FI893046A - MINI-PROINSULIN, DESS FRAMSTAELLNING OCH ANVAENDNING. - Google Patents

MINI-PROINSULIN, DESS FRAMSTAELLNING OCH ANVAENDNING. Download PDF

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Publication number
FI893046A
FI893046A FI893046A FI893046A FI893046A FI 893046 A FI893046 A FI 893046A FI 893046 A FI893046 A FI 893046A FI 893046 A FI893046 A FI 893046A FI 893046 A FI893046 A FI 893046A
Authority
FI
Finland
Prior art keywords
proinsulin
mini
insulin
framstaellning och
dess framstaellning
Prior art date
Application number
FI893046A
Other languages
Finnish (fi)
Other versions
FI102076B1 (en
FI893046A0 (en
FI102076B (en
Inventor
Michael Doerschug
Paul Habermann
Gerhard Seipke
Eugen Uhlmann
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI893046A0 publication Critical patent/FI893046A0/en
Publication of FI893046A publication Critical patent/FI893046A/en
Application granted granted Critical
Publication of FI102076B1 publication Critical patent/FI102076B1/en
Publication of FI102076B publication Critical patent/FI102076B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A mini-proinsulin in which the A and B chains are linked by the amino acid Arg in place of the C chain has insulin activity and is suitable for producing medicaments for the treatment of diabetes mellitus. It can also be converted straightforwardly with trypsin into an insulin derivative whose B chain is extended by Arg. The latter can be converted with carboxypeptidase B into insulin. However, it is also possible and advantageous to convert the mini-proinsulin directly into insulin in a one-pot process.
FI893046A 1988-06-23 1989-06-21 Method for the preparation of mini-proinsulin and insulin FI102076B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3821159 1988-06-23
DE3821159 1988-06-23

Publications (4)

Publication Number Publication Date
FI893046A0 FI893046A0 (en) 1989-06-21
FI893046A true FI893046A (en) 1989-12-24
FI102076B1 FI102076B1 (en) 1998-10-15
FI102076B FI102076B (en) 1998-10-15

Family

ID=6357053

Family Applications (1)

Application Number Title Priority Date Filing Date
FI893046A FI102076B (en) 1988-06-23 1989-06-21 Method for the preparation of mini-proinsulin and insulin

Country Status (18)

