ES2059677T3 - 1,2,3,4-tetrahidro-1,9-acridindiaminas, un procedimiento para su preparacion y su uso como medicamentos. - Google Patents

1,2,3,4-tetrahidro-1,9-acridindiaminas, un procedimiento para su preparacion y su uso como medicamentos.

Info

Publication number
ES2059677T3
ES2059677T3 ES89120463T ES89120463T ES2059677T3 ES 2059677 T3 ES2059677 T3 ES 2059677T3 ES 89120463 T ES89120463 T ES 89120463T ES 89120463 T ES89120463 T ES 89120463T ES 2059677 T3 ES2059677 T3 ES 2059677T3
Authority
ES
Spain
Prior art keywords
rent
medicines
acridindiaminas
tetrahidro
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89120463T
Other languages
English (en)
Inventor
Gregory Michael Shutske
Kevin James Kapples
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2059677T3 publication Critical patent/ES2059677T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Abstract

SE DESCUBREN COMPUESTOS TENIENDO LA FORMULA DONDE N ES 1,2 O 3; X ES HIDROGENO, ALQUILO INFERIOR, HALOGENO, HIDROXILO, NITROGENO O TRIFLUOROMETILO; R1 Y R2 SON CADA UNO INDEPENDIENTEMENTE HIDROGENO, ALQUILO INFERIOR O ARILO ALQUILO INFERIOR, PERO AMBOS NO PUEDEN SER ARILO ALQUILO INFERIOR SIMULTANEAMENTE; R3 Y R4 SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO INFERIOR, ARILO ALQUILO INFERIOR, FORMILO O ALQUILO INFERIOR CARBONILO, O ALTERNATIVAMENTE EL GRUPO -NR3R4 TOMADO EN SU TOTALIDAD CONSTITUYE ESTEREO ISOMEROS DE ELLOS Y SALES DE ADICCION ACIDA FARMACEUTICAMENTE ACEPTABLES DE ELLOS Y UN PROCESO PARA SU PREPARACION. LOS COMPUESTOS SE USAN PARA EL TRATAMIENTO DE VARIAS DISFUNCIONES DE MEMORIA CARACTERIZADAS POR REDUCCION DE LA FUNCION DEL COMPLEJO DE LA VITAMINA B, TALES COMO EL MAL DE ALZHEIMER, Y ADEMAS PUEDE, SER USADA COMO MEDICAMENTOS.
ES89120463T 1988-11-09 1989-11-06 1,2,3,4-tetrahidro-1,9-acridindiaminas, un procedimiento para su preparacion y su uso como medicamentos. Expired - Lifetime ES2059677T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/269,038 US4868177A (en) 1988-11-09 1988-11-09 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use

Publications (1)

Publication Number Publication Date
ES2059677T3 true ES2059677T3 (es) 1994-11-16

Family

ID=23025549

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89120463T Expired - Lifetime ES2059677T3 (es) 1988-11-09 1989-11-06 1,2,3,4-tetrahidro-1,9-acridindiaminas, un procedimiento para su preparacion y su uso como medicamentos.

Country Status (18)

