FI890127A0 - A process for preparing a therapeutically useful hirudin derivative - Google Patents

A process for preparing a therapeutically useful hirudin derivative

Info

Publication number
FI890127A0
FI890127A0 FI890127A FI890127A FI890127A0 FI 890127 A0 FI890127 A0 FI 890127A0 FI 890127 A FI890127 A FI 890127A FI 890127 A FI890127 A FI 890127A FI 890127 A0 FI890127 A0 FI 890127A0
Authority
FI
Finland
Prior art keywords
preparing
hirudin derivative
therapeutically useful
hirudin
derivative
Prior art date
Application number
FI890127A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI890127A (en
FI96956C (en
FI96956B (en
Inventor
Peter Crause
Paul Habermann
Dominique Tripier
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25865106&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI890127(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from HU851341A external-priority patent/HU198085B/en
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI890127A0 publication Critical patent/FI890127A0/en
Publication of FI890127A publication Critical patent/FI890127A/en
Application granted granted Critical
Publication of FI96956B publication Critical patent/FI96956B/en
Publication of FI96956C publication Critical patent/FI96956C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A hirudin derivative which has the N-terminal amino-acid sequence Leu-Thr-Tyr-Thr-Asp has high biological activity. This hirudin derivative can be obtained very efficiently by production in genetically engineered yeasts.
FI890127A 1985-04-11 1989-01-11 A process for preparing a therapeutically useful hirudin derivative FI96956C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU851341A HU198085B (en) 1984-04-18 1985-04-11 Process for producing new hirudine derivatives with anticoagulant effect and pharmaceutical compositions comprising same as active ingredient
HU134185 1985-04-11
DE3805540 1988-02-23
DE3805540 1988-02-23

Publications (4)

Publication Number Publication Date
FI890127A0 true FI890127A0 (en) 1989-01-11
FI890127A FI890127A (en) 1989-07-14
FI96956B FI96956B (en) 1996-06-14
FI96956C FI96956C (en) 1996-09-25

Family

ID=25865106

Family Applications (1)

Application Number Title Priority Date Filing Date
FI890127A FI96956C (en) 1985-04-11 1989-01-11 A process for preparing a therapeutically useful hirudin derivative

Country Status (9)

Country Link
EP (1) EP0324712B1 (en)
AT (1) ATE87938T1 (en)
DE (2) DE19775033I2 (en)
DK (1) DK172350B1 (en)
ES (1) ES2055149T3 (en)
FI (1) FI96956C (en)
IL (1) IL88925A (en)
LU (1) LU90127I2 (en)
NL (1) NL970027I2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3835815A1 (en) * 1988-10-21 1990-04-26 Hoechst Ag NEW ISOHIRUDINE
EP0502962B1 (en) * 1989-12-01 1996-03-13 BASF Aktiengesellschaft Hirudinmuteins and their polyalkylene glycol conjugates
DE4140381A1 (en) * 1991-12-07 1993-06-09 Hoechst Ag, 6230 Frankfurt, De NEW SYNTHETIC ISOHIRUDINE WITH IMPROVED STABILITY
DE4404168A1 (en) * 1994-02-10 1995-08-17 Hoechst Ag Hirudin derivatives and process for their preparation
DE19529997C1 (en) 1995-08-16 1997-04-10 Hoechst Ag A method for inactivating carboxypeptidase Y in hirudin-containing culture broths
DE19543737A1 (en) * 1995-11-24 1997-05-28 Hoechst Ag Process for the ultrafiltration of biological matrices containing peptides or proteins
DE19544233A1 (en) 1995-11-28 1997-06-05 Hoechst Ag Process for using the yeast ADH II promoter system for the biotechnological production of heterologous proteins in high yields
DE69624087T2 (en) 1996-01-31 2003-06-05 Sumitomo Bakelite Co Method of manufacturing semiconductor device encapsulated in epoxy resin
DE19607239A1 (en) 1996-02-27 1997-08-28 Behringwerke Ag Pharmaceutical composition containing hirudin and process for its preparation
DE19944870A1 (en) * 1999-09-18 2001-03-29 Aventis Pharma Gmbh Signal sequences for the production of Leu-hirudin via secretion by E. coli in the culture medium
DE10033195A1 (en) * 2000-07-07 2002-03-21 Aventis Pharma Gmbh Bifunctional fusion proteins from hirudin and TAP
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
JP2006096668A (en) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd Medicine comprising combination of elastase inhibitor with enzyme inhibitor of blood coagulation system and/or fibrinolysis system

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438296A1 (en) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt NEW POLYPEPTIDES WITH A BLOOD-CLOTHING EFFECT, METHOD FOR THE PRODUCTION OR THEIR RECOVERY, THEIR USE AND THE CONTAINERS THEREOF
EP0209061B1 (en) * 1985-07-17 1994-01-12 Hoechst Aktiengesellschaft Peptides having an anticoagulant activity, process for their preparation, obtention, their use and agents containing them

Also Published As

Publication number Publication date
DK13189D0 (en) 1989-01-12
DE58903988D1 (en) 1993-05-13
IL88925A (en) 1995-11-27
NL970027I1 (en) 1997-10-01
EP0324712A2 (en) 1989-07-19
EP0324712A3 (en) 1990-07-04
FI890127A (en) 1989-07-14
FI96956C (en) 1996-09-25
ATE87938T1 (en) 1993-04-15
LU90127I2 (en) 1997-10-06
DK172350B1 (en) 1998-04-06
ES2055149T3 (en) 1994-08-16
DE19775033I2 (en) 2011-01-20
EP0324712B1 (en) 1993-04-07
NL970027I2 (en) 1998-04-01
FI96956B (en) 1996-06-14
DK13189A (en) 1989-07-14

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Legal Events

Date Code Title Description
BB Publication of examined application
ND Supplementary protection certificate (spc) granted
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L92

Extension date: 20120313

FG Patent granted

Owner name: SCHERING AKTIENGESELLSCHAFT

MA Patent expired