Country Link
EP (1) EP0347781B1 (en)
JP (1) JP3043764B2 (en)
KR (1) KR0139629B1 (en)
AT (1) ATE101620T1 (en)
AU (1) AU611303B2 (en)
CA (1) CA1341211C (en)
DE (1) DE58906966D1 (en)
DK (1) DK175182B1 (en)
ES (1) ES2061797T3 (en)
FI (1) FI102076B (en)
HK (1) HK1006023A1 (en)
HU (3) HUT52548A (en)
IE (1) IE62511B1 (en)
IL (1) IL90694A (en)
NO (1) NO302376B1 (en)
NZ (1) NZ229645A (en)
PT (1) PT90939B (en)
ZA (1) ZA894742B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885163A (en) * 1987-02-24 1989-12-05 Eli Lilly And Company Topical use of IGF-II for wound healing
US5358857A (en) * 1989-08-29 1994-10-25 The General Hospital Corp. Method of preparing fusion proteins
US5227293A (en) * 1989-08-29 1993-07-13 The General Hospital Corporation Fusion proteins, their preparation and use
KR100188800B1 (en) 1990-09-05 1999-06-01 이센브룩, 라피세 Enzymatic process for the conversion of preproinsulins into insulins
ZA928916B (en) * 1991-11-26 1994-05-18 Lilly Co Eli Tri-arginine insulins
SG46612A1 (en) 1992-12-02 1998-02-20 Hoechst Ag Process for obtaining proinsulin in processing correctly linked cystine bridges
EP0622376B1 (en) * 1993-04-27 2001-08-08 Hoechst Aktiengesellschaft Amorphous monospheric forms of insulin derivatives
AU1272295A (en) * 1993-12-17 1995-07-03 Novo Nordisk A/S Proinsulin-like compounds
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
DE4405179A1 (en) * 1994-02-18 1995-08-24 Hoechst Ag Method of obtaining insulin with correctly connected cystine bridges
ES2196164T3 (en) 1995-07-25 2003-12-16 Novartis Ag BETA TRANSFORMABLE GROWTH FACTOR CRYSTALS.
DE19544233A1 (en) * 1995-11-28 1997-06-05 Hoechst Ag Process for using the yeast ADH II promoter system for the biotechnological production of heterologous proteins in high yields
PT821006E (en) 1996-07-26 2004-09-30 Aventis Pharma Gmbh INSULIN DERIVATIVES WITH ENHANCED ZINC LINK
DE19825447A1 (en) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh New insulin analogues with increased zinc formation
DE19915938A1 (en) * 1999-04-09 2000-10-19 Aventis Pharma Gmbh Production of pancreatic procarboxypeptidase B, isoforms and muteins thereof and their use
DE10108100A1 (en) * 2001-02-20 2002-08-29 Aventis Pharma Gmbh Use of super-secretable peptides in processes for their preparation and parallel improvement of the export of one or more other polypeptides of interest
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
ES2500918T3 (en) 2001-12-21 2014-10-01 Human Genome Sciences, Inc. Albumin and interferon beta fusion proteins
CA2514416C (en) * 2003-01-31 2012-08-14 Akzo Nobel N.V. Method for protein isolation in anoxic conditions
PL2307441T3 (en) 2008-08-07 2016-09-30 A process for preparation of insulin compounds
RU2447149C1 (en) * 2011-03-24 2012-04-10 Винсорт Менеджемент Инк RECOMBINANT PLASMID DNA pMSIN4, CODING HYBRIDE POLYPEPTIDE - HUMAN INSULIN PRECURSOR, BL21(DE3)VpMSIN4-PRODUCER STRAIN OF RECOMBINANT HUMAN INSULIN, METHOD FOR PRODUCING RECOMBINANT HUMAN INSULIN
DK2739646T3 (en) 2011-05-10 2018-02-26 Stefan Hermann COMPREHENSIVE BUFFER SYSTEM FOR RENATURING HUMAN PROINSULIN OR PROINSULIN DERIVATIVES
CN102849910A (en) * 2012-10-10 2013-01-02 清华大学深圳研究生院 Method for recovering humic acid from sludge and improving anaerobic digestion of sludge

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3326473A1 (en) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt PHARMACEUTICAL AGENT FOR TREATING THE DIABETES MELLITUS
DK58285D0 (en) * 1984-05-30 1985-02-08 Novo Industri As PEPTIDES AND MANUFACTURING AND USING THEREOF
DK129385A (en) * 1985-03-22 1986-09-23 Novo Industri As PEPTIDES AND PREPARATION THEREOF
DK437786D0 (en) * 1986-09-12 1986-09-12 Nordisk Gentofte insulin precursors
US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production
US4992418A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin

Also Published As

Publication number Publication date
DE58906966D1 (en) 1994-03-24
NO892597D0 (en) 1989-06-22
KR0139629B1 (en) 1998-07-01
ATE101620T1 (en) 1994-03-15
FI102076B1 (en) 1998-10-15
EP0347781A2 (en) 1989-12-27
FI893046A0 (en) 1989-06-21
DK175182B1 (en) 2004-06-28
JP3043764B2 (en) 2000-05-22
DK309989D0 (en) 1989-06-22
ES2061797T3 (en) 1994-12-16
EP0347781B1 (en) 1994-02-16
AU3671889A (en) 1990-01-04
HUT52548A (en) 1990-07-28
ZA894742B (en) 1990-03-28
CA1341211C (en) 2001-03-27
KR910000796A (en) 1991-01-30
JPH0285298A (en) 1990-03-26
EP0347781A3 (en) 1990-05-09
HU214704B (en) 2000-03-28
NZ229645A (en) 1991-02-26
NO302376B1 (en) 1998-02-23
IL90694A0 (en) 1990-01-18
HU211552A9 (en) 1995-12-28
NO892597L (en) 1989-12-27
PT90939B (en) 1994-11-30
FI102076B (en) 1998-10-15
IL90694A (en) 1995-07-31
HK1006023A1 (en) 1999-02-05
IE892032L (en) 1989-12-23
DK309989A (en) 1989-12-24
IE62511B1 (en) 1995-02-08
PT90939A (en) 1989-12-29
AU611303B2 (en) 1991-06-06

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: HOECHST AKTIENGESELLSCHAFT