Country Link
US (1) US4868177A (es)
EP (1) EP0368188B1 (es)
JP (1) JPH03153667A (es)
KR (1) KR900007808A (es)
AT (1) ATE111899T1 (es)
AU (1) AU623701B2 (es)
CA (1) CA2002531A1 (es)
DE (1) DE68918402T2 (es)
DK (1) DK166620B1 (es)
ES (1) ES2059677T3 (es)
FI (1) FI895288A0 (es)
HU (1) HU208530B (es)
IE (1) IE64499B1 (es)
IL (1) IL92233A0 (es)
NO (1) NO894445L (es)
NZ (1) NZ231293A (es)
PT (1) PT92234B (es)
ZA (1) ZA898498B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25124A (en) * 1987-03-17 1991-02-19 Hoechst Roussel Pharma Substituted 9-amino-tetrahydro acridines and related compounds
US6075144A (en) 1987-04-20 2000-06-13 Hoechst Marion Roussel, Inc. 9-hydroxyamino tetrahydroacridine and related compounds
US4970316A (en) * 1987-05-07 1990-11-13 American Home Products Corporation Pyrano-, thiopyrano- and cyclohexylquinolines as inhibitors of interleukin 1
US5053513A (en) * 1990-03-29 1991-10-01 Hoechst-Roussel Pharmaceuticals Incorporated Method of reducing a carbonyl containing acridine
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
US5929093A (en) * 1996-06-13 1999-07-27 Mayo Foundation For Medical Education And Research Bifunctional acetylcholinesterase reactivators
WO2000018391A1 (fr) 1998-09-30 2000-04-06 Takeda Chemical Industries, Ltd. Medicaments qui ameliorent le pouvoir de vidange de la vessie
UY28538A1 (es) 2003-09-26 2005-04-29 Vertex Pharma Derivados de fenil-piperazina como moduladores de receptores muscarínicos
US20050222123A1 (en) 2004-01-27 2005-10-06 North Shore-Long Island Jewish Research Institute Cholinesterase inhibitors for treating inflammation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
DK569087A (da) * 1986-10-31 1988-05-01 Sumitomo Pharma Quinolin-derivater, deres fremstilling og anvendelse
PH25124A (en) * 1987-03-17 1991-02-19 Hoechst Roussel Pharma Substituted 9-amino-tetrahydro acridines and related compounds
US5013741A (en) * 1987-09-08 1991-05-07 Hoechst-Roussel Pharmaceuticals Incorporated N-[substituted alkylidene]-1,2,3,4-tetrahydro-9-acridinamines useful for enhancing the cholinergic function in a mammal
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives

Also Published As

Publication number Publication date
NO894445D0 (no) 1989-11-08
AU623701B2 (en) 1992-05-21
KR900007808A (ko) 1990-06-02
PT92234A (pt) 1990-05-31
ZA898498B (en) 1990-08-29
DE68918402T2 (de) 1995-03-09
US4868177A (en) 1989-09-19
DK557189D0 (da) 1989-11-08
FI895288A0 (fi) 1989-11-07
DK166620B1 (da) 1993-06-21
ATE111899T1 (de) 1994-10-15
HU208530B (en) 1993-11-29
NO894445L (no) 1990-05-10
AU4442389A (en) 1990-05-17
CA2002531A1 (en) 1990-05-09
EP0368188A1 (en) 1990-05-16
NZ231293A (en) 1991-09-25
DK557189A (da) 1990-05-30
IE893592L (en) 1990-05-09
IL92233A0 (en) 1990-07-26
HU895830D0 (en) 1990-01-28
JPH03153667A (ja) 1991-07-01
PT92234B (pt) 1995-07-06
EP0368188B1 (en) 1994-09-21
IE64499B1 (en) 1995-08-09
DE68918402D1 (de) 1994-10-27

Similar Documents

Publication Publication Date Title
ES2104572T3 (es) N-aminocarbamatos afines a la fisostigmina, un procedimiento para su preparacion y su uso como medicamentos.
ES2061684T3 (es) Compuestos de benzoxazina y su uso farmaceutico.
NO931635L (no) Fremgangsmaate for fremstilling av kinazolin-derivater
NO20000313D0 (no) Nye forbindelser
NO173998C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater
ES2059677T3 (es) 1,2,3,4-tetrahidro-1,9-acridindiaminas, un procedimiento para su preparacion y su uso como medicamentos.
NO179612C (no) Analogifremgangsmåte for fremstilling av 3-arylkarbonyl-1-aminoalkyl-1H-indol-forbindelser
ES2037670T3 (es) Procedimiento para la preparacion de complejos de (2,2-bis(aminometil)-1,3-propanodiol-n,n') platino.
DE3752109T2 (de) Entzündungshemmende Mittel
SE8505887D0 (sv) Indoler
TR199901381A2 (xx) Diaza-spiro$3,5]nonan t�revleri.
SE9702563D0 (sv) Compounds
SE8700555D0 (sv) Purine derivatives, their production and medicaments containing them
TR199801949T2 (xx) Ast�m� tedavi edici ve ba����kl�k bast�r�c� maddeler olarak yeni spesifik imm�nofilin ligandlar.
NO870398D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive organiskeplatinakomplekser.
HUT45505A (en) Process for producing n-acylated derivatives of 9,10-anthracenedicarboxaldehide-bis(2-imidazolin-2-yl-hydrazole and pharmaceutics comprising the same as active ingredient

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 368188

Country of ref document: ES