DK309989D0 - MINI-PROINSULIN, ITS MANUFACTURING AND USE - Google Patents

MINI-PROINSULIN, ITS MANUFACTURING AND USE

Info

Publication number
DK309989D0
DK309989D0 DK309989A DK309989A DK309989D0 DK 309989 D0 DK309989 D0 DK 309989D0 DK 309989 A DK309989 A DK 309989A DK 309989 A DK309989 A DK 309989A DK 309989 D0 DK309989 D0 DK 309989D0
Authority
DK
Denmark
Prior art keywords
proinsulin
mini
insulin
chain
converted
Prior art date
Application number
DK309989A
Other languages
Danish (da)
Other versions
DK175182B1 (en
DK309989A (en
Inventor
Michael Doerschug
Paul Habermann
Gerhard Seipke
Eugen Uhlmann
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK309989D0 publication Critical patent/DK309989D0/en
Publication of DK309989A publication Critical patent/DK309989A/en
Application granted granted Critical
Publication of DK175182B1 publication Critical patent/DK175182B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A mini-proinsulin in which the A and B chains are linked by the amino acid Arg in place of the C chain has insulin activity and is suitable for producing medicaments for the treatment of diabetes mellitus. It can also be converted straightforwardly with trypsin into an insulin derivative whose B chain is extended by Arg. The latter can be converted with carboxypeptidase B into insulin. However, it is also possible and advantageous to convert the mini-proinsulin directly into insulin in a one-pot process.
DK198903099A 1988-06-23 1989-06-22 Mini-proinsulin, this compound for use as a drug, drug containing the compound, use of the compound for the preparation of mono-Arg insulin, method of preparation of the compound, DNA encoding the compound ...... DK175182B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3821159 1988-06-23
DE3821159 1988-06-23

Publications (3)

Publication Number Publication Date
DK309989D0 true DK309989D0 (en) 1989-06-22
DK309989A DK309989A (en) 1989-12-24
DK175182B1 DK175182B1 (en) 2004-06-28

Family

ID=6357053

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198903099A DK175182B1 (en) 1988-06-23 1989-06-22 Mini-proinsulin, this compound for use as a drug, drug containing the compound, use of the compound for the preparation of mono-Arg insulin, method of preparation of the compound, DNA encoding the compound ......

Country Status (18)

Country Link
EP (1) EP0347781B1 (en)
JP (1) JP3043764B2 (en)
KR (1) KR0139629B1 (en)
AT (1) ATE101620T1 (en)
AU (1) AU611303B2 (en)
CA (1) CA1341211C (en)
DE (1) DE58906966D1 (en)
DK (1) DK175182B1 (en)
ES (1) ES2061797T3 (en)
FI (1) FI102076B1 (en)
HK (1) HK1006023A1 (en)
HU (3) HUT52548A (en)
IE (1) IE62511B1 (en)
IL (1) IL90694A (en)
NO (1) NO302376B1 (en)
NZ (1) NZ229645A (en)
PT (1) PT90939B (en)
ZA (1) ZA894742B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885163A (en) * 1987-02-24 1989-12-05 Eli Lilly And Company Topical use of IGF-II for wound healing
US5227293A (en) * 1989-08-29 1993-07-13 The General Hospital Corporation Fusion proteins, their preparation and use
US5358857A (en) * 1989-08-29 1994-10-25 The General Hospital Corp. Method of preparing fusion proteins
NZ239652A (en) * 1990-09-05 1992-09-25 Hoechst Ag Hydrolysis of preproinsulin to insulin and analogues using clostripain and optionally carboxypeptidase
ZA928916B (en) * 1991-11-26 1994-05-18 Lilly Co Eli Tri-arginine insulins
DE59305396D1 (en) 1992-12-02 1997-03-20 Hoechst Ag Process for obtaining proinsulin with correctly connected cystine bridges
ATE203998T1 (en) * 1993-04-27 2001-08-15 Hoechst Ag AMORPHOUS MONOSPHERIC FORMS OF INSULIN DERIVATIVES
WO1995016708A1 (en) * 1993-12-17 1995-06-22 Novo Nordisk A/S Proinsulin-like compounds
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
DE4405179A1 (en) * 1994-02-18 1995-08-24 Hoechst Ag Method of obtaining insulin with correctly connected cystine bridges
AU6700696A (en) 1995-07-25 1997-02-26 Novartis Ag Transforming growth factor beta crystals
DE19544233A1 (en) * 1995-11-28 1997-06-05 Hoechst Ag Process for using the yeast ADH II promoter system for the biotechnological production of heterologous proteins in high yields
ATE264871T1 (en) 1996-07-26 2004-05-15 Aventis Pharma Gmbh INSULIN DERIVATIVES WITH INCREASED ZINC BINDING
DE19825447A1 (en) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh New insulin analogues with increased zinc formation
DE19915938A1 (en) * 1999-04-09 2000-10-19 Aventis Pharma Gmbh Production of pancreatic procarboxypeptidase B, isoforms and muteins thereof and their use
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
DE10108100A1 (en) * 2001-02-20 2002-08-29 Aventis Pharma Gmbh Use of super-secretable peptides in processes for their preparation and parallel improvement of the export of one or more other polypeptides of interest
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
EP2277889B1 (en) 2001-12-21 2014-07-09 Human Genome Sciences, Inc. Fusion proteins of albumin and interferon beta
EP1592703B1 (en) * 2003-01-31 2008-06-04 N.V. Organon Method for protein isolation in anoxic conditions
ES2570937T3 (en) 2008-08-07 2016-05-23 Biocon Ltd A process for the preparation of insulin compounds
RU2447149C1 (en) * 2011-03-24 2012-04-10 Винсорт Менеджемент Инк RECOMBINANT PLASMID DNA pMSIN4, CODING HYBRIDE POLYPEPTIDE - HUMAN INSULIN PRECURSOR, BL21(DE3)VpMSIN4-PRODUCER STRAIN OF RECOMBINANT HUMAN INSULIN, METHOD FOR PRODUCING RECOMBINANT HUMAN INSULIN
DK2739646T3 (en) 2011-05-10 2018-02-26 Stefan Hermann COMPREHENSIVE BUFFER SYSTEM FOR RENATURING HUMAN PROINSULIN OR PROINSULIN DERIVATIVES
CN102849910A (en) * 2012-10-10 2013-01-02 清华大学深圳研究生院 Method for recovering humic acid from sludge and improving anaerobic digestion of sludge

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3326473A1 (en) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt PHARMACEUTICAL AGENT FOR TREATING THE DIABETES MELLITUS
DK58285D0 (en) * 1984-05-30 1985-02-08 Novo Industri As PEPTIDES AND MANUFACTURING AND USING THEREOF
DK129385A (en) * 1985-03-22 1986-09-23 Novo Industri As PEPTIDES AND PREPARATION THEREOF
DK437786D0 (en) * 1986-09-12 1986-09-12 Nordisk Gentofte insulin precursors
US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production
US4992418A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin

Also Published As

Publication number Publication date
FI102076B (en) 1998-10-15
EP0347781A2 (en) 1989-12-27
NO892597D0 (en) 1989-06-22
PT90939B (en) 1994-11-30
JP3043764B2 (en) 2000-05-22
PT90939A (en) 1989-12-29
HK1006023A1 (en) 1999-02-05
NO302376B1 (en) 1998-02-23
FI893046A (en) 1989-12-24
IE62511B1 (en) 1995-02-08
HU214704B (en) 2000-03-28
AU611303B2 (en) 1991-06-06
IE892032L (en) 1989-12-23
KR0139629B1 (en) 1998-07-01
ATE101620T1 (en) 1994-03-15
IL90694A0 (en) 1990-01-18
ES2061797T3 (en) 1994-12-16
HUT52548A (en) 1990-07-28
FI893046A0 (en) 1989-06-21
FI102076B1 (en) 1998-10-15
AU3671889A (en) 1990-01-04
DE58906966D1 (en) 1994-03-24
DK175182B1 (en) 2004-06-28
KR910000796A (en) 1991-01-30
EP0347781A3 (en) 1990-05-09
NZ229645A (en) 1991-02-26
IL90694A (en) 1995-07-31
HU211552A9 (en) 1995-12-28
EP0347781B1 (en) 1994-02-16
CA1341211C (en) 2001-03-27
NO892597L (en) 1989-12-27
ZA894742B (en) 1990-03-28
JPH0285298A (en) 1990-03-26
DK309989A (en) 1989-12-24

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Legal Events

Date Code Title Description
PUP Patent expired