B (fr) |
| ZA (1) | ZA898498B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH25124A (en) * | 1987-03-17 | 1991-02-19 | Hoechst Roussel Pharma | Substituted 9-amino-tetrahydro acridines and related compounds |
| US6075144A (en) | 1987-04-20 | 2000-06-13 | Hoechst Marion Roussel, Inc. | 9-hydroxyamino tetrahydroacridine and related compounds |
| US4970316A (en) * | 1987-05-07 | 1990-11-13 | American Home Products Corporation | Pyrano-, thiopyrano- and cyclohexylquinolines as inhibitors of interleukin 1 |
| US5053513A (en) * | 1990-03-29 | 1991-10-01 | Hoechst-Roussel Pharmaceuticals Incorporated | Method of reducing a carbonyl containing acridine |
| US5783584A (en) * | 1995-12-11 | 1998-07-21 | Mayo Foundation For Medical Education And Research | THA analogs useful as cholinesterase inhibitors |
| US5929093A (en) * | 1996-06-13 | 1999-07-27 | Mayo Foundation For Medical Education And Research | Bifunctional acetylcholinesterase reactivators |
| WO2000018391A1 (fr) | 1998-09-30 | 2000-04-06 | Takeda Chemical Industries, Ltd. | Medicaments qui ameliorent le pouvoir de vidange de la vessie |
| UY28538A1 (es) | 2003-09-26 | 2005-04-29 | Vertex Pharma | Derivados de fenil-piperazina como moduladores de receptores muscarínicos |
| US20050222123A1 (en) | 2004-01-27 | 2005-10-06 | North Shore-Long Island Jewish Research Institute | Cholinesterase inhibitors for treating inflammation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695573A (en) * | 1984-10-25 | 1987-09-22 | Hoechst-Roussel Pharmaceuticals Inc. | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds |
| DK569087A (da) * | 1986-10-31 | 1988-05-01 | Sumitomo Pharma | Quinolin-derivater, deres fremstilling og anvendelse |
| PH25124A (en) * | 1987-03-17 | 1991-02-19 | Hoechst Roussel Pharma | Substituted 9-amino-tetrahydro acridines and related compounds |
| US5013741A (en) * | 1987-09-08 | 1991-05-07 | Hoechst-Roussel Pharmaceuticals Incorporated | N-[substituted alkylidene]-1,2,3,4-tetrahydro-9-acridinamines useful for enhancing the cholinergic function in a mammal |
| IL87861A0 (en) * | 1987-10-05 | 1989-03-31 | Pfizer | 4-aminopyridine derivatives |
-
1988
- 1988-11-09 US US07/269,038 patent/US4868177A/en not_active Expired - Lifetime
-
1989
- 1989-11-06 DE DE68918402T patent/DE68918402T2/de not_active Expired - Fee Related
- 1989-11-06 ES ES89120463T patent/ES2059677T3/es not_active Expired - Lifetime
- 1989-11-06 AT AT89120463T patent/ATE111899T1/de not_active IP Right Cessation
- 1989-11-06 EP EP89120463A patent/EP0368188B1/fr not_active Expired - Lifetime
- 1989-11-07 KR KR1019890016064A patent/KR900007808A/ko not_active Application Discontinuation
- 1989-11-07 NZ NZ231293A patent/NZ231293A/xx unknown
- 1989-11-07 IL IL92233A patent/IL92233A0/xx unknown
- 1989-11-07 FI FI895288A patent/FI895288A0/fi not_active Application Discontinuation
- 1989-11-07 AU AU44423/89A patent/AU623701B2/en not_active Ceased
- 1989-11-08 JP JP1288977A patent/JPH03153667A/ja active Pending
- 1989-11-08 PT PT92234A patent/PT92234B/pt not_active IP Right Cessation
- 1989-11-08 IE IE359289A patent/IE64499B1/en not_active IP Right Cessation
- 1989-11-08 HU HU895830A patent/HU208530B/hu not_active IP Right Cessation
- 1989-11-08 ZA ZA898498A patent/ZA898498B/xx unknown
- 1989-11-08 CA CA002002531A patent/CA2002531A1/fr not_active Abandoned
- 1989-11-08 DK DK557189A patent/DK166620B1/da not_active IP Right Cessation
- 1989-11-08 NO NO89894445A patent/NO894445L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO894445D0 (no) | 1989-11-08 |
| AU623701B2 (en) | 1992-05-21 |
| KR900007808A (ko) | 1990-06-02 |
| PT92234A (pt) | 1990-05-31 |
| ZA898498B (en) | 1990-08-29 |
| ES2059677T3 (es) | 1994-11-16 |
| DE68918402T2 (de) | 1995-03-09 |
| US4868177A (en) | 1989-09-19 |
| DK557189D0 (da) | 1989-11-08 |
| DK166620B1 (da) | 1993-06-21 |
| ATE111899T1 (de) | 1994-10-15 |
| HU208530B (en) | 1993-11-29 |
| NO894445L (no) | 1990-05-10 |
| AU4442389A (en) | 1990-05-17 |
| CA2002531A1 (fr) | 1990-05-09 |
| EP0368188A1 (fr) | 1990-05-16 |
| NZ231293A (en) | 1991-09-25 |
| DK557189A (da) | 1990-05-30 |
| IE893592L (en) | 1990-05-09 |
| IL92233A0 (en) | 1990-07-26 |
| HU895830D0 (en) | 1990-01-28 |
| JPH03153667A (ja) | 1991-07-01 |
| PT92234B (pt) | 1995-07-06 |
| EP0368188B1 (fr) | 1994-09-21 |
| IE64499B1 (en) | 1995-08-09 |
| DE68918402D1 (de) | 1994-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed | ||
| FD | Application lapsed |
Owner name: HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED |